Gunnar Hargus, MD, PHD

Specialties:
Neuropathology, Pathology - Anatomic

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Overview
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Credentials & Experience
Research

Overview

Email: gh2374@cumc.columbia.edu

Academic Appointments

Assistant Professor of Pathology & Cell Biology

Hospital Affiliations

NewYork-Presbyterian / Columbia University Irving Medical Center

Languages

German

Gender

Male

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Insurance Accepted

Aetna

Aetna Signature Administrators
EPO
Medicare Managed Care
NYP Employee Plan
NY Signature
POS

Cigna

EPO
Great West (National)
HMO
POS
PPO

Emblem/GHI

Medicare Managed Care
PPO

Emblem/HIP

ConnectiCare
EPO
Essential Plan
HMO
Medicaid Managed Care
Medicare Managed Care
POS
PPO
Select Care (Exchange)
Vytra

Empire Blue Cross/Blue Shield

HMO
PPO

Local 1199

Local 1199

MagnaCare (National)

MagnaCare

Medicare

Railroad
Traditional Medicare

Multiplan

Multiplan

Oxford Health Plans

Freedom

RiverSpring

Special Needs

UnitedHealthcare

Compass (Exchange)
Empire Plan
HMO
Medicare Managed Care
POS
PPO

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Credentials & Experience

Education & Training

MD, Med Hochschule Lubeck (Germany)
PhD, Univ of Hamburg/Center for Molecular Neurobiology Hannover (Germany)
Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
Residency: University of Munster/Max Planck Biomedicine Institute (Germany)
Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Board Certifications

Neuropathology

Research

Our research focuses on pluripotent stem cells and their application in developmental biology and in modeling of neurodegenerative diseases with a special focus on frontotemporal dementia (FTD). We have derived induced pluripotent stem (iPS) cells from patients with FTD carrying mutations in the gene encoding the microtubule-associated protein tau as an in vitro model for FTD. These mutations lead to abundant deposition of hyperphosphorylated tau protein within neurons and glial cells in various brain regions including the frontotemporal lobes and the brain stem.
Our aim is to identify mechanisms that lead to neural degeneration in FTD. We apply optimized differentiation protocols to efficiently derive neurons and astrocytes from patient-iPS cells and from CRISPR/CAS9-gene corrected control cells. We currently study metabolic profiles in FTD neurons and astrocytes and we determine phenotypes in these cells at a single cell level by applying single cell RNA sequencing.

Selected Publications

1. Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R (2009): Parkinson's disease patient- derived induced pluripotent stem cells free of viral reprogramming factors. Cell 136 (5): 964-77
2. Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett P, Osborn P, Jaenisch R, and Isacson O (2010): Differentiated Parkinson patient-derived iPS cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci USA 107 (36): 15921-6
3. Cooper O, Seo H, Andrabi S, Sundberg M, McLean J, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte-Thomasen H, Perez-Torres E, Clark L, Moskowitz C, Guardia-Laguarta C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang L, Opala G, Feng J, Ross OA, Trojanowski JQ, Lee V, Krainc D, Marder K, Pzedborski S, Surmeier J, Wszolek ZK, Dawson TM, Isacson O (2012): Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease. Science Translational Medicine 4(141): 141ra90
4. Reinhardt P, Schmid B, Burbulla LF, Sch??ndorf DC, Wagner L, Glatza M, H??ing S, Hargus G, Heck SA, Dhingra A, Wu G, M??ller S, Brockmann K, Kluba T, Maisel M, Kr??ger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, M??ller H, Gasser T, Sch??ler HR, Sterneckert J (2013): Genetic correction of a LRRK2 mutation in human iPSCs links Parkinsonian neurodegeneration to ERK- dependent changes in gene expression. Cell Stem Cell 7; 12 (3):354-67
5. Hargus G*, Ehrlich M*, Ara?ozo-Bravo MJ, Hemmer K, Hallmann AL, Reinhardt P, Kim KP, Adachi K, Santourlidis S, Ghanjati F, Fauser M, Ossig C, Storch A, Kim JB, Schwamborn JC, Sterneckert J, Sch??ler HR, Kuhlmann T, Zaehres H. (2014): Origin- dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain. Cell Rep. 8(6):1697-703
6. Hargus G, Ehrlich M, Hallmann AL, Kuhlmann T. (2014): Human stem cell models of neurodegeneration - A novel approach to study disease development. Acta Neuropathologica, 127(2):151-73
7. Ehrlich M, Hallmann AL, Reinhardt P, Ara?ozo-Bravo MJ, Korr S, R??pke A, Psathaki OE, Ehling P, Meuth SG, Oblak AL, Murrell JR, Ghetti B, Zaehres H, Sch??ler HR, Sterneckert J, Kuhlmann T*, Hargus G* (2015): Distinct neurodegenerative changes in an induced pluripotent stem cell model of frontotemporal dementia linked to mutant TAU protein. Stem Cell Reports Jul 14;5(1):83-96
8. Hallmann AL, Ara?ozo-Bravo MJ, Zerfass C, Senner V, Ehrlich M, Psathaki OE, Han DW, Tapia N, Zaehres H, Sch??ler HR, Kuhlmann T*, Hargus G*. (2016): Comparative transcriptome analysis in induced neural stem cells reveals defined neural cell identities in vitro and after transplantation into the adult rodent brain. Stem Cell Research 2016; May;16(3):776-81
9. Hallmann AL, Ara?ozo-Bravo MJ, Mavrommatis L, Ehrlich M, R?“?§pke A, Brockhaus J, Missler M, Sterneckert J, Sch??ler HR, Kuhlmann T*, Zaehres H*, Hargus G* (2017): Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Scientific Reports 7:42991


For a complete list of publications, please visit PubMed.gov