summary
(详细信息见:MY CV栏)
学术研究领域：适配体核酶由适配体与核酶构成。适配体不仅具备DNA 分子的丰富性、稳定性和对目标分子的高选择性，有望替代抗体，成为以分子识别为基础的生化诊断检验的优良载体；同时，核酶催化的微流控化学发光分析具有高灵敏、试样\/试剂消耗量小、分析时间短、平行性好、易与微型仪器结合等优点，且微通道与毛细血管微环境尺度的相近。一旦将微流控化学发光分析的特点与适配体的高特异性优势相结合，此分析方法有望超越经典的免疫分析，在临床生化分析领域的应用前景广阔。
研究生导师：本人2009年被聘为研究生导师；指导2013级学生邬期望完成论文“基于适配体核酶催化的微流控化学发光法在微量分析中的应用研究“，获2016年浙江省优秀硕士论文。
项目和奖励：主持国家自然科学基金面上项目（2010-2013）和浙江省自然科学基金面上项目（2016-2018）；获2008年教育部科学技术进步二等奖。作为骨干成员参与国家973项目、国家自然科学基金重大项目，国家自然科学基金仪器专项，浙江省自然科学基金项目等项目；编著学术专著和教材多部。
论著及其代表作：发表学术论文数十篇。主要论文如下：
1. Wu Y., Shen H.*.Selective neutrophil activation via a programmable stopped-flow injection approach: Multiple evidences of priming state of salivary polymorphonuclear neutrophils compared to circulatory polymorphonuclear neutrophils. Talanta. 2021. 222. 121449.
2. Xu H., Wu Q.,Shen H.*. A DNAzyme sensor based on target-catalyzed hairpin assembly for enzyme-free and non-label single nucleotide polymorphism genotyping. Talanta. 2017, 167, 630–637.
3. Shen H., Zhang B.,Xu H., Sun Y., Wu Q.,Shen H.*, Liu Y. Microfluidic-based G-quadruplex Ligand Displacement Assay for Alkaloid Anticancer Drug Screening. Journal of Pharmaceutical and Biochemical Analysis. 2017, 134 (5), 333-339.
4. Wu Q., Shen H., Shen H.*,Sun H., Song L.Study on Sensing Strategy and Performance of a Microfluidic Chemiluminescence Aptazyme Sensor. Talanta, 2016, 150(1), 531-538.
5. Wu Q., Shen H*.;NUPACK Prediction Assisted of Toehold Induced Strand Displacement Reaction for SNPs Genotyping with Microfluidic Chemiluminescence Detection. Chem. J. Chin. Univ., 2015, 36(12), 2386-2393.
6. Shen H., Dasgupta, P. K. Electrochemical Arsine Generators for Arsenic Determination. Anal. Chem., 2014, 86, 7705–7711
7. Song L. F., Pan X. Y., Shen H.*, Yu Y. L.; Microflow Injection Potassium Bioassay Based on Gquadruplex DNAzyme-enhanced Chemiluminescence. Luminescence, 2014, 29, 1066-1073.
8. Hu H. M., Yin X. F. Wang X Z., Shen H.*; A study on the system of nonaqueous microchip electrophoresis with on-line peroxyoxalate chemiluminescence detection. Journal of Separation Science, 2013, 36,713-720.
9. Song X. L., Shen H.*,Yin X. F., Wang X. Z., Cheng H. Y.; Microflow injection chemiluminescence of luminol and hypochlorite enhanced by phloxine B. Luminescence (The Journal of Biological and Chemical Luminescence), 2013, 28, 16-22.
10.Shen H.,Fang Q.,Fang Z. L.; A microfluidic chip based sequential injection system with trapped droplet liquid-liquid extraction and chemiluminescence detection. Lab on a Chip, 2006, 6, 1387–1389.
11. Shen H., Fang Q.; Improved microfluidic chip-based sequential-injection trapped-droplet array liquid-Liquid extraction system for determination of aluminium. Talanta, 2008, 77, 269-272.
12. Shen H., Ye M. Y., Fang Q., Yin X. F.; Multiphase laminar flow microfluidic chip with deep channel and charge coupled device photometric detection. Chinese Journal of Analytical Chemistry, 2005, 33, 1659-1662.
13. Shen H., Fang Q.; The Application of two kinds of liquidphase mass transfer in microfluidic analytical chip, Progress in Chemistry, 2008, 20, 2053-2060.
14. 第七章 微流控芯片的应用，微流控分析芯片，科学出版社，北京，2006.
15. 第25章 临床化学，第27章 基因时代——基因组和蛋白质组学：DNA测序和蛋白质分析，分析化学（原著第七版），华东理工大学出版社，2017.
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功能核酸相关生物和环境微量分析，微流控分析。
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2010-06-03 17:41:36
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(详细信息见:MY CV栏)
学术研究领域：适配体核酶由适配体与核酶构成。适配体不仅具备DNA 分子的丰富性、稳定性和对目标分子的高选择性，有望替代抗体，成为以分子识别为基础的生化诊断检验的优良载体；同时，核酶催化的微流控化学发光分析具有高灵敏、试样\/试剂消耗量小、分析时间短、平行性好、易与微型仪器结合等优点，且微通道与毛细血管微环境尺度的相近。一旦将微流控化学发光分析的特点与适配体的高特异性优势相结合，此分析方法有望超越经典的免疫分析，在临床生化分析领域的应用前景广阔。
研究生导师：本人2009年被聘为研究生导师；指导2013级学生邬期望完成论文“基于适配体核酶催化的微流控化学发光法在微量分析中的应用研究“，获2016年浙江省优秀硕士论文。
项目和奖励：主持国家自然科学基金面上项目（2010-2013）和浙江省自然科学基金面上项目（2016-2018）；获2008年教育部科学技术进步二等奖。作为骨干成员参与国家973项目、国家自然科学基金重大项目，国家自然科学基金仪器专项，浙江省自然科学基金项目等项目；编著学术专著和教材多部。
论著及其代表作：发表学术论文数十篇。主要论文如下：
1. Xu H., Wu Q.,Shen H.*. A DNAzyme sensor based on target-catalyzed hairpin assembly for enzyme-free and non-label single nucleotide polymorphism genotyping. Talanta. 2017, 167, 630–637.
2. Shen H., Zhang B.,Xu H., Sun Y., Wu Q.,Shen H.*, Liu Y. Microfluidic-based G-quadruplex Ligand Displacement Assay for Alkaloid Anticancer Drug Screening. Journal of Pharmaceutical and Biochemical Analysis. 2017, 134 (5), 333-339.
3. Wu Q., Shen H., Shen H.*,Sun H., Song L.Study on Sensing Strategy and Performance of a Microfluidic Chemiluminescence Aptazyme Sensor. Talanta, 2016, 150(1), 531-538.
4. Wu Q., Shen H*.;NUPACK Prediction Assisted of Toehold Induced Strand Displacement Reaction for SNPs Genotyping with Microfluidic Chemiluminescence Detection. Chem. J. Chin. Univ., 2015, 36(12), 2386-2393.
5. Shen H.,Dasgupta, P. K.; Electrochemical Arsine Generators for Arsenic Determination. Anal. Chem., 2014, 86, 7705–7711
6. Song L. F., Pan X. Y., Shen H.*, Yu Y. L.; Microflow Injection Potassium Bioassay Based on Gquadruplex DNAzyme-enhanced Chemiluminescence. Luminescence, 2014, 29, 1066-1073.
7. Hu H. M., Yin X. F. Wang X Z., Shen H.*; A study on the system of nonaqueous microchip electrophoresis with on-line peroxyoxalate chemiluminescence detection. Journal of Separation Sience, 2013, 36,713-720.
8. Song X. L., Shen H.*,Yin X. F., Wang X. Z., Cheng H. Y.; Microflow injection chemiluminescence of luminol and hypochlorite enhanced by phloxine B. Luminescence (The Journal of Biological and Chemical Luminescence), 2013, 28, 16-22.
9.Shen H.,Fang Q.,Fang Z. L.; A microfluidic chip based sequential injection system with trapped droplet liquid-liquid extraction and chemiluminescence detection. Lab on a Chip, 2006, 6, 1387–1389.
10. Shen H., Fang Q.; Improved microfluidic chip-based sequential-injection trapped-droplet array liquid-Liquid extraction system for determination of aluminium. Talanta, 2008, 77, 269-272.
11. Shen H., Ye M. Y., Fang Q., Yin X. F.; Multiphase laminar flow microfluidic chip with deep channel and charge coupled device photometric detection. Chinese Journal of Analytical Chemistry, 2005, 33, 1659-1662.
12. Shen H., Fang Q.; The Application of two kinds of liquidphase mass transfer in microfluidic analytical chip, Progress in Chemistry, 2008, 20, 2053-2060.
13. 第七章 微流控芯片的应用，微流控分析芯片，科学出版社，北京，2006.
14. 第25章 临床化学，第27章 基因时代——基因组和蛋白质组学：DNA测序和蛋白质分析，分析化学（原著第七版），华东理工大学出版社，2017.
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shzju@zju.edu.cn
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紫金港化学实验中心311室
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2021-01-24 22:34:41
content
(详细信息见:MY CV栏)
学术研究领域：适配体核酶由适配体与核酶构成。适配体不仅具备DNA 分子的丰富性、稳定性和对目标分子的高选择性，有望替代抗体，成为以分子识别为基础的生化诊断检验的优良载体；同时，核酶催化的微流控化学发光分析具有高灵敏、试样\/试剂消耗量小、分析时间短、平行性好、易与微型仪器结合等优点，且微通道与毛细血管微环境尺度的相近。一旦将微流控化学发光分析的特点与适配体的高特异性优势相结合，此分析方法有望超越经典的免疫分析，在临床生化分析领域的应用前景广阔。
研究生导师：本人2009年被聘为研究生导师；指导2013级学生邬期望完成论文“基于适配体核酶催化的微流控化学发光法在微量分析中的应用研究“，获2016年浙江省优秀硕士论文。
项目和奖励：主持国家自然科学基金面上项目（2010-2013）和浙江省自然科学基金面上项目（2016-2018）；获2008年教育部科学技术进步二等奖。作为骨干成员参与国家973项目、国家自然科学基金重大项目，国家自然科学基金仪器专项，浙江省自然科学基金项目等项目；编著学术专著和教材多部。
论著及其代表作：发表学术论文数十篇。主要论文如下：
1. Wu Y., Shen H.*.Selective neutrophil activation via a programmable stopped-flow injection approach: Multiple evidences of priming state of salivary polymorphonuclear neutrophils compared to circulatory polymorphonuclear neutrophils. Talanta. 2021. 222. 121449.
2. Xu H., Wu Q.,Shen H.*. A DNAzyme sensor based on target-catalyzed hairpin assembly for enzyme-free and non-label single nucleotide polymorphism genotyping. Talanta. 2017, 167, 630–637.
3. Shen H., Zhang B.,Xu H., Sun Y., Wu Q.,Shen H.*, Liu Y. Microfluidic-based G-quadruplex Ligand Displacement Assay for Alkaloid Anticancer Drug Screening. Journal of Pharmaceutical and Biochemical Analysis. 2017, 134 (5), 333-339.
4. Wu Q., Shen H., Shen H.*,Sun H., Song L.Study on Sensing Strategy and Performance of a Microfluidic Chemiluminescence Aptazyme Sensor. Talanta, 2016, 150(1), 531-538.
5. Wu Q., Shen H*.;NUPACK Prediction Assisted of Toehold Induced Strand Displacement Reaction for SNPs Genotyping with Microfluidic Chemiluminescence Detection. Chem. J. Chin. Univ., 2015, 36(12), 2386-2393.
6. Shen H., Dasgupta, P. K. Electrochemical Arsine Generators for Arsenic Determination. Anal. Chem., 2014, 86, 7705–7711
7. Song L. F., Pan X. Y., Shen H.*, Yu Y. L.; Microflow Injection Potassium Bioassay Based on Gquadruplex DNAzyme-enhanced Chemiluminescence. Luminescence, 2014, 29, 1066-1073.
8. Hu H. M., Yin X. F. Wang X Z., Shen H.*; A study on the system of nonaqueous microchip electrophoresis with on-line peroxyoxalate chemiluminescence detection. Journal of Separation Science, 2013, 36,713-720.
9. Song X. L., Shen H.*,Yin X. F., Wang X. Z., Cheng H. Y.; Microflow injection chemiluminescence of luminol and hypochlorite enhanced by phloxine B. Luminescence (The Journal of Biological and Chemical Luminescence), 2013, 28, 16-22.
10.Shen H.,Fang Q.,Fang Z. L.; A microfluidic chip based sequential injection system with trapped droplet liquid-liquid extraction and chemiluminescence detection. Lab on a Chip, 2006, 6, 1387–1389.
11. Shen H., Fang Q.; Improved microfluidic chip-based sequential-injection trapped-droplet array liquid-Liquid extraction system for determination of aluminium. Talanta, 2008, 77, 269-272.
12. Shen H., Ye M. Y., Fang Q., Yin X. F.; Multiphase laminar flow microfluidic chip with deep channel and charge coupled device photometric detection. Chinese Journal of Analytical Chemistry, 2005, 33, 1659-1662.
13. Shen H., Fang Q.; The Application of two kinds of liquidphase mass transfer in microfluidic analytical chip, Progress in Chemistry, 2008, 20, 2053-2060.
14. 第七章 微流控芯片的应用，微流控分析芯片，科学出版社，北京，2006.
15. 第25章 临床化学，第27章 基因时代——基因组和蛋白质组学：DNA测序和蛋白质分析，分析化学（原著第七版），华东理工大学出版社，2017.
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