Steven Owen Marx, MD

Specialties:
Cardiovascular Disease, Clinical Cardiac Electrophysiology, Electrophysiology Cardiology

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Overview
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Location(s)
Credentials & Experience
Research

Overview

Steven O. Marx, M.D., is the Director of the Cardiovascular Fellowship Program at Columbia University Medical Center/NewYork-Presbyterian Hospital and is director of the cardiology component of a NIH training grant for cardiology fellows and surgery residents.
His research program in cardiovascular diseases at Columbia has been focused in two major areas: molecular cardiology, particularly the regulation of ion channels in normal and pathological conditions in the heart, and vascular biology, particularly the molecular mechanisms of vascular smooth muscle proliferation, migration and contractility. Working with others at Columbia, Dr. Marx has identified rapamycin (sirolimus) as a therapeutic agent for preventing restenosis after angioplasty/stent implantation. He also characterized the dysfunction of the ryanodine receptor in heart failure. A major focus of Dr. Marx's current research is the regulation of arterial contractility and blood pressure by the ion channels.
Dr. Marx received his B.S. in Biology from Union College and M.D. from Albany Medical College as part of a six-year program. Following a one-year postdoctoral fellowship in ion channel research at Johns Hopkins, he completed an internship and residency at the University of Rochester-Strong Memorial Hospital followed by a Cardiology Fellowship and a Clinical Electrophysiology Fellowship at Mount Sinai Medical Center. He is board certified in Internal Medicine, Cardiology and Clinical Cardiac Electrophysiology. He is also the principal investigator of several NIH R01 grants and a T32 grant. Dr. Marx has served on NIH and AHA peer review committees, is a member of the AHA Founders Affiliate Research Committee, and serves on the New York Academy of Medicine Glorney-Raisbeck Selection Committee.

Areas of Expertise / Conditions Treated

Cardiac Electrophysiology
Clinical Cardiac Electrophysiology
Clinical Research Trials
Outcomes Research
Resident Education

Academic Appointments

Herbert and Florence Irving Professor of Cardiology (in Medicine) to Honor Dr. Le Roy E. Rabbani

Hospital Affiliations

NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

Male

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Phone Appointments

New and Existing Patients: (212) 305-0271

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Location(s)

CUIMC/Presbyterian Hospital and Vanderbilt Clinic
622 West 168th Street

New York, NY 10032

Primary

Phone: (212) 305-0271



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Credentials & Experience

Education & Training

Albany Medical College-Union University, NY
Internship: Strong Memorial Hospital, NY
Residency: Strong Memorial Hospital, NY
Fellowship: Mount Sinai Hospital - MD

Board Certifications

Clinical Cardiac Electrophysiology
Cardiovascular Disease

Honors & Awards

1982 Westinghouse Science Talent Search Semi-Finalist
1986 Magna Cum Laude, Biology/Sociology
1988 Alpha Omega Alpha (AOA)
1994-1995 American College of Cardiology/Merck Fellow
1995 American College of Cardiology, NYS Chapter Young Investigator Award
1995 Astra-Merck Young Investigator's Forum Second Prize in Basic Research
1994-1995 John C. Sable Memorial Heart Fund Research Award
1995 The Denber Prize for Research, Mount Sinai Cardiovascular Institute
1996 Katz Award Finalist, American Heart Association
1996-1997 Glorney-Raisbeck Fellowship of the NY Academy of Medicine
1996-2001 Clinician-Scientist Award, American Heart Association

Research

The Marx laboratory studies the regulation of ion channels by macromolecular complexes. We have demonstrated that specific sequences within the ion channel (leucine zippers) recruit regulatory proteins, which modulate the ion channel function in normal and pathologic conditions. The laboratory is now focused on understanding the molecular components and functional implications of macromolecular complex formation of the large conductance calcium-activated potassium channel (BKCa, maxi-K) and the L-type voltage gated calcium channel. The laboratory utilizes both molecular biologic and electrophysiologic (planar lipid bilayer, patch clamp) techniques to elucidate these fundamental processes and emphasizes the links between these fundamental molecular processes and systems function. To date our work has had significant impact in understanding the triggers of fatal cardiac arrhythmias and mechanical dysfunction in heart failure. Present experiments are very likely to impact our understanding of control of peripheral blood pressure by the sympathetic nervous system.

Research Interests

Molecular biology/macromolecular complex formation of ion channels



For a complete list of publications, please visit PubMed.gov