郭良宏
sex
1
title
研究员
department
质量与安全工程学院
college
生命科学学院
college2
计量测试工程学院
degree
博士
recruit":0,"firstDiscipline1
生物学
secondaryDiscipline1
仪器科学与技术
firstDiscipline2
资源与环境
secondaryDiscipline2
药学
executive

officePhone
**
mobilePhone

emailAddress
LHGuo@cjlu.edu.cn
businessAddress

individualResume
郭良宏，中国计量大学环境与健康科学研究院院长，博士生导师，国家基金委****基金获得者，国家科技部重大科学研究计划首席科学家，中国科学院“****”入选者，英国皇家化学会Fellow。主要从事环境毒理学和环境分析化学的研究，作为通讯作者在Environmental Health Perspectives, Achieves of Toxicology, Nanotoxicology, Environmental Science & Technology, Nano Letters, ACS Catalysis, Analytical Chemistry 等国际知名期刊上SCI论文120余篇，共同主编专著《环境纳米科学与技术》，撰写中英文专业书籍章节10个。研究工作得到国内外同行的广泛关注和好评，论文总引用超过5000次。任《环境化学》主编，英国皇家化学会期刊Environmental Science: Processes and Impacts副主编，中国毒理学会分析毒理专业委员会常务委员，中国化学会环境化学专业委员会委员，中国化学会分析质谱专业委员会委员，中国环境科学学会环境医学与健康分会委员，中国仪器仪表学会分析仪器分会电化学分析专业委员会委员。曾任环境化学与生态毒理学国家重点实验室副主任，国家自然科学奖初评会议化学组评审专家，国家自然科学基金委化学科学部科学基金评审会专家。荣获中国科学院杰出科技成就奖、中国分析测试协会科学技术奖二等奖、国家百千****才工程“有突出贡献中青年专家”称号。指导研究生40余名。
researchTopic
1. 项目名称：基于生物活性等效浓度评估杭州地区含氟有机物污染的健康风险，来源：国家基金委区域创新发展联合基金，项目编号：U20A20133，执行周期：2021.01-2024.12，主持。\r2. 项目名称：高端体外诊断检验仪器及试剂研发-高通量电化学发光免疫检测仪及其配套试剂盒的研发，来源：浙江省重点研发计划，项目编号：2021C03057，执行周期：2021.01-2024.11，主持。\r
awards
2010\t中国科学院优秀研究生导师奖 \r2013\t中国科学院杰出科技成就奖 （主要完成人）\r2013\t国家百千****才工程“有突出贡献中青年专家”\r2015\t中国分析测试协会科学技术奖二等奖（排名第二）\r2015\t国务院政府特殊津贴\t
researchProject
1. 科技部国家重大科学研究计划：“纳米材料的水处理器件化方法及其应用基础研究”，2010.10-2015.08，首席科学家。\r2. 国家基金委****基金项目：“生物分析化学”，2009.01-2012.12，主持。\r3. 中国科学院“****”项目：“生物分析与生态毒理”，2004.06-2007.05，主持。\r4. 国家基金委重大研究计划重点项目：“基于颗粒物模型研究PM2.5氧化应激效应的分子机制”， 2016.01-2019.12，主持。\r5. 国家基金委重大项目课题：“典型持久性污染物的累积代谢及其与生物分子的相互作用”，2009.01-2012.12，主持。\r6. 中国科学院先导专项B项目课题：“典型内分泌干扰物与激素相关生物大分子相互作用研究”，2014.07-2019.06，主持。\r7. 中国科学院前沿科学重点研究项目：“多溴联苯醚生殖发育毒性的关键生物通路”，2016.07-2021.06，主持。\r8. 中国科学院重大科研装备研制项目：“环境化合物遗传毒性快速检测仪”， 2008.03-2010.06，主持。\r9. 科技部国家高技术研究发展计划（863）项目：“环境中具有遗传毒性化学污染物的光电化学快速筛查技术”，2007.01-2009.12，主持。\r10. 国家基金委重大科研仪器设备研制项目：“高通量多功能成组毒理学分析系统”，2016.01-2020.12，技术骨干。\r11. 国家基金委创新研究群体：“持久性有毒污染物的环境过程与毒理效应”，2013.01-2016.12，群体成员。\r12. 国家基金委面上项目：“DNA损伤的电化学发光传感检测方法与应用研究”，2014.01-2017.12，主持。\r13. 科技部国家高技术研究发展计划（863）课题：“生活垃圾焚烧厂排放污染物生物检测传感器和生物活性检测技术”，2012.01-2014.12，技术骨干。\r14. 国家基金委面上项目：“基于酪氨酸电化学的蛋白质磷酸化检测”，2009.01-2011.12，主持。\r15. 科技部国家高技术研究发展计划（863）课题：“重大环境污染事件特征污染物实验室检测技术系统”，2007.11-2010.11，技术骨干。\r16. 国家基金委创新研究群体：“持久性有毒污染物形态、环境过程与毒理效应”， 2007.01-2012.12，600万，群体成员。\r17. 国家基金委面上项目：“电化学方法研究环境化合物与核酸的相互作用及其基因毒理”，2007.01-2009.12，28万，主持。
publications
(1) Cui, Xuejing; Wan, Bin*; Yang, Yu; Xin, Yan; Xie, Yi-Chun; Guo, Liang-Hong*; Mantell, Lin L.\r“Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion”\rToxicological Sciences. 2019, 172, 398-410.\r\r(2) Fengyan Liu, Ziyan Fan, Ning Song, Mingyong Han, Ming Yan, Liang-Hong Guo, Jia Jihui, Shili Liu*\r“XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity”\rJournal of Cellular Biochemistry. 2019, 120, 12665-12676.\r\r(3) Li, Chuan-Hai; Ren, Xiao-Min; Cao, Lin-Ying; Qin, Wei-Ping; Guo, Liang-Hong*\r“Investigation of Binding and Activity of Perfluoroalkyl Substances to the Human Peroxisome Proliferator-Activated Receptor beta/delta”\rEnvironmental Science: Processes & Impacts. 2019, 21, 1908-1914.\r\r(4) Chen, Fengjie; Yu, Wanchao; Qie, Yu; Zhao, Lixia; Zhang*, Hui; Guo, Liang-Hong \r“Enhanced photocatalytic removal of hexavalent chromium through localized electrons in polydopamine-modified TiO2 under visible irradiation”\rChemical Engineering Journal. 2019, 373, 58-67.\r\r(5) Ren, Xiao-Min; Li, Chuan-Hai; Zhang, Jian-Qing; Guo, Liang-Hong; Guo, Liang-Hong*\r“Binding and activity of sulfated metabolites of lower-chlorinated polychlorinated biphenyls towards thyroid hormone receptor alpha”\rEcotoxicology and Environmental Safety. 2019, 180, 686-692.\r\r(6) Gu, Yu-Xin; Liang, Xiao-Xing; Yin, Nuo-Ya; Yang, Yu*; Wan, Bin; Guo, Liang-Hong; Faiola, Francesco\r“New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells”\rArchives of Toxicology, 2019, 93, 2661-2671.\r\r(7) Wang, Dabin; Zhao, Lixia*; Song, Dean; Qiu, Jun; Kong, Fanyu; Guo, Liang-Hong\r“A formation model of superoxide radicals photogenerated in nano-TiO2 suspensions”\rRSC Advances, 2019, 9, 29429-29432.\r\r(8) Xin, Yan; Ren, Xiao-Min; Wan, Bin; Guo, Liang-Hong*\r“Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues”\rEnviron. Sci. Technol. 2019, 53, 8371-8380.\r\r(9) Yu, Wanchao; Zhao, Lixia*; Chen, Fengjie; Zhang, Hui; Guo, Liang-Hong\r“Surface Bridge Hydroxyl-Mediated Promotion of Reactive Oxygen Species in Different Particle Size TiO2 Suspensions”\rJournal of Physical Chemistry Letters, 2019, 10, 3024-3028.\r\r(10) Qin, Wei-Ping; Li, Chuan-Hai; Guo, Liang-Hong*; Ren, Xiao-Min*; Zhang, Jian-Qing\r“Binding and activity of polybrominated diphenyl ether sulfates to thyroid hormone transport proteins and nuclear receptors”\rEnvironmental Science: Processes & Impacts. 2019, 21, 1908-1914.\r\r(11) Zhang, Hui*; Wang, Weimin; Zhao, Huanxin; Zhao, Lixia; Gan, Li-Yong; Guo, Liang-Hong\r“Facet-mediated interaction between humic acid and TiO2 nanoparticles: implications for aggregation and stability kinetics in aquatic environments”\rEnvironmental Science: Nano. 2019, 6, 1754-1764.\r\r(12) Ma, Hai-Yan; Zhao, Lixia*; Guo, Liang-Hong; Zhang, Hui; Chen, Feng-Jie; Yu, Wan-Chao\r“Roles of reactive oxygen species (ROS) in the photocatalytic degradation of Check pentachlorophenol and its main toxic intermediates by TiO2/UV”\rJournal of Hazardous Materials. 2019, 369, 719-726.\r\r(13) Fadare, Oluniyi O.; Wan, Bin*; Guo, Liang-Hong*; Xin, Yan; Qin, Weiping; Yang, Yu\r“Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna”\rEnvironmental Science: Nano. 2019, 6, 1466-1477.\r\r(14) Li, Chuan-Hai; Ren, Xiao-Min; Guo, Liang-Hong*\r“Adipogenic Activity of Oligomeric Hexafluoropropylene Oxide (Perfluorooctanoic Acid Alternative) through Peroxisome Proliferator-Activated Receptor gamma Pathway”\rEnviron. Sci. Technol. 2019, 53, 3287-3295.\r\r(15) Xie, Yichun; Wan, Bin*; Yang, Yu; Cui, Xuejing; Xin, Yan; Guo, Liang-Hong\r“Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups”\rJournal of Environmental Sciences. 2019, 77, 198-209.\r\r(16) Cao, Lin-Ying; Zheng, Ziye; Ren, Xiao-Min; Andersson, Patrik L.*; Guo, Liang-Hong*\r“Structure-Dependent Activity of Polybrominated Diphenyl Ethers and Their Hydroxylated Metabolites on Estrogen Related Receptor gamma: in Vitro and in Silico Study”\rEnviron. Sci. Technol. 2018, 52, 8894-8902.\r\r(17) Hui Zhang, Weimin Wang, Huanxin Zhao, Lixia Zhao, Li-Yong Gan, Liang-Hong Guo*\r“Facet-Dependent Interfacial Charge Transfer in Fe(III)-Grafted TiO2 Nanostructures Activated by Visible Light”\rACS Catalysis, 2018, 8, 9399?9407.\r\r(18) Yan Xin, Bin Wan*, Yu Yang, Xue?Jing Cui, Yi?Chun Xie, Liang-Hong Guo*\r“Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells”\rArchives of Toxicology, 2018, 92, 3131-3147.\r\r(19) Yan Xin, Xiao-Min Ren, Ting Ruan, Chuan-Hai Li, Liang-Hong Guo*, Guibin Jiang\r“Chlorinated Polyfluoroalkylether Sulfonates Exhibit Similar Binding Potency and Activity to Thyroid Hormone Transport Proteins and Nuclear Receptors as Perfluorooctane sulfonate”\rEnviron. Sci. Technol. 2018, 52, 52, 9412-9418.\r\r(20) Dabin Wang, Lixia Zhao*, Dan Wang, Li Yan, Chuanyong Jing, Hui Zhang, Liang-Hong Guo*, Ning Tang\r“Direct evidence for surface long-lived superoxide radicals photo-generated in TiO2 and other metal oxide suspensions”\rPhys. Chem. Chem. Phys., 2018, 20, 18978-18985.\r\r(21) Lin-Ying Cao, Xiao-Min Ren*, Yu Yang, Bin Wan, Liang-Hong Guo*, De Chen, Yong Fan\r“Hydroxylated Polybrominated Diphenyl Ethers Exert Estrogenic Effects via\rNon-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways”\rEnvironmental Health Perspectives, 2018,126, doi: 10.1289/EHP2387.\r\r(22) G. Qin, J. Xia, Y. Zhang, L. Guo, R. Chen, N. Sang*\r“Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice”\rParticle and Fibre Toxicology, 2018, 15-27.\r\r(23) Yin-Feng Zhang, Xiao-Min Ren, Yuan-Yuan Li, Xiao-Fang Yao, Chuan-Hai Li, Zhan-Fen Qin*, Liang-Hong Guo\r“Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo”\rEnvironmental Pollution, 2018, 237, 1072-1079.\r\r(24) 马海艳，赵利霞*，张辉，郭良宏\r“H 2O2调控TiO2体系中活性氧物种的产生及其五氯酚的降解过程” \r《中国科学:化学》，2018，10, 1280-1289\r\r(25) Chuan-Hai Li, Xiao-Min Ren,* Ting Ruan, Lin-Ying Cao, Yan Xin, Liang-Hong Guo,* Guibin Jiang\r“Chlorinated Polyfluorinated Ether Sulfonates Exhibit Higher Activity toward Peroxisome Proliferator-Activated Receptors Signaling Pathways than Perfluorooctanesulfonate”\rEnviron. Sci. Technol. 2018, 52, 3232?3239\r\r(26)\t Hai-Yan Ma, Lixia Zhao,* Da-Bin Wang, Hui Zhang, Liang-Hong Guo*\r“Dynamic Tracking of Highly Toxic Intermediates in Photocatalytic Degradation of Pentachlorophenol by Continuous Flow Chemiluminescence”\rEnviron. Sci. Technol. 2018, 52, 2870?2877\r\r(27) Lin-Ying Cao, Xiao-Min Ren,* Chuan-Hai Li, Liang-Hong Guo*\r“Organophosphate Esters Bind to and Inhibit Estrogen-Related Receptor γ in Cells”\rEnviron. Sci. Technol. Lett. 2018, 5, 68?73\r\r(28)\t Yuxin Gu, Yu Yang,* Bin Wana, Minjie Li, Liang-Hong Guo*\r“Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells–A molecular mechanism of organophosphate flame retardants developmental neurotoxicity”\rBiochem. Pharmacol., 2018, 152, 21–33.\r\r(29)\t 王丹，赵利霞*，张辉，郭良宏\r“二氧化钛光催化产生超氧自由基的形态分布研究”\r《分析化学》, 2017, 45, 1882-1887\r\r(30) Tianyi Dong, Yanping Peng, Ning Zhong, Fengyan Liu, Hanyu Zhang, Mengchen Xu, Rutao Liu, Mingyong Han, Xingsong Tian, Jihui Jia, Lap Kam Chang, Liang-Hong Guo,* Shili Liu*\r“Per?uorodecanoic acid (PFDA) promotes gastric cell proliferation via sPLA2-IIA”\rOncotarget, 2017, 8, 50911-50920\r\r(31) Dan Wang, Lixia Zhao,* Haiyan Ma, Hui Zhang, Liang-Hong Guo*\r“Quantitative Analysis of Reactive Oxygen Species Photogenerated on Metal Oxide Nanoparticles and Their Bacteria Toxicity: The Role of Superoxide Radicals”\rEnviron. Sci. Technol. 2017, 51, 10137?10145\r\r(32) Lin-Ying Cao, Xiao-Min Ren,* Chuan-Hai Li, Jing Zhang, Wei-Ping Qin, Yu Yang, Bin Wan, Liang-Hong Guo*\r“Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway”\rEnviron. Sci. Technol. 2017, 51, 11423?11430.\r\r(33) Rui Feng, Gang Liang, Liang-Hong Guo*, Yi-Ping Wu \r“A chemical toxicity sensor based on the electrochemiluminescence quantification of apurinic/apyrimidinic sites in double-stranded DNA monolayer”\rSensors and Actuators B, 2017, 248, 512–518.\r\r(34) Yu Yang*, Yuxin Gu, Bin Wan, Xiaomin Ren, Liang-Hong Guo*\r“Label-free electrochemical biosensing of small-molecule inhibition on OGlcNAc glycosylation”\rBiosensors and Bioelectronics, 2017, 95, 94–99.\r\r(35)\tXuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo*\r“Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells”\rScientific Reports, 2017, 7, 1518 (DOI:10.1038/s41598-017-01746-9)\r\r(36)\tYu Yang, Qi?Yan Lv, Liang?Hong Guo*, Bin Wan, Xiao?Min Ren, Ya?Li Shi, Ya?Qi Cai\r“Identification of protein tyrosine phosphatase SHP?2 as a new target of perfluoroalkyl acids in HepG2 cells”\rArch. Toxicol., 2017, 91, 1697–1707.
others

correlation
researchDirection1
环境污染物的毒理学
researchDirection2
环境污染与人体暴露评估
researchDirection3
生物检测技术与仪器开发
researchDirection4