Rebecca F. Hough, MD, PHD

Specialties:
Pediatric Critical Care Medicine, Pediatrics

More specialties
Treats Children

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Overview
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Credentials & Experience
Research
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Overview

Dr. Rebecca Hough is an Assistant Professor in Pediatrics. She specializes in critical care medicine for children in the Pediatric Intensive Care Unit (PICU), including those recovering from surgery for neurosurgical and orthopedic conditions, as well as infants and children who need organ transplants, suffer trauma, or have respiratory and/or cardiovascular failure. Dr. Hough is a physician scientist, and her research interests are in the origins of pulmonary edema in the Acute Respiratory Distress Syndrome (ARDS).
Dr. Hough studied Chemistry at Boston University. She then went on to obtain her Ph.D. degree in Biophysics in 2008, and her M.D. in 2010 from the University of Wisconsin School of Medicine and Public Health, as part of their distinguished Medical Scientist Training Program. She completed her Pediatrics residency and Pediatric Critical Care Medicine fellowship at Columbia University Medical Center in 2017. During her fellowship, Dr. Hough obtained a training grant (T32) from the NIH to pursue her interests in ARDS. She began her work under the mentorship of the renowned lung biologist, Dr. Jahar Bhattacharya, learning highly specialized techniques in in situ imaging of mouse lungs. Dr. Hough was hired as faculty in the Division of Pediatric Critical Care Medicine after graduating from fellowship.
Dr. Hough's research is focused on the early events of Acute Lung Injury, which leads to ARDS. ARDS is deadly to both children and adults, with mortality rates of 10-15% in children. Using RNA interference and transgenic mouse lines, she has identified a novel role for lung capillary mitochondria in mediating the pulmonary edema that is essential for the development of Acute Lung Injury. It is Dr. Hough's hope that her work on elucidating the molecular mechanisms of ARDS will lead to targeted therapies to alleviate morbidity and mortality.

Areas of Expertise / Conditions Treated

Intensive Care
Pediatric Critical Care Specialist

Academic Appointments

Instructor in Pediatrics at CUMC

Hospital Affiliations

NewYork-Presbyterian / Columbia University Irving Medical Center
NewYork-Presbyterian Morgan Stanley Children's Hospital

Gender

Female

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Credentials & Experience

Education & Training

MD, PhD, University of Wisconsin Medical School
Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
Fellowship: Morgan Stanley Children's Hospital of NewYork-Presbyterian

Board Certifications

Pediatrics

Honors & Awards

2002 - 2010 Wisconsin Distinguished Rath Graduate Fellowship, University of Wisconsin School of Medicine and Public Health
2019 - present Parker B. Francis Fellowship

Research

Research Interests

Acute Lung Injury
alveolar-capillary crosstalk
endothelial mitochondria

Selected Publications

Hough RF, Islam MN, Gusarova GA, Jin G, Das S, Bhattacharya J. Endothelial mitochondria determine rapid barrier failure in chemical lung injury. JCI Insight. 2019 Feb 7;4(3).
Hough RF, Bhattacharya S, Bhattacharya J. Crosstalk signaling between alveoli and capillaries (2017 Grover Conference series). Pulm Circ. 2018 Jul-Sept;8(3):1-8.
Hough RF. Recent advances in Pediatric Acute Respiratory Distress Syndrome (PARDS). Curr Pediatr Rep. 2017 Dec;5(4):228-236.
Turcotte RF, Brozovich A, Corda R, Demmer RT, Biagas KV, Mangino D, Covington L, Ferris A, Thumm B, Bacha E, Smerling A, Saiman L. Health care-associated infections in children after cardiac surgery. Pediatr Cardiol. 2014 Dec;35(8):1448-55.
Murray MT, Corda R, Turcotte R, Bacha E, Saiman L, Krishnamurthy G. Implementing a standardized perioperative antibiotic prophylaxis protocol for neonates undergoing cardiac surgery. Ann Thorac Surg. 2014 Sep;98(3):927-33.
Murray MT, Krishnamurthy G, Corda R, Turcotte RF, Jia H, Bacha E, Saiman L. Surgical site infections and bloodstream infections in infants after cardiac surgery. J Thorac Cardiovasc Surg. 2014 Jul;148(1):259-65.
Turcotte RF, Lavis LD, Raines RT. Onconase cytotoxicity relies on the distribution of its positive charge. FEBS J. 2009 Jul;276(14):3846-57.
Turcotte RF, Raines RT. Interaction of onconase with the human ribonuclease inhibitor protein. Biochem Biophys Res Commun. 2008 Dec 12;377(2):512-4.
Turcotte RF, Raines RT. Design and characterization of an HIV-specific ribonuclease zymogen. AIDS Res Hum Retroviruses. 2008 Nov;24(11):1357-63.


For a complete list of publications, please visit PubMed.gov

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Profile: Rebecca Hough MD, PhD

July 13, 2020

Topic

Research