Associated Faculty, Ecology and Evolutionary Biology nd the Lewis-Sigler Institute for Integrative Genomics

Contact

csm7@princeton.edu
609-258-9598
Guyot Hall, M151

Research Area

Genetics & Genomics

Research Focus

Genes and Neural Circuits Underlying Behavioral Evolution



Research
Selected Publications

Genes and Neural Circuits Underlying Behavioral Evolution

Research in the McBride lab takes advantage of?evolution in natural populations to understand the genomic?and neuronal basis of behavior and?the mechanisms by which behaviors evolve. We are an interdisciplinary group with joint membership in the Princeton?Neuroscience Institute and the Department of Ecology and Evolutionary Biology. ?We therefore approach our research from multiple perspectives, including evolution, neuroscience, and public health. Methodologically, our work combines evolutionary genomics with field work, molecular genetics, electrophysiology, and neural imaging.?Please click on the links to the left?to find out more about our perspective, study system, methods, and specific research projects…





Zhao Z, Zung JL, Hinze A, Kriete AL, Iqbal A, Younger MA, et al. Mosquito brains encode unique features of human odour to drive host seeking. Nature. 2022 ;605(7911):706-712. PubMed
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Xia S, Dweck HKM, Lutomiah J, Sang R, McBride CS, Rose NH, et al. Larval sites of the mosquito in forest and domestic habitats in Africa and the potential association with oviposition evolution. Ecol Evol. 2021 ;11(22):16327-16343. PubMed
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Zhao Z, Tian D, McBride CS. Development of a pan-neuronal genetic driver in mosquitoes. Cell Rep Methods. 2021 ;1(3). PubMed
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Aubry F, Dabo S, Manet C, Filipovi? I, Rose NH, Miot EF, et al.. Enhanced Zika virus susceptibility of globally invasive populations. Science. 2020 ;370(6519):991-996. PubMed
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Zhao Z, McBride CS. Correction to: Evolution of olfactory circuits in insects. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020 ;206(4):663. PubMed
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Jové V, Gong Z, Hol FJH, Zhao Z, Sorrells TR, Carroll TS, et al.. Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes. Neuron. 2020 ;108(6):1163-1180.e12. PubMed
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Rose NH, Sylla M, Badolo A, Lutomiah J, Ayala D, Aribodor OB, et al. Climate and Urbanization Drive Mosquito Preference for Humans. Curr Biol. 2020 ;30(18):3570-3579.e6. PubMed
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Zhao Z, McBride CS. Evolution of olfactory circuits in insects. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020 ;206(3):353-367. PubMed
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Zung JL, McBride CS. How a fly came to love the vomit fruit. Nature. 2020 ;579(7799):345-346. PubMed
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Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, et al. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 2018 ;563(7732):501-507. PubMed
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Metz HC, McBride CS. Malaria Parasites Alter Human Odor to Attract Mosquito Vectors. Trends Parasitol. 2018 ;34(7):547-549. PubMed
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McBride CS. Genes and Odors Underlying the Recent Evolution of Mosquito Preference for Humans. Curr Biol. 2016 ;26(1):R41-6. PubMed
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Matthews BJ, McBride CS, DeGennaro M, Despo O, Vosshall LB. The neurotranscriptome of the Aedes aegypti mosquito. BMC Genomics. 2016 ;17:32. PubMed
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McBride CS, Baier F, Omondi AB, Spitzer SA, Lutomiah J, Sang R, et al. Evolution of mosquito preference for humans linked to an odorant receptor. Nature. 2014 ;515(7526):222-7. PubMed
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DeGennaro M, McBride CS, Seeholzer L, Nakagawa T, Dennis EJ, Goldman C, et al. orco mutant mosquitoes lose strong preference for humans and are not repelled by volatile DEET. Nature. 2013 ;498(7455):487-91. PubMed
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Brown JE, McBride CS, Johnson P, Ritchie S, Paupy C, Bossin H, et al. Worldwide patterns of genetic differentiation imply multiple 'domestications' of Aedes aegypti, a major vector of human diseases. Proc Biol Sci. 2011 ;278(1717):2446-54. PubMed
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McBride CS, Singer MC. Field studies reveal strong postmating isolation between ecologically divergent butterfly populations. PLoS Biol. 2010 ;8(10):e1000529. PubMed
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Singer MC, McBride CS. Multitrait, host-associated divergence among sets of butterfly populations: implications for reproductive isolation and ecological speciation. Evolution. 2010 ;64(4):921-33. PubMed
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