Riccardo Dalla-Favera, MD

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Overview
Research

Overview

Email: rd10@cumc.columbia.edu

Academic Appointments

Percy and Joanne Uris Professor of Clinical Medicine
Professor of Pathology & Cell Biology
Professor of Microbiology and Immunology (in the Institute for Cancer Genetis and the Herbert Irving Comprehensive Cancer Center)

Administrative Titles

Director, Institute for Cancer Genetics

Research

The research program in the Dalla-Favera laboratory is aimed at the identification of the molecular pathogenesis of human B cell malignancies. Functional and structural genomic approaches are used toward the identification of the genetic lesions leading to the transformation of B lymphocytes. The genomic landscape of the tumors is then recapitulated in genetically modified mice in order to construct models for pre-clinical testing of science-based new therapeutic modalities.

Selected Publications

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome
Holmes AB, Corinaldesi C, Shen Q, Kumar R, Compagno N, Wang Z, Nitzan M, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K
J Exp Med. 2020.
PMID: 32603407, DOI: 10.1084/jem.20200483

Chronic lymphocytic leukaemia: from genetics to treatment
Bosch F, Dalla-Favera R
Nat Rev Clin Oncol. 2019.
PMID: 31278397, DOI: 10.1038/s41571-019-0239-8

Repurposing dasatinib for diffuse large B cell lymphoma
Scuoppo C, Wang J, Persaud M, Mittan SK, Basso K, Pasqualucci L, Rabadan R, Inghirami G, Grandori C, Bosch F, Dalla-Favera R
Proc Natl Acad Sci USA. 2019.
PMID: 31383760, DOI: 10.1073/pnas.1905239116

MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis
Brescia P, Schneider C, Holmes AB, Shen Q, Hussein S, Pasqualucci L, Basso K, Dalla-Favera R
Cancer Cell. 2018.
PMID: 30205047, DOI: 10.1016/j.ccell.2018.08.006

Genetics of diffuse large B-cell lymphoma
Pasqualucci L, Dalla-Favera R
Blood. 2018.
PMID: 29666115, DOI: 10.1182/blood-2017-11-764332

The molecular pathogenesis of chronic lymphocytic leukaemia
Fabbri G, Dalla-Favera R
Nat Rev Cancer. 2016.
PMID: 26911189, DOI: 10.1038/nrc.2016.8

Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L
Nat Med. 2015.
PMID: 26366712, DOI: 10.1038/nm.3940

Germinal centres and B cell lymphomagenesis
Basso K, Dalla-Favera R
Nat Rev Immunol. 2015.
PMID: 25712152, DOI: 10.1038/nri3814

MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma
Ying CY, Dominguez-Sola D, Fabi M, Lorenz IC, Hussein S, Bansal M, Califano A, Pasqualucci L, Basso K, Dalla-Favera R
Nat Immunol. 2013.
PMID: 23974956, DOI: 10.1038/ni.2688

Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma
Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L, Dalla-Favera R
Cancer Cell. 2011.
PMID: 22137796, DOI: 10.1016/j.ccr.2011.11.006

Analysis of the coding genome of diffuse large B-cell lymphoma
Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R
Nat Genet. 2011.
PMID: 21804550, DOI: 10.1038/ng.892

Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R
Nature. 2011.
PMID: 21390126, DOI: 10.1038/nature09730

BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma
Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R
Cancer Cell. 2010.
PMID: 21156281, DOI: 10.1016/j.ccr.2010.10.030

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R
Science. 1993.
PMID: 8235596, DOI: 10.1126/science.8235596

Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma
Gelmann EP, Psallidopoulos MC, Papas TS, Dalla-Favera R
Nature. 1983.
PMID: 6419123, DOI: 10.1038/306799a0



For a complete list of publications, please visit PubMed.gov