Markus D Siegelin, MD

Specialties:
Anatomic Pathology, Pathology - Anatomic


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Overview
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Credentials & Experience
Research

Overview

Academic Appointments

Associate Professor of Pathology & Cell Biology

Hospital Affiliations

NewYork-Presbyterian / Columbia University Irving Medical Center

Languages

German

Gender

Male

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Credentials & Experience

Education & Training

MD, 2005 Johann Wolfgang Goethe University Faculty of Medicine (Germany)
2005 Johann Wolfgang Goethe University Medical School
Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
Residency: 2013 NewYork-Presbyterian/Columbia University Medical C
Fellowship: Ruprecht Karl University (Germany)

Board Certifications

Anatomic Pathology

Honors & Awards

2007 Rudi-Busse Dissertation Award for the best doctoral thesis in 2007, Johann-Wolfgang-Goethe University, Frankfurt am Main, Germany
2007 Young Investigator Award, Ruprecht-Karls-University, Heidelberg, Germany
2009 Post-Doctoral Research Fellowship awarded by German Research Foundation.
2012 Stowell-Orbison Award, United States & Canadian Academy of Pathology, Vancouver, BC, Canada.
2013 American Association for Cancer Research (AACR) and National Brain Tumor Society Career Development Award for Translational Brain Tumor Research
2013 Translational Grant Program, American Brain Tumor Association (ABTA)
2014-2019 National Institue of Health, NINDS, K08 Career Development Award
2016-2021 National Institue of Health, NINDS, R01 Research Grant
2016 BCURED Fighting Brain Cancer Award
2018-2023 National Institute of Health, NINDS, R01 Research Grant on synthetic lethal interactions in IDH1 mutant gliomas
2017 Louis V. Gerstner, Jr. Scholar
2017 ABTA Discovery Grant
2020 Schaefer Research Scholar
2021-2026 National Institute of Health, NINDS, R01 Research Grant on HDAC inhibitors and tumor metabolism in glioblastoma
2021 ABTA Discovery Grant

Research

Research Interests

Establishing Mechanisms of Drug Resistance in Brain Tumors
Identification of Novel Drug Combination Therapies for Brain Tumors
Targeting Cell Death Mechanisms in Brain Tumors
Targeting Tumor Cell Metabolism and The Epigenome for Brain Tumor Therapy

Selected Publications

Nguyen TTT, Shang E, Shu C, Kim S, Mela A, Humala N, Mahajan A, Yang HW, Akman HO, Quinzii CM, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma. Nat Commun. 2021 Sep 1;12(1):5203. doi: 10.1038/s41467-021-25501-x.
Nguyen TTT, Zhang Y, Shang E, Shu C, Torrini C, Zhao J, Bianchetti E, Mela A, Humala N, Mahajan A, Harmanci AO, Lei Z, Maienschein-Cline M, Quinzii CM, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models. J Clin Invest. 2020 Jul 1;130(7):3699-3716. doi: 10.1172/JCI129049.
Zhang Y, Nguyen TTT, Shang E, Mela A, Humala N, Mahajan A, Zhao J, Shu C, Torrini C, Sanchez-Quintero MJ, Kleiner G, Bianchetti E, Westhoff MA, Quinzii CM, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma. Cancer Res. 2020 Jan 1;80(1):30-43. doi: 10.1158/0008-5472.CAN-19-1389.?
Karpel-Massler G, Ishida CT, Bianchetti E, Shu C, Perez-Lorenzo R, Horst B, Banu M, Roth KA, Bruce JN, Canoll P, Altieri DC, Siegelin MD. Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses. Cancer Res. 2017 Jul 1;77(13):3513-3526. doi: 10.1158/0008-5472.CAN-16-3424.
Karpel-Massler G, Ishida CT, Bianchetti E, Zhang Y, Shu C, Tsujiuchi T, Banu MA, Garcia F, Roth KA, Bruce JN, Canoll P,?Siegelin MD. Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.?Nat Commun. 2017 Oct 20;8(1):1067. doi: 10.1038/s41467-017-00984-9.


For a complete list of publications, please visit PubMed.gov