基本信息
姓名: 许秋然 性别: 女
学历: 研究生 学位: 博士(硕导)
职称: 副主任医师 出生年份: 1985-06
博导类型: 博导专业: —— 博导学院: ——
硕导类型: 学术型/专业型 硕导专业: 外科学 硕导学院: 第二临床医学院
Email: windway626@sina.com 联系电话:
研究方向: 肝胰恶性肿瘤的基础及临床研究
工作单位: 浙江省人民医院
发表论文
1、HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma,Qiuran Xu,Kangsheng Tu,Molecular Cancer,SCI,2017-12,Zhejiang Provincial People's Hospital,医学1区,10.679,178

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2、替加环素和头孢哌酮钠舒巴坦钠治疗多重耐药鲍曼不动杆菌肺炎的比较研究,张可,许秋然,中华危重症医学杂志,中华级,2016-06,浙江省人民医院,0,0,116-119

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3、miR-130b在肝细胞癌中的表达及临床病理意义,许秋然,刘欣,，细胞与分子免疫学杂志，,二级,2016-03,浙江省人民医院,0,0,387 ~ 392

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4、FSTL1在骨髓间充质干细胞保护大鼠心肌缺血再灌注损伤中的作用,张美齐,许秋然,中华医学杂志,中华级,2016-03,浙江省人医院,0,0,2017-2022

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5、采用床旁超声波对重症患者鼻肠管快速定位方法的观察,张美齐,许秋然,中华医学杂志,中华级,2016-07,浙江省人民医院,0,0, 0376-2491

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6、Cardioprotective role of mesenchymal stem cell-secreted follistatin-like protein 1 in a rat model of ischemia/reperfusion injury,Meiqi Zhang,Qiuran Xu,International Journal of Clinical and Experimental Pathology,SCI,2017-03,Zhejiang Provincial People's Hospital,医学4区,0.181,3083-3093

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7、PKM2 regulates Gli1 expression in hepatocellular carcinoma,Qiuran Xu,Qingguang Liu,Oncology letters,SCI,2014-07,Zhejiang Provincial People's Hospital,医学（4区）,1.871,1973-1979

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8、The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma,Qiuran Xu,Qingguang Liu,international journal of molecular medicine,SCI,2014-06,The First Affliated Hospital of Medical College of Xi'an Jiaotong University,医学（3区）,2.928,733-741

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9、microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma,Xin Liu,Qiuran Xu,Molecular Cancer,SCI,2017-06,Zhejiang Provincial People's Hospital,医学1区,5.168,87737-87749

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10、MicroRNA-122 affects cell aggressiveness and apoptosis by targeting PKM2 in human hepatocellular carcinoma,Qiuran Xu,Xin Liu,Oncology Reports,SCI,2015-10,Zhejiang Provincial People's Hospital,医学（3区）,3.041,2054-2064

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11、LncRNA LINC00689 promotes the growth, metastasis and glycolysis of glioma cells by targeting miR-338-3p/PKM2 axis,Xin Liu,Qiuran Xu,Biomedicine & Pharmacotherapy,SCI,2019-06,Zhejiang Provincial People's Hospital,药理学（4区）,3.743,109069

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12、lncRNA A1BG-AS1 suppresses proliferation and invasion of hepatocellular carcinoma cells by targeting miR-216a-5p,Jigang Bai,Qiuran Xu,J Cell Biochem,SCI,2019-06,Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an,生化与分子生物学 3区,3.448,6045-6056

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13、Oviductus ranae protein hydrolysate (ORPH) inhibits the growth, metastasis and glycolysis of HCC by targeting miR-491-5p/PKM2 axis,Qiuran Xu,Dongsheng Huang,Biomedicine & Pharmacotherapy,SCI,2018-11,Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College),医学3区,3.743,1692-1704

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14、The tumor suppressive miR-302c-3p inhibits migration and invasion of hepatocellular carcinoma cells by targeting TRAF4,Liu Yang,Qiuran Xu, Journal of Cancer,SCI,2018-06,Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College),肿瘤学（3区）,3.182,2693-2701

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15、HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma,Xin Liu,Qiuran Xu,International Journal of Molecular Medicine,SCI,2016-03,Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College),医学，研究与实验（3区）,2.928,825-835

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16、AMPK regulates histone H2B O-GlcNAcylation, Nucleic Acids Research,Qiuran Xu,Huadong Pei,Nucleic Acids Research,SCI,2014-05,Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College of Xi'an Jiaotong University,生物1区,11.561,5594-5604

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17、 MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1,Qiuran Xu,Kangsheng Tu,Biomedicine & Pharmacotherapy,SCI,2018-04-24 00:00,Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College),医学3区,3.743,109069

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18、 A novel lcnRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis,Yufeng Wang,Qiuran Xu,Molecular Cancer,SCI,2019-02-19 00:00,Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University,医学1区,10.679,28

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19、TuHypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway,Qiuran Xu（共一）,Kangsheng Tu,Oncogene,SCI,2019-02-05 09:45,Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University,医学1区,6.634,1239-1255

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20、MicroRNA-301b-3p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4,Yang Guo,Qiuran Xu,Journal of Cellular and Molecular Medicine,SCI,2019-08-23 15:35,,医学，研究与实验（2区）,4.658,5037-5047

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科研项目
1、缺氧肿瘤微环境中TUFT1促进肝细胞癌生长和转移的机制研究,许秋然,浙江省人民医院,国家自然科学基金面上项目,国家级,2019-01,2022-12,57,57

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2、HSP90通过调控PKM2磷酸化促进肝癌细胞糖酵解及增殖侵袭转移的作用机制研究,许秋然,浙江省人民医院,国家自然科学基金青年项目,国家级,2016-01,2018-12,24,24

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3、Fbxw7通过泛素化蛋白酶解BCoR-L1蛋白调控肝癌细胞上皮间质转化的机制研究,许秋然,浙江省人民医院,浙江省自然科学基金面上项目,省自然,2016-01,2018-12,8,8

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4、长链非编码RNA MCM3AP-AS1作为肝癌诊断新型生物标志物及特异性治疗靶点的研究,许秋然,浙江省人民医院,浙江省医药科技计划省部共建重点项目,省部级,2019-01,2021-12,15,15

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5、Fbxw7通过泛素化蛋白酶解BCoR-L1蛋白调控肝癌细胞EMT的机制研究,许秋然,浙江省人民医院,浙江省浙江省卫生厅一般项目,省卫生厅,2016-01,2018-12,3,3

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6、蛋白质组学方法研究PCAF抑制肝细胞癌术后复发的信号传导机制,许秋然,浙江省人民医院,院优秀青年启动基金A类,院级,2015-07,2018-07,3,3

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科研成果
1、肝胰恶性肿瘤分子标志物及治疗新技术的研究和应用,黄东胜,4,浙江省人民医院,浙江省科学技术奖,浙江省科技进步二等奖,2016-08

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2、基于Claudin蛋白的中西医结合治疗“创伤失血性休克‘’急性肺损伤的临床及基础研究,郑悦亮,4,浙江省人民医院,浙江省中医药科技进步奖,浙江省中医药科技进步二等奖,2018-03

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3、肝胰恶性肿瘤分子标志物及治疗新技术的研究和应用,黄东胜,5,浙江省人民医院,浙江省医药科技进步奖,浙江省医药科技进步一等奖,2016-03-27 01:00

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4、一种电磁关节机械手的控制方法,许秋然,1,浙江省人民医院,国家发明专利,国家发明专利,2018-03-14 01:00

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5、2、一种急救冲锋衣,许秋然,1,浙江省人民医院,国家实用新型专利,国家实用新型专利,2017-07-27 00:00

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个人信息