俞晓春博士
Xiaochun Yu, M.D. Ph. D.
生命科学学院

基因组不稳定性和癌症发生发展实验室
联系
邮箱: yuxiaochun@westlake.edu.cn
网站:





俞晓春博士
Xiaochun Yu, M.D. Ph. D.
生命科学学院

基因组不稳定性和癌症发生发展实验室
联系
邮箱: yuxiaochun@westlake.edu.cn
网站:







个人简介


1991-1996年北京医科大学，医学士
1996-2002年日本久留米大学，细胞生物学博士
2002-2006年美国Mayo Clinic博士后
2006-2015年美国密歇根大学医学院内科系助理教授，副教授，正教授
2015-2020年美国希望之城贝克曼研究所正教授
2020年起 西湖大学生命科学学院正教授


学术成果


俞晓春教授长期致力于DNA损伤修复机制和癌症发生发展的研究。众所周知细胞内基因组随时面临着来自体外和体内的各种损伤因素的挑战，如果DNA的损伤得不到及时修复，则会导致细胞的细胞周期紊乱、细胞凋亡、癌症发生等等恶性结果。因此，如何正确完成DNA的损伤修复并维持基因组的稳定性，对于细胞的存活进而防止肿瘤等重大疾病的发生起着至关重要的作用。因而，与此相关的分子机制研究是DNA损伤修复生物学的核心内容，对于肿瘤的诊断、抗肿瘤药物的设计等都具有重要的理论指导意义。其学术成果特别对家族性乳腺癌，卵巢癌，胰腺癌和白血病检测和治疗产生巨大的影响。曾获2006年美国卵巢癌研究协会独立研究员奖，2007年美国癌症研究协会 （AACR）Susan G. Komen乳腺癌****奖，2008年美国癌症协会（ACS）****奖，2010年美国国防部乳腺癌项目划时代****奖，2014年白血病淋巴癌协会****奖，2018年Tower癌症研究基金会****奖，2019年胰腺癌联盟转化医学研究奖，2019年Taub癌症研究基金会白血病研究奖。


代表论文


1.Kim, H., Chen, J. * andYu, X. * (2007). Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responses.Science, 316, 1202-1205. (* co-corresponding authors).
2.Liu, Z., Wu, J., andYu, X. (2007). CCDC98 targets BRCA1 to DNA damage sites.Nature Structural and Molecular Biology, 14, 716-720.
3. Huen, M., Grant, R., Manke, I., Minn, K.,Yu, X.*, Yaffe, M.* and Chen, J.* (2007). The E3 ubiquitin ligase RNF8 propagates the DNA damage signal via an ubiquitin-dependent signaling pathway.Cell, 131, 901-914. (*co-corresponding authors)
4. Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B. * andYu, X.* (2009) PALB2 links BRCA1 and BRCA2 in the DNA damage response.Current Biology, 19: 524-529. (* co-corresponding authors)
5. Lu, L.Y., Wu, J., Ye, L. Gavrilina, G.B., Saunders, T.L. andYu, X.(2010). RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis.Developmental Cell.18, 371-384.
6. Zhang, F. andYu, X.(2011). WAC, a partner of RNF20/40 complex, regulates histone H2B ubiquitination and gene transcription.Molecular Cell. 41, 384-397.
7. Wu, J., Chen, Y., Lu, L.Y., Wu, Y., Paulsen, M.T., Ljungman, M., Ferguson, D.O. andYu, X.(2011). Chfr and RNF8 synergistically regulate ATM activation.Nature Structural and Molecular Biology.18: 761-768.
8. Chen, Q., Chen, Y., Bian, C., Fujiki, R. andYu, X. (2013) TET2 promotes histone O-GlcNacylation during gene transcription.Nature493:561-564.
9. Ma, T., Chen, Y., Zhang, F., Yang, C-Y., Wang, S. andYu, X. (2013) RNF111-dependent neddylation activates DNA damage-induced ubiquitination.Molecular Cell.49: 897-907.
10. Li, M. andYu, X. (2013) Function of BRCA1 in the DNA damage response is mediated by ADPribosylation.Cancer Cell. 23:693-704.
11. Lu, L, Korakavi, G., Kuang, H. andYu, X. (2013) Distinct DNA damage responses on male meiotic sex Chromosomes.Nature Communications.3015.
12. Li, M., Lu, L., Yang, C., Wang, S. andYu, X. (2013) The FHA and BRCT domains recognize ADPribosylation during DNA damage response.Genes&Development.27: 1752-1768.
13. Chen, Y., Chen, Q., McEachin, R.C., Cavalcoli J.D. andYu, X. (2014) H2A.B facilitates transcription elongation at methylated CpG loci.Genome Research.24:570-579.
14. Zhang, F., Chen, Y., Li, M. andYu, X.(2014) The OB-fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response.Proceedings of the National Academy of Sciences111:7278-7283.
15.Li M, Chen Q, Ma T, andYu X.(2017)Targeting reactive nitrogen species suppresses hereditary pancreatic cancerProceedings of the National Academy of Sciences114:7106-7111.
16. Wang J, Yuan Z, Cui Y, Xie R, Wang M, Ma Y,Yu X* and Liu X.* (2018)Structure basis for the inhibition of the methyl-lysine binding function of 53BP1 by NUDT16L1/TIRR. (* co-corresponding authors)Nature Communications.9:2689.
17. Chen Q, Kassab MA, Dantzer F andYu X.(2018)PARP2 mediates branched poly-ADP-ribosylation in response to DNA damage.Nature Communications.9: 3233.
18. Bian C, Zhang C, Vyas A, Chen S-H, Liu C, Luo T andYu X. (2019) NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.Nature Communications.10:693.
19.Chen S-H andYu X(2019)Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies.Science Advances. 5:eaav4340.
20. Singh AK, Zhao B, Wang X, Li H, Qin H, Wu X, Ma Y, Horne D andYu X(2020)Selective targeting of TET catalytic domain promotes somatic cell reprogramming.Proceedings of the National Academy of Sciences117:3621-3626.


联系方式


电子邮箱：yuxiaochun@westlake.edu.cn