Eduardo David Leonardo, MD, PHD
Specialties:
Psychiatry
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Credentials & Experience
Research
Overview
Dr. Leonardo graduated from Yale University and received his M.D. and Ph.D. from the University of California at San Francisco.He completed residency training at NYSPI/Columbia University, College of Physicians & Surgeons. He completed a Research Fellowship in Anxiety, Mood and related disorders in 2006 and has been on the faculty since then. He is currently an Associate Residency training director and director of Neuroscience Education and Research training for the Department of Psychiatry residency program at Columbia.
Areas of Expertise / Conditions Treated
Adjustment DisorderAdult Psychiatry
Adult Psychopharmacology
Anxiety and Depression
Anxiety Disorders
Attention Deficit Hyperactivity Disorder (ADHD)
Bipolar Disorder
Depression
Generalized Anxiety Disorder
General Psychiatry
Insomnia
Mental Health
Mood Disorders
Obsessive Compulsive Disorder (OCD)
Panic Disorder
Psychopharmacology
Psychopharmacology of Anxiety and Depression
Psychosis
Psychotherapy
Social Anxiety Disorder
Academic Appointments
Assistant Professor of Psychiatry at CUMCAdministrative Titles
Associate Director, Residency Training Department of PsychiatryHospital Affiliations
NewYork-Presbyterian / Columbia University Irving Medical CenterLanguages
SpanishGender
MaleSchedule an Appointment
Phone Appointments
New and Existing Patients: (646) 774-7105
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Location(s)
CUIMC/Herbert Pardes Building of the New York State Psychiatric Institute1051 Riverside Drive
New York, NY 10032
Phone: (646) 774-7105
Fax: (646) 774-7117
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ColumbiaDoctors - 119 West 57th Street
119 West 57th Street
New York, NY 10019
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Insurance Accepted
Medicare
Traditional Medicare*Please contact the provider’s office directly to verify that your particular insurance is accepted.
Credentials & Experience
Education & Training
1999 University of California San Francisco School of MedicineInternship: 2001 New York State Psychiatric Institute
Residency: 2003 NewYork-Presbyterian Hospital/Columbia University Medical Center
Board Certifications
PsychiatryResearch
Our primary interest is in understanding how temporal factors, genetic risk, and environmental milieu interact to impact on the expression of mental illness.? As the brain develops, distinct neural circuits develop within narrowly defined time periods. These precisely defined time windows provide the opportunity for short-lived gene X environment interactions that ultimately determine the functioning of mature circuitry and the behaviors that they mediate. In a longstanding collaboration with Alex Dranovsky, we are examining the effects of stressful and enriching experiences on mature and immature brain circuitry in the mouse, with the aim of understanding how such effects produce alterations in behavior.In another area of investigation, we use novel, regulatable, serotonin-1A receptor mutant mice to disrupt normal serotonergic signaling in early development.? Using this system, we can independently manipulate either specific cortical 5-HT1A medicated signaling by selectively removing cortical receptors, or globally disrupt serotonergic signaling by removing 5-HT1A receptors in the raphe, which provide negative feedback for serotonergic neurons.? Using this model system, we have already identified distinct effects of cortical receptors on depression related behavior and raphe receptors on anxiety related behavior.? We are currently investigating the time course during which the distinct circuits mediating these behaviors are vulnerable to disruption.
Research Interests
Models of Psychiatric DisordersMood Disorder
Neurobiology of Disease
Neurogenetics
Synapses and Circuits
Selected Publications
Garcia-Garcia, A.L., Meng, Q., Canetta, S., Gardier, A.M., Guiard, B.P., Kellendonk, C., Dranovsky, A., *Leonardo, E.D. Serotonin signaling through Prefrontal Cortex 5-HT1A receptors during adolescence can determine baseline mood-related behaviors. (2017) Cell Reports. Jan 31;18(5) 1144-1156.Garcia-Garcia, A.L., Meng, Q., Richardson-Jones, J., Dranovsky, A., Leonardo, E.D. (2015) Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. doi:10.1016/j.neuroscience.2015.05.076.
Kirshenbaum GS, Lieberman SR, Briner TJ, Leonardo ED, Dranovsky A. (2014) Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat. Front Behav Neurosci. 8:289.
Richardson-Jones JW1, Craige CP, Guiard BP, Stephen A, Metzger KL, Kung HF, Gardier AM, Dranovsky A, David DJ, Beck SG, Hen R, Leonardo ED. (2010) 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron. 65:40-52. doi: 10.1016/j.neuron.2009.12.003.
Leonardo, E.D. (2010). 5-HT1A autoreceptors determine vulnerability to stress and response to antidepressants. Neuron 65: 40-52.
Leonardo, E. D., and Hen, R. (2007) Anxiety as a Developmental Disorder. Neuropsychopharmacology reviews 2007: 1: 1-7.