Darrell J. Yamashiro, MD
Specialties:
Cancer Care, Pediatric Hematology-Oncology, Pediatrics
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Accepting New Patients
Treats Children
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Credentials & Experience
Research
Overview
pediatric_oncology_-_newyork-presbyterianmorgan_stanley_childrens_hospital
I am a pediatric oncologist who specializes in caring for children with solid tumors, especially neuroblastoma, Wilms' and other kidney tumors, and liver tumors such hepatoblastoma and hepatocellular carcinoma. I serve as chief of the Division of Hematology, Oncology and Stem Cell Transplantation at Columbia University Irving Medical Center and NewYork-Presbyterian Morgan Stanley Children's Hospital.
I treat children of all ages, from infants to young adults. Some of the cancers I treat are rare (liver tumors account for one to two percent of childhood cancers), but they can be very complex and require a multidisciplinary approach so patients have the best outcomes. I enjoy working as part of a team of physicians, nurse practitioners, nurses, social workers, child life specialists, and other dedicated professionals who care deeply about our patients and provide care with compassion and comfort.
I also conduct basic science research. The latest advances in tumor genetics and the design of innovative therapies make this a very exciting time for cancer research. My team and I have done extensive research on the genetics of hepatoblastoma. We have developed mouse models of this disease and are entering a new phase where we are offering a personalized/precision medicine approach to children with this disease. We are also identifying novel genes that specifically target neuroblastoma—information that may be used to create targeted therapies.
Areas of Expertise / Conditions Treated
AngiogenesisHepatoblastoma
Neuroblastoma
Pediatric Liver Cancer
Pediatric Solid Tumors
Wilm's Tumor
Academic Appointments
Robert and Ellen Kapito Associate Professor of Pediatrics at the Columbia University Medical CenterAdministrative Titles
Chief, Division of Hematology, Oncology, and Stem Cell TransplantationHospital Affiliations
NewYork-Presbyterian / Columbia University Irving Medical CenterNewYork-Presbyterian Morgan Stanley Children's Hospital
Gender
MaleSchedule an Appointment
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Insurance Accepted
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*Please contact the provider’s office directly to verify that your particular insurance is accepted.
Credentials & Experience
Education & Training
Internship: Children's Hospital of PhiladelphiaResidency: Children's Hospital of Philadelphia
Fellowship: Children's Hospital of Philadelphia
Board Certifications
PediatricsPediatric Hematology-Oncology
NY Top Doctor
Research
Selected Publications
Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe-Chiweshe A, Connolly EP, Kandel JJ, Rajbhandari P, Silva JM, **Califano A, **Yamashiro DJ. Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma. Oncogene. 2018. Epub 2018/06/09. doi: 10.1038/s41388-018-0326-9. PubMed PMID: 29880876.Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 2016. doi: 10.1038/nm.4180. PubMed PMID: 27618649.
Oberg JA, Glade Bender JL, Sulis ML, Pendrick D, Sireci AN, Hsiao SJ, Turk AT, Dela Cruz FS, Hibshoosh H, Remotti H, Zylber RJ, Pang J, Diolaiti D, Koval C, Andrews SJ, Garvin JH, Yamashiro DJ, Chung WK, Emerson SG, Nagy PL, Mansukhani MM, Kung AL. Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations. Genome Med. 2016;8(1):133. doi: 10.1186/s13073-016-0389-6. PubMed PMID: 28007021; PMCID: PMC5180407.
Dela Cruz FS, Diolaiti D, Turk AT, Rainey AR, Ambesi-Impiombato A, Andrews SJ, Mansukhani MM, Nagy PL, Alvarez MJ, Califano A, Forouhar F, Modzelewski B, Mitchell CM, Yamashiro DJ, Marks LJ, Bender JL, Kung AL. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016;8(1):116. doi: 10.1186/s13073-016-0366-0. PubMed PMID: 27799065.
Jani A, Shaikh F, Barton S, Willis C, Banerjee D, Mitchell J, Hernandez SL, Hei T, Kadenhe-Chiweshe A, **Yamashiro DJ, **Connolly EP. High-Dose, Single-Fraction Irradiation Rapidly Reduces Tumor Vasculature and Perfusion in a Xenograft Model of Neuroblastoma. Int J Radiat Oncol Biol Phys. 2016;94(5):1173-80. doi: 10.1016/j.ijrobp.2015.12.367. PubMed PMID: 26907918.
Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, **Kandel JJ, **Yamashiro DJ. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res. 2015;75(8):1592-1602. PMID: 25744722; PMCID: PMCPMC4401639.
For a complete list of publications, please visit PubMed.gov