Santiago Correa

Assistant Professor of Biomedical Engineering

Email[email protected]




Santiago Correa’s research operates at the interface of materials science, nanotechnology, and immunology to engineer the immune system and improve human health.

Research Interests

Drug Delivery, Nanotechnology, Nanomedicine, Gene Delivery, Biomimetic Materials, Supramolecular Chemistry, Immune Modulation, Immunoengineering, Cancer Therapy, Autoimmune Therapy, Neuroimmunotherapy, , Biomaterials, Cell-Material Interfaces, Organ-On-A-Chip

Links

Lab Website

Dr. Correa develops biomaterials composed of nano-scale building blocks, which are used to reprogram the body’s immune system to fight cancer, autoimmune disease, and infection.
Taking inspiration from nature, Dr. Correa engineers this next-generation technology via supramolecular self-assembly across length scales – first by constructing bioinspired multifunctional nanoparticles that, in turn, self-assemble to produce macroscopic biomaterials imbued with unprecedented immuno-modulatory capabilities.
Dr. Correa obtained his BS in Biomedical Engineering at Yale prior to completing a PhD in Biological Engineering at MIT. While in the Hammond Lab at MIT, he explored how nanoparticle surface chemistry could be engineered to better target ovarian cancer and to fabricate multifunctional nanomaterials. Afterwards, Dr. Correa completed his postdoctoral training as an NCI F32 Fellow in the Appel Lab at Stanford, where he developed immunomodulatory biomaterials to treat cancer.

RESEARCH EXPERIENCE

PROFESSIONAL EXPERIENCE

PROFESSIONAL AFFILIATIONS

HONORS & AWARDS

SELECTED PUBLICATIONS

RESEARCH EXPERIENCE

Postdoctoral Fellow, Stanford University, 2018-2022
Ph.D. in Biological Engineering, Massachusetts Institute of Technology, 2012-2018
B.S. in Biomedical Engineering, Yale University, 2008-2012

PROFESSIONAL EXPERIENCE

Assistant Professor of Biomedical Engineering, Columbia University, 2023-

PROFESSIONAL AFFILIATIONS

Society for Biomaterials
Biomedical Engineering Society
American Chemical Society, Division of Polymeric Materials: Science and Engineering
Out in Science, Technology, Engineering, and Mathematics (oSTEM) LatinXinBME
Society for Advancement of Chicanos/Hispanics & Native Americans in Science (SACNAS)

HONORS & AWARDS

Rising Stars in Biomedical Engineering, Northwestern University, 2021
Soft Matter for All Early Career Speaker, Princeton University & University of Delaware, 2021
UNITE Featured Speaker, Biomedical Engineering Society, 2021
PMSE Future Faculty Scholar, American Chemical Society, 2021
Rising Stars in Engineering in Health, Columbia University, 2020
Ruth L. Kirschstein Postdoctoral Individual National Research Service Award (F32), National Cancer Institute 2019
Siebel Scholar, Siebel Foundation, 2018
Sloan University Centers for Exemplary Mentoring Scholar, Alfred P. Sloan Foundation, 2016
Graduate Research Fellowship, National Science Foundation, 2012
Lemelson Engineering Presidential Fellowship, Massachusetts Institute of Technology, 2012
Dean’s Diversity Fellowship, Massachusetts Institute of Technology, 2012
Science, Technology and Research Scholar, Yale University, 2012

SELECTED PUBLICATIONS

Select pre-prints
Correa S, Gale EC, Mayer AT, Xiao Z, Liong C, Klich JH, Brown RA, Meany E, Saouaf O, Maikawa CL, Grosskopf AK, Mann JL, Idoyaga J, Appel EA. Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies. bioRxiv. 2021 June 28. doi.org/10.1101/2021.06.27.449987
Select peer-reviewed publications
Correa S?, Grosskopf AK?, Klich JH, Hernandez HL, Appel EA. Injectable Liposome Based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs. Matter. (In press)
Correa S, Grosskopf A, Lopez Hernandez H, Chan D, Yu A, Stapleton L, Appel EA. Translational Applications of Hydrogels. Chemical Reviews. 2021; Article ASAP. doi: 10.1021/acs.chemrev.0c01177
Correa S, Boehnke N, Barberio AE, Deiss-Yehiely E, Shi A, Oberlton B, Smith SG, Zervantonakis I, Dreaden EC, Hammond PT. Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry. ACS Nano. 2020; 14(2):2224-37. doi: 10.1021/acsnano.9b09213
Boehnke N?, Correa S?, Hao L?, Wang W, Straehla JP, Bhatia SN, Hammond PT. Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing. Angewandte Chemie. 2020; 59, 2776. doi: 10.1002/anie.201911762
Correa S?, Boehnke N?, Deiss-Yehiely E, Hammond PT. Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes. ACS Nano. 2019;13(5):5623-5634. doi: 10.1021/acsnano.9b00792
Correa S?, Dreaden EC?, Gu L, Hammond PT. Engineering Nanolayered Particles for Modular Drug Delivery. Journal of Controlled Release. 2016;240:364-386. doi: 10.1016/j.jconrel.2016.01.040
Correa S, Choi KY, Dreaden EC, Renggli K, Shi A, Gu L, Shopsowitz KE, Quadir MA, Ben-Akiva E, Hammond PT. Highly Scalable, Closed-Loop Synthesis of Drug-Loaded, Layer-by-Layer Nanoparticles. Advanced Functional Materials. 2016;26(7):991-1003. doi: 10.1002/adfm.201504385
? Indicates co-first authors