吴文武 男，1983年01月，生物信息学博士，教授。
研究方向
研究主要涉及基因转录和调控、选择性剪接、基因家族和生物演化等。
现阶段，主要利用生物信息学手段，基于生物大数据对基因组、调控组和转录组等各组学进行研究，尝试对生物表型下（如抗逆）的分子机制进行多层次多维度的解析
学习与工作经历
2017/01—至今 浙江农林大学林业与生物技术学院教授
2016/05—2017/01 浙江农林大学林业与生物技术学院副研究员
2014/11—2016/05 中科院上海植物逆境研究中心副研究员朱健康课题组
2012/10—2014/10 中科院上海生科院营养所博士后冯英课题组
2010/10—2011/09 中科院北京植物研究所联合培养孔宏智课题组
2007/09—2012/09 西北农林科技大学博士研究生陶士珩课题组
教学工作
生物信息学
科研项目
1.2017 年浙江省科技厅重大科技专项，主要参与人
2.2015年国家自然科学基金青年科学基金主持
3.2014年中国博士后科学基金第7批特别资助主持
4.2013年中国博士后科学基金第54批面上资助主持
论文与专著（*第一作者&通讯作者）
1.Wu W*^&, Zong J*, Wei N, Cheng I, Zhou X, Cheng Y, Chen D, Guo Q, Zhang B and Feng Y^&. (2017). CASH: A constructing comprehensive splice site method for detecting alternative splicing events. Brief Bioinform.DOI: 10.1093/bib/bbx034. IF= 8.399
2.Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z, Wu W^& and Feng Y^&. (2017). SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development. Cancer Res 77, 1168-1178.IF=8.556
3.Zhou X*, Wu W*, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H and Feng Y. (2014). Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Res 42, 4019-4030.IF= 9.202
4.Cheng J*, Xu Z*, Wu W*, Zhao L, Li X, Liu Y and Tao S. (2014). Training set selection for the prediction of essential genes. Plos One 9, e86805.IF= 3.057
5.Cheng J*, Wu W*, Zhang Y, Li X, Jiang X, Wei G and Tao S. (2013). A new computational strategy for predicting essential genes. BMC Genomics 14, 910.IF= 3.867
6.Wu W, de Folter S, Shen X, Zhang W and Tao S. (2011). Vertebrate Paralogous MEF2 Genes: Origin, Conservation, and Evolution. Plos One 6, e17334.IF= 3.057
7.Wu W, Huang X, Cheng J, Li Z, de Folter S, Huang Z, Jiang X, Pang H and Tao S. (2011). Conservation and Evolution in and among SRF- and MEF2-Type MADS Domains and Their Binding Sites. Mol Biol Evol 28, 501-511.IF= 13.649
8.Wu W, Shen X and Tao S. (2010). Characteristics of the CArG-SRF binding context in mammalian genomes. Mamm Genome 21, 104-113.IF= 2.078
9.Wang L, Li H, Zhao C, Li S, Kong L, Wu W, Kong W, Liu Y, Wei Y, Zhu JK and Zhang H. (2017). The inhibition of protein translation mediated by AtGCN1 is essential for cold tolerance in Arabidopsis thaliana. Plant Cell Environ 40, 56-68. IF= 6.169
10.Cheng Y, Luo C, Wu W, Xie Z, Fu X and Feng Y. (2016). Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol Cell Biol 36, 1628-1638. IF= 4.427
11.Zhan X, Qian B, Cao F, Wu W, Yang L, Guan Q, Gu X, Wang P, Okusolubo TA, Dunn SL, Zhu JK and Zhu J. (2015). An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses. Nat Commun 6, 8139.IF= 11.329
12.Zhou X, Li X, Cheng Y, Wu W, Xie Z, Xi Q, Han J, Wu G, Fang J and Feng Y. (2014). BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells. Nat Commun 5, 4581.IF= 11.329
13.Li H, Cheng Y, Wu W, Liu Y, Wei N, Feng X, Xie Z and Feng Y. (2014). SRSF10 Regulates Alternative Splicing and Is Required for Adipocyte Differentiation. Mol Cell Biol 34, 2198-2207.IF= 4.427
14.Li L, Guo Y, Wu W, Shi Y, Cheng J and Tao S. (2012). A comparison and evaluation of five biclustering algorithms by quantifying goodness of biclusters for gene expression data. Biodata Min 5, 8. IF= 1.640
15.Marsch-Martínez N, Wu W and de Folter S. (2011). The MADS symphonies of transcriptional regulation. Front. Plant Sci. 2, 26. IF= 4.495
联系方式
电子信箱：wenwu_wu@aliyun.com
通讯地址:浙江省杭州市临安区武肃街666号智能实验楼N301
邮 编:311300
邮 箱:wenwu_wu@aliyun.com；wwwu@zafu.edu.cn