Henry L. Hillman Professor of Molecular Biology

Contact

icristea@princeton.edu
609-258-9417
Thomas Laboratory, 210
Cristea Lab

Faculty Assistant

Mary Gidaro

Education

Ph.D., Michael Barber Centre for Mass Spectrometry, University of Manchester Institute of Science and Technology
M.Chem., Medicinal Chemistry, University of Manchester Institute of Science and Technology

Curriculum Vitae

Research Area

Microbiology & Virology

Research Focus

Virology meets Proteomics: Cellular Host Defense versus Virus Immune Evasion



Research
Selected Publications
Biography
Honors & Awards
The research of our laboratory is at the interface between virology and proteomics. We are studying cellular mechanisms used in defense against viruses, as well as mechanisms used by viruses to inhibit or hijack host cell processes. For these studies, we use multidisciplinary approaches, integrating molecular virology, microscopy, mass spectrometry-based proteomics, and bioinformatics. We have developed a series of proteomics-based approaches for characterizing cellular processes occurring during the progression of viral infections, and we are exploring several areas of interest:
Dynamic regulation of host-virus protein-protein and protein-nucleic acid interactions during the progression of an infection
Mechanisms of sensing of pathogenic DNA within the nuclei of infected cells
Initiation and propagation of intrinsic and innate immune responses following infection with nuclear-replicating herpesviruses
Roles and regulation of human deacetylases (histone deacetylases - HDACs and sirtuins - SIRTs) during viral infections
Global remodeling of cellular organelles during the progression of viral infection
Developing targeted and large-scale proteomic tools for quantifying proteins, identifying protein interactions, determining the specificity of interactions, defining distinct protein complexes, and measuring the relative stability of interactions




Taylor IR, Murray-Nerger LA, Greco TM, Liu D, Cristea IM, Bassler BL. Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa. mBio. 2022 ;:e0155922. PubMed
BibTex

Kennedy MA, Greco TM, Song B, Cristea IM. HTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration. Mol Cell Proteomics. 2022 ;:100275. PubMed
BibTex

Justice JL, Cristea IM. Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair. Trends Microbiol. 2022 ;. PubMed
BibTex

Howard TR, Lum KK, Kennedy MA, Cristea IM. The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection. mSystems. 2022 ;7(3):e0019822. PubMed
BibTex

Cook KC, Tsopurashvili E, Needham JM, Thompson SR, Cristea IM. Restructured membrane contacts rewire organelles for human cytomegalovirus infection. Nat Commun. 2022 ;13(1):4720. PubMed
BibTex

Kennedy MA, Tyl MD, Betsinger CN, Federspiel JD, Sheng X, Arbuckle JH, et al. A TRUSTED targeted mass spectrometry assay for pan-herpesvirus protein detection. Cell Rep. 2022 ;39(6):110810. PubMed
BibTex

Serrero MC, Girault V, Weigang S, Greco TM, Ramos-Nascimento A, Anderson F, et al. The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses. Elife. 2022 ;11. PubMed
BibTex

Greco TM, Secker C, Ramos ESilva, Federspiel JD, Liu J-P, Perez AM, et al. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell Syst. 2022 ;13(4):304-320.e5. PubMed
BibTex

Robbe ZL, Shi W, Wasson LK, Scialdone AP, Wilczewski CM, Sheng X, et al. CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart. Genes Dev. 2022 ;36(7-8):468-482. PubMed
BibTex

Tyl MD, Betsinger CN, Cristea IM. Virus-host protein interactions as footprints of human cytomegalovirus replication. Curr Opin Virol. 2022 ;52:135-147. PubMed
BibTex

Christopher JA, Stadler C, Martin CE, Morgenstern M, Pan Y, Betsinger CN, et al. Subcellular proteomics. Nat Rev Methods Primers. 2021 ;1. PubMed
BibTex

Howard TR, Crow MS, Greco TM, Lum KK, Li T, Cristea IM. The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle. mSystems. 2021 ;6(3):e0039721. PubMed
BibTex

Omenn GS, Lane L, Overall CM, Paik Y-K, Cristea IM, Corrales FJ, et al. Progress Identifying and Analyzing the Human Proteome: 2021?Metrics from the HUPO Human Proteome Project. J Proteome Res. 2021 ;20(12):5227-5240. PubMed
BibTex

Shi W, Sheng X, Dorr KM, Hutton JE, Emerson JI, Davies HA, et al. Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation. Dev Cell. 2021 ;56(21):3019-3034.e7. PubMed
BibTex

Murray-Nerger LA, Cristea IM. Lamin post-translational modifications: emerging toggles of nuclear organization and function. Trends Biochem Sci. 2021 ;46(10):832-847. PubMed
BibTex

Betsinger CN, Jankowski CSR, Hofstadter WA, Federspiel JD, Otter CJ, Beltran PMJean, et al. The human cytomegalovirus protein pUL13 targets mitochondrial cristae architecture to increase cellular respiration during infection. Proc Natl Acad Sci U S A. 2021 ;118(32). PubMed
BibTex

Justice JL, Kennedy MA, Hutton JE, Liu D, Song B, Phelan B, et al. Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity. Sci Adv. 2021 ;7(25). PubMed
BibTex

Sheng X, Cristea IM. The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection. PLoS Pathog. 2021 ;17(4):e1009506. PubMed
BibTex

Esposito M, Fang C, Cook KC, Park N, Wei Y, Spadazzi C, et al. TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis. Nat Cell Biol. 2021 ;23(3):257-267. PubMed
BibTex

Murray-Nerger LA, Justice JL, Rekapalli P, Hutton JE, Cristea IM. Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair. Nucleic Acids Res. 2021 ;49(4):2044-2064. PubMed
BibTex

Song B, Liu D, Greco TM, Cristea IM. Post-translational modification control of viral DNA sensors and innate immune signaling. Adv Virus Res. 2021 ;109:163-199. PubMed
BibTex

Lum KK, Cristea IM. Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection. Curr Issues Mol Biol. 2021 ;42:635-686. PubMed
BibTex

Howard TR, Cristea IM. Interrogating Host Antiviral Environments Driven by Nuclear DNA Sensing: A Multiomic Perspective. Biomolecules. 2020 ;10(12). PubMed
BibTex

Kennedy MA, Hofstadter WA, Cristea IM. TRANSPIRE: A Computational Pipeline to Elucidate Intracellular Protein Movements from Spatial Proteomics Data Sets. J Am Soc Mass Spectrom. 2020 ;31(7):1422-1439. PubMed
BibTex

Omenn GS, Lane L, Overall CM, Cristea IM, Corrales FJ, Lindskog C, et al. Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project. J Proteome Res. 2020 ;19(12):4735-4746. PubMed
BibTex

Tanneti NS, Federspiel JD, Cristea IM, Enquist LW. The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation. PLoS Pathog. 2020 ;16(12):e1008861. PubMed
BibTex

Adhikari S, Nice EC, Deutsch EW, Lane L, Omenn GS, Pennington SR, et al. A high-stringency blueprint of the human proteome. Nat Commun. 2020 ;11(1):5301. PubMed
BibTex

Federspiel JD, Cook KC, Kennedy MA, Venkatesh SS, Otter CJ, Hofstadter WA, et al. Mitochondria and Peroxisome Remodeling across Cytomegalovirus Infection Time Viewed through the Lens of Inter-ViSTA. Cell Rep. 2020 ;32(4):107943. PubMed
BibTex

Song B, Greco TM, Lum KK, Taber CE, Cristea IM. The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling. Mol Cell Proteomics. 2020 ;19(7):1193-1208. PubMed
BibTex

Greco TM, Kennedy MA, Cristea IM. Proteomic Technologies for Deciphering Local and Global Protein Interactions. Trends Biochem Sci. 2020 ;45(5):454-455. PubMed
BibTex

Kinoshita N, Hashimoto Y, Yasue N, Suzuki M, Cristea IM, Ueno N. Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis. Cell Rep. 2020 ;30(11):3875-3888.e3. PubMed
BibTex

Hashimoto Y, Sheng X, Murray-Nerger LA, Cristea IM. Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection. Nat Commun. 2020 ;11(1):806. PubMed
BibTex

Hartenian E, Gilbertson S, Federspiel JD, Cristea IM, Glaunsinger BA. RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters. PLoS Pathog. 2020 ;16(2):e1008269. PubMed
BibTex

Cristea IM, Dorrestein PC, Eisen JA, Gilbert JA, Huber JA, Jansson JK, et al. Early-Career Scientists Shaping the World. mSystems. 2019 ;4(3). PubMed
BibTex

Cook KC, Moreno JA, Beltran PMJean, Cristea IM. Peroxisome Plasticity at the Virus-Host Interface. Trends Microbiol. 2019 ;27(11):906-914. PubMed
BibTex

Federspiel JD, Tandon P, Wilczewski CM, Wasson L, Herring LE, Venkatesh SS, et al. Conservation and divergence of protein pathways in the vertebrate heart. PLoS Biol. 2019 ;17(9):e3000437. PubMed
BibTex

Federspiel JD, Greco TM, Lum KK, Cristea IM. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Mol Cell Proteomics. 2019 ;18(8 suppl 1):S92-S113. PubMed
BibTex

Lum KK, Howard TR, Pan C, Cristea IM. Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA. mBio. 2019 ;10(4). PubMed
BibTex

Durán AHernández, Greco TM, Vollmer B, Cristea IM, Grünewald K, Topf M. Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol. 2019 ;17(6):e3000316. PubMed
BibTex

Betsinger CN, Cristea IM. Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions. J Proteome Res. 2019 ;18(5):1929-1938. PubMed
BibTex

Hashimoto Y, Kinoshita N, Greco TM, Federspiel JD, Beltran PMJean, Ueno N, et al. Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos. Cell Syst. 2019 ;8(3):226-241.e7. PubMed
BibTex

Carabetta VJ, Greco TM, Cristea IM, Dubnau D. YfmK is an N-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in . Proc Natl Acad Sci U S A. 2019 ;116(9):3752-3757. PubMed
BibTex

Cristea IM, Lilley KS. Editorial overview: Untangling proteome organization in space and time. Curr Opin Chem Biol. 2019 ;48:A1-A4. PubMed
BibTex

Cook KC, Cristea IM. Location is everything: protein translocations as a viral infection strategy. Curr Opin Chem Biol. 2019 ;48:34-43. PubMed
BibTex

Shen M, Jiang Y-Z, Wei Y, Ell B, Sheng X, Esposito M, et al. Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling. Cancer Cell. 2019 ;35(1):64-80.e7. PubMed
BibTex

Federspiel JD, Cristea IM. Considerations for Identifying Endogenous Protein Complexes from Tissue via Immunoaffinity Purification and Quantitative Mass Spectrometry. Methods Mol Biol. 2019 ;1977:115-143. PubMed
BibTex

Hashimoto Y, Greco TM, Cristea IM. Contribution of Mass Spectrometry-Based Proteomics to Discoveries in Developmental Biology. Adv Exp Med Biol. 2019 ;1140:143-154. PubMed
BibTex

Murray LA, Combs AN, Rekapalli P, Cristea IM. Methods for characterizing protein acetylation during viral infection. Methods Enzymol. 2019 ;626:587-620. PubMed
BibTex

Howard TR, Song B, Cristea IM. Workflows and considerations for investigating protein interactions of viral DNA sensors. Methods Enzymol. 2019 ;625:309-338. PubMed
BibTex

Roy NA, Bak JHyun, Akrami A, Brody CD, Pillow JW. Efficient inference for time-varying behavior during learning. Adv Neural Inf Process Syst. 2018 ;31:5695-5705. PubMed
BibTex

Lum KK, Song B, Federspiel JD, Diner BA, Howard T, Cristea IM. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Cell Syst. 2018 ;7(6):627-642.e6. PubMed
BibTex

Murray LA, Sheng X, Cristea IM. Orchestration of protein acetylation as a toggle for cellular defense and virus replication. Nat Commun. 2018 ;9(1):4967. PubMed
BibTex

Murray LA, Sheng X, Cristea IM. Orchestration of protein acetylation as a toggle for cellular defense and virus replication. Nat Commun. 2018 ;9(1):4967. PubMed
BibTex

Beltran PMJean, Cook KC, Hashimoto Y, Galitzine C, Murray LA, Vitek O, et al. Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Cell Host Microbe. 2018 ;24(4):526-541.e7. PubMed
BibTex

Gilbertson S, Federspiel JD, Hartenian E, Cristea IM, Glaunsinger B. Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription. Elife. 2018 ;7. PubMed
BibTex

Sauls K, Greco TM, Wang L, Zou M, Villasmil M, Qian L, et al. Initiating Events in Direct Cardiomyocyte Reprogramming. Cell Rep. 2018 ;22(7):1913-1922. PubMed
BibTex

Rowland EA, Snowden CK, Cristea IM. Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease. Curr Opin Chem Biol. 2018 ;42:76-85. PubMed
BibTex

Kennedy L, Kaltenbrun E, Greco TM, Temple B, Herring LE, Cristea IM, et al. Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis. PLoS Genet. 2017 ;13(9):e1007011. PubMed
BibTex

Santos JMendonca, Josling G, Ross P, Joshi P, Orchard L, Campbell T, et al. Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor. Cell Host Microbe. 2017 ;21(6):731-741.e10. PubMed
BibTex

Alfonso-Dunn R, Turner A-MW, Beltran PMJean, Arbuckle JH, Budayeva HG, Cristea IM, et al. Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from Latency. Cell Host Microbe. 2017 ;21(4):507-517.e5. PubMed
BibTex

Mirzaei M, Gupta VB, Chick JM, Greco TM, Wu Y, Chitranshi N, et al. Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Sci Rep. 2017 ;7(1):12685. PubMed
BibTex

Beltran PMJean, Cook KC, Cristea IM. Exploring and Exploiting Proteome Organization during Viral Infection. J Virol. 2017 ;91(18). PubMed
BibTex

Rowland EA, Greco TM, Snowden CK, McCabe AL, Silhavy TJ, Cristea IM. Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes. mBio. 2017 ;8(5). PubMed
BibTex

Carabetta VJ, Cristea IM. Regulation, Function, and Detection of Protein Acetylation in Bacteria. J Bacteriol. 2017 ;199(16). PubMed
BibTex

Pastino AK, Greco TM, Mathias RA, Cristea IM, Schwarzbauer JE. Stimulatory effects of advanced glycation endproducts (AGEs) on fibronectin matrix assembly. Matrix Biol. 2017 ;59:39-53. PubMed
BibTex

Crow MS, Cristea IM. Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation. Mol Cell Proteomics. 2017 ;16(4 suppl 1):S200-S214. PubMed
BibTex

Greco TM, Cristea IM. Proteomics Tracing the Footsteps of Infectious Disease. Mol Cell Proteomics. 2017 ;16(4 suppl 1):S5-S14. PubMed
BibTex

Cristea IM. The Host-Pathogen Ecosystem Viewed Through the Prism of Proteomics. Mol Cell Proteomics. 2017 ;16(4 suppl 1):S1-S4. PubMed
BibTex

Beltran PMJean, Federspiel JD, Sheng X, Cristea IM. Proteomics and integrative omic approaches for understanding host-pathogen interactions and infectious diseases. Mol Syst Biol. 2017 ;13(3):922. PubMed
BibTex

Crow MS, Lum KK, Sheng X, Song B, Cristea IM. Diverse mechanisms evolved by DNA viruses to inhibit early host defenses. Crit Rev Biochem Mol Biol. 2016 ;51(6):452-481. PubMed
BibTex

Carabetta VJ, Greco TM, Tanner AW, Cristea IM, Dubnau D. Temporal Regulation of the Acetylome and Evidence for a Role of MreB Acetylation in Cell Wall Growth. mSystems. 2016 ;1(3). PubMed
BibTex

Giguère SSB, Guise AJ, Beltran PMJean, Joshi PM, Greco TM, Quach OL, et al.. The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression. Mol Cell Proteomics. 2016 ;15(3):791-809. PubMed
BibTex

Luo Y, Jacobs EY, Greco TM, Mohammed KD, Tong T, Keegan S, et al. HIV-host interactome revealed directly from infected cells. Nat Microbiol. 2016 ;1(7):16068. PubMed
BibTex

Greco TM, Cristea IM. The Biochemical Evolution of Protein Complexes. Trends Biochem Sci. 2016 ;41(1):4-6. PubMed
BibTex

Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, et al. The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell. 2016 ;36(3):262-75. PubMed
BibTex

Song R, Koyuncu OO, Greco TM, Diner BA, Cristea IM, Enquist LW. Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion. mBio. 2016 ;7(1):e02145-15. PubMed
BibTex

Diner BA, Lum KK, Toettcher JE, Cristea IM. Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection. mBio. 2016 ;7(6). PubMed
BibTex

Beltran PMJean, Mathias RA, Cristea IM. A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection. Cell Syst. 2016 ;3(4):361-373.e6. PubMed
BibTex

Budayeva HG, Cristea IM. Human Sirtuin 2 Localization, Transient Interactions, and Impact on the Proteome Point to Its Role in Intracellular Trafficking. Mol Cell Proteomics. 2016 ;15(10):3107-3125. PubMed
BibTex

Crow MS, Lum KK, Sheng X, Song B, Cristea IM. Diverse mechanisms evolved by DNA viruses to inhibit early host defenses. Crit Rev Biochem Mol Biol. 2016 ;:1-30. PubMed
BibTex

McDonald KR, Guise AJ, Pourbozorgi-Langroudi P, Cristea IM, Zakian VA, Capra JA, et al. Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. PLoS Genet. 2016 ;12(9):e1006238. PubMed
BibTex

Ashford P, Hernandez A, Greco TMichael, Buch A, Sodeik B, Cristea IMihaela, et al. HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1. Mol Cell Proteomics. 2016 ;15(9):2939-53. PubMed
BibTex

Viktorovskaya OV, Greco TM, Cristea IM, Thompson SR. Identification of RNA Binding Proteins Associated with Dengue Virus RNA in Infected Cells Reveals Temporally Distinct Host Factor Requirements. PLoS Negl Trop Dis. 2016 ;10(8):e0004921. PubMed
BibTex

Budayeva HG, Rowland EA, Cristea IM. Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens. J Virol. 2016 ;90(1):5-8. PubMed
BibTex

Mathias RA, Greco TM, Cristea IM. Identification of Sirtuin4 (SIRT4) Protein Interactions: Uncovering Candidate Acyl-Modified Mitochondrial Substrates and Enzymatic Regulators. Methods Mol Biol. 2016 ;1436:213-39. PubMed
BibTex

Guise AJ, Cristea IM. Approaches for Studying the Subcellular Localization, Interactions, and Regulation of Histone Deacetylase 5 (HDAC5). Methods Mol Biol. 2016 ;1436:47-84. PubMed
BibTex

Greco TM, Guise AJ, Cristea IM. Determining the Composition and Stability of Protein Complexes Using an Integrated Label-Free and Stable Isotope Labeling Strategy. Methods Mol Biol. 2016 ;1410:39-63. PubMed
BibTex

Lum KK, Cristea IM. Proteomic approaches to uncovering virus-host protein interactions during the progression of viral infection. Expert Rev Proteomics. 2016 ;13(3):325-40. PubMed
BibTex

Lin K-W, McDonald KR, Guise AJ, Chan A, Cristea IM, Zakian VA. Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length. Nat Commun. 2015 ;6:8290. PubMed
BibTex

Diner BA, Cristea IM. Blowing Off Steam: Virus Inhibition of cGAS DNA Sensing. Cell Host Microbe. 2015 ;18(3):270-2. PubMed
BibTex

Diner BA, Lum KK, Javitt A, Cristea IM. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Mol Cell Proteomics. 2015 ;14(9):2341-56. PubMed
BibTex

Rowles DL, Tsai Y-C, Greco TM, Lin AE, Li M, Yeh J, et al. DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection. Proteomics. 2015 ;15(12):1968-82. PubMed
BibTex

Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, et al. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015 ;11(1):787. PubMed
BibTex

Hahn J, Tanner AW, Carabetta VJ, Cristea IM, Dubnau D. ComGA-RelA interaction and persistence in the Bacillus subtilis?K-state. Mol Microbiol. 2015 ;97(3):454-71. PubMed
BibTex




Dr. Ileana Cristea has performed her graduate research at the Michael Barber Center for Mass Spectrometry, University of Manchester, U.K., under the supervision of Simon Gaskell, and at the Toxicology Research & Development Department at GlaxoSmithKline, U.K. She pursued her postdoctoral work in the mass spectrometry laboratory of Brian Chait at The Rockefeller University. She is currently an Associate Professor in the Department of Molecular Biology at Princeton University. The research of her group is at the interface between proteomics and virology. Her goal is to build an understanding of viral infection from a proteomics perspective. Broad questions that her lab is addressing are: How do viruses effectively modulate cellular pathways? How do hosts respond to viral infection? Can proteomics identify key host proteins to harness for therapeutic development? To accomplish these goals, her laboratory utilizes a multi-disciplinary approach that integrates proteomics techniques with genomics, microscopy, bioinformatics, and virology. These approaches have allowed her group to bridge developments in mass spectrometry to critical findings in biology, identifying mechanisms used by viruses to manipulate their hosts, as well as defenses hosts deploy to protect themselves from viral attack. Dr. Cristea is a member of the Executive Board of the US Human Proteome Organization (2012-present), US-HUPO Education Committee (2011-present), the American Society for Mass Spectrometry Education Committee (2008-2010), and on the Editorial Boards of?Molecular & Cellular Proteomics, Proteomics,Journal of Proteome Research, andJournal of Neuroimmune Pharmacology. She also chairs the Infectious Disease initiative of the HUPO World organization. She acts as a head instructor of the summer Proteomics Course at Cold Spring Harbor Laboratory, having taught there since 2006. She has taught related workshops at ASMS, HUPO World Congress, US-HUPO, AOHUPO, and ABRF. She is the recipient of the Bordoli Prize from the British Mass Spectrometry Society (2001), NIDA Avant-Garde Director Pioneer Award for HIV/AIDS Research (2008), Human Frontiers Science Program Young Investigator Award (2009), Early Career Award in Mass Spectrometry from the American Chemical Society NJ Section (2011), the American Society for Mass Spectrometry Research Award (2012), and the Molecular & Cellular Proteomics Lectureship (2013).

2015

Mallinckrodt Scholar Award, Edward Mallinckrodt, Jr. Foundation

2012

American Society for Mass Spectrometry Research Award, American Society for Mass Spectrometry

2011

Early Career Award in Mass Spectometry, American Chemical Society