summary
1982年 获浙江医科大学医学学士学位
\r1988年 获浙江医科大学医学硕士学位
\r1998年 获香港大学博士学位
\r1998-2005,美国辛辛那提大学,加拿大卡尔加里大学博士后
\r2005-2008,加拿大卡尔加里大学Assistant Professor
\r2009年至今 浙江大学教授,博士生导师
\r在Diabetes, Molecular Aspects of Medicine, FASEB Journal, Journal of Biological Chemistry, Journal of Molecular Medicine, American Journal of Physiology, Journal of Pharmacology & Experimental Therapeutics, Biophysical Journal, British Journal of Pharmacology, Journal of Clinical Endocrinology & Metabolism, Biology of Reproduction, Human Reproduction, Fertility & Sterility等SCI杂志发表论文数十篇。
\r主要研究兴趣:FSHR与更年期血管功能紊乱;胚胎着床机制;胚胎干细胞分化
\r主要研究平台:实验室隶属生殖遗传教育部重点实验室。拥有离子荧光成像,荧光显微镜,膜片钳,细胞内微注射,小血管收缩,无创伤小动物动脉血压检测,实时RNA检测,酶标仪,以及其它分子生物学,生物化学和生理学实验设备。
\r在研基金:
\r1. 国家重点基础研究发展计划(973计划):辅助生殖诱发胚胎源性疾病的风险评估和机制研究No.2012CB944900-2012CB944903,250万,2012.1-2016.12。子项目研究ART出生子代心血管疾病相关因子表达异常的分子调控机制研究。
\r2. 国家重点基础研究发展计划(973计划):雌性生育力维持调节机制研究及生殖资源库建立No.2011CB944500-2011CB944502,250万,2011.1-2015.12。子项目研究卵母细胞中水通道在卵母细胞冰冻保存中的作用。
\r3.国家自然科学基金: 血管内皮细胞FSH受体介导的更年期血管功能紊乱的分子机制研究。No.**,32万,2011.1-2013.12。
\r4.浙江省自然科学基金: No.Y**, 10万,2010.10-2013.9。
\r5.教育部博士点基金:6万,2011-2013
\r6.浙江省卫生厅生殖医学研究团队建设基金:50万,2010-2014。
\r2009年后发表SCI论文
\r1.Ding GL, Wang FF, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PCK, Sheng JZ(共同通讯作者), Huang HF. Transgenerational Glucose intolerance with Igf2\/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes 2012 March [Epub ahead of print]. doi: 10.2337\/db11-1314(SCI收录,IF8.889)
\r2.Zhang RJ, Zou LB, Zhang D, Tan YJ, Wang TT, Liu AX, Qu F, Meng Y, Ding GL, Lu YC, Lv PP, Sheng JZ(共同通讯作者), Huang HF. Functional Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Endometrium: A Novel Mechanism Involved in Endometrial Receptivity and Embryo Implantation. J Clin Endocrinol Metab. 2012 Feb;97(2):543-53(SCI收录,IF6.495)
\r3.Zhang D, Tan YJ, Qu F, Sheng JZ, Huang HF. Functions of water channels in male and female reproductive systems. Molecular Aspects of Medicine 2012 March [Epub ahead of print],doi.org\/10.1016\/j.mam.2012.02.002(SCI收录,IF10.552)
\r4.Qu F, Wang FF, Yin R, Ding GL, El-prince M, Gao Q, Shi BW, Pan HH, Huang YT, Jin M, Leung PCK, Sheng JZ, Huang HF. A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: Hyperandrogenism induces epigenetic alterations in the granulosa cells. J Mol Med. 2012 March [Epub ahead of print],doi: 10.1007\/s00109-012-0881-4(SCI收录,IF5.192)
\r5.Lu YC, Ding GL, Yang J, Zhang YL, Shi S, Zhang RJ, Zhang D, Pan JX, Sheng JZ, Huang HF. Small-conductance calcium-activated K+ channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration. Hum Reprod. 2012 March [Epub ahead of print],doi: 10.1093\/humrep\/des060(SCI收录,IF4.357)
\r6.Zou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, He RH, Liu AX, Wang TT, Leung PC, Sheng JZ(共同通讯作者), Huang HF. Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab. 2011 Sep;96(9):E1399-408.(SCI收录,IF6.495)
\r7.Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PC, Huang HF. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab. 2011 Mar;96(3):E493-7.(SCI收录,IF6.495)
\r8.Raqeeb A, Sheng J, Ao N, Braun AP. Purinergic P2Y2 receptors mediate rapid Ca(2+) mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium. 2011 Apr;49(4):240-8.(SCI收录,IF3.553)
\r9.Feng C, Tian S, Zhang Y, He J, Zhu XM, Zhang D, Sheng JZ, Huang HF. General imprinting status is stable in assisted reproduction-conceived offspring. Fertil Steril. 2011 Dec;96(6):1417-1423.e9.(SCI收录,IF3.958)
\r10.Zhang D, Lv P, Zhang R, Luo Q, Ding G, Yin L, Li J, Xu G, Qu F, Sheng J, Huang H. A new model for embryo implantation: coculture of blastocysts and Ishikawa cells. Gynecol Endocrinol. 2011 Nov 22. [Epub ahead of print](SCI收录,IF1.461)
\r11.Wang N, Wang L, Le F, Zhan Q, Zheng Y, Ding G, Chen X, Sheng J, Dong M, Huang H, Jin F. Altered expression of Armet and Mrlp
\r12.Li L, Wang L, Xu X, Lou H, Le F, Li L, Sheng J, Huang H, Jin F. Genome-wide DNA methylation patterns in IVF-conceived mice and their progeny: a putative model for ART-conceived humans. Reprod Toxicol. 2011 Jul;32(1):98-105.(SCI收录,IF3.137)
\r13.Li L, Wang L, Le F, Liu X, Yu P, Sheng J, Huang H, Jin F. Evaluation of DNA methylation status at differentially methylated regions in IVF-conceived newborn twins. Fertil Steril. 2011 May;95(6):1975-9.(SCI收录,IF3.958)
\r14.Wang TT, Wu YT, Dong MY, Sheng JZ, Leung PC, Huang HF. G
\r15.Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin
\r16.Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun AP, Davis GE, Davis MJ. Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation. J Biol Chem. 2010 Jan 1;285(1):131-41.(SCI收录,IF5.520)
\r17.Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PC, Sheng JZ, Huang HF. Involvement of cyclin B
\r18.Sheng JZ, Ella S, Hill M, Davis M, Braun A. Openers of SKCa and IKCa Channels Enhance Agonist-evoked Endothelial Nitric Oxide Synthesis and Arteriolar Vasodilation. FASEB J. 2009 Apr;23(4):1138-45.(SCI收录,IF7.049)
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主要研究方向:1. 更年期血管功能紊乱的分子机制\r 2. 胚胎着床机制\r
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1982年 获浙江医科大学医学学士学位
\r1988年 获浙江医科大学医学硕士学位
\r1998年 获香港大学博士学位
\r1998-2005,美国辛辛那提大学,加拿大卡尔加里大学博士后
\r2005-2008,加拿大卡尔加里大学Assistant Professor
\r2009年至今 浙江大学教授,博士生导师
\r在Diabetes, Molecular Aspects of Medicine, FASEB Journal, Journal of Biological Chemistry, Journal of Molecular Medicine, American Journal of Physiology, Journal of Pharmacology & Experimental Therapeutics, Biophysical Journal, British Journal of Pharmacology, Journal of Clinical Endocrinology & Metabolism, Biology of Reproduction, Human Reproduction, Fertility & Sterility等SCI杂志发表论文数十篇。
\r主要研究兴趣:FSHR与更年期血管功能紊乱;胚胎着床机制;胚胎干细胞分化
\r主要研究平台:实验室隶属生殖遗传教育部重点实验室。拥有离子荧光成像,荧光显微镜,膜片钳,细胞内微注射,小血管收缩,无创伤小动物动脉血压检测,实时RNA检测,酶标仪,以及其它分子生物学,生物化学和生理学实验设备。
\r在研基金:
\r1. 国家重点基础研究发展计划(973计划):辅助生殖诱发胚胎源性疾病的风险评估和机制研究No.2012CB944900-2012CB944903,250万,2012.1-2016.12。子项目研究ART出生子代心血管疾病相关因子表达异常的分子调控机制研究。
\r2. 国家重点基础研究发展计划(973计划):雌性生育力维持调节机制研究及生殖资源库建立No.2011CB944500-2011CB944502,250万,2011.1-2015.12。子项目研究卵母细胞中水通道在卵母细胞冰冻保存中的作用。
\r3.国家自然科学基金: 血管内皮细胞FSH受体介导的更年期血管功能紊乱的分子机制研究。No.**,32万,2011.1-2013.12。
\r4.浙江省自然科学基金: No.Y**, 10万,2010.10-2013.9。
\r5.教育部博士点基金:6万,2011-2013
\r6.浙江省卫生厅生殖医学研究团队建设基金:50万,2010-2014。
\r2009年后发表SCI论文
\r1.Ding GL, Wang FF, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PCK, Sheng JZ(共同通讯作者), Huang HF. Transgenerational Glucose intolerance with Igf2\/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes 2012 March [Epub ahead of print]. doi: 10.2337\/db11-1314(SCI收录,IF8.889)
\r2.Zhang RJ, Zou LB, Zhang D, Tan YJ, Wang TT, Liu AX, Qu F, Meng Y, Ding GL, Lu YC, Lv PP, Sheng JZ(共同通讯作者), Huang HF. Functional Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Endometrium: A Novel Mechanism Involved in Endometrial Receptivity and Embryo Implantation. J Clin Endocrinol Metab. 2012 Feb;97(2):543-53(SCI收录,IF6.495)
\r3.Zhang D, Tan YJ, Qu F, Sheng JZ, Huang HF. Functions of water channels in male and female reproductive systems. Molecular Aspects of Medicine 2012 March [Epub ahead of print],doi.org\/10.1016\/j.mam.2012.02.002(SCI收录,IF10.552)
\r4.Qu F, Wang FF, Yin R, Ding GL, El-prince M, Gao Q, Shi BW, Pan HH, Huang YT, Jin M, Leung PCK, Sheng JZ, Huang HF. A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: Hyperandrogenism induces epigenetic alterations in the granulosa cells. J Mol Med. 2012 March [Epub ahead of print],doi: 10.1007\/s00109-012-0881-4(SCI收录,IF5.192)
\r5.Lu YC, Ding GL, Yang J, Zhang YL, Shi S, Zhang RJ, Zhang D, Pan JX, Sheng JZ, Huang HF. Small-conductance calcium-activated K+ channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration. Hum Reprod. 2012 March [Epub ahead of print],doi: 10.1093\/humrep\/des060(SCI收录,IF4.357)
\r6.Zou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, He RH, Liu AX, Wang TT, Leung PC, Sheng JZ(共同通讯作者), Huang HF. Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab. 2011 Sep;96(9):E1399-408.(SCI收录,IF6.495)
\r7.Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PC, Huang HF. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab. 2011 Mar;96(3):E493-7.(SCI收录,IF6.495)
\r8.Raqeeb A, Sheng J, Ao N, Braun AP. Purinergic P2Y2 receptors mediate rapid Ca(2+) mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium. 2011 Apr;49(4):240-8.(SCI收录,IF3.553)
\r9.Feng C, Tian S, Zhang Y, He J, Zhu XM, Zhang D, Sheng JZ, Huang HF. General imprinting status is stable in assisted reproduction-conceived offspring. Fertil Steril. 2011 Dec;96(6):1417-1423.e9.(SCI收录,IF3.958)
\r10.Zhang D, Lv P, Zhang R, Luo Q, Ding G, Yin L, Li J, Xu G, Qu F, Sheng J, Huang H. A new model for embryo implantation: coculture of blastocysts and Ishikawa cells. Gynecol Endocrinol. 2011 Nov 22. [Epub ahead of print](SCI收录,IF1.461)
\r11.Wang N, Wang L, Le F, Zhan Q, Zheng Y, Ding G, Chen X, Sheng J, Dong M, Huang H, Jin F. Altered expression of Armet and Mrlp
\r12.Li L, Wang L, Xu X, Lou H, Le F, Li L, Sheng J, Huang H, Jin F. Genome-wide DNA methylation patterns in IVF-conceived mice and their progeny: a putative model for ART-conceived humans. Reprod Toxicol. 2011 Jul;32(1):98-105.(SCI收录,IF3.137)
\r13.Li L, Wang L, Le F, Liu X, Yu P, Sheng J, Huang H, Jin F. Evaluation of DNA methylation status at differentially methylated regions in IVF-conceived newborn twins. Fertil Steril. 2011 May;95(6):1975-9.(SCI收录,IF3.958)
\r14.Wang TT, Wu YT, Dong MY, Sheng JZ, Leung PC, Huang HF. G
\r15.Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin
\r16.Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun AP, Davis GE, Davis MJ. Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation. J Biol Chem. 2010 Jan 1;285(1):131-41.(SCI收录,IF5.520)
\r17.Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PC, Sheng JZ, Huang HF. Involvement of cyclin B
\r18.Sheng JZ, Ella S, Hill M, Davis M, Braun A. Openers of SKCa and IKCa Channels Enhance Agonist-evoked Endothelial Nitric Oxide Synthesis and Arteriolar Vasodilation. FASEB J. 2009 Apr;23(4):1138-45.(SCI收录,IF7.049)
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shengjz@zju.edu.cn
address
浙大紫金港校区医学院研究B楼603室
research
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shengjz
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2021-01-25 03:57:33
content
1982年 获浙江医科大学医学学士学位
\r1988年 获浙江医科大学医学硕士学位
\r1998年 获香港大学博士学位
\r1998-2005,美国辛辛那提大学,加拿大卡尔加里大学博士后
\r2005-2008,加拿大卡尔加里大学Assistant Professor
\r2009年至今 浙江大学教授,博士生导师
\r在Diabetes, Molecular Aspects of Medicine, FASEB Journal, Journal of Biological Chemistry, Journal of Molecular Medicine, American Journal of Physiology, Journal of Pharmacology & Experimental Therapeutics, Biophysical Journal, British Journal of Pharmacology, Journal of Clinical Endocrinology & Metabolism, Biology of Reproduction, Human Reproduction, Fertility & Sterility等SCI杂志发表论文数十篇。
\r主要研究兴趣:FSHR与更年期血管功能紊乱;胚胎着床机制;胚胎干细胞分化
\r主要研究平台:实验室隶属生殖遗传教育部重点实验室。拥有离子荧光成像,荧光显微镜,膜片钳,细胞内微注射,小血管收缩,无创伤小动物动脉血压检测,实时RNA检测,酶标仪,以及其它分子生物学,生物化学和生理学实验设备。
\r在研基金:
\r1. 国家重点基础研究发展计划(973计划):辅助生殖诱发胚胎源性疾病的风险评估和机制研究No.2012CB944900-2012CB944903,250万,2012.1-2016.12。子项目研究ART出生子代心血管疾病相关因子表达异常的分子调控机制研究。
\r2. 国家重点基础研究发展计划(973计划):雌性生育力维持调节机制研究及生殖资源库建立No.2011CB944500-2011CB944502,250万,2011.1-2015.12。子项目研究卵母细胞中水通道在卵母细胞冰冻保存中的作用。
\r3.国家自然科学基金: 血管内皮细胞FSH受体介导的更年期血管功能紊乱的分子机制研究。No.**,32万,2011.1-2013.12。
\r4.浙江省自然科学基金: No.Y**, 10万,2010.10-2013.9。
\r5.教育部博士点基金:6万,2011-2013
\r6.浙江省卫生厅生殖医学研究团队建设基金:50万,2010-2014。
\r2009年后发表SCI论文
\r1.Ding GL, Wang FF, Shu J, Tian S, Jiang Y, Zhang D, Wang N, Luo Q, Zhang Y, Jin F, Leung PCK, Sheng JZ(共同通讯作者), Huang HF. Transgenerational Glucose intolerance with Igf2\/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes 2012 March [Epub ahead of print]. doi: 10.2337\/db11-1314(SCI收录,IF8.889)
\r2.Zhang RJ, Zou LB, Zhang D, Tan YJ, Wang TT, Liu AX, Qu F, Meng Y, Ding GL, Lu YC, Lv PP, Sheng JZ(共同通讯作者), Huang HF. Functional Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Endometrium: A Novel Mechanism Involved in Endometrial Receptivity and Embryo Implantation. J Clin Endocrinol Metab. 2012 Feb;97(2):543-53(SCI收录,IF6.495)
\r3.Zhang D, Tan YJ, Qu F, Sheng JZ, Huang HF. Functions of water channels in male and female reproductive systems. Molecular Aspects of Medicine 2012 March [Epub ahead of print],doi.org\/10.1016\/j.mam.2012.02.002(SCI收录,IF10.552)
\r4.Qu F, Wang FF, Yin R, Ding GL, El-prince M, Gao Q, Shi BW, Pan HH, Huang YT, Jin M, Leung PCK, Sheng JZ, Huang HF. A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: Hyperandrogenism induces epigenetic alterations in the granulosa cells. J Mol Med. 2012 March [Epub ahead of print],doi: 10.1007\/s00109-012-0881-4(SCI收录,IF5.192)
\r5.Lu YC, Ding GL, Yang J, Zhang YL, Shi S, Zhang RJ, Zhang D, Pan JX, Sheng JZ, Huang HF. Small-conductance calcium-activated K+ channels 3 (SK3) regulate blastocyst hatching by control of intracellular calcium concentration. Hum Reprod. 2012 March [Epub ahead of print],doi: 10.1093\/humrep\/des060(SCI收录,IF4.357)
\r6.Zou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, He RH, Liu AX, Wang TT, Leung PC, Sheng JZ(共同通讯作者), Huang HF. Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab. 2011 Sep;96(9):E1399-408.(SCI收录,IF6.495)
\r7.Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PC, Huang HF. Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss. J Clin Endocrinol Metab. 2011 Mar;96(3):E493-7.(SCI收录,IF6.495)
\r8.Raqeeb A, Sheng J, Ao N, Braun AP. Purinergic P2Y2 receptors mediate rapid Ca(2+) mobilization, membrane hyperpolarization and nitric oxide production in human vascular endothelial cells. Cell Calcium. 2011 Apr;49(4):240-8.(SCI收录,IF3.553)
\r9.Feng C, Tian S, Zhang Y, He J, Zhu XM, Zhang D, Sheng JZ, Huang HF. General imprinting status is stable in assisted reproduction-conceived offspring. Fertil Steril. 2011 Dec;96(6):1417-1423.e9.(SCI收录,IF3.958)
\r10.Zhang D, Lv P, Zhang R, Luo Q, Ding G, Yin L, Li J, Xu G, Qu F, Sheng J, Huang H. A new model for embryo implantation: coculture of blastocysts and Ishikawa cells. Gynecol Endocrinol. 2011 Nov 22. [Epub ahead of print](SCI收录,IF1.461)
\r11.Wang N, Wang L, Le F, Zhan Q, Zheng Y, Ding G, Chen X, Sheng J, Dong M, Huang H, Jin F. Altered expression of Armet and Mrlp
\r12.Li L, Wang L, Xu X, Lou H, Le F, Li L, Sheng J, Huang H, Jin F. Genome-wide DNA methylation patterns in IVF-conceived mice and their progeny: a putative model for ART-conceived humans. Reprod Toxicol. 2011 Jul;32(1):98-105.(SCI收录,IF3.137)
\r13.Li L, Wang L, Le F, Liu X, Yu P, Sheng J, Huang H, Jin F. Evaluation of DNA methylation status at differentially methylated regions in IVF-conceived newborn twins. Fertil Steril. 2011 May;95(6):1975-9.(SCI收录,IF3.958)
\r14.Wang TT, Wu YT, Dong MY, Sheng JZ, Leung PC, Huang HF. G
\r15.Qu F, Wang FF, Lu XE, Dong MY, Sheng JZ, Lv PP, Ding GL, Shi BW, Zhang D, Huang HF. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin
\r16.Yang Y, Wu X, Gui P, Wu J, Sheng JZ, Ling S, Braun AP, Davis GE, Davis MJ. Alpha5beta1 integrin engagement increases large conductance, Ca2+-activated K+ channel current and Ca2+ sensitivity through c-src-mediated channel phosphorylation. J Biol Chem. 2010 Jan 1;285(1):131-41.(SCI收录,IF5.520)
\r17.Tang L, Zhang Y, Pan H, Luo Q, Zhu XM, Dong MY, Leung PC, Sheng JZ, Huang HF. Involvement of cyclin B
\r18.Sheng JZ, Ella S, Hill M, Davis M, Braun A. Openers of SKCa and IKCa Channels Enhance Agonist-evoked Endothelial Nitric Oxide Synthesis and Arteriolar Vasodilation. FASEB J. 2009 Apr;23(4):1138-45.(SCI收录,IF7.049)
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