付笑影，女，教授，医学博士，博士后。天津中医药大学海外引进人才，现任中西医结合学院病理学与病理生理学教研室主任。

2004年博士毕业于日本国立信州大学医学部，加龄生物学教研室，获医学博士甲级学位。同年留校任该教研室教学及科研助手。2008年赴美国Emory大学医学院血液学和医学肿瘤学系从事博士后研究工作。主持完成日本厚生省2项科研项目，并作为主要研究人员参与多项美国NIH基金项目。海外留学工作期间共发表SCI收录学术论文三十余篇。研究结果曾被American Journal of Pathology 和FEBS Letters 杂志采用为封面图片。除科学研究工作外，还长期从事、参与本科生及研究生的教学及培养工作。2012年以海外人才引进回国，现从事病理教学及科研工作。目前主持国家自然科学基金一项。并获得天津市高层次人才认定及科研奖励基金。

主要研究方向：（1）老年性淀粉样变疾病的致病及传播机制；

（2）中医药对老年性淀粉样变的抑制的研究；

（3）乳腺癌及前列腺癌的抑癌基因及其机理的研究。



主要发表论文:

1. Yan J,Fu X (通讯作者), Ge F, Zhang B, Yao J, Zhang H, Qian J, Tomozawa H, Naiki H, Sawashita J, Mori M, Higuchi K.Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils and protein A amyloid fibrils. Am J Pathol 2007, 171 (1): 172-180.

2. Korenaga T, Yan J, Sawashita J, Matsushita T, Naiki H, Hosokawa M, Mori M, Higuchi K,Fu X (通讯作者).Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis. Am J Pathol 2006, 168: 898-906.

3. Fu X, Korenaga T, Xing Y, Fu L, Guo Z, Matsushita T, Hosokawa M, Naiki H, Baba S, Kawata Y, Ikeda S, Ishihara T, Mori M, Higuchi K.Induction of AApoAII amyloidosis by various heterogeneous amyloid fibrils. FEBS Letter 2004, 563: 179-184.

4. Su D,Fu X（共同第一作者）, Fan S, Dong X, Zhu Z, Fu L, Dong J. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. Am J Pathol. 2012, 180(3): 1189-1201.

5. Zhang P,Fu X（共同第一作者）, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K. Mouse model to study human A?2M amyloidosis: Generation of a transgenic mouse with excessive expression of human ?2-microglobulin. Amyloid 2010, 17(2): 50-62.

6. Zhang B, Une Y,Fu X, Yan J, Ge F, Yao J, Sawashita J, Tomozawa H, Kametani F, Higuchi K. Fecal translation of AA amyloidosis in the cheetah contributions to high incidence of disease. Proc Nat Acad Sci USA 2008, 105: 7263-7268.

7. Dong X,Fu X, Fan S, Guo P, Su D, Sun X, Dong J. Estrogen causes ATBF1 protein degradation through the estrogen-responsive E3 ubiquitin ligase EFP. Biocheme J. 2012, 444(3): 581-90.

8. Li M,Fu X, Ma G, Sun X, Dong X, Nagy T, Xing C, Li J, Dong JT.Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling.PLoS One. 2012; 7(12):e51283.

9. Xing C,Fu X, Sun X, Guo P, Li M, and Dong JT. Different expression patterns and functions of acetylated and unacetylated Klf5 in the proliferation and differentiation of prostatic epithelial cells. PLoS One, 2013; 8(6):e65538.

10. Sun X,Fu X, Li J, Xing C, Frierson H, Wu H, Ding X, Ju T, Cummings R and Dong J. Deletion of Atbf1/Zfhx3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways. Neoplasia, 2014, 16(5):377-89.