田裕涛 职称：教授
邮箱：yutao.tian@tju.edu.cn
电话：
地址：天津大学医工院2号楼101室



个人简介 田裕涛，天津大学教授，美国生物物理学会会员。2011年9月至2019年11月于美国宾夕法尼亚大学医学院生理系任博士后研究员和研究助理。研究方向为钾离子通道门控过程和调节机制，以及离子通道在神经系统，心血管系统，内分泌系统中重要的生理或病理功能。相关研究成果表于PNAS，JournalofGeneral Physiology等生理学领域顶级期刊及重要期刊，曾多次被邀请参加国际国内外会议并做报告。


教育背景 2006.09-2011.06，南开大学，博士.
2002.09-2006.06，天津师范大学，本科.


工作经历 2020.01-天津大学，医学工程与转化医学研究院，教授
2016.09-2019.11，UniversityofPennsylvania，研究助理.
2011.09-2016.09，UniversityofPennsylvania，博士后研究员


主要研究方向 应用电生理学，计算化学，化学生物学等手段，通过膜片钳记录，分子动力学模拟等方法，对离子通道（钾离子通道，氯离子通道等）门控动力学过程和相关调节机制进行相关研究。探索相关离子通道的生理和病理功能。对相关离子通道的药理学特性进行分析。开发离子通道在神经工程学中的应用。


代表性学术成果 论文：
YutaoTian^*, Stefan H Heinemann, Toshinori Hoshi^*(2019) Large-conductance Ca²⁺- and voltage-gated K⁺channels form and break interactions with membrane lipids during each gating cycle. Proc Natl Acad Sci USA. 116 (17), 8591-8596. PMID: **
Yutao Tian^*, Marius Aursnes, Trond Vidar Hansen, J?rn Eivind Tungen, Jason D Galpin, Lilia Leisle, Christopher A Ahern, Rong Xu, Stefan H Heinemann, Toshinori Hoshi^*(2016) Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proc Natl Acad Sci USA 113 (48), 13905-13910. PMID: **.
Yutao Tian^*, Florian Ullrich, Rong Xu, Stefan H Heinemann, Shangwei Hou, Toshinori Hoshi^*(2015) Two distinct effects of PIP₂underlie auxiliary subunit-dependent modulation of Slo1 BK channels. J Gen Physiol 145 (4), 331-343. PMID: **.
Kevin A Strauss*, Sander Markx, Benjamin Georgi, Steven M Paul, Robert N Jinks, Toshinori Hoshi, Ann McDonald, Michael B First, Wencheng Liu, Abigail R Benkert, Adam D Heaps, Yutao Tian, Aravinda Chakravarti, Maja Bucan, Erik G Puffenberger (2014) A population-based study of KCNH7 p. Arg394His and bipolar spectrum disorder. Hum Mol Genet23 (23), 6395-6406. PMID: PMID: **.
Toshinori Hoshi^*, Rong Xu, Shangwei Hou, Stefan H Heinemann, Yutao Tian(2013) A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. J Gen Physiol 142 (5), 507-522. PMID: **.
Toshinori Hoshi^*, Yutao Tian, Rong Xu, Stefan H Heinemann, Shangwei Hou (2013) Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. Proc Natl Acad Sci USA 110 (12), 4822-4827.PMID: **.
Toshinori Hoshi^*, Bianka Wissuwa, Yutao Tian, Nobuyoshi Tajima, Rong Xu, Michael Bauer, Stefan H Heinemann, Shangwei Hou (2013) Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺channels. Proc Natl Acad Sci USA 110 (12), 4816-4821. PMID: **.
Yutao Tian, Ting Lei, Zhuo Yang, Tao Zhang^*(2012) Urethane suppresses hippocampal CA1 neuron excitability via changes in presynaptic glutamate release and in potassium channel activity. Brain Res Bull 87 (4-5), 420-426. PMID: **.
Meina Quan, Chenguang Zheng, Nan Zhang, Dadong Han, Yutao Tian, Tao Zhang, Zhuo Yang^*(2011) Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression. Brain Res Bull 85 (3-4), 109-116. PMID: **.
Dadong Han, Yutao Tian, Tao Zhang, Guogang Ren, Zhuo Yang^*(2011) Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats. Int J Nanomedicine6, 1453. PMID: **.
Yutao Tian, Zhuo Yang, Tao Zhang^*(2011) Zinc ion as modulator effects on excitability and synaptic transmission in hippocampal CA1 neurons in Wistar rats. Neurosci Res 68 (3), 167-175. PMID: **.
Meina Quan, Yutao Tian, Kunhan Xu, Tao Zhang, Zhuo Yang^*(2010) Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats. Neuroscience 169 (1), 214-222. PMID: **.
Jiajia Yang, Yutao Tian, Zhuo Yang, Tao Zhang^*(2010) Effect of melamine on potassium currents in rat hippocampal CA1 neurons. Toxicol in Vitro 24 (2), 397-403. PMID: **.
Yutao Tian, Zhaowei Liu, Yang Yao, Zhuo Yang, Tao Zhang^*(2009) Effect of alpha-cypermethrin and theta-cypermethrin on delayed rectifier potassium currents in rat hippocampal neurons. Neurotoxicology 30 (2), 269-273. PMID: **.
Yutao Tian, Zhaowei Liu, Yang Yao, Tao Zhang^*, Zhuo Yang^*(2008) Effects of alpha-and theta-cypermethrin insecticide on transient outward potassium current in rat hippocampal CA3 neurons. Pestic Biochem Physiol 90 (1), 1-7.



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