李冰 职称：副主任医师
邮箱：ykb@tju.edu.cn
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个人简介 长期致力于骨与关节疾病的临床和基础研究，主持国家科学基金1项，省部级医学研究课题3项，作为主要参与人参与国家级课题5项，天津市科委重大专项1项，同时担任天津市创新创业团队骨干成员。先后赴英国牛津大学和美国纽约州立大学学习深造，作为第一作者和通讯作者发表SCI论文10余篇，核心期刊5篇，累计影响因子超过30分。




教育背景 2012.09-2018.06, 天津医科大学/天津市天津医院，博士后(已出站)
2010.09-2011.09，University of Oxford, UK， 联合培养博士
2008.09-2011.07，天津医科大学， 博士
2005.09-2008.07，哈尔滨医科大学，硕士
2000.09-2005.07，哈尔滨医科大学，本科




工作经历 2019.09-2019.12, the State University of New York in Stony Brook, Biomedical Engineering, Visiting Faculty.
2017.12-至今， 天津市天津医院，关节外科，副主任医师
2014.12-2017.12，天津市天津医院，关节外科，主治医师
2013.09-2014.09，the State University of New York in Stony Brook, Biomedical Engineering, Visiting Faculty.
2011.09-2014.12，天津市天津医院，骨科，医师




主要研究方向 主要从表观遗传(Epigenetics)角度研究废用性骨质疏松症(Disuse Osteoporosis, DOP)发病的分子生物学机制，为疾病的精准治疗开发分子靶点。利用先进影像处理技术构建脊柱侧突动态进展模型，为疾病的诊疗和预后的判断建立了新的方法。




代表性学术成果 (1)Li B, Zhao J, Ma JX, Li GM, Zhang Y, Xing GS, Liu J, Ma XL. Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis. Bone4.14. 2018 Jun;111:82-91. doi: 10.1016/j.bone.2018.03.017. IF:4.45. Citation: 4


(2)Bing Li, Jing Yu, Jill Urban*. Development of spinal deformities in the tight-skin mouse. Bone Research (2017) 5, 16053; doi:10.1038/ boneres.2016.53. IF:12.354. Citation: 1


(3)Li B, Liu J, Zhao J, Ma JX, Jia HB, Zhang Y, Xing GS, Ma XL*. LncRNA-H19 Modulates Wnt/β-catenin Signaling by Targeting Dkk4 in Hindlimb Unloaded Rat. Orthop Surg. 2017 Apr 26. doi: 10.1111/os.12321. IF:1.2. Citation: 7


(4)Bing Li, Sanaran JS, Stefan Judex*. Trabecular and Cortical Bone of Growing C3H Mice is Highly Response to the Removal of Weight bearing, Plos One, 2016, 11(5):e**. IF:2.766. Citation: 2


(5)Li Bing, Xiao Yu, Xing Dan, Ma Xin-Long*, Liu Jun*. Circulating interleukin-6 and rheumatoid arthritis: A Mendelian randomization meta-analysis, Medicine (Baltimore), 2016, 95(23):e3855. IF:2.1. Citation: 7


(6)Li B, Urban JP, Yu J*. The distribution of fibrillin-2 and LTBP-2, and their co-localisation with fibrillin-1 in adult bovine tail disc, J Anat, 2012, 220(2): 164-172. IF:2.479. Citation: 10


(7)Li B, Wang XD, Sun X, Ma J, Yang Y, Ma X*. Lack of association between TNF-α promoter polymorphisms and multiple myeloma: A meta-analysis, Leuk Res, 2012, S0145-2126(12): 360-368. IF:3.0. Citation: 7


(8)Li B*, Wang P, Li H. The association between TNF-alpha promoter polymorphisms and ankylosing spondylitis: a meta-analysis, Clin Rheumatol, 2010, 29(9): 983-990. IF:1.9. Citation: 29


(9)Li B, Wang P, Li H, Ma XL*. An individualized and bioactive artificial intervertebral disc, Orthop Surg, 2010, 2(4): 310-312. IF:1.2


(10)Li GM, Zhao J, Li B, Zhang XF, Ma JX, Ma XL, Liu J. The anti-inflammatory effects of statins on patients with rheumatoid arthritis: A systemic review and meta-analysis of 15 randomized controlled trials. Autoimmun Rev. 2018 Mar;17(3):215-225. IF: 8.745. Citation: 14


(11)Li G, Zhao J, Li B, Ma J, Zhao Q, Wang X, Lv Z, Li K, Du Z, Ma X, Liu J. Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis. Rheumatol Int. 2017 Oct;37(10):1673-1681. IF:1.952. Citation: 3


(12)Sanaran JS, Li B, Donahue LR, Judex S*. Modulation of unloading-induced bone loss in mice with altered ERK signaling, Mamm Genome, 2016, 27(1-2): 47-61. IF:2.5. Citation: 7


(13)Yang, Yang, Wang Yawei, Wang Yumin, Zhao Meng, Jia Haobo, Li Bing, Xing Dan. Tormentic Acid Inhibits IL-1β-Induced Inflammatory Response in Human Osteoarthritic Chondrocytes, Inflammation, 2016, 39(3):1151-9. IF:2.9. Citation: 8


(14)Zhao B, Sun X, Li X, Yang Q, Li Y, Zhang Y, Li B, Ma X*. Improved preparation of acellular nerve scaffold and application of PKH26 fluorescent labeling combined with invivo fluorescent imaging system in nerve tissue engineering, Neurosci Lett, 2013, 556: 52-57. IF:2.2. Citation: 13


(15)Wei W, Liu T, Zhao J, Li B, Li S, Liu J. Does the hepatitis C virus affect the outcomes of total joint arthroplasty? A meta-analysis of ten studies. J Orthop Sci, 2019, pii: S0949-2658(19)30005-3. doi: 10.1016/j.jos.2018.12.026.


(16)Xiao Y, Li B, Liu J. MicroRNA?148a inhibitionprotects against ovariectomy?induced osteoporosis through PI3K/AKT signaling by estrogen receptor α. Mol Med Rep, 2018, 17(6):7789-7796. doi: 10.3892/mmr.2018.8845. Citation: 1


(17)Xiao Y, Li B, Liu J. miRNA?27a regulates arthritis via PPARγ in vivo and in vitro. Mol Med Rep. 2018, 17(4):5454-5462. doi: 10.3892/mmr.2018.8531. Citation: 3


(18)Xiao Y, Li B, Liu J, Ma X. Carvacrol ameliorates inflammatory response in interleukin 1β-stimulated human chondrocytes. Mol Med Rep, 2018, 17(3):3987-3992. doi: 10.3892/mmr.2017.8308. Citation: 5


(19)Wang Y, Gao F, Zhao M, Li B, Xing D, Wang J, Yang Y. Prognostic significance of EZH2 expression in patients with oesophageal cancer: a meta-analysis. J Cell Mol Med. 2016 May;20(5):836-41. doi: 10.1111/jcmm.12791. Citation: 4


(20)Yang Y, Wang Y, Zhao M, Jia H, Li B, Xing D. Tormentic acid inhibits IL-1β-induced chondrocyte apoptosis by activating the PI3K/Akt signaling pathway. Mol Med Rep. 2018, 17(3):4753-4758. doi: 10.3892/mmr.2018.8425. Citation: 2


(21)Zhang X, Bu Y, Zhu B, Zhao Q, Lv Z, Li B, Liu J. Global transcriptome analysis to identify critical genes involved in the pathology of osteoarthritis. Bone Joint Res. 2018, 7(4):298-307. doi: 10.1302/2046-3758.74.BJR-2017-0245.R1. Citation: 3


(22)Zhen Lyu, Bing Li, Xiaofei Zhang, Xinglong Ma, Jianxiong Ma, Jun Liu. Collagen5A1 and collagen12A1 gene polymorphisms as a risk marker for anterior cruciate ligament ruptures: a meta-analysis. Int J Clin Exp Med 2018, 11(3): 1425- 1436.




科研项目 已完成项目：
2013年01月—2016年01月，活体Micro-CT成像建立脊柱侧凸动态模型的实验研究，中国博士后基金面上项目
2013年06月—2016年12月，应用活体Micro-CT成像构建脊柱侧凸动态模型的实验研究，天津市企业博士后择优资助项目
2016年01月—2018年12月，可溶性Fas和FasL与废用性骨质疏松的关系及治疗意义的实验研究，天津市外专局择优资助项目


在研项目：
2017年04月-至今，LncRNA-H19 作为 ceRNA 调控 lrp6 在废用性骨质疏松发病中的机制研究，天津市自然科学基金，主持，5万元
2018年，天津市优秀博士后国际化培养，主持，10万元
2018年，天津市青年医学新锐，主持，60万元
2018年10月-至今，国人单间室膝关节假体系统核心技术的研发，天津市生物医学工程科技重大专项，主要参与人，800万




获奖情况

社会学术兼职 天津中医药大学, 中西医结合临床，硕士研究生导师
天津市抗衰老学会骨科专业委员会，秘书
中华预防医学会骨与关节病预防与控制专业委员会，青年委员
中华医学会运动医疗分会，青年委员
中国中西医结合学会骨伤专业委员会，青年委员
欧美同学会医师协会，青年委员