Ran Reshef, MD

Specialties:
Blood and Marrow Stem Cell Transplantation, Hematology/Oncology

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Overview
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Credentials & Experience
Research

Overview

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Dr. Reshef trained in Hematology, Oncology and Bone Marrow Transplantation and received a Master of Science degree in Translational Research from the University of Pennsylvania. He joined Columbia University in 2015 as Director of Translational Research for the Blood and Marrow Transplantation program. He is the Clinical Lead for the CAR-T Cell Program at Columbia, a principal investigator at the Columbia Center for Translational Immunology and a member of the Herbert Irving Comprehensive Cancer Center.

Areas of Expertise / Conditions Treated

Amyloidosis
Bone Marrow Transplant
Cancer Immunotherapy
Cellular Therapy
Leukemia
Lymphoma
Multiple Myeloma

Academic Appointments

Associate Professor of Medicine at CUMC

Administrative Titles

Director, Translational Research, Blood and Marrow Transplantation
Clinical Lead, CAR-T Cell Program

Hospital Affiliations

NewYork-Presbyterian / Columbia University Irving Medical Center

Languages

Hebrew

Gender

Male

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New and Existing Patients: (212) 305-5098

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Location(s)

CUIMC/Herbert Irving Pavilion
161 Fort Washington Avenue

New York, NY 10032



Phone: (212) 305-5098


Fax: (212) 305-8111



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Credentials & Experience

Education & Training

MD, 2003 Medicine, Sackler School of Medicine, Tel Aviv University (Israel)
MSc, 2011 Translational Research, Perelman School of Medicine University of Pennsylvania
Internship: 1998 Tel Aviv Sourasky Medical Center, Israel
Residency: 2007 Tel Aviv Sourasky Medical Center, Israel
Fellowship: 2009 Perelman School of Medicine University of Pennsylvania

Honors & Awards

Sternberg Research Award, Abramson Cancer Center, University of Pennsylvania (2008)
Bradley Fellow Research Award, Department of Medicine, University of Pennsylvania (2011)
Austrian Junior Faculty Award, Department of Medicine, University of Pennsylvania (2012)
Amy Strelzer Manasevit Award for the Study of Post-Transplant Complications, National Marrow Donor Program (2013)

Research

The Reshef lab combines efforts in both basic research and clinical investigation to advance the understanding of immune responses following hematopoietic stem-cell transplantation and other forms of cell therapy.
The lab is focused on two primary areas:
1. Investigating lymphocyte migration mechanisms and how they affect the clinical and immunologic outcomes of stem-cell transplantation. The lab pioneered the use of chemokine receptor blockade after allogeneic stem-cell transplantation to reduce immune-mediated complications.
2. Developing methodologies for the study of human samples from transplant recipients at the single-cell level in order to unravel novel immunologic mechanisms that would lead to new therapeutic approaches. The lab works with blood, stool and tissue samples and uses a diverse toolset that includes genomic and immunophenotypic methods to identify new therapeutic modalities. Our ultimate goal is to identify new targets that improve transplant outcomes using evidence in both mice and humans and to test these targets clinically.
Dr. Reshef’s research is funded by the National Cancer Institute, Conquer Cancer Foundation, National Marrow Donor Program and Department of Defense. He previously received awards from the Leukemia & Lymphoma Society and the American Society of Hematology.

Selected Publications

Reshef R, Luger SM, Hexner EO, Loren AW, Frey NV, Nasta, SD, Goldstein SC, Stadtmauer EA, Smith J, Bailey S, Mick R, Heitjan DF, Emerson SG, Hoxie J, Vonderheide RH, Porter DL (2012). "Effect of Blocking Lymphocyte Chemotaxis on Visceral Graft-vs-Host Disease." N Engl J Med 367:135-145
Reshef R, Huffman AP, Gao A, Luskin MR, Hexner EO, Loren AW, Frey NV, Stadtmauer EA, Luger SM, Mangan JK, Nasta SD, Gill SI, Sell M, Kambayashi T, Richman LP, Vonderheide RH, Mick R, Porter DL (2015). "High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection In Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning" J Clin Oncol 33:2392-2398.
Ryan H. Moy, Austin P. Huffman, Lee P. Richman, Lisa Crisalli, Ximi K. Wang, James A. Hoxie, Rosemarie Mick, Stephen G. Emerson, Yi Zhang, Robert H. Vonderheide, David L. Porter and Ran Reshef (2017) "Clinical and immunologic impact of CCR5 blockade in graft-versus-host disease prophylaxis" Blood 129:906-916
Mishkin AD, Mapara MY, Reshef R (2018). "Iatrogenic Infertility After Curative Stem Cell Transplantation in Sickle Cell Disease Patients". Ann Intern Med 2018 Jun 19;168(12):881-88


For a complete list of publications, please visit PubMed.gov