Helen C. Causton, DPhil

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Overview
Research

Overview

Email: hc2415@cumc.columbia.edu

Academic Appointments

Assistant Professor of Pathology & Cell Biology

Research

Rhythms are found throughout biology and allow an organism to temporally orchestrate its internal state to anticipate changes and/or resonate with the external environment. Despite the importance of a healthy circadian rhythm, the central mechanism has been hard to dissect as the known ‘clock’ proteins are not conserved across organisms. I have shown that respiratory oscillations in yeast share a number of features with circadian rhythms in other organisms and, in collaboration, use a comparative chronobiology approach, to identify characteristics that are common in mediating rhythmicity. My current focus is directed towards using the yeast respiratory oscillation to probe (i) how cells are regulated in time and (ii) the relationship between cell biology and metabolism.

Research Interests

Understanding how cells are regulated in time

Selected Publications

Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis
John S. O'Neill, Nathaniel P. Hoyle, J. Brian Robertson, Rachel S. Edgar, Andrew D. Beale, Sew Y. Peak-Chew, Jason Day, Ana S. H. Costa, Christian Frezza, Helen C. Causton
bioRxiv 2020.05.14.095521; doi: https://doi.org/10.1101/2020.05.14.095521
Nature Communications (in press)
Metabolic rhythms: A framework for coordinating cellular function.
Causton HC.Eur J Neurosci. 2020 Jan;51(1):1-12. doi: 10.1111/ejn.14296.
PMID: 30548718
Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms.
Causton HC, Feeney KA, Ziegler CA, O'Neill JS.
Curr Biol. 2015 Apr 20;25(8):1056-62. doi: 10.1016/j.cub.2015.02.035.
PMID: 25866393


For a complete list of publications, please visit PubMed.gov