马文学，男，河南开封人。1989年浙江大学医学院（原浙江医科大学）临床医学系本科，住院医师；1997年浙江大学医学院临床肿瘤学硕士，主治医师；2002年浙江大学医学院肿瘤学博士；2002年8月至2007年7月分别在美国UniversityofNebraskaMedicalCenter,UniversityofWisconsin-Madison,UniversityofCalifornia-SanDiego做博士后；2007年7月至2013年6月，在美国UniversityofCalifornia-SanDiego分别任AssistantProjectScientistI、II、III级（equivalenttoAssistantResearchProfessor）andTeamLeader；2013年7月至9月，在美国UniversityofCalifornia-SanDiego任AssociateProjectScientist（equivalenttoAssociateResearchProfessor）andTeamLeader。2013年9月至今，在浙江湖州师范学院医学院、护理学院任院长、特聘教授和学科带头人及硕士生导师。

一、教学工作：
研究生医学英语

二、研究方向：
1、肿瘤干细胞自我更新信号通路抑制及临床前治疗研究
2、肿瘤抗原肽纳米疫苗在肿瘤治疗和预防中的作用
3、免疫细胞的活化及其抗肿瘤作用研究

三、学术团体和社会兼职：
1.ISSCR(InternationalSocietyforStemCellResearch)国际干细胞研究协会会员，ID#21285
2.AACR(AmericanAssociationforCancerResearch)美国肿瘤研究协会会员,ID#123779
3.ASCO(AmericanSocietyofClinicalOncology)美国临床肿瘤学协会会员，ID#182831
4.ASH(AmericanAssociationofHematology)美国血液学协会会员，ID#1043131
5.ANO(AmericanNanoSociety)美国纳米学会高级荣誉会员，ID#114812
6.COHON(ChineseAmericanHematologistOncologistNetwork)美国华裔血液及肿瘤专家学会会员
7.浙江省生物医学学会理事
8.浙江省医学会医学教育分会委员

四、国际学术期刊特约专家审稿人：
1.DrugDelivery(2014)
2.ImmunoTargetsandTherapy(2013)
3.InternationalJournalofNanomedicine(2010,2011,2012,2013)
4.WorldJournalofGastroenterology(2011,2012)
5.AsianJournalofPharmaceutics(2012)
6.MolecularPharmaceutics(2012)
7.BiochemicalandBiophysicalResearchCommunications(2006)

五、国际发明专利：
2013_Inventors(发明人)CatrionaJamieson,WenxueMa(马文学).Methodstotreatand/orpreventrelapseinNotch1-drivenmalignancies.PCT/US2012/056747
http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2013044164

六、主要学术成就：
（一）主持的主要课题(ResearchProjects)：
1.浙江湖州师范学院科研启动基金。2013,PI
2.Telomerase-specificCytotoxicTlymphocytes(CTLs)inductionwithhumanDCs.GeronCorporationFoundation,PI(WM001)
3.PreclinicaldevelopmentofapanBCL2inhibitorforcancerstemcelldirectedtherapy.2010-2014,CIRM(美国加州再生医学研究院)，Co-Investigator(effort65%).
4.PreclinicaltrialofNOTCHinhibitionforLeukemiaStemCellsinT-ALL.2008-2012,PfizerInc,TeamLeader
5.TodevelopnanoparticlevaccinesbasedontheantigenSTEAPusinglymphocytesfromhealthydonors.2004-2008,DOD(美国国防部)，PrimaryScientist
6.NewapproachtoImmunotherapyofgliomawithsyntheticvaccines.2004-2006,NationalSocietyofBrainTumor(美国脑肿瘤协会)，PrimaryScientist
7.BiodegradableNanospheresforGeneDelivery.2002-2004,NebraskaResearchInitiatingProgram(美国Nebraska科研启动基金-基因治疗),PrimaryScientist
8.ApplicationofmutantSEAastheattenuatedsuperantigenincancerimmunotherapy.2001-2004,浙江省自然科学基金，批准号301580,Co-PI.

（二）主要获奖成果：
1.2010年WenxueMa.Scholar-inTrainingAward,AmericanAssociationforCancerResearch(AACR)
2.2010年WenxueMa.TravelAward,InternationalSocietyforStemCellResearch(ISSCR)
3.2010年第五届春晖杯中国留学人员创新创业大赛二等奖（马文学）
4.2007年第二届春晖杯中国留学人员创新创业大赛二等奖（马文学）
5.2005年浙江省医药卫生科技创新一等奖（余海王青青马文学黄常新李达曹雪涛)
6.2005年浙江省科技进步奖二等奖（余海王青青马文学黄常新李达曹雪涛)
7.2002年浙江省科技进步奖二等奖(余海王青青曹雪涛金洪传鱼达周伦马文学)
8.2002年浙江省医药卫生科技创新一等奖(余海王青青曹雪涛金洪传鱼达周伦马文学)

（三）发表的SCI论文
1.PanyamJ,DaliMM,SahooSK,MaW,ChakravarthiSS,AmidonGL,LevyRJ,LabhasetwarV.Polymerdegradationandinvitroreleaseofamodelproteinfrompoly(D,L-lactide-co-glycolide)nano-andmicroparticles.JControlRelease2003;92(1-2):173-187.


2.HuangC,YuH,WangQ,MaW,XiaD,YiP,ZhangL,CaoX.Potentantitumoreffectelicitedbysuperantigen-linkedtumorcellstransducedwithheatshockprotein70gene.CancerSci.2004;95(2):160-167


3.SahooSK,MaW,LabhasetwarV.Efficacyoftransferrin-conjugatedpaclitaxelloadednanoparticlesinamurinemodelofprostatecancer.IntJCancer2004;112(2):335-340[ListedonNCIwebsiteunderNCIAllianceforNanotechnologyinCancer]


4.MaW?*,YuH,WangQ,BaoJ,YanJ,JinH.InvitrobiologicalactivitiesoftransmembranesuperantigenstaphylococcalenterotoxinAfusionprotein.CancerImmunolImmunother.2004;53(2):118-124[^＊通讯作者]


5.MaW*,YuH,WangQ,JinH,SolheimJ,LabhasetwarV.ANovelapproachforCancerImmunotherapy:TumorCellsAnchoredwithSuperantigenSEAGenerateEffectiveAntitumorImmunity.JClinImmunol.2004;24(3):294-301[^＊通讯作者]


6.HuangC,YuH,WangQ,YangG,MaW,XiaD,ChenX,YiP,ShenF,ZhengH,CaoX.Anovelanticancerapproach:SEAanchoredtumorcellsexpressingheatshockprotein70ontothesurfaceelicitstronganticancerefficacy.ImmunolLett.2005;101(1):71-80


7.MaW*,YuH,YiP,WangQ,MinevBR.PreparationofmurineB7.1-glycosyl-phosphatidylinositolandtransmembrane-anchoredstaphylococcalenterotoxin.Adual-anchoredtumorcellvaccineanditsantitumoreffect.Cancer2005;103(7):1519-1528[^＊通讯作者]


8.MaW*,DengY,ZhouL.TheprognosticvalueofadhesionmoleculeCD44v6inwomenwithprimarybreastcarcinoma:aclinicopathologicstudy.ClinOncol.2005;17(4):258-263[^＊通讯作者]


9.TelusmaG,DarraS,MihajlovI,MaW,LiJ,YangH,NewmanW,MessmerB,MinevB,SchmidtWoftI,TraceyK,ChiorazziN,MessmerD.Dendriticcellactivatingpeptidesinducedistinctcytokineprofiles.IntImmunol.2006;18(11):1563-1573


10.ZhangJ.,EguchiJ.,KruseC.,GomezG.,FakhraiH.,SchroterS.,MaW.,HoaN.,MinevB.,DelgadoC.,WepsicH.,OkadaH.andJadusM.Antigenicprofilesofhumangliomacelllines:ImplicationsforpatientCTLtargetingoftumorassociatedantigenswithallogeneictumorcell-basedvaccineorotherimmune-cellbasedtherapies.ClinCancerRes.2007;13:566-575


11.LiuW,GuW,ZhouY,TangH,LiM,MaW*.Theeffectofpreoperativetranscatherterarterialchemo-embolizationonWilms’tumor.EurJClinInvest.2008;38(12):931-938[^＊通讯作者]


12.GutierrezA,SandaT,MaW,ZhangJ,GrebliunaiteR,DahlbergS,NeubergD,ProtopopovA,WinterSS,LarsonRS,BorowitzMJ,SilvermanLB,ChinL,HungerSP,JamiesonC,SallanSE,LookAT.InactivationofLEF1inT-cellacutelymphoblasticleukemia.Blood.2010;115(14):2845-2851.


13.ClawsonC,HuangCT,FutalanD,MartinSeibleD,SaenzR,LarssonM,MaW,MinevB,ZhangF,OzkanM,OzkanC,EsenerS,MessmerD.Deliveryofapeptideviapoly(d,l-lactic-coglycolic)acidnanoparticlesenhancesitsdendriticcell-stimulatorycapacity.Nanomedicine.2010;6(5):651-661


14.ZhouJ,BasheyA,ZhongR,CorringhamS,MesserK,PuM,MaW,SoifferR,MitrovichRC,LowyI,BallED.CTLA4BlockadefollowingRelapseofMalignancyafterAllogeneicStemCellTransplantationisAssociatedwithTcellActivationbutnotIncreasedLevelsofTRegulatoryCells.BiolBloodMarrowTransplant.2011;17(5):682-692


15.MaW,SharmaB,PanyamJ,AdjeiI,DimitrijevicS,LabhasetwarV.Nanoparticle-mediatedp53genedeliveryfortumorinhibition.DrugDelivTranslRes.2011;1(1):43-52.



16.MaW*,SmithT,ZhangY,OzkanC,OzkanM,HaydenM,SchroterS,CarrierE,MessmerD,KumarV,MinevB.EnhancedAntigenPresentationofMHCClassIrestrictedandCD8αα+TregActivatingPeptidesEncapsulatedinBiodegradableNanoparticles.JTranslMed.2011;31;9(1):34.[^＊通讯作者]


17.MaW*,ChenM,KaushalS,McElroyM,ZhangY,OzkanC,BouvetM,MinevB.PLGANanoparticle-mediateddeliveryoftumorantigenicpeptideselicitseffectiveimmuneresponses.IntJNanomedicine.2012;7:1475-1487.[^＊通讯作者]


18.SandaT,LawtonLN,BarrasaMI,FanZP,KohlhammerH,GutierrezA,MaW,TatarekJ,AhnY,KelliherMA,JamiesonCH,StaudtLM,YoungRA,LookAT.CoretranscriptionalregulatorycircuitcontrolledbytheTAL1complexinhumanTcellacutelymphoblasticleukemia.CancerCell.2012;22(2):20921


19.MaW,GutierrezA,GoffDJ,GeronI,SadaranganiA,JamiesonCA,CourtAC,ShihAY,JiangQ,WuCC,LiK,SmithKM,CrewsLA,GibsonNW,DeichaiteI,MorrisSR,WeiP,CarsonDA,LookAT,JamiesonCH.NOTCH1signalingpromoteshumanTcellacutelymphoblasticleukemiainitiatingcellregenerationinsupportiveniches.PLoSOne.2012;7(6):e39725.


20.SandaT,TynerJW,GutierrezA,NgoVN,GloverJ,ChangBH,YostA,MaW,FleischmanAG,ZhouW,YangY,KleppeM,AhnY,TatarekJ,KelliherM,NeubergD,LevineRL,MorigglR,MullerM,GrayNS,JamiesonCH,WengAP,StaudtLM,DrukerBJ,LookAT.TYK2-STAT1-BCL2PathwayDependenceinT-CellAcuteLymphoblasticLeukemia.CancerDiscov.2013;3(5):564-577


21.GoffDJ,RecartAC,SadaranganiA,ChunHJ,BarrettCL,KrajewskaM,LeuH,Low-MarchelliJ,MaW,ShihAY,WeiJ,ZhaiD,GeronI,PuM,BaoL,ChuangR,BalaianL,GotlibJ,MindenM,MartinelliG,RusertJ,DaoKH,ShazandK,WentworthP,SmithKM,JamiesonCA,MorrisSR,MesserK,GoldsteinLS,HudsonTJ,MarraM,FrazerKA,PellecchiaM,ReedJC,JamiesonCH.APan-BCL2InhibitorRendersBone-MarrowResidentHumanLeukemiaStemCellsSensitivetoTyrosineKinaseInhibition.CellStemCell.2013;12(3):316-28.

（四）发表的中文论文(ChineseJournals)21篇(略)

七、发表的论著：
1.马文学，余海。重组超抗原葡萄球菌肠毒素A基因膜型表达载体的构建。杨晓、邓初夏主编《基因打靶和功能基因组学》2001北京军事医学科学出版社


2.PrabhaS,MaW,andLabhasetwarV.BiodegradablenanoparticlesasGeneExpressionVector.PolymericGeneDelivery:PrinciplesandApplications.EditedbyMansoorM.Amiji,CRCPress.357-366,2004


3.SchroterS,HaydenM,MaW,RehanN,andMinevB.CancerVaccines.IN:CancerManagementinMan:Chemotherapy,BiologicalTherapy,HyperthermiaandSupportingMeasures,Minev,B.(Ed.);CancerGrowthandProgressionBookSeries.ISBN978-90-481-9703-3.SpringerPress.Vol.13:257-284,2011

八、主要国际会议（Peer-ReviewedInternationalConferenceAbstracts）
1.WenxueMa.TargetingCMLStemCellswithNovelPan-BCL2InhibitorCombinedwithBCR-ABLTyrosineKinaseInhibitor.5^thAnnualInternationalForum:Regional&TargetingTherapiesCancer.Nov.7-10,2013,Shanghai,China(OralPresentation).


2.WenxueMa,JanineLowMarchelli,HeatherS.Leu,AngelaCourtRecart,JunWei,MaurizioPellecchia,MarylaKrajewska,XianshuHuang,CatrionaH.M.Jamieson*.Combinationoftyrosine-kinaseinhibitorandanovelpanBCL2familyproteininhibitoroffernewtreatmentforblastcrisischronicmyeloidleukemiastemcells.104thAACRAnnualConference,April6-10,2013,WashingtonDC,USA(PosterPresentation).


3.WenxueMa,AlejandroGutierrez,PingWei,AnilSadarangani,DanielJ.Goff,AliceY.Shih,AngelaC.Court,QingfeiJiang,HeatherLeu,RussellH.Wall,LeslieA.Crews,A.ThomasLook,andCatrionaH.M.Jamieson*.NOTCH1signalingisessentialforleukemiainitiatingcellself-renewalinT-ALL.103rdAACRAnnualConference,March31-April4,2012.CancerResearch,2012;72(8),Supplement1?doi:10.1158/1538-7445.AM2012-1011,Chicago,IL,USA(OralPresentationatthesessionof“RegulationofCancerStemCells”)


4.WenxueMa,AlejandroGutierrez,DanielGoff,IfatGeron,AnilSadarangani,AliceShih,AngelaCourtRecart,QingfeiJiang,JerryC.Wu,ChristinaC.Wu,HeatherLeu,RussellWall,RhonnieGeyrozaga,MitchellDiccianni,KangLi,ToddVanArsdale,PingWei,DennisCarson,A.ThomasLook,andCatrionaJamieson*.AselectiveNotch1mAbtargetsleukemiaprogenitorcellsinT-ALL.102ndAACRAnnualMeeting,April2-6,2011,Orlando,FL,USA.CancerResearch,2011;71(8),Supplement1doi:10.1158/1538-7445.AM2011-974(OralPresentationat“StemCellsinCancerBiologyandTherapy”)


5.WenxueMa,AlejandroGutierrez,QinghaiPeng,DanielGoff,ChristinaWu,AliceShih,AngelaCourt,IfatGeron,KangLi,MitchellDiccianni,AliceL.Yu,A.ThomasLookandCatrionaJamieson*.MousemodelofhumanT-cellacutelymphoblasticleukemiastemcells.101stAACRannualmeeting,April17-21,2010,WashingtonDC,USA.CancerResearch,2010;70(8),Supplement1doi:10.1158/1538-7445.AM10-4313(PosterPresentation)


6.WenxueMa.EnhancedantigenpresentationofMHCclassIrestrictedpeptidesencapsulatedinbiodegradablenanoparticles.99thAACRannualmeeting,April12-16,2008.SanDiego,CA,USA(PosterPresentation)


7.WenxueMa,KristenM.Smith,AlejandroGutierrez,HeatherS.Leu,QingfeiJiang,ChristinaC.N.Wu,AliceY.Shih,AngelaC.Court-Recart,AnilSadarangani,DanielJ.Goff,PingWei,A.ThomasLookandCatrionaH.M.Jamieson*.NOTCH1SignalingDefinesaLeukemiaInitiatingCellPopulationinT-CellAcuteLymphoblasticLeukemia.53rdASHAnnualMeeting,December10-13,2011.SanDiego,CA,USA(PosterPresentation)


8.WenxueMa,AlejandroGutierrez,DanielGoff,AngelaCourt-Recart,AliceYShih,QingfeiJiang,AnilSadarangani,ChristinaC.N.Wu,ChristinaJamieson,MitchellDiccianni,PingWei,ToddVanArsdale,ThomasLook,andCatrionaJamieson.ANotchMutationalHierarchyAmongHumanT-ALLLeukemiaStemCells.December4-7,2010.Orlando,FL,USA(PosterPresentation)


9.WenxueMa,AlejandroGutierrez,AnilSadarangani,DanielJ.Goff,SheldonR.Morris,PingWei,DennisA.Carson,A.ThomasLook,CatrionaJamieson.Notch1signalingdriveshumanT-cellacutelymphoblasticleukemiainitiatingcellsurvivalandself-renewal.June13-16,2012.Yokohama,Japan(PosterPresentation)


10.WenxueMa,AlejandroGutierrez,QinghaiPeng,KangLi,DanielGoff,AliceShih,AngelaCourt,IfatGeron,ChristinaWu,MitchellDiccianni,AliceLYu,A.ThomasLook,CatrionaJamieson*.MousemodelofhumanT-cellacutelymphoblasticleukemiastemcellsandtreatmentwithNotch1monoclonalantibody.8thISSCRAnnualMeeting.June16-19,2010.SanFrancisco,CAUSA(PosterPresentation)

11.WenxueMa,AnnelieSchairer,AlejandroGutierrez,DanielGoff,MitchellDiccianni,AliceL.Yu,ThomasLook,CatrionaJamieson.CD34+CD38-Lin-CD4-CD7-proportionascandidateleukemiastemcellsinT-cellacutelymphoblasticleukemia(T-ALL).7thISSCRAnnualMeeting.July8-11,2009.Barcelona,Spain(PosterPresentation)


九、联系方式

wma@hutc.zj.cn








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