基本情况


姓名 出生年月职称/职务学历/学位所在部门研究方向联系方式
陈凌峰 1992 年 2 月 17 日
讲师博士
药学院（药物研究所）药物化学 lfchen@hmc.edu.cn

学术情况



*教育背景
·研究生/博士：2016 年 9 月–2020 年 11 月，南京理工大学化工学院，药物化学专业；
·公派联培/博士：2018 年 3 月–2020 年 5 月，纽约大学 Langone 医学中心，结构生物学专业；
·研究生/硕士：2013 年 9 月–2016 年 6 月，温州医科大学药学院，药学专业；
·本科/学士：2009 年 9 月–2013 年 6 月，温州医科大学药学院，制药工程专业。

*工作经历
·2021 年 1 月-至今，杭州医学院，药学院，讲师

*学术任职
无。

*主持项目
1.基于炎症靶点的药物化学研究和靶点确证，校科研启动基金，2021 年-2026 年。

*发表论文
1.Lingfeng Chen#, William M. Marsiglia#, Huaibin Chen#, Joseph Katigbak, Hediye Erdjument-Bromage,
David J. Kemble, Lili Fu, Jinghong Ma, Gongqin Sun, Yingkai Zhang, Guang Liang, Thomas A. Neubert,
Xiaokun Li, Nathaniel
J. Traaseth* & Moosa Mohammadi*. Molecular basis for receptor tyrosine kinase A-loop tyrosine
transphosphorylation. Nature Chemical Biology, 2020, 16(3):267-277.
2.Lingfeng Chen# ， Lulu Zheng# ， Pengqin Chen ， Guang Liang*. Myeloid Differentiation Primary
Response Protein 88 (MyD88): the central hub of TLR/IL-1R signaling. Journal of Medicinal
Chemistry, 2020. doi: 10.1021/acs.jmedchem.0c00884.
3.Lingfeng Chen#, Hongjin Chen#, Pengqin Chen#, Wenxin Zhang, Chao Wu, Chuchu Sun, Wu Luo, Lulu
Zheng, Zhiguo Liu, Guang Liang*. Development of 2-amino-4-phenylthiazole analogues to disrupt
myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury. European
Journal of Medicinal Chemistry, 2018, 161:22-38.
4.Lingfeng Chen#, Yiyi Jin#, Hongjin Chen#, Chuchu Sun#, Weitao Fu, Lulu Zheng, Min Lu, Pengqin
Chen, Gaozhi Chen, Yali Zhang, Zhiguo Liu, Yi Wang, Zengqiang Song*, Guang Liang*. Discovery of
caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for
treatment of acute lung injury. European Journal of Medicinal Chemistry, 2018, 143: 361-375.
5.Lingfeng Chen, Weitao Fu, Lulu Zheng, Yi Wang*, Guang Liang*. Recent Progress in the Discovery of
Myeloid Differentiation 2 (MD-2) Modulators for Inflammatory Diseases. Drug Discovery Today, 2018,
23(6):1187-1202. 6.Lingfeng Chen, Weitao Fu, Lulu Zheng, Zhiguo Liu, Guang Liang*. Recent progress
of small-molecule epidermal growth factor receptor (EGFR) inhibitors against C797S resistance
in non-small-cell lung cancer. Journal
of Medicinal Chemistry. 2018, 61(10):4290-4300.
7.Lingfeng Chen#, Weitao Fu#, Chen Feng#, Rong Qu, Linjiang Tong, Lulu Zheng, Bo Fang, Yinda Qiu,
Jie Hu, Peng Zou, Jianpeng Feng, Hua Xie, Jian Ding*, Zhiguo Liu*, Guang Liang*.
Structure-based design and synthesis of L858R/T790M selective epidermal growth factor receptor
inhibitors for NSCLC. European Journal of Medicinal Chemistry, 2017, 20;140:510-527.

8.Lingfeng Chen#, Yiyi Jin, Weitao Fu, Chen Feng, Bo Fang, Yugui Gu, Chenglong Li, Yunjie Zhao*,
Zhiguo Liu*, Guang Liang*. Design, synthesis and structure-activity relationship analysis of novel
thiazolo[3,2-a] pyrimidin derivatives with anti-inflammatory activity in acute lung injury.
ChemMedChem, 2017, 12: 1022-1032.
9.Zhiguo Liu, #, * Lingfeng Chen#（并列第一）, Pengtian Yu, Yali Zhang, Bo Fang, Chao Wu, Wu Luo, Xianxin
Chen, Chenglong Li, Guang Liang*. Discovery of 3-(indol-5-yl)-indazole derivatives as novel
myeloid differentiation protein 2/toll-like receptor 4 antagonists for treatment of acute lung
injury. Journal of Medicinal Chemistry, 2019, 62(11):5453-5469.
10.Gaozhi Chen#, Bing Xiao#, Lingfeng Chen#（并列第一）, Bin Bai, Yali Zhang, Zheng Xu, Lili Fu, Zhiguo
Liu, Xiaokun Li*, Yunjie Zhao*, Guang Liang*. Discovery of new MD2-targeted anti-inflammatory
compounds for the treatment of sepsis and acute lung injury. European Journal of Medicinal
Chemistry, 2017, 139: 726-740.

*奖励荣誉
无。