基本情况
姓名：
樊保敏


职称：
教授

学历：
博士研究生

学位：
博士

职务：
常务副院长

通信地址：
云南省昆明市呈贡区云南民族大学

邮编：
650500

办公电话：


电子邮箱：
adams.bmf@hotmail.com

个人简介：
博士，二级教授，博士生导师，云南民族大学化学与环境学院常务副院长（正处），云南省中青年学术和技术带头人、云南省“****”青年拔尖人才，云南省高校天然源抗癌药物靶向递送研发重点实验室、云南省高校氘代氨基酸合成与应用工程研究中心负责人，云南民族大学学术特区建设负责人。迄今已主持完成国家自然科学基金项目4项，主持在研云南省基础研究计划重点项目1项，主持完成省部级及其它科研项目多项。樊保敏教授长期从事不对称催化与手性合成方面的研究工作，取得了一批优秀的科研成果，并得到了国内外同行的高度评价和认可。在国内外知名专业期刊发表论文近100篇，其中第一作者或通讯作者SCI论文70余篇，并且过半的论文发表在一区或二区的国际著名专业期刊上，发表于Angew. Chem. Int. Ed. (IF=12.257)2篇，Green Chem. (IF=9.405) 2篇、Org. Lett. (IF=6.555) 9篇、Chem. Commun. (IF=6.164) 3篇、Org. Chem. Front. (IF=5.076) 5篇、Adv. Syn. Catal. (IF=5.451) 12篇、Chem. Eur. J.(IF=5.1) 1篇等。其研究受到同行广泛关注，并有11篇文章被国际权威评述期刊Synfacts 杂志作为亮点文章予以介绍。此外，与香港浸会大学研究团队合作申请的美国专利已有4项获得授权，申请并获得授权的中国专利1项。获得云南省自然科学奖三等奖。
课题组网页：https://www.x-mol.com/groups/Fan_Baomin

研究方向及硕士研究生招生专业
1.研究方向

手性合成、过渡金属催化、光催化、小分子催化

2.硕士研究生招生专业

有机化学、化学生物学

科研项目
[1] **,无水碘化氢的制备及其与α，β-不饱和羰基化合物的不对称共轭加成反应研究，项目负责人，国家自然科学基金，65万，2016.01-2019.12。
[2] **，端基炔烃对氧/氮杂苯并降冰片烯的不对称催化开环反应研究，项目负责人，国家自然科学基金，50万，2014.01-2017.12。
[3] **，端基炔烃C-H键和冰片烯类化合物中C=C双键的不对称加成反应及其产物的抗癌活性，项目负责人，国家自然科学基金，55万，2012.01-2015.12。
[4] **，不对称催化的[2+2]环化反应及其在斑蝥素类抗癌活性分子合成中的应用研究，项目负责人，国家自然科学基金，19万，2010.01-2012.12。
[5] 2017FA004，氮杂苯并降冰片烯与醇的不对称开环反应及其在神经活性药物中的应用研究，项目负责人，云南省应用基础研究计划重点项目，50万，2017.06-2020.05。
[6] 2012FB170，氧杂苯并冰片烯的不对称硅氢化反应及其在新型除草剂合成中的应用研究，项目负责人，云南省应用基础研究计划面上项目， 10万，2012.01-2015.12。
[7] ZD**，无水碘化氢溶液的制备及其在碘代有机化合物合成中的应用研究，项目负责人，云南省教育厅科学研究基金重大专项， 10万，2015.09-2017.08。
[8] 201505，路易斯酸共催化剂在过渡金属催化的氧/氮杂苯并冰片烯中的不对称开环反应研究，项目负责人，元素有机化学国家重点实验室开放基金项目，3万， 2015.12-2016.12。
[9] 201302，氧杂苯并降冰片烯与端基炔烃间的新型反应研究，项目负责人，元素有机化学国家重点实验室开放基金项目，3万，2013.12-2014.12。
[10] 201206 ，冰片烯类化合物不对称氢化炔基化反应中手性铑催化剂的开发研究，项目负责人，项目负责人，元素有机化学国家重点实验室开放基金项目，3万，2012.12-2013.12。

教学工作
讲授本科生课程：有机化学、有机化学实验、药用有机化学实验、仪器分析实验、无机及分析化学
讲授研究生课程：金属有机化学、研究专题、色谱分析、有机化学专业英语及论文写作

近五年学术成果
[1] Ruhima Khan, Jingchao Chen, Baomin Fan*.Versatile Catalytic Reactions of Norbornadiene Derivatives with Alkynes . Adv.Synth.Catal. 2020, DOI:10.1002/adsc. .
[2] Guangrui Shi, Ruhima Khan, Xuexin Zhang, Yong Yang*, Yong Zhan, Juan Li, Yang Luo, Baomin Fan*. Rhodium-Catalyzed Direct ortho C-H Thiolation of Cyclic N-Sulfonyl Ketimines. Asian J. Org. Chem. 2020, DOI: 10.1002/ajoc..
[3] Keyang Zhang,Ruhima Khan,Jingchao Chen,Xuexin Zhang,Yang Gao,Yongyun Zhou*, Kangkui Li, Youxian Tian, Baomin Fan*. Directing- Group-Controlled Ring-Opening Addition and Hydroarylation of Oxa/azabenzonorbornadienes with Arenes via C–H Activation. Org. Lett.2020, 22, 3339-3344.
[4] Jiayan Li,Ronibala Devi Laishram, Jingchao Chen*, Dandan Xu, Guangrui Shi, Haiping Lv, Ruifeng Fan, Baomin Fan*. Regioselective Hydroiodination of Alkynes by the in situ Generated HI. Asian J. Org. Chem. 2020, 9, 73 – 76.
[5] Kangkui Li, Xuexin Zhang, Jingchao Chen*, Yang Gao, Chunhui Yang, Keyang Zhang, Yongyun Zhou, Baomin Fan*. Blue Light Induced Difluoroalkylation of Alkynes and Alkenes . Org. Lett., 2019, 21, 9914-9918 .
[6] Xia Zhang, Jingchao Chen*, Ruhima Khan, Guoli Shen, Zhenxiu He, Yongyun Zhou, Baomin Fan*, Rhodium-Catalyzed Transfer Hydrogenation of Quinoxalines with Water as Hydrogen Source. Org. Biomol. Chem., 2019, 17, 10142–10147 .
[7] Yongyun Zhou, Ruhima Khana, Baomin Fan*, Lijin Xu*, Ruthenium-Catalyzed Selective Reduction of Carboxylic Esters and Carboxamides. Synthesis. 2019, 51, 2491-2505.
[8] Jianxiao Ni, Jingchao Chen, Yongyun Zhou*, Gaowei Wang, Sida Li, Zhenxiu He, Weiqing Sun, Baomin Fan*. Rhodium-Catalyzed Asymmetric [2+2+2] Cycloaddition Reactions of 1,6-Enynes and Oxabenzonorbornadienes. Adv.Synth. Catal., 2019. 361. 3543-3547.
[9] Yang Gao, Xuexin Zhang, Ronibala Devi Laishram,Jingchao Chen*, Kangkui Li, Keyang Zhang, Guangzhi Zeng, Baomin Fan *. Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H₂O as Hydrogen Source. Adv.Synth. Catal., 2019. 361. 3991-3997.
[10] Xuexin Zhang, Yang Gao, Jingchao Chen*, Ruifeng Fan, Guangrui Shi, Zhenxiu He, Baomin Fan*. Rh(III)-Catalyzed Ring-Opening Addition of Azabenzonorbornadienes with Cyclic N-Sulfony Ketimines via C-H Bond Activation. Adv.Synth. Catal., 2019. 361,4495-4499 .
[11] Sida Li, Ruhima Khan, Xia Zhang, Yong Yang*, Zheting Wang, Yong Zhan, Yuze Dai, Yue-e Liu, Baomin Fan* . One Stone Two Birds: Cobalt Catalyzed in situ Generation of Isocyanate and Benzyl alcohol for the Synthesis of N-aryl Carbamates. Org. Biomol. Chem., 2019, 17, 5891-5896 .
[12] Xuexin Zhang, Jingchao Chen,* Yang Gao, Kangkui Li, Yongyun Zhou, Weiqing Sun, Baomin Fan* .Photocatalyzed Transfer Hydrogenation and Deuteriation of Cyclic N-Sulfonylimines. Org. Chem. Front., 2019, 6, 2410-2414.
[13] Haiping Lv, Ronibala Devi Laishram, Jiayan Li, Yongyun Zhou*, Dandan Xu, Sagar More,Yuze Dai, Baomin Fan*. Photocatalyzed Oxidative Dehydrogenation of Hydrazobenzenes to Azobenzenes. Green Chem., 2019, 21, 4055-4061.
[14] Kangkui Li, Ruhima Khan, Xuexin Zhang, Yang Gao, Yongyun Zhou*, Heng Tan, Jingchao Chen, Baomin Fan *. Cobalt catalyzed stereodivergent semi- Q2 hydrogenation of alkynes using H₂O as the hydrogen source. Chem. Commun., 2019, 55, 5663—5666.
[15] Guoli Shen, Ruhima Khan*, Haiping Lv, Yong Yang, Xia Zhang, Yong Zhan,Yongyun Zhou and Baomin Fan*. Palladium/silver co-catalyzed syn-stereoselective asymmetric ring-opening reactions of azabenzonorbornadienes with amides. Org. Chem. Front.,2019, 6, 1423–1427.
[16] Haiping Lv, Ronibala Devi Laishram, Jiayan Li, Guangrui Shi, Weiqing Sun*, Jianbin Xu, Yong Yang,Yang Luo, Baomin Fan*. Nickel(0) catalyzed oxidation of organosilanes to disiloxanes by air as an oxidant. Tetrahedron Letters.2019,60, 971–974.
[17] He Zhenxiu,Zhou Yongyun*,Sun,Weiqing,Fan Ruifeng,Shen,Guoli,Fan Baomin*. Asymmetric Ring Opening Reaction of Oxabenzonorbornadienes With Phenols Promoted By Rhodium/Zinc Complexes. Chin. J. Org. Chem., 2019, 39, 754-760.
[18] Guoli Shen, Jingchao Chen,* Dandan Xu, Xia Zhang, Yongyun Zhou,and Baomin Fan*. Asymmetric Transfer Hydrogenation of Heterobicyclic Alkenes with Water as Hydrogen Source. Org. Lett.,2019, 21, 1364?1367.
[19] Xuexin Zhang, Yang Gao, Ronibala Devi Laishram, Kangkui Li,Yong Yang*, Yong Zhan, Yang Luo,
Baomin Fan *. Pd(II)/Zn co-catalyzed chemo-selectivehydrogenation ofα-methylene-γ-ketocarboxylic acids. Org. Biomol. Chem., 2019, 17, 2174–2181.
[20] Lingling Zou, Weiqing Sun*, Ruhima Khan, Haiping Lv, Heng Tan, Jianbin Xu, Junlin Yin, Baomin Fan*, Palladium Catalyzed Tandem Reaction of Oxabenzonorbornadienes with Anhydrides, Eur. J. Org. Chem., 2019, 746–752.
[21] GuoliShen, Ruhima Khan, Fan Yang, Yong Yang,* DongdongPu, Yang Gao, Yong Zhan, Yang Luo Baomin Fan*. Pd/Zn Co-catalyzed Asymmetric Ring-opening Reactions of Aza/Oxabicyclic alkenes with Oximes.Asian J. Org. Chem. 2019, 8, 97 -102.
[22] Chaoyuan Zeng, Guoli Shen, Fan Yang, Jingchao Chen,* Xuexin Zhang, Cuiping Gu, Yongyun Zhou, Baomin Fan*. Rhodium-Catalyzed Generation of Anhydrous Hydrogen Iodide: An Effective Method for the Preparation of Iodoalkanes. Org. Lett., 2018, 20, 6859-6862.
[23] Yang Gao, Yang Fan, Dongdong Pu, Ronibala Devi Laishram*, Ruifeng Fan, Guoli Shen, Xuexin Zhang, Jingchao Chen, Baomin Fan*. Pd/Zn(OTf)? Co‐catalyzed Asymmetric Hydrogenation of Imines under Normal Pressure of Hydrogen. Eur.J. Org.Chem., 2018, 45, 6274-6279.
[24] Dongdong Pu, Yongyun Zhou,* Fan Yang,Guoli Shen,Yang Gao, Weiqing Sun,Ruhima Khan and Baomin Fan*.Asymmetric ring-opening reactions ofazabenzonorbornadienes through transfer
hydrogenation using secondary amines ashydrogen sources: tuning of absoluteconfiguration by acids.Org. Chem. Front., 2018, 5, 3077-3082.
[25] Dapeng Zhang, Ruhima Khan,* Fan Yang, Xuexin Zhang, Guoli Shen, Yang Gao, Ruifeng Fan, Weiqing Sun, and Baomin Fan*.Palladium and Lewis acid Co-catalyzed Reductive Asymmetric Ring-Opening Reaction of Azabenzonorbornadienes with TertiaryAmines as Hydrogen Source. Eur. J. Org. Chem. 2018, 26, 3464–3470.
[26] Hongyu Qin, Jingchao Chen,* Kangkui Li, Zhenxiu He, Yongyun Zhou, Baomin Fan*. Nickel-Catalyzed Asymmetric [2+2] Cycloaddition Reaction ofHetero-Bicyclic Alkenes with Internal Alkynes.Chem. Asian J. 2018, 13, 2431-2434.
[27] Jirong Hu,JianbinXu*,LinglingaZou,HaipingLv,Ruifeng Fan, Na Liu, Yongyun Zhou, Baomin Fan*.Rhodium Catalyzed Asymmetric Ring-Opening Reaction of OxabenzonorbornadieneswithAnhydride. Chin. J. Org. Chem., 2018, 38, 1687-1694.
[28] Zhenxiu He, Yongyun Zhou*, Baiqiu Han, XinXu, Yun Li, HongyuQin,Ruifeng Fan, Ronibala Devi Laishram, Baomin Fan*. Asymmetric ring-opening reaction of azabenzonorbornadienes with phenols promoted by palladium/(R,R)-DIOP complex. Tetrahedron, 2018, 74, 2174-2181.
[29] Fan Yang, Jingchao Chen*, GuoliShen, Xuexin Zhang, Baomin Fan*. Asymmetric Transfer Hydrogenation Reactions of N-Sulfonylimines by Using Alcohols as Hydrogen Sources. Chem.Comm., 2018, 54, 4963-4966.
[30] Jingchao Chen,* Lingling Zou, ChaoyuanZeng, Yongyun Zhou, Baomin Fan*. Rhodium-Catalyzed Asymmetric ArylativeRing-Opening Reactions ofHeterobicyclic Alkenes with Anilines. Org. Lett., 2018, 20, 1283?1286.
[31] Yongyun Zhou, Lu Yu,Jingchao Chen, Jianbin Xu, Zhenxiu He, Guoli Shen, and Baomin Fan*. Rhodium-Catalyzed Asymmetric Cyclization/Addition Reactions of 1,6-Enynes and Oxa/Azabenzonorbornadienes. Org. Lett., 2018, 20, 1291?1294.
[32] Yun Li, Jingchao Chen,* Zhenxiu He, Hongyu Qin, Yongyun Zhou, Ruhima Khan, Baomin Fan*.Cobalt-catalyzed asymmetric reactions of heterobicyclic alkenes with in situ generated organozinc halides. Org. Chem. Front., 2018, 5, 1108-1112.
[33] Jingchao Chen, Xin Xu,* Zhenxiu He, Hongyu Qin, Weiqing Sun, Baomin Fan*. Nickel/Zinc Iodide Co-catalytic Asymmetric [2+2] Cycloaddition Reactions of Azabenzonorbornadienes with Terminal Alkynes. Adv. Synth. Catal., 2018, 3, 427-431.
[34] Fujie Ma, Jingchao Chen,* Fan Yang, Madhuri Vikas Shinde, Yongyun Zhou, Baomin Fan*. Palladium/Zinc Co-catalyzed Asymmetric Transfer Hydrogenation of Oxabenzonorbornadienes with Alcohols as Hydrogen Sources. Org. Biomol. Chem., 2017, 15, 2359-2362.
[35] Meina Zhu, Jingchao Chen,* Xiaobo He, Cuiping Gu, Jianbin Xu, Baomin Fan*. Iridium-Catalyzed Anti-Stereoselective Asymmetric Ring Opening Reactions of Azabenzonorbornadienes with Carboxylic Acids. J. Org. Chem., 2017, 82, 3167-3172.
[36] Wei Zhang, Jingchao Chen,*Guangzhi Zeng, Fan Yang, Jianbin Xu, Weiqing Sun, Madhuri Vikas hinde, Baomin Fan*. Asymmetric Ring-Opening Reactions of Aza- and Oxa-bicyclic Alkenes with Boronic Acids Using a Palladium/Zinc Co-catalytic System. J. Org. Chem., 2017, 82, 2641-2647.
[37] Xiaobo He, Jingchao Chen*, Xin Xu, Fan Yang, Cuiping Gu, Yongyun Zhou, Baomin Fan*. Rhodium/zinc co-catalyzed asymmetric ring opening reactions of oxabenzonorbornadienes with carboxylic acids. Tetrahedron: Asymmetry, 2017, 28, 62-68.
[38] Fan Yang, Jingchao Chen ,Jianbin Xu, Fujie Ma, Yongyun Zhou, Madhuri Vikas Shinde, Baomin Fan*. Palladium/Lewis Acid Co-catalyzed Divergent Asymmetric Ring-Opening Reactions of Azabenzonorbornadienes with Alcohols. Org. Lett., 2016, 18, 4832-4835.
[39] Yongyun Zhou, Cuiping Gu, Jingchao Chen, Meina Zhu, Fan Yang, Jianbin Xu, and Baomin Fan*. Enantioselective Ring Opening Reactions of Azabenzonorbornadienes with Carboxylic Acids. Adv. Synth. Catal., 2016, 358, 3167-3172.
[40] Qingjing Yang, Pui Ying Choy, Yinuo Wu,* Baomin Fan* and Fuk Yee Kwong*. Oxidative coupling between C(sp2)–H andC(sp3)–H bonds of indoles and cyclic ethers/cycloalkanes. Org. Biomol. Chem., 2016, 14, 2608-2612.
[41] Xin Xu, Jingchao Chen, Zhenxiu He, Yongyun Zhou and Baomin Fan*. Rhodium-catalyzed a symmetric ring openingreaction of oxabenzonorbornadienes with amines using ZnI₂ as the activator. Org. Biomol. Chem., 2016, 14, 2480-2486.
[42] Yongyun Zhou, Zhiwu Lu, Baiqiu Han, Chaoyuan Zeng, Zhenhua Zhang, Baomin Fan*. Iridium-catalyzed highly enantioselective ring opening reaction of oxabenzonorbornadienes with amines. Tetrahedron: Asymmetry, 2015, 26, 1354-1359.
[43] Zhiwu Lu, Jun Wang,* Baiqiu Han, Sifeng Li, Yongyun Zhou, Baomin Fan*. Palladium-Catalyzed
Asymmetric Ring Opening Reaction of Azabenzonorbornadienes with Aromatic Amines. Adv. Synth. Catal. ,2015, 357, 3121 -3125.
[44] Chaoyuan Zeng, Fan Yang, Jingchao Chen, Jun Wang,* Baomin Fan*. Iridium/Copper-Cocatalyzed Asymmetric Ring Opening Reaction of Azabenzonorbornadienes with Amines. Org. Biomol. Chem., 2015, 13, 8425-8428.
[45] Jingchao Chen, Shanshan Liu, Yongyun Zhou, Sifeng Li, Chengyuan Lin, Zhaoxiang Bian, Baomin Fan*. Palladium/Silver Cocatalyzed Tandem Reactions of Oxabenzonorbornadienes with Substituted Arylacetylenes: A Simple Method for the Preparation of 1,2-Diarylethanones and 1,2-Diarylacetylenes. Organometallics, 2015, 34, 4318-4322.
[45] Yongyun Zhou, Shanshan Liu, Hualei Chen, Jingchao Chen, Weiqing Sun, Sifeng Li, Qingjing Yang, Baomin Fan*. AgOTf-Catalyzed Tandem Reaction of Oxabenzonorbornadienes With Arylacetylenes. Chin. J. Chem.,2015, 33, 1115-1118.
[46] Qingjing Yang, Yongyun Zhou, Jingchao Chen, Xiaobo He, Jianbin Xu, Fuk Yee Kwong, Baomin Fan*. Pd-Catalyzed Allylic Alkynylation of Allylic Acetates with Terminal Alkynes. Eur. J. Org. Chem., 2015, 5330-5333.
[47] Qingjing Yang, Puiying Choy, Baomin Fan,* and Fukyee Kwong*. Enantioselective Hydroalkynylation of Non-Polar Carbon-Carbon Double Bonds: Iridium-Catalyzed Asymmetric Addition Reaction of Terminal Alkyne C-H Bonds to Substituted Norbornadienes. Adv. Synth. Catal., 2015, 357, 2345 -2350.
[48] Sifeng Li, Jianbin Xu, Baomin Fan,* Zhiwu Lu, Chaoyuan Zeng, Zhaoxiang Bian, Yongyun Zhou, and Jun Wang*. Palladium/Zinc Co-Catalyzed syn-StereoselectivelyAsymmetricRing-Opening Reaction of Oxabenzonorbornadienes with Phenols. Chem. Eur. J., 2015, 21, 9003 -9007.

申请和授权专利
授权专利:
[1] Zhaoxiang Bian, Baomin Fan, Chengyuan Lin, Yongyun Zhou, Jingchao Chen. Method for The Preparation of Iodoalkanes. 2018.08.07. USA. US**B2.
[2] Zhaoxiang Bian, Chengyuan Lin, Huaixue Mu, Baomin Fan, Yongyun Zhou, Jingchao Chen, Aiping Lu, Albert Sun-Chi Chan. Palladium/Silver Co-Catalyzed Tandem Reactions Syntheis of Phenylacetophenone Derivatives by Oxabenzonorborn Adienes and Their Anti-tumor or Anti-cancer Activities. 2017.10.10. USA. US**B2.
[3] Zhaoxiang Bian, Chengyuan Lin, Baomin Fan, Huaixue Mu, Yongyun Zhou, Weimin Zeng, Aiping Lu, Albert Sun-Chi Chan. Oxanorbornadiene Derivatives and Their Anticancer Activities. 2015.09.01. USA. US**B2.
[4] Albert Sun-Chi Chan, Baomin Fan, Jun Wang, Chengyuan Lin, Chao Huang, Qingjing Yang, Jianbin Xu, Zhaoxiang Bian, Aiping Lu, Jun Hu. Asymmetric Synthesis of Norcantharidin Analogues by Alkynylation of Oxabenzonorbornadienes and Their Anticancer Activities. 2014.09.16. USA. US**B2.
[5]樊保敏, 徐歆, 周永云, 陈景超.一种新型化合物及其制备方法和应用. 2019.03.15.CN.ZL7.9
申请专利：
1、樊保敏，陈景超，周永云，曾广智，尹俊林，林成源，孙蔚青， 一种铑催化制备碘代烷烃方法. 2017.11.14.6.0
2、樊保敏，陈景超，周永云，曾广智，尹俊林，林成源，孙蔚青，一种铑催化制备碘代烷烃方法， 6.0
3、樊保敏、陈景超、樊瑞峰、周永云、孙蔚青、尹俊林，一种高效制备碘化苄及其衍生物的方法，1.X
4、樊保敏，陈景超，周永云，樊瑞峰，孙蔚青，曾广智，尹俊林，林成源，郝朝威，一种特异性检测铜离子和硫离子的多肽、化学荧光传感器及其制备方法与应用，2.7
5、樊保敏，陈景超，周永云，樊瑞峰，孙蔚青，曾广智，尹俊林，林成源，吕海平，一种硅醇类有机化合物及制备方法，1.0
6、樊保敏、周永云、陈景超、曾广智、尹俊林、徐丽娟、李瑞涛，一种凤尾茶天然凉茶饮料及其制备方法，7.3
7、樊保敏，陈景超，周永云，樊瑞峰，孙蔚青，林成源，吕海平，一种芳香偶氮苯类有机化合物的制备方法，6.5
8、樊保敏，杨大坚，詹永，罗杨，李娟，陈景超，周永云，沈国礼，一种制备手性氨基酸酯和手性氘代氨基酸酯的方法，9.7
9、樊保敏，陈景超，周永云，和振秀，樊瑞峰，孙蔚青，沈国礼，一种以重水为制备氘代氨基酸酯的方法，20**

获奖与荣誉
2015.02 ****
2016.01 云南省中青年学术和技术带头人
2019.02 云南省****青年拔尖人才
2019.05 云南省自然科学三等奖