Shan Zha, MD, PhD

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Overview
Research

Overview

Email: sz2296@cumc.columbia.edu

Academic Appointments

Associate Professor of Pathology and Cell Biology and of Microbiology and Immunology (in the Institute for Cancer Genetics and in the Herbert Irving Comprehensive Cancer Center)
James A Wolff Associate Professor of Pediatrics

Research

The Zha lab investigates how defects in DNA repair and DNA damage responses impact normal immune system development, lymphomagenesis, and treatment responses. The lab has developed cutting-edge technologies, including high-throughput translocation sequencing, sing cell-seq, multi-color flow-cytometry, CRISPR-based depletion and activation screens, high-content live-cell imaging, and a collection of over sixty-five unique mouse models, including the serial of mouse models expressing catalytically inactive ATM, ATR, DNA-PKcs, and now PARP1 and PARP2, which revealed unexpected structural function of DNA damage response factors. More details can be found at zhalab.org. We invite committed young scientists to join us in the adventures.

Selected Publications

The cancer-associated ATM R3008H mutation reveals the link between ATM activation and its exchange
Milanovic M, Houghton LM, Menolfi D, Lee JH, Yamamoto K, Li Y, Lee BJ, Xu J, Estes VM, Wang D, McKinnon PJ, Paull TT, Zha S
Cancer Res. 2020.
PMID: 33239428, DOI: 10.1158/0008-5472.CAN-20-2447

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
Shao Z, Lee BJ, Rouleau-Turcotte é, Langelier MF, Lin X, Estes VM, Pascal JM, Zha S
Nucleic Acids Res. 2020.
PMID: 32890402, DOI: 10.1093/nar/gkaa718

Dual-Color Plasmonic Nanosensor for Radiation Dosimetry
Tao Y, Li M, Liu X, Leong KW, Gautier J, Zha S
ACS Appl Mater Interfaces. 2020.
PMID: 32337977, DOI: 10.1021/acsami.0c03001

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
Shao Z, Flynn RA, Crowe JL, Zhu Y, Liang J, Jiang W, Aryan F, Aoude P, Bertozzi CR, Estes VM, Lee BJ, Bhagat G, Zha S, Calo E
Nature. 2020.
PMID: 32103174, DOI: 10.1038/s41586-020-2041-2

CtIP is essential for early B cell proliferation and development in mice
Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S
J Exp Med. 2019.
PMID: 31097467, DOI: 10.1084/jem.20181139

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA
Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S
Nat Commun. 2018.
PMID: 30559436, DOI: 10.1038/s41467-018-07798-3

Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination
Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S
Proc Natl Acad Sci USA. 2018.
PMID: 30072430, DOI: 10.1073/pnas.1808490115

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
Liu X, Shao Z, Jiang W, Lee BJ, Zha S
Nat Commun. 2017.
PMID: 28051062, DOI: 10.1038/ncomms13816

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S
Elife. 2016.
PMID: 27304073, DOI: 10.7554/eLife.14709

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining
Jiang W, Crowe JL, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S
Mol Cell. 2015.
PMID: 25818648, DOI: 10.1016/j.molcel.2015.02.024

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice
Yamamoto K, Wang Y, Jiang W, Liu X, Dubois RL, Lin CS, Ludwig T, Bakkenist CJ, Zha S
J Cell Biol. 2012.
PMID: 22869596, DOI: 10.1083/jcb.201204098

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks
Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW
Nature. 2011.
PMID: 21160472, DOI: 10.1038/nature09604

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination
Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S
Mol Cell. 2008.
PMID: 18775323, DOI: 10.1016/j.molcel.2008.07.017



For a complete list of publications, please visit PubMed.gov