junbo_gong@tju.edu.cn
化学工程
未公开
教授
多品种盐开发、智能化关键技术研究及产业化示范

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甜菊糖结晶新技术研究

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布洛芬结晶工艺优化研究

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阿托伐他汀钙原料药结晶工艺开发

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丙氨酸结晶新技术与新设备研发

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吡唑醚菌酯结晶晶型研究与制备

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头孢美唑钠结晶新技术与新设备研发

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连续结晶新技术与新设备研发

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化合物CPY1401晶型筛选及制备方法技术开发

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硫酸钠与氢氧化锂混和溶液冷冻析十水硫酸钠结晶小试研究开发

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蛋氨酸结晶新技术与新设备研发

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维生素B1/B6结晶新技术与新设备研发

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γ-氨基丁酸结晶新技术与新设备研发

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高纯碳酸锂结晶技术研究

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3-氨基丙酸结晶工业化设计

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甲苯磺酸索拉非尼结晶新技术与新设备研发

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果糖结晶小试研究开发

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两性霉素B结晶小试研究开发

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头孢克肟三水合物结晶研究开发

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布洛芬钠二水合物结晶小试研究开发

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甜菊糖结晶研究开发

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阿加曲班多晶型与手性结晶分离应用研究

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盐酸莫西沙星一水合物结晶小试研究开发

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十二碳二元酸结晶新技术的研究与开发

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醋酸丁酸纤维素结晶新技术研究开发

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(S)-氯吡格雷硫酸氢盐球形结晶工艺研究开发

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阿奇霉素结晶工艺研究

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左旋肉碱结晶技术研究

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新型结晶技术与设备在肌苷酸二钠和鸟苷酸二钠混合结晶生产中的应用开发

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2R,4R-4-甲基哌啶－2-羧酸乙酯结晶工艺小试研究开发

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阿托伐他汀水合物晶型鉴定研究

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克林霉素磷酸酯结晶新技术研究

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FM胺盐结晶技术研究

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I+G混合结晶技术

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人参皂苷晶型研究

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麦芽糖醇制备及晶型研究

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I晶型盐酸多奈哌齐制备工艺研究

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生物制造分离过程技术与装备

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奥拉西坦冻干过程研究

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3-氨基丙酸结晶研究开发技术

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奥拉西坦冻干过程研究

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生物法生产长链二元酸关机技术及应用示范

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右佐匹克隆结晶新技术与新设备开发

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维生素B5结晶新技术与新设备开发

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硫酸铝铵氨沉结晶工艺研究

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磷霉素钠结晶技术研究

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双嘧达莫晶型一致性研究

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头孢美唑钠结晶新技术与新设备研发

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多晶型食用盐产品研发

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化合物CPY1302新晶型纯度定量分析方法开发和方法学验证

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鱼籽盐产品技术

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阿利沙坦酯、EXP3174与NEP抑制剂复合物或复合物盐的合成工艺研究

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四溴双酚A工业结晶过程优化与设计

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精制盐产业化装备的研发与应用

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炸药结晶机理及形貌控制技术研究

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泰地罗新新晶型筛选与稳定性研究

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盐酸左米那普仑项目晶型研究

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LCZ696晶型筛选与稳定性研究

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橡胶助剂结晶技术开发及应用

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来那度胺（Lenalidomide）的晶型筛选与稳定性研究

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哌拉西林钠晶型筛选与稳定性研究

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依鲁替尼新晶型筛选

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与汉沽盐场项目合作协议

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丙硫菌唑结晶晶型研究与制备

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药物拟多晶型（溶剂化物）形成与转化机理研究

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多晶型食用海盐产品研发与产业化

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溶液前聚体成核机理、模型与多晶型应用研究

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碳酸锂沉锂结晶过程与碳化热析反应结晶过程计算机模拟及设备优化

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TEDA结晶新技术与新设备研发

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基于功能性生物材料和靶向递送策略的再生医学

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溶剂介导药物晶型转化的过程研究

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药物球形粒子工业结晶过程机理与应用研究

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柠檬酸、葡萄糖酸的生物转化技术

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有机药物共晶超分子设计与高通量筛选方法学研究

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药物多晶型在溶液中的转晶机理研究

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年产5000吨呈味核苷酸二钠结晶产业化项目

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高纯碳酸锂工业结晶技术研究

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2013XS-0100

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药物高效化的晶体形态学应用基础研究

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有机酸分离精制技术及装备研发
一种制备麦芽糖醇晶体的方法

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克林霉素磷酸酯的新晶型β及制备方法

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拉莫三嗪与2,2’-联吡啶药物共晶及其制备方法

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一种多级真空绝热闪蒸连续结晶设备

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克林霉素磷酸酯的新晶型α及制备方法

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一种制备球形硫酸氢氯吡格雷I晶型的方法

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一种加巴喷丁与己二酸共晶及其制备方法

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克林霉素磷酸酯二甲基亚砜溶剂化合物晶体及制备方法

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克林霉素磷酸酯甲醇-水溶剂化合物晶体及制备方法

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一种盐酸硫胺晶体产品的制备方法

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一种硝酸硫胺块状晶体产品的制备方法

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一种长春西汀管状晶体及制备方法

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一维棒状空心二氧化硅纳米囊及其制备方法

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一种阿加曲班新晶型及其制备方法

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一种阿加曲班新晶型及其制备方法

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一种多级真空绝热闪蒸连续结晶方法及设备

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一种制备高堆密度呈味核苷酸二钠混晶的方法

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新型拉莫三嗪药物共晶及其制备方法

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一种人参皂苷C-K一水合物晶体及制备方法

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一种盐酸多奈哌齐新晶型及制备方法

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一种人参皂苷C-K半水合物晶体及制备方法

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一种阿加曲班新晶型及其制备方法

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克林霉素磷酸酯水合物晶体及制备方法

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在线监测有机盐体系结晶过程中溶解度、介稳区和溶液浓度的方法

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一种头孢羟氨苄单水合物的结晶方法及结晶
本发明涉及一种制备麦芽糖醇晶体的方法，将麦芽糖醇水溶液，真空蒸发浓缩，加入麦芽糖醇晶种，通过向麦芽糖醇的过饱和溶液中加入晶种，使溶液的过饱和度维持在较低的水平，从而有效的控制了晶体成核，促进晶体生长。本发明是通过溶析-冷却耦合结晶的方法生产麦芽糖醇晶体，提高麦芽糖醇的结晶收率；避免结晶过程中细晶的产生，得到粒度分布均匀、稳定的产品；与冷却结晶相比缩短了结晶周期，与蒸发结晶相比减小了能量的消耗；干燥后产品的流动性好、稳定性高，产品室温下长期储存也不会结块。

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本发明涉及克林霉素磷酸酯的新晶型β及制备方法。晶体的稳定性能好，在高温60℃下放置10天，晶体颜色保持白色粉末，X-射线衍射图谱未发生明显变化。

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本发明涉及一种拉莫三嗪与2,2’-联吡啶药物共晶及其制备方法。新的共晶大幅度提高了拉莫三嗪在水中的溶解度和溶解速率。溶液中得到的共晶在水中的溶解度为≧1.36mg/ml；同时溶解速率在溶解度范围内提高了20%以上；尤其是研磨得到的共晶溶解速率更快，提高了拉莫三嗪的生物利用度。便于在工业制药中大量推广，成本低廉。

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本实用新型涉及一种多级真空绝热闪蒸连续结晶设备。由多个结晶器串联；各个结晶器上部设置有喷淋管。生产晶体粒径均匀，外观较好，晶体粒度较大且稳定。

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本发明提供了克林霉素磷酸酯的新晶型α及制备方法。新晶型α晶体的稳定性能好，在高温50℃下放置10天，晶体颜色保持白色粉末，X-射线衍射图谱未发生明显变化。

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本发明提供了一种制备球形硫酸氢氯吡格雷I晶型的新方法，采用单一的2-丁醇作为溶剂，通过控制用于成盐的硫酸的浓度、加入方式和加入速度，在缩短工艺时间的同时，使得硫酸氢氯吡格雷以球状稳定从溶液体系中析出，所得硫酸氢氯吡格雷在溶剂残留、堆密度和流动性等方面均符合后续制剂工艺的需要。

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本发明涉及一种加巴喷丁与己二酸药物共晶及其制备方法，加巴喷丁和己二酸形成2:1共晶，形成共晶改善晶体晶习，提高堆密度、溶解度等物理化学性质。提高了药物生物利用度。

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本发明提供了克林霉素磷酸酯二甲基亚砜溶剂化合物晶体及制备方法。晶体为克林霉素磷酸酯二甲基亚砜溶剂化合物晶体。1分子克林霉素磷酸酯二甲基亚砜溶剂化物晶体中包含1分子克林霉素磷酸酯、1分子二甲基亚砜。

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本发明提供了克林霉素磷酸酯甲醇-水溶剂化合物晶体及制备方法；晶体为克林霉素磷酸酯甲醇-水溶剂化合物晶体。1分子克林霉素磷酸酯甲醇-水溶剂化物晶体中包含1分子克林霉素磷酸酯、1分子甲醇和2分子水。

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一种盐酸硫胺晶体产品的制备方法

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一种硝酸硫胺块状晶体产品的制备方法

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本发明涉及一种长春西汀管状晶体及制备方法。本发明制备的长春西汀为品具有晶体结构，具有闭合或非闭合孔道；收率为60~85%，堆密度为0.25~0.4g/ml。溶出速率提高20%~40%，应用于药物领域，改善长春西汀在水中溶出速率低的问题，促进药物吸收，提高药效及生物利用度。采用简单的一步溶析方法制备，生产工艺简单，易于实现工业化生产。

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本发明是涉及一维棒状空心二氧化硅纳米囊及其制备方法；本发明首次制得了长径比可以灵活控制、内部空间大、形貌均一和易修饰的一维棒状空心二氧化硅纳米囊。在合成、催化、控释和生物应用等方面有着广阔的应用前景，为纳米材料领域新增加了特殊的一员；本发明的制备方法原料来源广泛、操作条件简单、制备成本低廉及易于大批量生产。

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一种阿加曲班新晶型及其制备方法

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一种阿加曲班新晶型及其制备方法

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一种多级真空绝热闪蒸连续结晶方法及设备

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一种制备高堆密度呈味核苷酸二钠混晶的方法

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本发明涉及一种新型拉莫三嗪药物共晶及其制备方法。。采用溶液介导转变法或研磨法制备。本发明制备的药物共晶在继承了传统原料药在治疗顽固性癫痫症特性外，在其溶解性，稳定性和生物利用度上都有了明显的改观。

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本发明涉及一种人参皂苷C-K一水合物晶体及制备方法，一分子人参皂苷C-K一水合物中含1分子人参皂苷C-K和1分子水。将人参皂苷C-K原料加入到乙腈和水的混合溶剂中，在冷却过程中将晶种加入到人参皂苷C-K过饱和溶液中，诱导其出晶，促进晶体生长, 本发明提高C-K的结晶收率；稳定的产品。

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本发明涉及一种盐酸多奈哌齐新晶型及制备方法。将粗品盐酸多奈哌齐溶于低级醇中，初始浓度为0.04~0.06g/mL，加热后使盐酸多奈哌齐粗品全部溶解，当降至40~35℃时向溶液中流加低级醚至出晶，养晶，加低级醚，搅拌不超过2小时；真空干燥3~7小时，得长片状盐酸多奈哌齐新晶型。新晶型稳定性能好，为盐酸多奈哌齐新药物的开发与应用提供新晶型的支持。

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本发明涉及一种人参皂苷C-K半水合物晶体及制备方法，本发明是通过冷却结晶的方法制备人参皂苷C-K半水合物，提高C-K的结晶收率；避免结晶过程中爆发成核，得到粒度分布均匀、稳定的产品。

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本发明涉及一种阿加曲班新晶型及其制备方法，得到阿加曲班新晶型。将产品均匀分摊在敞口的培养皿中，样品厚度小于5mm，密封置于干燥器内，温度50~80℃，分别于30天、60天取样进行XRD检测，并与第0天的结果进行对照，结果显示阿加曲班的新晶型未发生改变，稳定性好。

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本发明的提供了克林霉素磷酸酯新的水合物的结晶制备方法。得到的克林霉素磷酸酯水合物晶体的稳定性能好，在常温30℃下放置10天，克林霉素磷酸酯水合物晶体稳定，晶体颜色保持白色粉末，X-射线衍射图谱未发生明显变化。为克林霉素磷酸酯药物的利用提供一种新的晶体和制备方法。

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本发明涉及在线监测有机盐体系结晶过程中溶解度、介稳区和溶液浓度的方法，根据升温过程中电导率与温度关系曲线中的突变点就可以确定溶质在该溶剂中的溶解度曲线、降温速率下溶液体系的介稳区、待测溶液的过饱和度。该方法适用于不同操作条件下各种有机盐类在极性有机溶剂中工业结晶过程的测量。实用简便、可实现在线测量、而且测量温度范围宽，溶液浓度范围宽、操作仪器简单、成本低、实用性强。

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本发明涉及一种生产头孢羟氨苄单水合物晶体的方法。得到产品为四方片状晶体形式的头孢羟氨苄单水合物。通过此方法得到的四方片状头孢羟氨苄单水合物，其产品粒度分布均匀，不发生聚结，适用于工业生产。
Novel Strategy to Control Polymorph Nucleation of Gamma Pyrazinamide by Preferred Intermolecular Interactions during Heteroge

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Seed-Assisted Effects on Solution-Mediated Phase Transformation: A Case Study of l-Histidine in Antisolvent Crystallization

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Insight into Solvent-Dependent Conformational Polymorph Selectivity: The Case of Undecanedioic Acid

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Oiling-out investigation and morphology control of β-alanine based on ternary phase diagrams

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Effect of Mixing on the Particle Size Distribution of Paracetamol Continuous Cooling Crystallization Products Using a Comput

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Revealing the roles of solvation in D-mannitol's polymorphic nucleation

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Effects of Additives on the Morphology of Thiamine Nitrate: The Great Difference of Two Kinds of Similar Additives

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Caking of crystals: Characterization, mechanisms and prevention

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Design and mechanism of the formation of spherical KCl particles using cooling crystallization without additives

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Interplay between Kinetics and Thermodynamics on the Probability Nucleation Rate of a Urea–Water Crystallization System

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Solubility of L-histidine in different aqueous binary solvent mixtures from 283.15 K to 318.15 K with experimental measuremen

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Effect of b-alanine and the solvent composition on the solubility of solvate of calcium D-pantothenate containing four molec

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Determination and correlation of Avermectin B1a solubility in different binary solvent mixtures at temperatures from (283.15

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Determination and correlation of solubility and thermodynamics of mixing of 4-aminobutyric acid in mono-solvents and binary s

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Measurement of Solubility of Thiamine Hydrochloride Hemihydrate in Three Binary Solvents and Mixing Properties of Solutions

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Determination and correlation of solubility and thermodynamic properties of pyraclostrobin in pure and binary solvents.

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Determination and correlation of solubility and thermodynamic properties of eszopiclone in pure and mixed solvents

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Determination and correlation of solubility and thermodynamic properties of L-methionine in binary solvents of water plus (me

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Agglomeration Mechanism of Azithromycin Dihydrate in Acetone-Water Mixtures and Optimization of the Powder Properties

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Measurement and Correlation of Solubility of Cefathiamidine in Water plus (Acetone, Ethanol, or 2-Propanol) from (278.15 to 3

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Nucleation behavior of eszopiclone-butyl acetate solutions from metastable zone widths.

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Highly efficient, stable and controllable multi-core, rattle-type Ag@SiO2 catalyst for the reduction of 4-nitrophenol

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Solubility determination and thermodynamic modelling of allisartan isoproxil in different binary solvent mixtures from T = (

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Correlation and thermodynamic analysis of solubility of cefmetazole acid in three (alcohol plus water) binary solvents at tem

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Solvent penetration mediated phase transformation for the preparation of aggregated particles with well-defined shape

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The liquid-liquid phase separation and crystallization of vanillin in 1-propanol/water solution

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Correlation and thermodynamic analysis of solubility of diphenhydramine hydrochloride in pure and binary solvents

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Measurement and Correlation of Solubility of gamma-Aminobutyric Acid in Different Binary Solvents.

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Determination and correlation of pyridoxine hydrochloride solubility in different binary mixtures at temperatures from (278.1

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Measurement and Correlation of the Solubility of Maltitol in Different Pure Solvents, Methanol-Water Mixtures, and Ethanol-Wa

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Industrial Crystallization in China.

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Determination and correlation of solubility and solution thermodynamics of oxiracetam in three (alcohol plus water) binary so

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Mechanism and inhibition of trisodium phosphate particle caking: Effect of particle shape and solubility.

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Oiling out and Polymorphism Control of Pyraclostrobin in Cooling Crystallization

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Self-template synthesis of core-shell ZnO@ZIF-8 nanospheres and the photocatalysis under UV irradiation

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Solubility of tridecanedioic acid in pure solvent systems: An experimental and computational study.

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Size Control of Atorvastatin Calcium Particles Based on Spherical Agglomeration.

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Determination and correlation of solubility of thiamine nitrate in water + ethanol mixtures and aqueous solution with differe

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Experimental and Modeling Studies on the Solubility of d-Pantolactone in Four Pure Solvents and Ethanol–Water Mixtures

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Measurement and Correlation of the Solubility of Penicillin V Potassium in Ethanol + Water and 1-Butyl Alcohol + Water Syste

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Measurement and correlation of solubility and dissolution properties of flunixin meglumine in pure and binary solvents

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Caking and adhesion free energy of maltitol: Studying of mechanism in adhesion process.

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Determination and Correlation of Solubility Data and Dissolution Thermodynamic Data of Cefixime Trihydrate in Seven Pure Solv

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Measurement and Correlation of Solubility of Azithromycin Monohydrate in Five Pure Solvents

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Solubility of androstenedione in lower alcohols

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Experimental Determination and Computational Prediction of Androstenedione Solubility in Alcohol + Water Mixtures

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easurement and Correlation of the Solubility of l-Carnitine in Different Pure Solvents and Ethanol–Acetone Solvent Mixture

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The Role of Diastereomer Impurity in Oiling-Out during the Resolution of trans-4-Methyl-2-piperidine Carboxylic Ethyl Ester E

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Solubility of 2-Hydroxypropane-1,2,3-tricarboxylic Acid Monohydrate in Different Binary Solvents from (278.15 to 303.15) K

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Investigation of the Crystallization of Disodium 5′-Inosinate in a Water + Ethanol System: Solubility, Nucleation Mechanism,

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Solubility of Ibuprofen Sodium Dihydrate in Acetone + Water Mixtures: Experimental Measurement and Thermodynamic Modeling

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果糖结晶过程优化

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CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery,

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Solid–Liquid Phase Equilibria of Ternary Mixtures Containing 1,2-Dihydroacenaphthylene and Dibenzofuran

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Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment

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Effects of Solvent on Polymorph Formation and Nucleation of Prasugrel Hydrochloride

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Determination of the Solubility, Dissolution Enthalpy and Entropy of Donepezil Hydrochloride Polymorphic Form III in Differen

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In Situ Monitoring of the Solvent-Mediated Transformation of Cefadroxil DMF Solvate into Monohydrate

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Transformations among the New Solid-State Forms of Clindamycin Phosphate

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Concomitant Polymorphism of Prasugrel Hydrochloride in Reactive Crystallization

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Template synthesis of PMAA@chitosan hollow nanorods for docetaxel delivery

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Measurement and correlation of the solubility of 4,4′-oxydianiline in different organic solvents

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Solution-Mediated Phase Transformation of a Hydrate to its Anhydrous Form of Donepezil Hydrochloride.

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Novel Glutaric Acid Cocrystal Formation via Cogrinding and Solution Crystallization

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Molecular modeling of crystal morphology of ginsenoside compound K solvates and its crystal habit modification by solvent

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Thermodynamic analysis and correlation of solubility of candesartan cilexetil in aqueous solvent mixtures.

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头孢地嗪钠溶剂化物结晶过程自催化动力学

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等离子体法制备掺杂Ni碳材料的储氢性能

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药物晶型转化与控制的研究进展

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Determination of the Solubility, Dissolution Enthalpy, and Entropy of Pioglitazone Hydrochloride (Form II) in Different Pure

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Ultrasound-mediated targeted microbubbles: a new vehicle for cancer therapy,

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The induction time, interfacial energy and growth mechanism of maltitol in batch cooling crystallization

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Correlation of Solubility and Prediction of the Mixing Properties of Ginsenoside Compound K in Various Solvents

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Experimental determination of the solid liquid equilibrium, metastable zone, and nucleation parameters of the flunixin meglum

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Isolation, characterization and phase transformation of new ginsenoside compound k hydrate and methanol solvates

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Correlation of solubilities of hydrophilic pharmaceuticals versus dielectric constants of binary solvents.

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Phase Equilibria, Crystallization, and Microstructural Studies of the Flunixin Meglumine plus Meglumine System

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Polymorphic Crystallization and Transformation of Candesartan Cilexetil

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头孢羟氨苄单水合物反应结晶工艺优化

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Immobilized thermolysin for highly efficient production of low-molecular-weight protamine-An attractive cell-penetrating pept

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Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchyma

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单分散介孔纳米载体合成及表征

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Solubility of minoxidil in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and water from (278.15 to 333.15) K

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Solubility of candesartan cilexetil in different solvents at various temperatures

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Measurement and correlation of solubility of clopidogrel hydrogen sulfate (Metastable Form) in lower alcohols

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氨苄西林钠溶析结晶的工艺研究

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Determination of the solubility, dissolution enthalpy and entropy of Deflazacort in different solvents

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Solubility of Clopidogrel Hydrogen Sulfate (Form II) in Different Solvents

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Immobilization of penicillin G acylase onto amino-modified silica hydrogel

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在线过程分析技术在抗生素等药物结晶中的应

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以化学化工创新人才培养引领文献信息课程教学的探讨,

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Solubility of Deflazacort in Binary Solvent Mixtures

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Solubility of 5-Amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide in Ethanol plus Water Mixtures

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Determination of nucleation kinetics of lovastatin in acetone solution

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Developing macromolecular therapeutics: the future drug-of-choice

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Solubility of Form B Pravastatin Sodium in (Water+2-Propanol)

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Isoelectrical Points and Solubility of 6-Aminopenicillanic Acid in Water+1-Butanol + Butyl Acetate

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Solubility of Form A Pravastatin Sodium in Aqueous 2-Propanol Mixtures,

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[mu-1,2-bis(phenylsulfanyl)ethane-kappa S-2 : S ']-bis[dibromomercury(II)]

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Formation of mixed crystals in crystallization of 11 alpha-hydroxy-16 alpha,17 alpha-epoxyprogesterone and 16 alpha,17 alpha-

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Simulation and scale-up of barium sulphate precipitation process using CFD modeling

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Solubility of lovastatin in acetone, methanol, ethanol, ethyl acetate, and butyl acetate between 283 K and 323 K

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Effect of mixed solvents and additives on the habit modification of 6-APA crystals

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The effect of ultrasonic on induction period and metastable zone width of roxithromycin crystallization

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可持续发展时代的过程集成

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固定化青霉素酰化酶反应器研究进展

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头孢羟氨苄反应结晶过程的研究

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过饱和度和温度对6-氨基青霉烷酸生长晶习的影响

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6APA反应结晶热力学性质的研究,

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Comparison of different methods to prepare MgO whiskers

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Solubility of potassium clavulanate in ethanol, 1-propanol, 1-butanol, 2-propanol, and 2-methyl-1-propanol between 273 K and

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7-氨基头孢烷酸结晶过程聚结现象与晶体表面性质

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克拉维酸钾反应结晶研究

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=21世纪中国绿色化学与化工发展的思考