牛昱宇博士
“国家高层次人才”****项目入选者、科技部重点研发计划项目首席科学家
Yuyu Niu, Ph.D.
Dean & Professor of Faculty of Life Science and Technology, KUST
Associate Director and Professor of State Key Laboratory of Primate Biomedical Research
一、工作学习经历
2019年-，昆明理工大学生命科学与技术学院，教授，院长
2014年-，昆明理工大学灵长类转化医学研究院，教授，副院长
2007年-2014年，中国科学院昆明动物研究所，副研究员
2006年-2008年，德国柏林野生与笼养动物研究所，访问****
2001年-2007年，中国科学院昆明动物研究所，博士
1995年-1999年，云南师范大学生命科学系，本科
二、研究领域
灵长类基因编辑
灵长类胚胎发育与疾病
Gene editing
Primate embryonic development
Neurodegenerative disease
早期胚胎发育是哺乳动物生命发生的重要阶段，这一时期的关键生物学事件，如合子基因启动，表观遗传维持与重建，胚层分化和器官形成等等，是发育生物学的重要基础理论，又和人类健康和疾病密切相关。然而，我们对其中的诸多科学问题却知之甚少。本实验室结合灵长类早期胚胎（体外受精，单性生殖和体细胞核移植）培养，基因编辑，干细胞与示踪，单细胞组学和灵长类疾病动物模型等技术体系，系统研究灵长类细胞多能性的维持与重建，表观遗传维持与胚层分化的关系，退行性疾病的早期诊断和干预等等重要科学问题，以期揭示人类生命发生和疾病形成的奥秘。
Research in Yuyu Niu's laboratory is focused on early embryo development and reprogramming, particularly preimplantation embryo development which play an important role in cell differentiation and organ initiation, and therefore have a significant on human disease. Over the last decade, Dr. Niu has made significant contributions to non-human primate genetic engineering and early embryo development that include: 1) the first transgenic rhesus monkey in China (PNAS 2010); 2) the first monkey model with genome engineered by precision gene-targeting methods (Cell 2014; Cell 2017); 3) the continuous development of monkey embryos in vitro beyond early gastrulation and to 20 days post fertilization (Science 2019). Built on the strength in non-human primate research, the Yuyu Niu's laboratory has expanded its capability to use a variety of state-of-the-art techniques, including single cell transcriptomics, cell lineage tracing, stem cells, somatic cell nuclear transfer and CRISPR/Cas9-based genomic editing to understand the molecular events at the beginning of primate life and cell reprogramming. In addition, the lab has studied on mechanism and biomarker of neurodegeneration diseases, such as Parkinson’s disease and Amyotrophic lateral sclerosis.
三、开设课程
细胞生物学、发育生物学
四、代表性论文
1.C. Chu, W. Zhang^*, Y. Kang, C. Si, W. Ji^*,Y. Niu^*,Y. Zhang^*, Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta.Developmental Cell56, 1–15 (2021). (* co-corresponding author)
2.R. Yang, A. Goedel, Y. Kang, C. Si, C. Chu, Y. Zheng, Z. Chen, P. J. Gruber, Y. Xiao, C. Zhou, N. Witman, E. Eroglu, C. Leung, Y. Chen, J. Fu, W. Ji^*, F. Lanner^*,Y. Niu^*, K. R. Chien^*. Amnion signals are essential for mesoderm formation in primates.NatureCommunications12, 5126 (2021). (* co-corresponding author)
3.C Chen, W Ji^*,Y Niu^*. Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research.Trends in BiotechnologyS0167-7799(21)00085-8. doi: 10.1016/j.tibtech.2021.03.010. (2021). (* co-corresponding author)
4.T. Tan^*, J. Wu^*, C. Si, S. Dai, Y. Zhang, N. Sun, E. Zhang, H. Shao, W. Si, P. Yang, H. Wang, Z. Chen, R. Zhu, Y. Kang, R. H.-Benitez, L. M. Martinez, E. N. Delicado, W. T. Berggren, M. Schwarz, Z. Ai, T. Li, C. R. Esteban, W. Ji^*,Y. Niu^*, J. C. I. Belmonte^*. Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo.Cell184(8):2020-2032.e14. (2021). (* co-corresponding author)
5.F. Wang, W. Zhang, Q. Yang, Y. Kang, Y. Fan, J. Wei, Z. Liu, S. Dai, H. Li, Z. Li, L. Xu, C. Chu, J. Qu, C. Si, W. Ji^*, G. H. Liu^*, C. Long^*,Y. Niu^*, Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing.Protein Cell11, 809-824 (2020). (* co-corresponding author)
6.Y. Niu^*, N. Sun, C. Li, Y. Lei, Z. Huang, J. Wu, C. Si, X. Dai, C. Liu, J. Wei, L. Liu, S. Feng, Y. Kang, W. Si, H. Wang, E. Zhang, L. Zhao, Z. Li, X. Luo, G. Cui, G. Peng, J. C. Izpisúa Belmonte^*, W. Ji^*, T. Tan^*, Dissecting primate early post-implantation development using long-term in vitro embryo culture.Science366 (2019). (* co-corresponding author)
7.Y. Niu, T. Li, W. Ji, Paving the road for biomedicine: genome editing and stem cells in primates.National Science Review4, 543-549 (2017).
8.Y. Niu, B. Shen, Y. Cui, Y. Chen, J. Wang, L. Wang, Y. Kang, X. Zhao, W. Si, W. Li, A. P. Xiang, J. Zhou, X. Guo, Y. Bi, C. Si, B. Hu, G. Dong, H. Wang, Z. Zhou, T. Li, T. Tan, X. Pu, F. Wang, S. Ji, Q. Zhou, X. Huang, W. Ji, J. Sha, Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.Cell156, 836-843 (2014)
五、主持项目
1. 国家重点研发计划“干细胞及转化研究”专项项目，2016YFA**，靶向基因编辑建立神经系统疾病猴模型及干细胞治疗研究，2016-2012，2915万元，首席科学家。
2. 国家自然科学基金联合重点项目，U**，帕金森氏症转基因灵长类动物模型的构建与致病机理研究，2014-2017，210万元，项目负责人
3. 国家重大科学研究计划（973计划），2012CBA01304，神经退行疾病致病机理及转基因动物模型的建立，2012/01-2016/12，420万元，课题负责人。
4. 国家高技术研究发展计划（863计划），2012AA020701，神经退行性疾病灵长类动物模型制备关键技术及利用，2012/01-2015/12，710万元，课题负责人。
5. 国家科技重大专项，2009ZX09501-028，评价抗HCV化学药物疗效和安全性的动物模型，2009/01-2011/12，690万元，已结题，项目负责人。
六、联系方式
地址：云南省昆明市呈贡区大学城景明南路727号昆明理工大学生命科学与技术学院
电话：
E-mail：niuyy@kust.edu.cn