基本信息
姓名: 沈敏鹤 性别: 男
学历: 本科 学位: 学士(硕导)
职称: 主任医师 出生年份: 1963
博导类型: 博导专业: 中医内科学 博导学院: 第一临床医学院
硕导类型: 学术型/专业型 硕导专业: 中医内科学 硕导学院: 第一临床医学院
Email: shenminhe@aliyun.com 联系电话:
研究方向: 中医药防治肿瘤疾病的研究
工作单位: 浙江中医药大学附属第一医院
发表论文
1、 抑制糖酵解途径治疗结直肠癌的研究进展,孙磊涛, 沈敏鹤,肿瘤防治研究,一级期刊,2018-09,浙江中医药大学附属第一医院,, ,695-700

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2、基因变异检测技术在恶性肿瘤精准医疗中的应用,张乐吟, 沈敏鹤,中国肿瘤生物治疗杂志,一级期刊,2019-01, 浙江中医药大学附属第一医院,, ,22-28

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3、基于聚类分析1080份处方总结沈敏鹤辨治乳腺癌经验,袁莉, 沈敏鹤, 中国中西医结合杂志,一级期刊,2019-03, 浙江中医药大学附属第一医院,, ,369-373

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4、解毒三根汤调控糖酵解逆转人结肠癌LOVO/5-FU细胞株耐药的机制,严卿莹, 沈敏鹤, 中华中医药杂志,一级期刊,2019-04, 浙江中医药大学附属第一医院,, , 1751-1756

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5、从中医阴阳观探究肿瘤表型辨识,孙磊涛, 沈敏鹤, 中医杂志,一级期刊,2019-06, 浙江中医药大学附属第一医院,, , 1030-1034

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6、Clinical efficacy and safety of anti-PD-1/PD-L1 inhibitors for the treatment of advanced or metastatic cancer: a systematic review and meta-analysis.,Leitao Sun,Mingruan Shan,Scientific Reports,SCI,2020-02, The First Clinical Medical College of Zhejiang Chinese Medical University,三区,4.011,

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7、CXCR4 and CXCR3 are two distinct prognostic biomarkers in breast cancer: Database mining for CXCR family members., Kaibo Guo, Shanming Ruan@,Molecular Medicine Reports,SCI,2019-10,he First Clinical Medical College of Zhejiang Chinese Medical University,四区,1.851,4791-4802

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8、Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial? mesenchymal transition via the AKT/GSK?3β/Snail signaling pathway., Li Yuan,Shanming Ruan,Molecular Medicine Reports,SCI,2019-07,The First Clinical Medical College of Zhejiang Chinese Medical University,四区,1.851,2783-2795

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9、Jiedu Sangen Decoction Inhibits the Invasion and Metastasis of Colorectal Cancer Cells by Regulating EMT through the Hippo Signaling Pathway,Li Yuan,Shanming Ruan,Evid Based Complement Alternat Med,SCI,2019-06,The First Clinical Medical College of Zhejiang Chinese Medical University,四区,1.984,

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10、The Method of Activating Blood and Dredging Collaterals for Reducing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.,Zhaoyi Li,Shanming Ruan,Evid Based Complement Alternat Med,SCI,2019-06,The First Clinical Medical College of Zhejiang Chinese Medical University,四区,1.984,

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11、Comparison of Immune Checkpoint Inhibitors between Older and Younger Patients with Advanced or Metastatic Lung Cancer: A Systematic Review and Meta-Analysis,Leyin Zhang,Shanming Ruan,biomed research international,SCI,2019-05,The First Clinical Medical College of Zhejiang Chinese Medical University,三区,2.197,

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12、HIT promotes gastric cancer cell proliferation and migration through upregulation of HMGA2 expression,Leitao Sun,Leitao Sun,oncol letter,SCI,2019-07,First Clinical Medical College, Zhejiang Chinese Medicine University,四区,1.871,4957–4963

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13、Expression of Protein 4.1 Family in Breast Cancer: Database Mining for 4.1 Family Members in Malignancies.,Guan Feng,Shanming Ruan,medical science monitor,SCI,2019-05,The First Clinical College of Zhejiang Chinese Medical University,四区,1.98,

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14、Value of tumor size as a prognostic factor in metastatic colorectal cancer patients after chemotherapy: a population-based study.,Qingying Yan, Shanming Ruan,future oncology,SCI,2019-05,The First Clinical Medical College of Zhejiang Chinese Medical University,三区,2.279,1745-1758

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15、Jiedu Sangen Decoction Inhibits Migration and Invasion of Colon Cancer SW480 Cells via Suppressing Epithelial Mesenchymal Transition.,Kai Zhang, Shanming Ruan,Evidence-based complementary and alternative medicine,SCI,2018-09,The First Clinical Medical College of Zhejiang Chinese Medical University,四区,1.984,

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16、Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function, galactose and fatty acid metabolism.,Shanming Ruan,Fangfang Tao,Journal of Cancer ,SCI,2018-09,Department of Medical Oncology, First Affiliated Hospital of Zhejiang Chinese Medical University,三区,1.746,3382-3393

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17、Association between the overexpression of Her3 and clinical pathology and prognosis of colorectal cancer: A meta-analysis,Qingying Yan,Shanming Ruan,Midicine,SCI,2018-09,The First Clinical Medical College of Zhejiang Chinese Medical University.,四区,1.87,

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18、The Role of Combination Maintenance with Pemetrexed and Bevacizumab for Advanced Stage Nonsquamous Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.,Feiyu Shan,Shanming Ruan,BioMed Research International,SCI,2018-05,The First Clinical Medical Institute of Zhejiang Chinese Medical University,三区,2.197,

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19、miR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma.,Fangfang Tao, Shanming Ruan,faseb journal,SCI,2018-06,Department of Immunology and Microbiology, Basic Medical College, Zhejiang Chinese Medical University,二区,5.391,

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20、VEGF-C in rectal cancer tissues promotes tumor invasion and metastasis.,Haojun Miao,Shanming Ruan,Journal of BUON ,SCI,2018-02, Internal Medicine of Traditional Chinese Medicine, First Clinical Medical College, Zhejiang Chinese Medical University,四区,1.379,

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21、Metabolomics Analysis for Defining Serum Biochemical Markers in Colorectal Cancer Patients with Qi Deficiency Syndrome or Yin Deficiency Syndrome.,Fangfang Tao,Shanming Ruan,evid based complement alternat med,SCI,2017-07,Department of Immunology and Microbiology, Basic Medical College, Zhejiang Chinese Medical University,四区,1.984,

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22、Fuling Granule, a Traditional Chinese Medicine Compound, Suppresses Cell Proliferation and TGFβ-Induced EMT in Ovarian Cancer.,Fangfang Tao,Shanming Ruan,PLoS One,SCI,2016-12,Department of Immunology and Microbiology, Basic Medical College, Zhejiang Chinese Medical University,三区,2.776,

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科研项目
1、解毒三根汤调控Hippo信号通路 与Akt/GSK-3β信号通路串话抑制结肠癌侵袭转移的机制研究,沈敏鹤,浙江中医药大学附属第一医院,国家自然科学基金面上项目,面上项目,2016-01,2019-12,59,0

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2、解毒三根颗粒“病证结合”抗Ⅱ~Ⅲ期结直肠癌术后复发转移的临床研究,沈敏鹤,浙江中医药大学（浙江省中医院）,浙江省科技厅,重大科技专项计划项目,2016-01,2019-12,120,0

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3、解毒三根汤基于PI3K/AKT/HIF1α轴调控糖酵解逆转结肠癌5-FU耐药机制的研究,沈敏鹤,浙江省中医院,浙江省中管局,重点项目,2015-01,2019-12,15,15

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4、吴良村“病证结合”治疗常见恶性肿瘤气虚、阴虚的临证经验传承,沈敏鹤,浙江省中医院,浙江省中管局,一般项目,2014-06,2016-12,3,3

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科研成果
1、水中草颗粒治疗复发性口腔溃疡的分子机制,沈敏鹤,1/7,浙江中医药大学附属第一医院,浙江省卫生和计划生育委员会,浙江省中医药科学技术奖三等奖,2016-06

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2、吴良村临证经验、学术思想,沈敏鹤,1/6,浙江中医药大学附属第一医院,浙江省人民政府,浙江省科技进步奖三等奖,2015-06

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3、吴良村临证经验、学术思想传承研究,沈敏鹤,1/6,浙江中医药大学附属第一医院,浙江省卫生厅,浙江省中医药科学技术奖二等奖,2015-04-20 00:00

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4、解毒三根汤基于SIRT1调控肿瘤相关成纤维细胞抑制结肠癌侵袭转移的研究,阮善明,2/7,浙江中医药大学附属第一医院,浙江省卫生和计划生育委员会,浙江省中医药科学技术奖三等奖,2017-06

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5、中医解毒法优化干预BALB/c结肠癌小鼠的实验研究,阮善明,2/9,浙江中医药大学附属第一医院,浙江省卫生和计划生育委员会,江省中医药科学技术奖二等奖,2014-06

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6、行血益气温阳法干预卵巢癌的基础研究和应用,陶方方,4/7,浙江中医药大学附属第一医院,浙江省卫生和计划生育委员会,浙江省中医药科学技术奖，二等奖,2018-06

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个人信息