分子生理与生物物理实验室
summary
郭江涛，浙江大学“****”研究员，博士生导师，海外高层次人才项目入选者，研究方向为分子生理与生物物理学。实验室主要采用冷冻电镜、X射线晶体学等生物物理和生物化学方法研究离子通道、离子转运蛋白等膜蛋白的结构生物学。实验室近年来在膜蛋白结构生物学领域做出了一系列出色研究成果，以第一作者或通讯作者在国际顶级期刊Nature、Science等杂志发表了多篇重要研究论文。
学习和工作经历：
2003.9-2007.6浙江大学生命科学学院理学学士
2013.12-2018.1美国德州大学西南医学中心\/霍华德休斯医学研究院 博士后
2018.1至今浙江大学医学院基础医学系\/邵逸夫医院病理科 研究员博士生导师
发表论文 (* Corresponding Authors, # First Authors)
2018年至今
1 Xie Y, Chang S, Zhao C, Wang F, Liu S, Wang J, Delpire E*, Ye S*, Guo J*. Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv 6, eabc5883 (2020).
2. Liu J, Wan F, Jin Q, Li X, Bhat EA, Guo J, Lei M, Guan F*, Wu J*, Ye S*. Cryo-EM structures of human calcium homeostasis modulator 5. Cell Discov 6, 81 (2020).
3. Li X#, Zhang Q#, Guo P#, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H*, Guo J*. Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res doi.org\/10.1038\/s41422-020-00410-8 (2020).
4. Zhang B#, Jin Q#, Xu L #, Li N #, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N*, Zhang X*, Yang F*, Guo J*, Ye S*. Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun 11, 2429 (2020)
5. Jin Q#, Zhang B#, Zheng X#, Li N#, Xu L, Xie Y, Song F, Bhat EA, Chen Y, Gao N, Guo, J*, Zhang X*, Ye S*. Cryo-EM structures of human pannexin 1 channel. Cell Res 30, 449–451 (2020).
6. Delpire E*, Guo J. Cryo-EM structures of DrNKCC1 and hKCC1: a new milestone in the physiology of cation-chloride cotransporters. American Journal of Physiology - Cell Physiology 318(2): C225-C237 (2020).
7. Liu S#, Chang S#, Han B#, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J*, Delpire E*, Ye S*, Bai X*, Guo J*. Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science 366, 505–508 (2019)
8. She J, Zeng W, Guo J, Chen Q, Bai X*, Jiang Y*. Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife 2019 Mar 12;8. pii: e45222. doi: 10.7554\/eLife.45222 (2019).
9. She J#, Guo J#, Chen Q#, Zeng W, Jiang Y*, Bai X*. Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130-134 (2018)
2018年之前
10. Guo J#, She J#, Zeng W, Chen Q, Bai X*, Jiang Y*. Structures of the Calcium-activated Non-Selective Cation Channel TRPM4. Nature 552: 205–209 (2017)
11. Chen Q#, She J#, Zeng W, Guo J, Xu H, Bai X*, Jiang Y*. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550:415-418 (2017)
12. Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, and Jiang Y*. The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature 547: 472-475 (2017)
13. Guo J, Zeng W, Jiang Y*. Tuning the ion selectivity of two-pore channels. Proc Natl Acad Sci USA 114(5):1009-1014 (2017)
14. Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y*. Structure of the voltage-gated two-pore channel from Arabidopsis thaliana. Nature 531:196–201 (2016)
15. Wei X, Guo J, Li M and Liu Z*. Structural mechanism underlying the specific recognition between the Arabidopsis state-transition phosphatase TAP38\/PPH1 and phosphorylated light-harvesting complex protein Lhcb1. The Plant Cell 27(4):1113-27 (2015)
16. Guo J, Wei X, Li M, Pan X, Chang W* and Liu Z*. Structure of the catalytic domain of a State transition kinase homolog from Micromonas algae. Protein Cell 4(8):607-19 (2013)
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1. 离子通道的结构生物学\r2. 离子转运蛋白的结构生物学\r3. 离子通道和转运蛋白的靶向药物研究
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2018-05-06 00:15:55
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浙江大学“****”特聘研究员，博士生导师，主要采用冷冻电镜、X射线晶体学和电生理等方法研究离子通道等膜蛋白的结构生物学。近年来在离子通道结构生物学领域做出了一系列出色研究成果，在国际顶级期刊发表了多篇重要研究论文，包括3篇第一作者的Nature研究论文和1篇PNAS研究论文。
学习和工作经历：
2003.9-2007.6浙江大学生命科学学院理学学士
2013.12-2018.1美国德州大学西南医学中心\/霍华德休斯医学研究院 博士后
2018.1至今浙江大学医学院研究员博士生导师
近5年发表的主要论文：
1.She J*, Guo J*, Chen Q*, Zeng W, Jiang Y, Bai X. Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature556,130-134(2018)(*co-first authors)
2.Guo J*, She J*, Zeng W, Chen Q, Bai X, Jiang Y. Structures of the Calcium-activated Non-Selective Cation Channel TRPM4. Nature552:205–209 (2017) (*co-first authors)
3. Chen Q*, She J*, Zeng W, Guo J, Xu H, Bai X, Jiang Y. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature550:415-418 (2017) (* co-first authors)
4. Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, and Jiang Y. The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature 547: 472-475 (2017)
5. Guo J, Zeng W, Jiang Y. Tuning the ion selectivity of two-pore channels. Proc Natl Acad Sci USA114(5):1009-1014 (2017)
6. Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y. Structure of the voltage-gated two-pore channel from Arabidopsis thaliana. Nature531:196–201 (2016)
7. Wei X, Guo J, Li M and Liu Z. Structural mechanism underlying the specific recognition between the Arabidopsisstate-transition phosphatase TAP38\/PPH1 and phosphorylated light-harvesting complex protein Lhcb1. The Plant Cell27(4):1113-27 (2015)
8. Guo J, Wei X, Li M, Pan X, Chang W and Liu Z. Structure of the catalytic domain of a State transition kinase homolog from Micromonasalgae. Protein Cell4(8):607-19 (2013)
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jiangtaoguo(AT)zju.edu.cn （将AT替换为@）
address
浙大紫金港医学院教学楼C307
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6896
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guo_jiangtao_lab1
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2021-01-24 17:14:52
content
郭江涛，浙江大学“****”研究员，博士生导师，海外高层次人才项目入选者，研究方向为分子生理与生物物理学。实验室主要采用冷冻电镜、X射线晶体学等生物物理和生物化学方法研究离子通道、离子转运蛋白等膜蛋白的结构生物学。实验室近年来在膜蛋白结构生物学领域做出了一系列出色研究成果，以第一作者或通讯作者在国际顶级期刊Nature、Science等杂志发表了多篇重要研究论文。
学习和工作经历：
2003.9-2007.6浙江大学生命科学学院理学学士
2013.12-2018.1美国德州大学西南医学中心\/霍华德休斯医学研究院 博士后
2018.1至今浙江大学医学院基础医学系\/邵逸夫医院病理科 研究员博士生导师
发表论文 (* Corresponding Authors, # First Authors)
2018年至今
1 Xie Y, Chang S, Zhao C, Wang F, Liu S, Wang J, Delpire E*, Ye S*, Guo J*. Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv 6, eabc5883 (2020).
2. Liu J, Wan F, Jin Q, Li X, Bhat EA, Guo J, Lei M, Guan F*, Wu J*, Ye S*. Cryo-EM structures of human calcium homeostasis modulator 5. Cell Discov 6, 81 (2020).
3. Li X#, Zhang Q#, Guo P#, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang H*, Guo J*. Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res doi.org\/10.1038\/s41422-020-00410-8 (2020).
4. Zhang B#, Jin Q#, Xu L #, Li N #, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N*, Zhang X*, Yang F*, Guo J*, Ye S*. Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun 11, 2429 (2020)
5. Jin Q#, Zhang B#, Zheng X#, Li N#, Xu L, Xie Y, Song F, Bhat EA, Chen Y, Gao N, Guo, J*, Zhang X*, Ye S*. Cryo-EM structures of human pannexin 1 channel. Cell Res 30, 449–451 (2020).
6. Delpire E*, Guo J. Cryo-EM structures of DrNKCC1 and hKCC1: a new milestone in the physiology of cation-chloride cotransporters. American Journal of Physiology - Cell Physiology 318(2): C225-C237 (2020).
7. Liu S#, Chang S#, Han B#, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J*, Delpire E*, Ye S*, Bai X*, Guo J*. Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science 366, 505–508 (2019)
8. She J, Zeng W, Guo J, Chen Q, Bai X*, Jiang Y*. Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife 2019 Mar 12;8. pii: e45222. doi: 10.7554\/eLife.45222 (2019).
9. She J#, Guo J#, Chen Q#, Zeng W, Jiang Y*, Bai X*. Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130-134 (2018)
2018年之前
10. Guo J#, She J#, Zeng W, Chen Q, Bai X*, Jiang Y*. Structures of the Calcium-activated Non-Selective Cation Channel TRPM4. Nature 552: 205–209 (2017)
11. Chen Q#, She J#, Zeng W, Guo J, Xu H, Bai X*, Jiang Y*. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550:415-418 (2017)
12. Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, and Jiang Y*. The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature 547: 472-475 (2017)
13. Guo J, Zeng W, Jiang Y*. Tuning the ion selectivity of two-pore channels. Proc Natl Acad Sci USA 114(5):1009-1014 (2017)
14. Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y*. Structure of the voltage-gated two-pore channel from Arabidopsis thaliana. Nature 531:196–201 (2016)
15. Wei X, Guo J, Li M and Liu Z*. Structural mechanism underlying the specific recognition between the Arabidopsis state-transition phosphatase TAP38\/PPH1 and phosphorylated light-harvesting complex protein Lhcb1. The Plant Cell 27(4):1113-27 (2015)
16. Guo J, Wei X, Li M, Pan X, Chang W* and Liu Z*. Structure of the catalytic domain of a State transition kinase homolog from Micromonas algae. Protein Cell 4(8):607-19 (2013)
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