龚燕华

职称：教授
邮箱：gongyanhua@tju.edu.cn
电话：-210
地址：天津大学灾难医学研究院10号东配楼210
个人简介
龚燕华，男，1977年12月生于江苏省海门，博士，教授，硕导。主要从事医学分子生物学与灾难医学生物救治研究。国家科技部“863计划”、国家重点研发计划项目、国家自然科学基金项目负责人。全军生物化学专业委员会常委。军队优秀专业技术人才二类岗位津贴获得者。

教育背景
2001.9-2005.11，中国协和医科大学（北京协和医学院），生物化学与分子生物学，博士（直博，提前毕业）
1996.9-2001.7，华中科技大学同济医学院，临床医学系，学士

工作经历
2019.1-至今 天津大学灾难医学研究院，教授
2013.12-2018.12 中国人民武装警察部队后勤学院，卫生勤务系人体机能学教研室，主任、教授
2011.9-2013.11 中国人民武装警察部队后勤学院，临床医学系生物化学与分子生物学教研室主任、副教授
2010.4-2011.8 中国人民武装警察部队医学院（特招入伍），基础部生物化学与分子生物学教研室，主任、副教授　
2008.7-2010.3 中国医学科学院，基础医学研究所生化系，副研究员、硕士生指导教师（北京协和医学院第十八批研究生导师）
2005.12-2008.6 中国医学科学院，基础医学研究所生化系，助理研究员

代表性学术成果
【期刊论文】
1. Gong Yanhua, Wang Xu, Liu Jin, Shi Lei, Yin Bin, Peng Xiaozhong, Qiang Boqin & Yuan Jiangang NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183. FEBS lett, 2005, 579(1), 115-121 (IF:3.83)
2. Yan-hua Gong, Ji-Ping Yue, Xu-Dong Wu, Xu Wang, Jian-Yan Wen, Xiaozhong Peng, Jiangang Yuan, Boqin Qiang. NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element. Nucleic Acid Res，2006,34(21): 6158-69. (IF:11.561)
3. Xiuhua Dong, Feng Xu, Yanhua Gong, Feng Wang, Jin Gao, Xiaozhong Peng, Jiangang Yuan, Boqin Qiang, Zihe Rao, Crystal Structure of the First Domain of Human Nectin-like Molecule-1/ TSLL1/ SynCAM3, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. J Biol Chem., 2006,281(15):10610-7 (IF: 5.854)
4. Lei Shi, Jiping Yue, Yuangang You, Bin Yin, Yanhua Gong, Caimin Xu, Boqin Qiang, Jiangang Yuan, Yongjian Liu*, and Xiaozhong Peng*. Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation. Cellualr Signalling. 2006,18(11):1995-2003(IF: 4.887)
5．Xingqi Yan, Tengfei Chao，Kang Tu , Yu Zhang , Lu Xie, Yanhua Gong, Jiangang Yuan*, Boqin Qiang, Xiaozhong Peng* Improving the prediction of human microRNA target genes by using combined SVM based algorithm. FEBS lett. 2007, 581,1587–1593 (IF:3.83)
6.Jianyan Wen, Qing Xia, Cailing Lu, Lina Yin, Juan Hu, Yanhua Gong, Bin Yin, Koshiro Monzen, Jiangang Yuan, Boqin Qiang, Xuemin Zhang, Xiaozhong Peng* Proteomic analysis of cardiomyocytes differentiation in mouse embryonic carcinoma P19CL6 cells. J Cell Biochem. 2007,102(1):149-60 (IF:3.871)
7. Yanhua Gong, Jing Wu, Hua Qiang , Ben Liu, Zhikai Chi, Tao Chen, Bin Yin, Xiaozhong Peng & Jiangang Yuan. BRI(3) Associates with SCG10 and Attenuates NGF-induced Neurite Outgrowth in PC12 Cells. BMB Rep. 2008,41(4):287-93 (IF:3.089)
8.Xudong Wu, Yanhua Gong, Jiping Yue, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng . Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing. Nucleic Acids Research,2008,36(11):3590-3599 (IF:11.561)
9.Fengwei Tan , Lifang Lu , Yun Cai, Jinglan Wang, Lin Wang, Yanhua Gong , Bing-e Xu, Jun Wu, Ying Luo, Boqin Qiang, Jiangang Yuan, Xiaoqing Sun, and Xiaozhong Peng. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. Proteomics. 2008,8(14):2885-96 (IF:5.735)
10.Jing Gao, Tao Chen, Guangyu Hu, Yanhua Gong, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng. Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity. BBA-Biomembranes 2008, 1778：1429–1435 (IF: 4.18)
11.Chen Y, Liu W, Chao T, Zhang Y, Yan X, Gong Y, Qiang B, Yuan J, Sun M, Peng X. MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G. Cancer Lett. 2008,272(2):197-205. (IF: 6.491)
12．Zheng G, Liu W, Gong Y, Yang H, Yin B, Zhu J, Xie Y, Peng X, Qiang B, Yuan J.Human D-Tyr-tRNATyr deacylase contributes to cell's resistance to D-amino acids. Biochem J. 2009,417(1):85-94 (IF: 4.371)
13: Jing Gao, Tao Chen, Guangyu Hu, Jin Liu, Yanhua Gong, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng. NECL1, a novel glioma repressor can be reexpressed by TSA treatment in glioma cell lines. Glia 2009,57(9):989-99 (IF: 6.209)
14.Yu Zhang, Tengfei Chao, Ran Li, Wei Liu, Wei Liu,Yang Chen, Xingqi Yan, Jizhong Zhao, Yanhua Gong, Bin Yin, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a. J. Mol. Med. 2009,87(1):43-51. (IF:4.82)
15.LIU Wei*, GONG Yan-hua*, CHAO Teng-fei, PENG Xiao-zhong, YUAN Jian-gang, MA Zhen-yu, JIA Ge and ZHAO Ji-zong? Identification of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas C.M.J. 2009,122(20): 2405-2411 (* co-first author) (IF: 1.064)
16.Xianping Wang, Zhiyong Lou, Xiuhua Dong, Wen Yang,Yong Peng, Bin Yin, Yanhua Gong, Jiangang Yuan, Weihong Zhou,Mark Bartlam, Xiaozhong Peng and Zihe Rao Crystal Structure of the C-Terminal Domain of Human DPY-30-Like Protein: A Component of the Histone Methyltransferase Complex J. Mol. Biol. 2009,390: 530–537
17.Jianyan Wen, Qing Xia, Wei Liu, Yang Chen, Jing Gao, Yanhua Gong, Yuannan Ke, Boqin Qiang , Jiangang Yuan , Xiaozhong Peng Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway. J. Mol. Cell. Cardiol. 2009, 47(6): 761-769 (IF: 5.682)
18.Yuangang You; Weiqi Li; Yanhua Gong; Bin Yin; Boqin Qiang; Jiangang Yuan; Xiaozhong Peng，ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation . BMB Reports 2010,43（7）:485-90 (IF3.089)
19．Weiqi Li*, Lei Shi*, Yuangang You, Yanhua Gong, Bin Yin, Jiangang Yuan, Xiaozhong Peng Dok6，as a novel substrate of TrkC receptor, exerted pivotal roles in NT-3 mediated neurite outgrowth of mice cortex cells BMC Bioloby 2010, 8:86 (IF: 6.779)
20．Wei Liu*, Chang Liu*, Jingxi Zhu, Pengcheng Shu ,Bin Yin, Yanhua Gong, Boqin Qiang, Jiangang Yuan, Xiaozhong Peng microRNA-16 targets APP to potentially modulate AD pathogenesis in SAMP8 mice Neurobiology of Aging, 2012,33: 522–534 (IF: 5.959)
21. Wang R M, Liu Z Z, Gong Y H, Chen L J, Jia Q, Wang Y J, Fang F, Lv H, Zhang G J, Kang X X. Association analysis of USF1 gene polymorphisms and total unstable carotid plaque area in atherosclerotic stroke patients. J Thromb Thrombolysis, 2013，3: 317-23
22. Hui Li, Rong Fan, Mingze Sun, Tao Jiang, Yanhua Gong* Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4.Biochemical and Biophysical Research Communications,2013, 440: 527-532 (IF: 2.466)
23.Yuheng Shan, Xian Chen, Yanchen Lin, Yuliang Wang, Shijiang Zhong, Yanhua Gong，Value of magnetic resonance spectroscopy and perfusion-weighted imaging in distinguishing glioma recurrence from PTRE: a meta-analysis Int J Clin Exp Med 2016,9(6):10006-10017 (IF:1.069)
24.Shijiang Zhong，Yanhua Gong, Yanchen Lin，Combined intranasal nerve growth factor and ventricle neural stem cell grafts prolong survival and improve disease outcome in amyotrophic lateral sclerosis transgenic mice. Neuroscience Letters, 2017,656:1–8 (IF: 2.188)
25.Yuliang Wang , Zhikong Liang , Hui Li, Jinglong Tao, Yi Sun ,Yanhua Gong.NSPc1 polycomb protein complex binds and cross-talks to lncRNAs in glioma H4 cells. Oncology Report, 2019,41（4）:2575-2584 (IF: 2.976)
26.Zhikong Liang, Yuliang Wang, Hui Li, Yi Sun*,Yanhua Gong*. LncRNAs combine and crosstalk with NSPc1 in ATRA induced differentiation of U87 glioma cells. Oncology Letters,2019,17: 5821-5829 (IF: 1.871)
27. Weizhou Wu, Shijiang Zhong,Yanhua Gong,Yuheng Shan, LiNa Yuan, Li Wang, Jian Chen* , Zhe Zhang*A new molecular probe: An NRP-1 targeting probe for the grading diagnosis of glioma in nude mice. Neurosci Lett. 2020;714:134617 doi: 10.1016/j.neulet.2019.134617. (IF: 2.188)




【承担科研项目】




1、国家重点研发计划项目（课题），2019YFC**，突发重特大自然灾害事件食品安全应急保障技术体系集成与应用，2019 /12- 2022 /12 ，326万（自筹经费1500万），在研，主持。
2、天津大学“双一流大学”人才项目，挤压综合征急性肾损伤的生物救治研究平台，2019/01-2020/12，80万，在研，主持。
3、中央军委科技委创新项目，C**, 2019/06-2020/12，200万，在研，子课题负责人。
4、国家自然科学基金面上项目，**，microRNA-206靶向ZFP580调控球囊损伤后平滑肌细胞表型转换的分子机制，2014/01-2017/12，65万元，已结题，第二承担人。
5、武警总部科研项目，WJHQ2012-13，NSPc1在部队作业辐射损伤过程中对机体保护作用的机制研究，2013/01-2015/12，18万元，已结题，主持。
6、国家自然科学基金青年项目，**，多梳家族成员NSPc1对脑胶质瘤干细胞辐射抗性的调控作用及机制研究，2013/01-2015/12，23万元，已结题，第二承担人。
7、国家自然科学基金面上项目，**，NSPc1 调控小鼠神经干细胞体外增殖与分化的分子机制，2011/01-2013/12，34万元，已结题，主持。
8、国家科技部973计划，2006CB504100，高原低氧等环境因素损伤适应机理与干预措施 （子课题：神经缺氧与分化的关系），2006/09-2011/09，50万元，已结题，子课题负责人。
9、国家自然科学基金项目（主任基金），**，干细胞中表观抑制因子NSPc1 的调控作用，2010/01-2010/12，8万元，已结题，主持。
10、国家自然科学基金青年项目，**，神经系统多梳蛋白NSPc1抑制转录与促细胞增殖的表观调控机制，2007/01-2009/12，30万元，已结题，主持。
11、国家科技部863计划项目（探索导向类），2006AA02Z137，神经肿瘤细胞分化相关蛋白网络调控节点的识别和筛选，2006/12-2008/12，90万元，已结题，主持。
【专著】
1. 《基因组2》 2006年，科学出版社，参译
2. 《基因组3》 2009年，科学出版社，参译
3. 《蛋白质相互作用及亚细胞定位原理与技术》 2010年，中国协和医科大学出版社，主编
4. 《医学分子生物学》 2011年，人民军医出版社，副主编
5. 《人体功能学》 2012年，人民军医出版社，副主编
6. 《中国灾难医学高级教程》，2019年，华中科技大学出版社，参编