钱永常 博士，男，出生于1962年2月，教授，浙江农林大学校学术委员会委员，美国Texas A&M大学兼职副教授，国家林业局铁皮石斛工程技术研发中心副主任，浙江省生物工程学会理事、省毒理学学会理事、省药学会生化药物专业委员会理。
研究方向
中药资源功效成分；神经细胞功能恢复；细胞水平血糖控制；细胞水平免疫调控
工作经历
1991.4-1993.7 美国加州大学戴维斯分校（UC-Davis），植物生理与生化博士后
1993.8-1997.10，美国德州农工大学（Texas A&M），生化与分子生物学博士后
1997.11-1999.10，美国德州农工大学（Texas A&M），生物医学研究员
1999.11-2012.1，美国德州农工大学（Texas A&M），助理教授、副教授
2012.2-至今，美国德州农工大学（Texas A&M），兼职副教授
2012.4-至今，浙江农林大学，教授
学术及科研项目、成果情况
承担教学工作
本科生：Developmental Neurotoxicology；生物制剂与生物检测；化学生物学导论
研究生：Chemical Hazard Assessment；Neuroanatomical Systems: Neurodegenerative Diseases；Neurobiology；化学生物学
科研项目
1.美国德州A&M大学CVM优先计划, "Lead and Copper Competitively Bind to HMB of ATP7A and GRP78" (项目主任, 25%贡献)
2.美国国立环境与健康研究所项目NIEHS P42 ES04917, “Stress Gene Induction in Mammalian Cells” (项目副主任, 40%贡献)
3.美国国防部项目DOD-CDMRP Concept Award W81XWH-05-1-0163, "The Function of Neurofibromin in Astrocytes" (项目副主任, 40%贡献)
4.美国德州A&M大学基金, “The Function of Astrocytes in Brain Glucose Utilization” (项目主任, 50% 贡献)
5.美国国立环境与健康研究所项目NIH-NIEHS R21, “Long-Term Monitoring of Dementia-Related Markers in Lead Workers from China” (项目主任, 30% 贡献)
6.浙江农林大学科研发展基金RF**，“天然产物功能因子筛选平台的建立”（项目主任，50%贡献）
7.浙江省林业厅省院合作林业科技项目2015SY04，“山核桃神经功能因子挖掘与产品开发的研究”（项目主任，50%贡献）
发表的主要论文
1.Fei Gao, Xiangjun Wang, Aicun Zhou, Evelyn Tiffany-Castiglioni, Lijun Xie, Yongchang Qian(钱永常)* Cellular Evaluation of Anti-tumor Components from Toad Venom. Oncology Letters, in press,2016
2.FeiGao, W.F. Xu, Lingping Tang, Mengmeng Wang, Xiangjun Wang, Yongchang Qian(钱永常)*. Characteristic of cathelicidin-Bg, a novel gene expressed in ear-side gland of Bufo gargarizans. Genetics and Molecular Research, in press, 2016.
3.高 飞，李彤彤，汤玲平，王向军，林莉燕，钱永常^*。基于DNA条形码的龙葵系统发育及变异为点分析。中草药，47(1): 114-121, 2016 (abstract in English).
4.李彤彤，高 飞，段承俐，王向军，钱永常^*。滇重楼中VEGF结合因子的活性研究。中草药, 46(15): 2251-2256，2015 (abstract in English).
5.高 飞，周 瑜，王向军，李彤彤，张 宇，黄瑜秋，钱永常*。竹叶提取物抗肿瘤和神经保护作用研究。中草药，46(5): 710-715,2015 (abstract in English).
6.周 瑜，黄坚钦，高 飞，王向军，钱永常^*。交联聚乙烯吡咯烷酮（PVPP）对山核桃中多酚去除效果的毒理学评价。食品工业科技, 36(6): 104-108,2015 (abstract in English).
7.Wang Xiang-jun, Wu Huai-xiu, Ye Shan-shan, Pan Lan-ying, Qian Yongchang (钱永常)* Expression of recombinant human acetylcholinesterase and its application in screening inhibitors. Acta Pharmaceutica Sinica, 49 (1): 50-54, 2014
8.Yongchang Qian (钱永常)*, Bingchao Meng, Xuchu Zhang, Ying Zheng, Robert Taylor, Evelyn Tiffany-Castiglioni.HSPA5 Forms Specific Complexes with Copper. Neurochemical Research 38: 321-329, 2013.
9.Tiffany-Castiglioni, E., Qian, Yongchang (钱永常). ER Chaperone-Metal Interactions: Links to Protein Folding Disorders. Neurotoxicology 33: 545-557, 2012. (7)
10.Qian, Yongchang (钱永常)*, Zheng, Y., Taylor, R., Tiffany-Castiglioni, E. Involvement of the Molecular Chaperone HSPA5 in Copper Homeostasis in Astrocytes. Brain Research 1447: 9-19, 2012. (11)
11.Tiffany-Castiglioni, E., Hong, S., Qian, Yongchang (钱永常). Copper Handling by Astrocytes: Insights into Neurodegenerative Diseases. International Journal of Developmental Neuroscience 29: 811-818, 2011. (28)
11.Tiffany-Castiglioni, E., Qian, Yongchang (钱永常), Barhoumi, R., Zheng, Y. Determination of Metal Interactions with the Chaperone Hspa5 in Human Astrocytoma Cells and Rat Astrocyte Primary Cultures. Methods in Molecular Biology, 758: 29-48, 2011.
12.Barhoumi, R., Qian, Yongchang (钱永常), Burghardt, R., Tiffany-Castiglioni, E. Image Analysis of Ca²⁺ Signals as a Basis for Neurotoxicity Assays: Promises and Challenges. Neurotoxicology and Teratology. 32: 16-24, 2010. (11)
13.Qian, Yongchang (钱永常)*, Zheng, Y, Tiffany-Castiglioni, E. Valproate Reversibly Reduces Neurite Outgrowth by Human SY5Y Neuroblastoma Cells. Brain Research 1302:21-33, 2009. (9)
14.Wang, LJ, Zheng, Y, 钱永常*. 断乳仔鼠器官中铅分布和78000糖调蛋白的变化. 《中华预防医学杂志》第42卷，第10期：731-734页, 2008(abstract in English).
15.White, LD., Cory-Slechta, DA., Gilbert, ME., Tiffany-Castiglioni, E., Zawia, NH., Virgolini, M., Rossi-George, A., Lasley, SM., Qian, Yongchang (钱永常), Basha, MR. New and Evolving Concepts in the Neurotoxicology of Lead. Toxicology and Applied Pharmacology 225: 1-27, 2007.(192)
16.Qian, Yongchang (钱永常)*, Zheng, Y, Weber, D, Tiffany-Castiglioni, E. A 78kD Glucose-Regulated Protein Is Involved In Decrease Of Interleukin-6 Secretion By Lead Treatment From Astrocytes. American Journal of Physiology-Cell Physiology293: C897-C905, 2007. (16)
17.Wang, L. J., Zheng, Y., 钱永常*. 低水平铅暴露对仔鼠白细胞78kd糖调蛋白表达的影响. 《国际医药卫生导报》第13卷，第12期：8-12页，2007(abstract in English).
18.Falahatpisheh, H., Nanez, A., Montoya-Durago, D., Qian, Yongchang (钱永常), Tiffany-Castiglioni, E., Ramos, KS. Activation Profiles of HSPA5 During the Glomerular Mesangial Cell Stress Response to Chemical Injury. Cell Stress & Chaperones 12: 209-218, 2007. (13)
19.Barhoumi, R., Burghardt, R., Qian, Yongchang (钱永常), Tiffany-Castiglioni, E. Effects of propofol on intracellular Ca²⁺ homeostasis in human astrocytoma cells. Brain Research 1145: 11-18, 2007. (19)
20.Qian, Yongchang (钱永常), Venkatraj, J., Barhoumi, R., Pal, R., Datta, A., Wild, J. R., Tiffany-Castiglioni, E. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) human neuroblastoma and astrocytoma cell lines. Toxicology and Applied Pharmacology219: 162-171, 2007. (16)
21.Tiffany-Castiglioni, E., Hong, S., Qian, Yongchang (钱永常), Tang, Y., Donnelly, K.C. COMMENTARY: In Vitro Models for Assessing Neurotoxicity of Mixtures. Neurotoxicology 27: 835-839, 2006. (20)
22.Tiffany-Castiglioni, E., Venkatraj, J.S., Qian, Yongchang (钱永常). Genetic polymorphisms and mechanisms of neurotoxicity: overview. Neurotoxicology 26: 641-649, 2005.
23.Qian, Yongchang (钱永常)*, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. The Involvement of Copper Transporter in Lead-induced Oxidative Stress in Astroglia. Neurochemical Research 30: 429-438, 2005. (27)
24.Qian, Yongchang (钱永常)*, Zheng, Y., Abraham, L., Ramos, K.S., Tiffany-Castiglioni, E. Differential Profiles of Copper-induced ROS Generation in Human Neuroblastoma and Astrocytoma Cells. Molecular Brain Research 134: 323-332, 2005. (30)
25.Qian, Yongchang (钱永常)*, Zheng, Y., Ramos, K.S., Tiffany-Castiglioni, E. GRP78 compartmentalized redistribution in pb-treated glia: role of grp78 in lead-induced oxidative stress. Neurotoxicology26: 267-275, 2005. (45)
出版专著
1.Yongchang Qian(钱永常)*,Evelyn Tiffany-Castiglioni. Lead-Induced Developmental Neurotoxicity and Modulated Gene Expression. In: Comprehensive Toxicology, Third Edition. Charlene A. McQueen (ed.). Elsevier, 2016, pp. xxx.
2.Yongchang Qian(钱永常)^*, Linjing Wang, Evelyn Tiffany-Castiglioni. Lead-Modulated Gene Expression in the Central Nervous System. In: Reference Module in Biomedical Sciences Reviews. Michael Caplan (ed). Elsevier, 2014, pp. 29
3.Qian, Yongchang (钱永常). Heavy Metal-Regulated Gene Expression in the Nervous System. In: Comprehensive Toxicology, Second Edition. Kenneth S. Ramos (ed.). Elsevier, Oxford, 2010, pp. 495-521.
4.Tiffany-Castiglioni, E., Venkatraj, J.S., Qian, Yongchang (钱永常), Wild, J.R. Chapter 22 In vitro models for testing organophosphate-induced neurotoxicity and remediation. In: Toxicology of Organophosphate & Carbamate Pesticides, Ramesh C. Gupta (ed). Elsevier, Amsterdam, 2006, pp. 315-337.
5.Tiffany-Castiglioni, E., Qian, Yongchang (钱永常). Chapter 26 Astroglia and Lead Neurotoxicity. In: The Role of Glia in Neurotoxicity, Second Edition. M. Aschner, L. G. Costa (eds), CRC Press, Boca Raton, FL, 2005, pp. 417-437.
6.Tiffany-Castiglioni, E., Qian, Yongchang (钱永常). Cell-Type Specific Responses of the Nervous System to Lead. In: Methods in Pharmacology and Toxicology: In Vitro Neurotoxicology: Principles and Challenges. E. Tiffany-Castiglioni (ed), Humana Press Inc., Totowa, NJ, 2004, pp.151-186
7.Harris, E. D., Reddy, M. C. M., Qian, Yongchang (钱永常), Tiffany-Castiglioni, E., Majumdar, S., Nelson, J. Multiple forms of the Menkes Cu-ATPase. In: Leone, A., Mercer, J. F. B. (Ed.), Copper Transport and Its Disorders. Kluwer Academic/ Plenum Publishers, New York, 1999, pp. 39-51.
8.Harris, E.D., Tiffany-Castiglioni, E., Qian, Yongchang (钱永常). Copper in cell culture. In: Trace Element in Laboratory Rodents: Nutritional Research Methods, R.R. Watson (ed), CRC Publishers, Boca Raton, FL, 1996, pp.163-187
获奖情况
1.美国毒理学会Gulf Coast分会优秀博士后奖
2.浙江省省级创业人才
3.浙江省杭州市萧山区“优秀留学人员创业人才”
4.浙江省杭州市萧山区“十佳优秀科技人才”
5.浙江省杭州市萧山区首届“爱乡名士”
联系方式
联系地址：浙江农林大学林业与生物技术学院，浙江杭州临安，311300
电　　话：**
电子邮件：qian3906@zafu.edu.cn