Darrell J. Yamashiro, MD

Specialties:
Cancer Care, Pediatric Hematology-Oncology, Pediatrics

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Treats Children

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Overview
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Credentials & Experience
Research

Overview

pediatric_oncology_-_newyork-presbyterianmorgan_stanley_childrens_hospital

I am a pediatric oncologist who specializes in caring for children with solid tumors, especially neuroblastoma, Wilms' and other kidney tumors, and liver tumors such hepatoblastoma and hepatocellular carcinoma. I serve as chief of the Division of Hematology, Oncology and Stem Cell Transplantation at Columbia University Irving Medical Center and NewYork-Presbyterian Morgan Stanley Children's Hospital.
I treat children of all ages, from infants to young adults. Some of the cancers I treat are rare (liver tumors account for one to two percent of childhood cancers), but they can be very complex and require a multidisciplinary approach so patients have the best outcomes. I enjoy working as part of a team of physicians, nurse practitioners, nurses, social workers, child life specialists, and other dedicated professionals who care deeply about our patients and provide care with compassion and comfort.
I also conduct basic science research. The latest advances in tumor genetics and the design of innovative therapies make this a very exciting time for cancer research. My team and I have done extensive research on the genetics of hepatoblastoma. We have developed mouse models of this disease and are entering a new phase where we are offering a personalized/precision medicine approach to children with this disease. We are also identifying novel genes that specifically target neuroblastoma—information that may be used to create targeted therapies.

Areas of Expertise / Conditions Treated

Angiogenesis
Hepatoblastoma
Neuroblastoma
Pediatric Liver Cancer
Pediatric Solid Tumors
Wilm's Tumor

Academic Appointments

Robert and Ellen Kapito Associate Professor of Pediatrics at the Columbia University Medical Center

Administrative Titles

Chief, Division of Hematology, Oncology, and Stem Cell Transplantation

Hospital Affiliations

NewYork-Presbyterian / Columbia University Irving Medical Center
NewYork-Presbyterian Morgan Stanley Children's Hospital

Gender

Male

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Insurance Accepted

Aetna

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Local 1199

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Multiplan

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Oxford Health Plans

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VNSNY CHOICE

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WellCare

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*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Credentials & Experience

Education & Training

Internship: Children's Hospital of Philadelphia
Residency: Children's Hospital of Philadelphia
Fellowship: Children's Hospital of Philadelphia

Board Certifications

Pediatrics
Pediatric Hematology-Oncology



NY Top Doctor

Research

Selected Publications

Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe-Chiweshe A, Connolly EP, Kandel JJ, Rajbhandari P, Silva JM, **Califano A, **Yamashiro DJ. Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma. Oncogene. 2018. Epub 2018/06/09. doi: 10.1038/s41388-018-0326-9. PubMed PMID: 29880876.
Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 2016. doi: 10.1038/nm.4180. PubMed PMID: 27618649.
Oberg JA, Glade Bender JL, Sulis ML, Pendrick D, Sireci AN, Hsiao SJ, Turk AT, Dela Cruz FS, Hibshoosh H, Remotti H, Zylber RJ, Pang J, Diolaiti D, Koval C, Andrews SJ, Garvin JH, Yamashiro DJ, Chung WK, Emerson SG, Nagy PL, Mansukhani MM, Kung AL. Implementation of next generation sequencing into pediatric hematology-oncology practice: moving beyond actionable alterations. Genome Med. 2016;8(1):133. doi: 10.1186/s13073-016-0389-6. PubMed PMID: 28007021; PMCID: PMC5180407.
Dela Cruz FS, Diolaiti D, Turk AT, Rainey AR, Ambesi-Impiombato A, Andrews SJ, Mansukhani MM, Nagy PL, Alvarez MJ, Califano A, Forouhar F, Modzelewski B, Mitchell CM, Yamashiro DJ, Marks LJ, Bender JL, Kung AL. A case study of an integrative genomic and experimental therapeutic approach for rare tumors: identification of vulnerabilities in a pediatric poorly differentiated carcinoma. Genome Med. 2016;8(1):116. doi: 10.1186/s13073-016-0366-0. PubMed PMID: 27799065.
Jani A, Shaikh F, Barton S, Willis C, Banerjee D, Mitchell J, Hernandez SL, Hei T, Kadenhe-Chiweshe A, **Yamashiro DJ, **Connolly EP. High-Dose, Single-Fraction Irradiation Rapidly Reduces Tumor Vasculature and Perfusion in a Xenograft Model of Neuroblastoma. Int J Radiat Oncol Biol Phys. 2016;94(5):1173-80. doi: 10.1016/j.ijrobp.2015.12.367. PubMed PMID: 26907918.
Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, **Kandel JJ, **Yamashiro DJ. Notch suppresses angiogenesis and progression of hepatic metastases. Cancer Res. 2015;75(8):1592-1602. PMID: 25744722; PMCID: PMCPMC4401639.


For a complete list of publications, please visit PubMed.gov