sye@tju.edu.cn
国家****基金获得者、****中青年科技创新领军人才、教育部新世纪优秀人才
教授
微生物生物化学

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激动剂、拮抗剂及异构调节剂与GABAA受体相互作用的分子机制

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Z环收缩的能量转化及其精密调控机制研究
一种吲哚骨架化合物及其应用

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Crystallization of fibroblast activation protein alpha (FAPα)

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Crystallization of MvaS

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Crystal structure of MVAS

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Crystallization of dipeptidyl peptidase IV (DPPIV)
本发明公开了一种吲哚骨架化合物及其应用。本发明提供的吲哚骨架化合物的结构式如式Ⅰ、式Ⅱ或式Ⅲ所示化合物，本发明提供的化合物或其药学上可接受的盐以及以其作为活性成分的药物组合物可用于制备治疗DPP4相关疾病的产品。本发明通过在吲哚骨架类分子的C-1位上引入甲胺(或取代甲胺)基团，在C-2上引入芳香基团的衍生物，以及在N-1位引入乙酰基或磺酰基团，得到了具有很好的抑制DPP4活性能力的新的化合物。该类化合物具有很好的生物活性、生物稳定性和选择性。

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Provided are crystals relating to FAPα and its various uses.

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Provided are crystals relating to MvaS (HMG-CoA Synthase) and its various uses.

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Provided are structure coordinates relating to MvaS and its various uses.

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Provided are crystals relating to DPPIV and its various uses.
Cooperative transport mechanism of human monocarboxylate transporter 2.

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Cryo-EM structures of human pannexin 1 channel

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Cryo-EM structures of the human cation-chloride cotransporter KCC1

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Emerging Structure-Function Paradigm of Endocrine FGFs in Metabolic Diseases

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Cryo-EM structure of the human 53 GABAA receptor

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Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division

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Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

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A kinase‐dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion

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Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage.

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A rational approach to enhancing antibody？Fc homodimer？formation for robust production of antibody mixture in a single cell l

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Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling

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Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1

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Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses.

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3D-Printed High-Density Droplet Array Chip for Miniaturized Protein Crystallization Screening under Vapor Diffusion Mode

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The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis

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RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity

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Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation

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Next generation sequencing detection and characterization of a heterozygous novel splice junction mutation in the 2B domain

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Functional analysis of novel splicing and missense mutations identified in the ASS1 gene in classical citrullinemia patients

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Ionic interactions of Ba2+ blockades in the MthK K+ channel

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Nanoliter-scale protein crystallization and screening with a microfluidic droplet robot

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Discovery of dipeptiyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold

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Cypher/ZASP is a novel A kinase anchoring protein

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FtsZ Protofilaments use a hinge-opening mechanism for constrictive force generation

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Structural Basis of Heparan Sulfate-Specific Degradation by Heparinase III

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Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel

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Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis

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Crucial Points within the Pore as Determinants of K(+) Channel Conductance and Gating

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Crystal structure of a potassium ion transporter, TrkH

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Novel insights into ion selectivity from high resolution structures of an open K+ channel pore

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Structure of the Gating Ring from the Human Large-conductance Ca2+-gated K+ Channel

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Crystal structures of a Ligand-free MthK gating ring: Insights into the ligand gating mechanism of K+ channel

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Control of FGF7- and FGF1-induced mitogenesis and downstream signaling by distinct heparin octasaccharide motifs

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Atomic Structure of a Na+ and K+ Conducting Channel

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Structural specificity in a FGF7-affinity purified heparin octasaccharide required for formation of a complex with FGF7 and F

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Kinetic and structural Characterization Phosphofructokinase from Lactobacillus bulgaricus

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Crystal structure of circadian clock protein KaiA from synechococcus elongatus

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N-linked glycosylation of dipeptidyl peptidase IV (CD26): Effects on enzyme activity, homodimer formation, and adenosine dea

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Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and

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The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode

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Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen acti

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Serpins and other covalent protease inhibitors

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The structure of a Michaelis Serpin-Protease Complex

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Structural Basis for Interaction of FGF-1, FGF-2 and FGF-7 with Different Heparan Sulfate Motifs

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Crystal structure of an N-terminal fragment SNR141 of Staphylococcal nuclease R refined at 1.9 angstrom resolution

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Crystallization and preliminary X-ray analysis of SNR 141 - an N-terminal fragment of staphylococcal nuclease R

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Crystallization and preliminary X-ray analysis of staphylococcal nuclease R

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Crystal structure of (L-Arg)-B0 bovine insulin at 0.21 nm resolution