严胜骄 教授
研究领域：有机合成、杂环药物合成

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实验室电话 : **
电子信箱：yansj@ynu.edu.cn



1991~1995年：云南大学应用化学系本科；

2000~2003年：云南大学化学系有机化学专业硕士
2003~2006年：中科院化学研究所，获理学博士学位（导师：黄志镗 院士 俞初一 研究员）；

2006~2009年：云南大学化工学院，讲师；
2009~2014年：云南大学化工学院，副教授；硕士导师；

2014年至今：云南大学化工学院，教授；硕士导师；

主讲课程：

药物合成反应（云南大学制药、化学专业本科生）; 绿色化学（云南大学化学、应用化学专业本科生）

研究领域与研究兴趣：

1、类天然杂环化合物的设计、合成及抗肿瘤活性研究 2、含氟化合物的合成及生物活性研究

主持在研项目：

多环喹啉衍生物的设计、合成及抗肿瘤活性研究; 茚并喹啉衍生物的设计、合成及抗肿瘤活性研究

代表性论文：

1. Shengjiao Yan, Yulan Chen, Lin Liu, Nengqin He, Jun Lin*, Three-Component Solvent-Free Synthesis of Highly Substituted Bicyclic Pyridines Containing a Ring-Junction Nitrogen, Green Chem. 2010, 12, 2043~2052.

2. Shengjiao Yan, Chao Huang, Cunxiang Su, Yongfen Ni, and Jun Lin*, Facile Route to 1,3-Diazaheterocycle-Fused[1,2b]Isoquinolin-1(2H)-one Derivatives via Substitution- Cyclization Reactions, J. Comb. Chem. 2010, 12, 91~94.

3. Yu, F.-C., Yan, S.-J.*, Hu, L., Wang, Y.-C., Lin, J.*, Cascade Reaction of Indoline-2,3-dione with Heterocyclic Ketene Aminals: Synthesis of Indenoquinoline Derivatives, Org. Lett. 2011, 13, 4782~4785.

4. Fuchao Yu, Rong Huang, Hangchen Ni, Juan Fan, Shengjiao Yan* and Jun Lin*, Three-component stereoselective synthesis of spirooxindole derivatives, Green Chem., 2013, 15, 453~462.

5. Zhang, Y.-C.; Liu, Z.-C.; Yang, R.; Zhang, J.-H. Yan, S.-J.*; Lin, J.* Regioselective construction of 1,3-diazaheterocycle fused [1,2-a][1,8]naphthyridine derivatives via cascade reaction of quinolines with heterocyclic ketene aminals: a joint experimental–computational approach, Org. Biomol. Chem. 2013, 11, 7276?7288 (杂志封面文章)

6. Chen, X.-B.; Liu, X.-M.; Huang, R.; Yan, S.-J.*; Lin, J.* Three-Component Synthesis of Indanone-Fused Spirooxindole Derivatives, Eur. J. Org. Chem. 2013, 4607?4613.

7. Zhou, B.; Liu, Z.-C.; Qu, W.-W.; Yang, R.; Lin, X.-R.; Yan, S.-J.*; Lin, J.* An environmentally benign, mild, and catalyst-free reaction of quinones with heterocyclic ketene aminals in ethanol: site-selective synthesis of rarely fused [1,2-a]indolone derivatives via an unexpected anti-Nenitzescu strategy, Green Chem., 2014, 16, 4359~4370.

8. Chen, X.-B. Liu, Z.-C.; Lin, X.-R.; Huang, R.; Yan, S.-J.*; Lin, J.* Highly Diastereoselective Convergent Synthesis of Polycyclic Pyrroles with Consecutive Quaternary Stereocenters: Cascade Construction of Multiple C?C and C?Hetero Bonds, ACS Sustainable Chem. Eng. 2014, 2, 2391?2398.

9. Wang, K.-M.; Yan, S.-J.*; Lin, J.* Heterocyclic Ketene Aminals: Scaffolds for Heterocycle Molecular Diversity, Eur. J. Org. Chem. 2014, 1129?1145.

10. Huang, C.; Yan, S.-J.*; Zeng, X.-H.; Sun, B.; Lan, M.-B.; Lin, J.* Synthesis and evaluation of the antitumor activityof polyhalo acridone derivatives, RSC Adv. 2015, 5, 17444?17450.






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