蔡乐（博士，教授，硕士生导师） 专业：分析化学

团队：分离分析团队

电话：
电子信箱：caile@ynu.edu.cn
受教育经历及工作经历：

2000、2003和2006年先后获华西医科大学理学学士、四川大学理学硕士和博士学位；
2007年，云南大学化学科学与工程学院工作。
教学：
主讲《药用植物学》、《微生物学概论》和《化合物结构鉴定与表征》。
研究领域和兴趣：
微生物发酵改性中药材，微生物转化反应以及天然药物化学研究。
论文、专著：
[1] Cai, Le; Zhao, Mian; Liu, Shi-Xi Yin, Tian-Peng Zhou, Hao; Dong, Jian-Wei; Yang, Ya-Bin; Ding, Zhong-Tao* Pashinintide A, the first plant cyclopeptide from Rosaceae, included a sucrose, suggests a new natural receptor for saccharide. Tetrahedron Letters 2014, 55, 6231-6235.
[2] Dong, Jian-Wei; Cai, Le*; Xiong, Jie; Chen, Xiu-Hua Wang, Wei-Ying; Shen, Ni; Liu, Bei-Lei; Ding, Zhong-Tao* Improving the antioxidant and antibacterial activities of fermented Bletilla striata with Fusarium avenaceum and Fusarium oxysporum. Process Biochemistry 2015, 50, 8-13.
[3] Dong, Jian-Wei; Cai, Le*; Zhu, Xiu-Fang, Huang, Xing, Yin, Tian-Peng, Fang, Hai-Xian; Ding, Zhong-Tao* Antioxidant activities and phenolic compounds of Cornhusk, Corncob and Stigma Maydis. Journal of the Brazilian Chemical Society 2014, 25, 1956-1964.
[4] Cai, Le; Liu, Chuan-Shui; Fu, Xiao-Wei; Shen, Xiao-Jing; Yin, Tian-Peng; Yang, Ya-Bin; Ding, Zhong-Tao*. Two new glucosides from the pellicle of the walnut (Juglans regia). Natural Product and Bioprospecting 2012, 2, 150-153
[5] Cai, Le, Fang, Hai-Xian, Yin, Tian-Peng, Yu, Jing, Li, Zhen-Jie, Dong, Jian-Wei, Ding, Zhong-Tao*. Unusual C₁₉-diterpenoid alkaloids from Aconitum vilmorinianum var. patentipilum. Phytochemistry Letters 2015, 14, 106-110.
[6] Yang, Ming-Hui; Fang, Yun-Shan; Cai, Le*; Li, Ying; Dong, Jian-Wei; Yin, Tian-Peng; Huang, Cai-Li; Ding, Zhong-Tao. A new flavone C-glycoside and a new bibenzyl from Bulbophyllum retusiusculum. Natural Product Research 2016, 30, 1617–1622.
[7] Cai, Le; Dong, Jian-Wei; Zhao, Li- Xing; Zhou, Hao; Xing, Yun; Li, Ying; Li, Zhen-Jie; Duan, Wei-He; Li, Xue-Jiao; Ding, Zhong-Tao. An improved water-soluble/stereospecific biotransformation of aporphine alkaloids in Stephania epigaea to 4R-hydroxyaporphine alkaloids by Clonostachys rogersoniana. Process Biochemistry 2016, 51, 933-940.
[8] Xing, Yun; Cai, Le*; Yin, Tian-Peng; Chen, Yang; Yu, Jing; Wang, Ya-Rong; Ding, Zhong-Tao*. Improving the antioxidant activity and enriching salvianolic acids by the fermentation of Salvia miltiorrhizae with Geomyces luteus. Journal of Zhejiang University-Science B (Biomedicine & Biotechnology) 2016, 17, 391-398.
[9] Dong, Jian-Wei; Cai, Le*; Xing, Yun; Yu, Jing; Ding, Zhong-Tao. Re-evaluation of ABTS*+ Assay for Total Antioxidant Capacity of Natural Products. Natural product communications 2015, 10, 2169-2172.
[10] Yin, Tian-Peng, Cai, Le, Fang, Hai-Xian, Fang, Yun-Shan, Li, Zhen-Jie, Ding, Zhong-Tao*. Diterpenoid alkaloids from Aconitum vilmorinianum. Phytochemistry 2015, 116, 314-319.
[11] Li, Ying, Cai, Le, Dong, Jian-Wei, Xing, Yun, Duan, Wei-He, Zhou, Hao, Ding, Zhong-Tao*. Innovative approach to the accumulation of rubrosterone by fermentation of Asparagus filicinus with Fusarium oxysporum. Journal of Agricultural and Food Chemistry 2015, 63, 6596-6602.
[12] 马迎聪，俞静，王家鹏，蔡乐*，丁中涛．韭菜根的化学成分研究．中国药学杂志 2016, 51, 972-975.
[13] 韦琨，蔡乐*，刘金，周皓，曹秋娥．我校新开教学实验“荷包牡丹碱的分离纯化”的设计．中国医药导报 2016, 13, 167-169.
科研项目、成果和专利：
1．苏铁蕨活性成分研究以及brainicine B 及其异构体的合成研究，国家自然科学基金(**)，2011.1-2013.12。（负责，已结题）
2．四种滇产乌头的发酵改性及发酵乌头的镇痛抗炎活性物质基础研究，国家自然科学基金(**)，2015.1-2018.12。（负责，在研）
3．棠梨花和短瓣兰的抗肿瘤和抗氧化活性成分研究，云南省自然科学基金(2010CD017)，2015.1-2018.12。（负责，在研）
4．丁中涛，蔡乐，李莹．“通过尖孢镰刀菌发酵改性小百部富集红苋甾酮的新方法”，中国发明专利，专利号：5.1。
5．丁中涛，蔡乐，李振杰．“苯丙烯酸类化合物顺反两种异构体相互转化的方法”，中国发明专利，专利号：4.X。
6．丁中涛，蔡乐，董建伟．“通过Clonostachys sp. 发酵转化荷包牡丹碱为(4S,6aR)-4-羟基荷包牡丹碱的方法”，中国发明专利，专利号：8.X。