职 务：PI
联系电话：(0571) **
E-mail：shen@idrbio.org
研究方向：中枢神经环路发育可塑性和视觉行为的调控机制
通讯地址：浙江省杭州市下沙高教园区学林街16号，310036
个人简历：
1994－1998 中国药科大学化学制药专业，本科
1999－2002 徐州医学院生物化学与分子生物学专业，硕士
2002－2006 中国科学院上海神经科学研究所，博士
2006－2008 美国冷泉港实验室，博士后
2008－2012 美国斯克里普斯研究所，博士后
2012－至今 杭州师范大学生命与环境科学学院，
科研项目
1. 国家自然科学基金面上项目**（2013-2016）（主持）：兴奋抑制平衡对神经环路可塑性及行为学的研究

论文专著
1. Shen W, Liu HH, Schiapparelli L, McClatchy D, He HY, Yates JR 3rd, Cline HT.(2014)Acute Synthesis of CPEB Is Required for Plasticity of Visual Avoidance Behavior in Xenopus. Cell Rep. S2211-1247(14)00041-2. [Epub ahead of print]
2. McKeown CR, Sharma P, Sharipov HE, Shen W, Cline HT. (2013) Neurogenesis is required for behavioral recovery after injury in the visual system of Xenopus laevis. J Comp Neurol. 521(10):2262-78.
3. Shen, W. H., Mckeown, C., Demas, J., and Cline, H. T. (2011) Inhibition to excitation ratio regulates visual system responses and behavior in vivo, J. Neurophysiol.106(5), 2285-302.
4. Ji Y.Y., Lu Y., Yang F., Shen W. H., Tang T.T., Feng L., Duan S., Lu B. (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nat Neurosci. 13(3), 302-309.
5. Chen, C. M., Chiu, S. L., Shen, W. H., and Cline, H. T. (2009) Co-expression of Argonaute2 enhances short hairpin RNA-induced RNA interference in Xenopus CNS neurons in vivo, Frontiers Neurosci. 3, 63.
6. Tong, X. P., Li, X. Y., Zhou, B., Shen, W. H., Zhang, Z. J., Xu, T. L., and Duan, S. M. (2009) Ca2+ signaling evoked by activation of Na+ channels and Na+/Ca2+ exchangers is required for GABA-induced NG2 cell migration, J. Cell Biol. 186, 113-128.
7. Shen, W. H.*, Da Silva, J. S.*, He, H. Y, and Cline, H. T. (2009) Type A GABA-receptor-dependent synaptic transmission sculpts dendritic arbor structure in Xenopus tadpoles in vivo, J. Neurosci. 29, 5032-5043.
8. Zheng, J., Shen, W. H., Lu, T. J., Zhou, Y., Chen, Q., Wang, Z., Xiang, T., Zhu, Y. C., Zhang, C., Duan, S. M., and Xiong, Z. Q. (2008) Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth, J Biol Chem 283, 13280-13288.
9. Yu, H.-M., Wen, J., Wang, R., Shen, W. H., Duan, S. M., and Yang, H.-T. (2008) Critical role of type 2 ryanodine receptor in mediating activity-dependent neurogenesis from embryonic stem cells, Cell Calcium 43, 417-431.
10. Shen, W. H.*, Wu, B.*, Zhang, Z. J., Dou, Y., Rao, Z. R., Chen, Y. R., and Duan, S. M. (2006) Activity-induced rapid synaptic maturation mediated by presynaptic cdc42 signaling, Neuron 50, 401-414. (This article was featured on this month's NEURON cover and preview by Atasoy and Kavalali)
11. Ge, W. P.*, Yang, X. J.*, Zhang, Z. J., Wang, H. K., Shen, W. H., Deng, Q. D., and Duan, S. M. (2006) Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors, Science 312, 1533-1537.
13. Yang, Y. L., Ge, W. P., Chen, Y. R., Zhang, Z. J., Shen, W. H., Wu, C. P., Poo, M. M., and Duan, S. M. (2003) Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine, Proc Natl Acad Sci U S A 100, 15194-15199.
14. Shen, W. H., Zhang, C. Y., and Zhang, G. Y. (2003) Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia, Acta Pharmacol Sin 24, 311-315.
15. Shen, W. H., Zhang, C. Y., and Zhang, G. Y. (2003) Antioxidants attenuate reperfusion injury after global brain ischemia through inhibiting nuclear factor-kappa B activity in rats, Acta Pharmacol Sin 24, 1125-1130.
18. Zhang, C. Y., Shen, W. H., and Zhang, G. Y. (2002) N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel antagonists suppress the release of cytochrome c and the expression of procaspase-3 in rat hippocampus after global brain ischemia, Neurosci Lett 328, 265-268.
19. Shen, W. H., Zhang, C. Y., and Zhang, G. Y. (2002) Nuclear factor kappaB activation is mediated by NMDA and non-NMDA receptor and L-type voltage-gated Ca2+ channel following severe global ischemia in rat hippocampus, Brain Res 933, 23-30.