Title
Professor

Department
Dept of Molecular & Cell Biology


Faculty URL
http://mcb.berkeley.edu/faculty/BMB/collinsk.html

Research Group
https://sites.google.com/berkeley.edu/kcollinslab

Email
kcollins@berkeley.edu

Phone
(510) 643-1598


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Research Expertise and Interest
RNA, reverse transcriptase, retroelement biology, gene integration, RNA sequencing

Research Description
Biology, biochemistry,?and biotechnology of retroelements,?retroelement reverse transcriptases, and functional RNAs.
We are?applying our insights from decades of studying telomerase and telomere maintenance to investigate?eukaryotic retroelements,?their reverse transcriptases, and the biogenesis and RNP assembly of processed?RNA used as template for nick-primed cDNA synthesis. Site-specific targeting of transgene cDNA insertion has promise as a genome engineering method complementary to CRISPR/Cas. Also, retroelement reverse transcriptases have fascinating biochemical properties that we are discovering and exploiting for RNA-seq. Our?new approaches for cDNA library production capture comprehensive, end-to-end RNA sequence inventory of even fragmented or damaged RNAs.
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