职　　务： 神经基因组学学科组负责人
学　　历：
电　　话： +86
传　　真：
电子邮件： shilei@mail.kiz.ac.cn
通讯地址： 云南省昆明市盘龙区龙欣路17号　中国科学院昆明动物研究所 650201
其他主页：

简　　历

学习和研究经历
2020.10-至今 研究员， 博士生导师，中国科学院昆明动物研究所神经基因组学学科组负责人
2019.03-2020.10 索尔克生物研究所， 博士后 (Postdoctoral Fellow, Salk Institute for Biological Studies, La Jolla)
2015.07-2019.03 密歇根大学安娜堡分校， 博士后 (Postdoctoral Research Fellow, University of Michigan, Ann Arbor)
2012.07-2015.07 中国科学院昆明动物研究所， 助理研究员
2013.01-2013.07 北卡罗莱纳大学教堂山分校， 访问**** (Visiting Scholar, University of North Carolina, Chapel Hill)
2007.09-2012.07 中国科学院昆明动物研究所， 遗传学 理学博士
2003.09-2007.07 西南大学生命科学学院， 生物技术 理学学士



研究方向

大脑是哺乳动物神经系统进化出来的高度复杂的结构，参与调控，动物的感觉，运动，认知，语言等功能。大脑的进化发育和衰老一直是神经科学研究中的重要问题。近年来细胞3D培养，组学测序技术以及基因编辑技术的不断进步让我们研究大脑处于一个快速发展的时期。课题组依托中国科学院昆明动物研究所相关平台，利用经典模式动物小鼠以及西南地区丰富的灵长类实验动物资源，结合功能基因组学的技术手段，系统深入开展脑科学方面的研究。总体研究主要集中在三个方面：
（1）人类大脑进化的分子遗传机制研究；
（2）脑发育过程中，神经前体细胞如何维持基因组稳定性；
（3）大脑衰老过程中的分子细胞机制研究；


承担科研项目

2012-2014 小头症基因MCPH1的进化和功能研究 西部之光博士项目 (已结题) 20万 RMB
2013-2016 人类大脑进化关键基因调控和功能研究 自然科学基金青年项目 (NSFC **) (已结题) 23万 RMB


专家类别

研究员
社会任职


获奖及荣誉


代表论著

1. Liu, H., Li, R., Liao, H.-K., Min, Z., Wang, C., Yu, Y., Shi, L., Dan, J., Hayek, A., Martinez Martinez, L., et al. (2021). Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells. Nature Communications 12, 3330.
2. Wang, C., Rabadan Ros, R., Martinez-Redondo, P., Ma, Z., Shi, L., Xue, Y., Guillen-Guillen, I., Huang, L., Hishida, T., Liao, H.-K., et al. (2021). In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. Nature Communications 12, 3094.
3. Keil, J.M., Doyle, D.Z., Qalieh, A., Lam, M.M., Funk, O.H., Qalieh, Y., Shi, L., Mohan, N., Sorel, A., and Kwan, K.Y. (2020). Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nature Communications 11, 3839.
4. Li, R., Zhong, C., Yu, Y., Liu, H., Sakurai, M., Yu, L., Min, Z., Shi, L., Wei, Y., Takahashi, Y., et al. (2019). Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell 179, 687-702
5. Shi, L., Qalieh, A., Lam, M. M., Keil, J. M., and Kwan, K. Y. (2019). Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nature Communications 10 (1):2588
6. Shi, L., and Su, B. (2019). A transgenic monkey model for the study of human brain evolution. Zoological Research 40 (3):236-38
7. Shi, L.#, Luo, X.#, Jiang, J.#, Chen, Y.#, Liu, C.#, Hu, T., Li, M., Lin, Q., Li, Y., Huang, J., Wang, H., Niu, Y., Shi, Y., Styner, M., Wang, J., Lu, Y., Sun, X., Yu, H., Ji, W., and Su, B. (2019). Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review 6 (3):480-93（#co-first author）
8.Shi, L.#, Hu, E. Z.#, Wang, Z. B.#, Liu, J. W., Li, J., Li, M., Chen, H., Yu, C. S., Jiang, T. Z., and Su, B. (2017). Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution. Human Genetics 136 (2):193-204（#co-first author）
9.Mendizabal, I.#, Shi, L.#, Keller, T. E., Konopka, G., Preuss, T. M., Hsieh, T. F., Hu, E. Z., Zhang, Z., Su, B.*, and Yi, S. V.* (2016). Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution. Molecular Biology and Evolution 33 (11):2947-59 （#co-first author）
10.Shi, L.#, Zhang, Z.#, and Su, B. (2016). Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages. Scientific Reports 6（#co-first author）
11.Shi, L., Lin, Q., and Su, B. (2015). Estrogen regulation of microcephaly genes and evolution of brain sexual dimorphism in primates. BMC Evol Biol 15:127
12.Shi, L.#, Lin, Q.#, and Su, B. (2014). Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator. Molecular Biology and Evolution 31 (3):594-604（#co-first author）
13.Li, M., Luo, X. J., Rietschel, M., Lewis, C. M., Mattheisen, M., Muller-Myhsok, B., Jamain, S., Leboyer, M., Landen, M., Thompson, P. M., Cichon, S., Nothen, M. M., Schulze, T. G., Sullivan, P. F., Bergen, S. E., Donohoe, G., Morris, D. W., Hargreaves, A., Gill, M., Corvin, A., Hultman, C., Toga, A. W., Shi, L., Lin, Q., Shi, H., Gan, L., Meyer-Lindenberg, A., Czamara, D., Henry, C., Etain, B., Bis, J. C., Ikram, M. A., Fornage, M., Debette, S., Launer, L. J., Seshadri, S., Erk, S., Walter, H., Heinz, A., Bellivier, F., Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Franke, B., Martin, N. G., Wright, M. J., Su, B., Consortium, M. B., Group, S. B. S., Neuroimaging, A. s. D., Consortium, E., and Consortium, C. (2014). Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Molecular Psychiatry 19 (4):452-61
14.Shi, L., Li, M., Lin, Q., Qi, X. B., and Su, B. (2013). Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans. BMC Biology 11
15.Li, M., Luo, X. J., Xiao, X., Shi, L., Liu, X. Y., Yin, L. D., Ma, X. Y., Yang, S. Y., Pu, X. F., Yu, J., Diao, H. B., Shi, H., and Su, B. (2013). Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population. World Journal of Biological Psychiatry 14 (2):91-99
16.Shi, L., and Su, B. (2012). Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression. FEBS Journal 279 (3):491-503
17. Shi, L., Li, M., and Su, B. (2012). MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene. Gene 495 (1):1-9
18. Li, M., Luo, X. J., Xiao, X., Shi, L., Liu, X. Y., Yin, L. D., Diao, H. B., and Su, B. (2011). Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia. American Journal of Psychiatry 168 (12):1318-25
19. Li, M., Mo, Y., Luo, X. J., Xiao, X., Shi, L., Peng, Y. M., Qi, X. B., Liu, X. Y., Yin, L. D., Diao, H. B., and Su, B. (2011). Genetic association and identification of a functional SNP at GSK3 beta for schizophrenia susceptibility. Schizophrenia Research 133 (1-3):165-71
20. Niu, Y. Y., Yu, Y., Bernat, A., Yang, S. H., He, X. C., Guo, X. Y., Chen, D. L., Chen, Y. C., Ji, S. H., Si, W., Lv, Y. Q., Tan, T., Wei, Q. A., Wang, H., Shi, L., Guan, J. A., Zhu, X. M., Afanassieff, M., Savatier, P., Zhang, K., Zhou, Q., and Ji, W. Z. (2010). Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proceedings of the National Academy of Sciences of the United States of America 107 (41):17663-67

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