Title
Assistant Professor

Department
Dept of Molecular & Cell Biology


Faculty URL
https://mcb.berkeley.edu/faculty/BBS/nunezj

Research Group
https://www.nunezlab.org/

Email
jamesnunez@berkeley.edu


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Research Expertise and Interest
biochemistry, biophysics, Structural Biology, genetics

Research Description
James Nu?ez is an assistant professor of biochemistry, biophysics and structural biology?in the Department of Molecular & Cell Biology.? The core interest of his research group is to understand the regulatory principles of the human genome. Specifically, they investigate the molecular principles underlying epigenetic memory and inheritance in mammalian cells: how do cells establish the ‘epigenome’ to dictate gene expression programs and genome organization; how is the epigenome maintained and remodeled as cells divide and differentiate; and how do defects in these pathways lead to disease? The Nu?ez lab combines functional genomics CRISPR screens, cell biology, and biochemistry to answer their research questions. Concurrently, the Nu?ez lab?develops and applies CRISPR-based programmable technologies for editing the epigenome by writing/erasing DNA and histone modifications at any genomic locus, enabling perturbations of gene expression programs without changing the DNA sequence of the human genome.