Jean Gautier, PhD

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Overview
Research
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Overview

Email: jg130@cumc.columbia.edu

Academic Appointments

Professor of Genetics and Development (in the Institute for Cancer Genetics)

Administrative Titles

Leader, Cancer Genomics and Epigenomics Program, Herbert Irving Comprehensive Cancer Center

Research

Jean Gautier studies the mechanisms responsible for the maintenance of genome stability. The laboratory employs diverse experimental approaches to elucidate the causes and the role of genome instability in cancer. Cell-free extracts derived from the egg of the frog Xenopus laevis are used as a simple model system to study processes that govern genome stability, including DNA replication control, DNA repair, and the cellular response to DNA damage. In addition, cultured normal and tumor cells and mouse models are exploited to analyze biological responses to DNA damage. The Gautier laboratory use a range of techniques including biochemistry, proteomics, live-cell imaging, super-resolution microscopy, Hi-C and genome-wide translocation sequencing.

Selected Publications

Dual-Color Plasmonic Nanosensor for Radiation Dosimetry
Tao Y, Li M, Liu X, Leong KW, Gautier J, Zha S
ACS Appl Mater Interfaces. 2020.
PMID: 32337977, DOI: 10.1021/acsami.0c03001

Assembling nuclear domains: Lessons from DNA repair
Schrank B, Gautier J
J Cell Biol. 2019.
PMID: 31324649, DOI: 10.1083/jcb.201904202

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair
Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J
Nature. 2018.
PMID: 29925947, DOI: 10.1038/s41586-018-0237-5

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway
Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Sch?rer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J
Cell Rep. 2017.
PMID: 29091773, DOI: 10.1016/j.celrep.2017.10.032

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts
Aparicio T, Baer R, Gottesman M, Gautier J
J Cell Biol. 2016.
PMID: 26880199, DOI: 10.1083/jcb.201504005

MYC is a critical target of FBXW7
Sato M, Rodriguez-Barrueco R, Yu J, Do C, Silva JM, Gautier J
Oncotarget. 2015.
PMID: 25669969, DOI: 10.18632/oncotarget.3203

Cdc45 is a critical effector of myc-dependent DNA replication stress
Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J
Cell Rep. 2013.
PMID: 23643534, DOI: 10.1016/j.celrep.2013.04.002

Activation of DSB processing requires phosphorylation of CtIP by ATR
Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J
Mol Cell. 2013.
PMID: 23273981, DOI: 10.1016/j.molcel.2012.11.020

Replication-independent repair of DNA interstrand crosslinks
Williams HL, Gottesman ME, Gautier J
Mol Cell. 2012.
PMID: 22658724, DOI: 10.1016/j.molcel.2012.05.001

Double-strand break end resection and repair pathway choice
Symington LS, Gautier J
Annu Rev Genet. 2011.
PMID: 21910633, DOI: 10.1146/annurev-genet-110410-132435

Checkpoint signaling from a single DNA interstrand crosslink
Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J
Mol Cell. 2009.
PMID: 19748363, DOI: 10.1016/j.molcel.2009.08.014

A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
Dupr?? A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J
Nat Chem Biol. 2008.
PMID: 18176557, DOI: 10.1038/nchembio.63

Non-transcriptional control of DNA replication by c-Myc
Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R
Nature. 2007.
PMID: 17597761, DOI: 10.1038/nature05953

ATR and ATM regulate the timing of DNA replication origin firing
Shechter D, Costanzo V, Gautier J
Nat Cell Biol. 2004.
PMID: 15220931, DOI: 10.1038/ncb1145

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J
Mol Cell. 2003.
PMID: 12535533, DOI: 10.1016/s1097-2765(02)00799-2


For a complete list of publications, please visit PubMed.gov

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Congratulations to the winners of the Columbia Life Science Accelerator pilot grants Lab-to-Market ideas!

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July 13, 2021