个人信息
赵大克，男，博士，副教授。
联系方式
地址：云南省昆明市 云南大学呈贡校区生命科学学院2栋2317；
邮箱：zhaodk2012@ynu.edu.cn
研究兴趣
植物天然产物在增强植物抗逆、适应生境方面具有关键的生态学意义，具有重要的学术探究价值；植物天然产物还具有多种独特的药用活性，为人类提供了不可或缺的天然药物资源。专注于探究植物天然产物的结构和生物活性多样性，发掘具有治疗疾病效果的先导化合物，揭示其生物合成机制及生态学功能。具体研究方向如下：
1. 乌头属植物二萜生物碱多样性及生物合成途径解析、活性物质生物全合成和生态学功能发掘；
2. 褪黑素生物合成途径解析，转录水平及表观遗传调控、生物学功能及进化机制解析；
3. 兰科种子与真菌共萌发的信号化学物质基础及分子基础。
教学与课程
《植物学》、《植物生物技术》。
教育背景和工作经历
2012-至今 云南大学 讲师/副教授
2017-2019 云南白药集团/中国科学院西双版纳热带植物园 药学 博士后
2013-2016 云南大学 生命科学学院 生物学 博士后；
2009-2012 中国科学院昆明植物研究生 植物学 博士；
2003-2009 云南农业大学 园林园艺学院 园林/园林植物与观赏园艺 学士/硕士；
主持项目
云南省自然科学基金重点项目，具有重要生物活性的二萜生物碱合成途径中初始骨架的生物合成，2021-2023，在研；
云南省“****”青年拔尖人才，云南省委组织部人才项目，2021-2025，在研；

国家自然科学基金，“生态专一型”兰科菌根真菌促进金沙江石斛种子萌发机理研究 （**）， 2020.01-2023.12，在研；
国家自然科学基金，乌头剧毒特性关键BAHD酰基转移酶基因的鉴定与功能研究**，2016-2019；
云南白药集团，基于代谢组学定向鉴定低毒（无毒）乌头种质资源中高效镇痛活性成分， 201-2018；
“云南大学青年骨干教师”培养计划，2016-2019；
浙江省植物有害生物防控重点实验室—省部共建国家重点实验室培育基地培育开放基金项目，野生小米椒辣椒素合成关键酶基因鉴定及其与‘高辣’特性的关联分析， 2015-2017。
发表主要论文(第一及通讯作者)
一、乌头属植物二萜生物碱多样性及生物合成途径解析、活性物质生物全合成和生态学功能发掘；
1. Shen, Y., Liang, W.J., Shi, Y.N., Kennelly*, E.J., Zhao, D.K.* (2020) Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids.Natural Product Reports. 37, 763-796. (封面论文) (JCR 1区)
2. Shi, Y.N. , Zhao, Y., Qian, J., Dong, Z., Wen, G.S.*, Zhao, D.K.*, Kennelly, E.J.* (2021) Aconitum Diterpenoid Alkaloid Profiling to Distinguish between the Official Traditional Chinese Medicine (TCM) Fuzi and Adulterant Species Using LC-qToF-MS with Chemometrics. Journal of Natural Products. Doi:10.1021/acs.jnatprod.0c00851. (JCR 2区)
3. Zhao, D.K.^＃; Shen, Y.^＃; Shi, Y.N.^＃; Shi, X.Q.; Qiao, Q.; Zi, S.H.; Zhao, E.Q.; Yu, D.Q.; Kennelly, E.J. (2018) Probing the transcriptome of Aconitum carmichaelii reveals the candidate genes associated with the biosynthesis of the toxic aconitine-type C₁₉-diterpenoid alkaloids. Phytochemistry. 152 :113-124. (JCR 2区)
4. Zhao, D.K.; Shi, X.Q.; Zhang, L.M.; Yang, D.Q.; Guo, H.C.; Chen, Y.P.; Shen, Y. 2017. Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum. Chinese Chemcal Letters. 28(2): 358–361. (JCR 2区)
5. Guo, R; Guo, C; He, D; Zhao, D*; Shen, Y. * (2017). Two New C19‐Diterpenoid alkaloids with anti‐inflammatory activity from Aconitum iochanicum. Chinese Journal of Chemistry. 35 (10): 1644–1647.(JCR 2区)
6. Zhao, D.K.; Ai, H.; Zi, S.; Zhang, L.; Yang, S.; Guo, H.; Shen, Y.; Chen, Y.; Chen, J. 2013. Four new C₁₈–diterpenoid alkaloids with analgesic activity from Aconitum weixiense. Fitoterapia. 91: 280–283. (JCR 3区)
7. Zhao, D.^＃; Shi, Y.^＃; Zhu, X.; Liu, L.; Ji, P.; Long, C.; Shen, Y.; Kennelly, E.J. (2018). Identification of potential biomarkers from Aconitum carmichaelii, a traditional Chinese medicine, using a metabolomic approach. Planta Medica. 84(06/07):434-441. (JCR 3区)
8. Li, G.Q.; Zhang, L.M.; Zhao, D.K.*_; Chen, Y.P.; Shen, Y.* (2016). Two new C₁₉–diterpenoid alkaloids from Aconitum tsaii. Journal Asian Natural Product Research. 19(5):1–5.
9. Lv, Y., Shen, Y. Shi, Y. Shen, F. Chen, Y. Zi, S. Zhu, Z. Kennelly, E. J. Zhao, D*. (2019) Root-Endophytic Fungi Diversity Of Fuzi (Aconitum Carmichaelii) And Their Anti-Fungal Activity. Applied Ecology And Environmental Research 17(6):15289-15300.
10. Duan, X.Y.; Zhao, D.K. *; Shen, Y*. (2018). Two new bis–C₂₀–diterpenoid alkaloids with anti–inflammation activity from Aconitum bulleyanum. Journal Asian Natural Product Research. 21(4):323-330.
11. Liu, W.Y.; Zhao, D.K.*; Chen, Y.P.; Shen, Y. (2018) Four new C₁₉-diterpenoid alkaloids from the roots of Aconitum ouvrardianum. Journal Asian Natural Product Research. 21(1), 9-16.

二、褪黑素生物合成途径解析，转录水平及表观遗传调控、生物学功能及进化解析；
1. Zhao, D.K.,* Wang, H.P., Chen, S.Y., Yu, D.Q., Reiter, J.R. Phytomelatonin: an emerging regulator of plant biotic stress resistance. Trends in Plant Science. 2020; doi: 10.1016/j.tplants.2020.08.009. (JCR 1区)
2. Yu, Y., Teng, Z., Mou, Z., Lv, Y., Li, T., Chen, S. Zhao, D.K.,* Zhao, Z.* Melatonin confers heavy metal-induced tolerance by alleviating oxidative stress and reducing the heavy metal accumulation in Exophiala pisciphila, a dark septate endophyte (DSE). BMC Microbiology. 2021, 21:40. (JCR 2区)
3. Jiemei Zhang, ZhengpingYao, Renjun Zhang, Zongmin Mou, Honghui Yin,Tianyang Xu, Zhao D.K.*;and Suiyun Chen*. Genome-Wide Identification and Expression Profile of the SNAT Gene Family in Tobacco (Nicotiana tabacum). Frontiers in Genetics. doi: 10.3389/fgene.2020.591984 (JCR 2区)
4. Zhao, D.K., Yu, Y., Shen, Y., Liu, Q., Zhao, Z, Sharma, R., and Reiter, R.J. (2019) Melatonin Synthesis and Function: Evolutionary History in Animals and Plants. Frontiers in Endocrinology. 10:249. (WOS高被引论文) (JCR 2区)
5. Liu, DD, Sun XS , Liu L , Shi HD , Chen SY*, Zhao DK. *. Overexpression of the melatonin synthesis-related gene slcomt1 improves the resistance of tomato to salt stress. Molecules. 2019, 24(8)，1514. (JCR 3区)
6. Yu, Y.; Lv, Y.; Shi, Y.; Li, T.; Chen, Y.; Zhao, D.K. *; Zhao, Z*. 2018. The role of phyto-melatonin and related metabolites in response to stress. Molecules. 2018, 23(8), 1887. (JCR 3区)

三、兰科种子与真菌共萌发的信号化学物质基础及分子基础解析；
1. Shao, S.C., Wang, Q.X., Beng, K.C., Zhao, D.K.* Jacquemyn H*. Fungi isolated from host protocorms accelerate symbiotic seed germination in an endangered orchid species (Dendrobium chrysotoxum) from southern China. Mycorrhiza. 2020;30(4):529-539. (JCR 2区)
2. Wang, Q., Shao. S., Su, Y., Hu, X,, Shen, Y*, Zhao, D.K. (2019) A novel case of autogamy and cleistogamy in Dendrobium wangliangii: A rare orchid distributed in the dry‐hot valley. Ecology and Evolution. 9(22):12906-12914. (JCR 2区)
3. Zhao, D.K.^＃; Shi, Y.^＃; Senthilkumar, H.A.; Qiao, Q.; Wang, Q.; Shen, Y.; Hu G. 2019. Enriched networks ‘nucleoside/nucleotide and ribonucleoside/ ribonucleotide metabolic processes’ and ‘response to stimulus’ potentially conferred to drought adaptation of the epiphytic orchid Dendrobium wangliangii. Physiology and Molecular Biology Plants. 25(1):31-45. (JCR 3区)
4. Zhao, D.K.; Hu, G.W.; Chen, Z.Y.; Shi, Y.N.; Zheng, L.; Tang, A.J.; Long, C.L. 2013. Micropropagation and in vitro flowering of Dendrobium wangliangii– a critically endangered medicinal orchid. Journal of Medicinal Plants Research. 7(28): 2098–2110.

四、其他研究；
1. Zhao, D.K.^＃; Shi, Y.N.^＃; Petrova, V.; Grace, G. L. Y.; Negrin, A.; Wu, S.B.; D’Armiento, J. M.; Lau, C. B. S.; Kennelly E. J. 2019. Jaboticabin and Related Polyphenols from Jaboticaba (Myrciaria cauliflora) with Anti-inflammatory Activity for Chronic Obstructive Pulmonary Disease. Journal of Agricultural and Food Chemistry. 67(5):1513-1520.(JCR 1区)
2. He, J., Pu, C.J., Wang, M., Li, Z.H., Feng, T.,* Zhao, D.K.,* Liu, J.K.* Conosiligins A?D, ring-rearranged tremulane sesquiterpenoids from Conocybe siliginea. Journal of Natural Products. 2020; doi:10.1021/acs.jnatprod.0c00681.(JCR 2区)
3. Zhao, D.K.; Li, T.; Shen, M.; Wang, J.L.;Zhao, Z.W. 2015. Diverse strategies conferring extreme cadmium (Cd) tolerance in the dark septate endophyte (DSE), Exophiala pisciphila: evidence from RNA–seq data. Microbiological Research. 170: 27–35. (JCR 2区)
4. Shen, M.*; Zhao, D.K. *; Qiao, Q.; Liu, L.; Wang, J.L.; Cao, G.H.;Li, T.;Zhao, Z.W. 2015. Identification of glutathione S–transferase (GST) genes from a dark septate endophytic fungus (Exophiala pisciphila) and their expression patterns under varied metals stress. PLOS One. e** (JCR 3区)

研究生招生
(1) 植物学专业（生态学与环境学院）
硕士招生方向：植物学
(2) 生物工程专业（生命科学学院）
硕士招生方向：生物工程；