Research Expertise and Interest biochemistry, genetics, cancer, biology, microtubule cytoskeleton, cell cycle controls, cellular imaging
Research Description
Research Interests
The mitotic spindle segregates chromosomes to daughter cells. ?Mistakes in chromosome segregation contribute to cancer and birth defects. Our goal is to identify the molecular mechanisms that control the fidelity of mitosis and meiosis. By employing proteomics, genetics, cellular imaging, and biochemistry, we have identified novel protein components of yeast spindles and kinetochores, and have mapped their phosphorylation sites, allowing us to perform genetic tests of the importance of these proteins and their modification by protein phosphorylation.