史志周副教授、硕士生导师、博士

毕业学校：

北京协和医学院



所学专业：

细胞生物学



所属教研室：

医学生物学教研室



研究方向：

肿瘤分子生物学



主要特长：

肿瘤基因组改变及功能驱动基因的致癌机制研究



在研项目：

1、国家自然科学基金《氯离子通道蛋白ANO1在食管鳞癌细胞增殖中的作用机制研究》；

2、云南省应用基础研究计划青年项目《CPT1A在食管鳞癌上皮-间质转化中的作用及分子机制研究》；

3、云南省人才培养项目《CPT1A基因在食管癌转移中的作用研究》；

4、云南省肿瘤转化工程中心子课题《Mir-93与TXNIP在肺癌中的相互关系研究》。



个人经历：

2002年就读于兰州大学生命科学学院生物学基地班，2006年保送进入清华大学北京协和医学院中国医学科学院分子肿瘤学国家重点实验室直接攻读博士学位，从事食管鳞癌和直肠癌基因组改变和扩增靶基因的致癌机制研究。2011年博士毕业后进入昆明理工大学工作。从博士至今在扩增靶基因的致癌机制研究和食管癌基因组改变的研究方面积累了较为丰富的经验，以第一作者和通讯作者发表SCI论文7篇，单篇最高影响因子8.193，累计影响因子23.476。



所获奖项：

1、2013年获青年教师讲课比赛优秀奖；

2、2013年获昆明理工大学《红云园丁奖》。



发表文章及专利：

1）Liang JW, Shi ZZ*(correspondence author), Shen TY, Che X, Wang Z, Shi SS, Xu X, Cai Y, Zhao P, Wang CF, Zhou ZX, Wang MR*. Identification of genomic alterations in pancreatic cancer using array-based comparative genomic hybridization. Plos One. [Accepted]

2）Shi ZZ, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Shang L, Liu SG, Shi F, Wang MR*. Identification of putative target genes for amplification within 11q13.2 and 3q27.1 in esophageal squamous cell carcinoma. Clin Transl Oncol 2014 Jul;16(7):606-15.

3）Shi ZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, Gong T, Zhan QM, Wang MR*. Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res 2013 Nov 1;19(21):5867-78.

4）Shi ZZ, Zhang YM, Shang L, Hao JJ, Zhang TT, Wang BS, Liang JW, Chen X, Zhang Y, Wang GQ, Wang MR*, Zhang Y*. Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization. BMC Med Genomics 2012 Nov 16;5:52.

5）Shi ZZ, Liang JW, Zhan T, Wang BS, Lin DC, Liu SG, Hao JJ, Yang H, Zhang Y, Zhan QM, Zhang KT*, Wang MR*. Genomic Alterations with Impact on Survival in Esophageal Squamous Cell Carcinoma Identified by Array Comparative Genomic Hybridization. Genes Chromosomes Cancer 2011 Jul;50(7):518-26.

6）Zhou HT^#, Shi ZZ^#(Co-first auther), Zhou ZX, Jiang YY, Hao JJ, Zhang TT, Shi F, Xu X, Wang MR, Zhang Y*. Genomic changes in rectal adenocarcinoma associated with liver metastasis. Cancer Biomark 2013 Jan 1;13(4):281-8.

7）Liang JW^#, Shi ZZ^#(Co-first auther), Zhang TT, Hao JJ, Wang Z, Wang XM, Yang H, Wang MR, Zhou ZX*, Zhang Y*. Analysis of genomic aberrations associated with the clinicopathological parameters of rectal cancer by array comparative genomic hybridization. Oncol Rep 2013 May;29(5):1827-34.

8）Zhang TT, Jiang YY, Shang L, Shi ZZ, Liang JW, Wang Z, Zhang Y, Hao JJ, Jia XM, Xu X, Cai Y, Zhan QM, Wang MR.Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway.Mol Carcinog. 2014. [Epub ahead of print]

9）Li N, Hou JL, Shi ZZ, Li XG, Li N, Sun YC, Xu X, Cai Y, Zhang X, Zhang KT, Wang MR, Wu LY. Copy number changes of 4-gene set may predict early relapse in advanced epithelial ovarian cancer after initial platinum-paclitaxel chemotherapy.Am J Cancer Res. 2014 May 26;4(3):285-92.

10）Lin DC*, Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ, Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR*, Koeffler HP.Genomic and molecular characterization of esophageal squamous cell carcinoma.Nat Genet. 2014 May;46(5):467-73.

11) Wang BS, Yang Y, Lu HZ, Shang L, Zhang Y, Hao JJ, Shi ZZ, Wang XM, Liu YZ, Zhan QM, Jia XM, Wang MR*. Inhibition of atypical protein kinase Cι induces apoptosis through autophagic degradation of β-catenin in esophageal cancer cells. Mol Carcinog 2013 Jan 28. [Epub ahead of print]

12）Wang BS, Yang Y, Yang H, Liu YZ, Hao JJ, Zhang Y, Shi ZZ, Jia XM, Zhan QM, Wang MR*. PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line. Cell Stress Chaperones 2013 May;18(3):359-66.

13）Hao JJ, Shi ZZ, Zhao ZX, Zhang Y, Gong T, Li CX, Zhan T, Cai Y, Dong JT, Fu SB, Zhan QM, Wang MR*. Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors. BMC Cancer 2012 Aug 24;12(1):367.

14）Hao JJ, Gong T, Zhang Y, Shi ZZ, Xu X, Dong JT, Zhan QM, Fu SB, Wang MR*. Characterization of gene rearrangements resulted from genomic structural aberrations in human esophageal squamous cell carcinoma KYSE150 cells. Gene 2013 Jan 15;513(1):196-201.

15）Lin DC, Zhang Y, Pan QJ, Yang H, Shi ZZ, Xie ZH, Wang BS, Hao JJ, Zhang TT, Xu X, Zhan QM, Wang MR*. PLK1 Is transcriptionally activated by NF-κB during cell detachment and enhances anoikis resistance through inhibiting β-catenin degradation in esophageal squamous cell carcinoma. Clin Cancer Res 2011 Jul 1;17(13):4285-95.

16）Liu SG, Wang BS, Jiang YY, Zhang TT, Shi ZZ, Yang Y, Yang YL, Wang XC, Lin DC, Zhang Y, Yang H, Cai Y, Zhan QM, Wang MR*. Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway. Mol Cancer Res 2011 Apr;9(4):390-402.



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