个人信息
姓　　名: 郑宏 性　　別: 男 院　　系: 药学院（分析测试中心）
行政职务: 职　　称: 副研究员 学术兼职:
导师类别: 学术型硕导 任硕导年月: 2016-12-30 任博导年月:
从事专业1: 药物分析学 从事专业2: 药理学 办公电话:
学　　历: 博士研究生 学　　位: 博士 E-mail: 123zhenghong321@163.com
毕业院校: 丹麦奥胡斯大学 毕业专业: 代谢组学 毕业时间:
人才类别: 校级“优青培养工程”培养对象 ， 温州市青年拔尖人才





本人从事的主要研究方向的特点、意义及其水平:2015年毕业于丹麦奥胡斯大学，获博士学位，同年9月入职温州医科大学药学院从事科研工作。近年来在国际SCI期刊 Anal. Chem., Anal. Chim. Acta, BBA-Mol. Basis Dis., mSystems等发表论文60余篇，其中第一或通讯作者40余篇，总影响因子200余点，引用1000余次。主持国家自然科学基金面上项目、国家自然科学基金青年项目、浙江省公益技术应用研究项目等5项，参与国家自然科学基金项目6项。获得温州市科技创新青年拔尖人才、浙江省“钱江人才”计划，温医大“****优青培养工程”和温医大药学院“瓯江青年”培养工程。获得浙江省科技进步奖二等奖和浙江省中医药科学技术奖二等奖各1项。



学术团体任职情况:

招生专业情况
招生专业1研究方向1招生专业2研究方向2招生专业3研究方向3招生备注
疾病代谢表型分析 药物代谢机制 肠道微生物

近五年发表期刊论文
论文名称期刊名称卷期 期刊类型影响因子本人排序
NMR-based metabolomics reveal a recovery from metabolic changes in the striatum of 6-OHDA-induced rats treated with basic fibroblast growth factor. Molecular Neurobiology 53 SCI 6.190 1
The hypothalamus as the primary brain region of metabolic abnormalities in APP/PS1 transgenic mouse model of Alzheimer's disease. BBA-Molecular Basis of Disease 1864（1） SCI 5.476 1
Analysis of neuron–astrocyte metabolic cooperation in the brain of db/db mice with cognitive decline using 13C NMR spectroscopy. Journal of Cerebral Blood Flow & Metabolism 37 SCI 5.081 1
Cognitive decline in type 2 diabetic db/db mice may be associated with brain region-specific metabolic disorders. BBA-Molecular Basis of Disease 1863(1) SCI 5.476 1
Optimal preprocessing of serum and urine metabolomic data fusion for staging prostate cancer through design of experiment. Analytica Chimica Acta 991 SCI 4.950 1
Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation. Scientific Reports 6 SCI 4.259 7
Metabolic characterization of hepatitis B virus-related liver cirrhosis using NMR-based serum metabolomics. Metabolomics 13（10） SCI 3.692 1
Metabolic effects of a 24-week energy-restricted intervention combined with low or high dairy intake in overweight women: An NMR-based metabolomics investigation. Nutrients 8(3) SCI 3.550 1
Prediction of relationship between surface area, temperature, storage time and ascorbic acid retention of fresh-cut pineapple using adaptive neuro-fuzzy inference system (ANFIS). Postharvest Biology and Technology 113 SCI 3.248 1
Predictive diagnosis of major depression using NMR-based metabolomics and least-squares support vector machine. Clinica Chimica Acta 464 SCI 2.873 1
An NMR-based metabolomic approach to unravel the preventive effect of water-soluble extract from Dendrobium officinale Kimura & Migo on streptozotocin-induced diabetes in mice. Molecules 22(9) SCI 2.861 1
High glucose-induced PC12 cell death by increasing glutamate production and decreasing methyl group metabolism. BioMed Research International Article ID ** SCI 2.476 1
Early effect of amyloid β-peptide on hippocampal and serum metabolism in rats studied by an integrated method of NMR-based metabolomics and ANOVA-simultaneous component analysis. BioMed Research International Article ID ** SCI 2.476 1
NMR-based metabolomics reveals brain region-specific metabolic alterations in streptozotocin-induced diabetic rats with cognitive dysfunction. Metabolic Brain Disease 32(2) SCI 2.297 1
Chemometrics coupled with ultraviolet spectroscopy: a tool for the analysis of variety, adulteration, quality and ageing of apple juices. International Journal of Food Science & Technology 51 SCI 1.640 1
The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice Frontiers in Pharmacology 11 7
Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus BBA-Molecular Basis of Disease 1865 6
Antibiotic Exposure Disturbs the Gut Microbiota and Its Metabolic Phenotype Differently in Rats with Advanced-Stage Type 1 Diabetes and Age-Matched Controls Journal of Proteome Research 18 1
Antibiotic Exposure Has Sex-Dependent Effects on the Gut Microbiota and Metabolism of Short-Chain Fatty Acids and Amino Acids in Mice mSystems 4 8
Tissue-Specific Metabolomics Analysis Identifies the Liver as a Major Organ of Metabolic Disorders in Amyloid Precursor Protein/ Presenilin 1 Mice of Alzheimer's Disease Journal of Proteome Research 18 1


出版专著教材情况
著作名称著作类型出版社出版时间排名

成果获奖情况
奖项名称奖项级别颁奖部门颁奖时间证书号排名

近五年完成的科研项目
项目名称任务来源完成形式完成日期鉴定验收单位主要结论排名
基于活体注射13C标记底物的核磁共振技术研究FGF21对糖尿病大鼠认知功能障碍的潜在治疗作用及其机制 2019-12-31 1
融合基于核磁共振血清和尿液代谢组学特征谱的早期前列腺癌精准预测诊断研究 2019-12-31 1
融合血清和尿液代谢组学特征谱的早期前列腺癌精准预测诊断研究 2019-12-31 1

目前承担的主要项目
项目名称项目类型项目来源起讫时间项目经费本人承担任务
基于活体注射13C标记底物的核磁共振技术研究FGF21对糖尿病大鼠认知功能障碍的潜在治疗作用及其机制 青年基金 国家自然科学基金 2017-01-01 20
融合基于核磁共振血清和尿液代谢组学特征谱的早期前列腺癌精准预测诊断研究 基础项目 其它 2017-01-01 15
融合血清和尿液代谢组学特征谱的早期前列腺癌精准预测诊断研究 成果转化与推广项目 其它 2018-01-01 3