王光伟博士
天津大学理学院化学系研究员，博士生导师
北洋园校区第51教学楼536室
Tel：+86-150-2205-5628
Fax: +86-22-2740-3475
Email: wanggw@tju.edu.cn
研究方向
1. 过渡金属催化的不饱和烯烃和炔烃的碳金属化反应研究
2. 过渡金属催化的氟烷基化反应研究
3. 活性药物分子的合成
学习与工作简历：
1994.9–1998.7，兰州大学化学系, 本科生
1998.8–2003.7，中科院上海有机所金属有机化学国家重点实验室, 研究助理
2003.8–2004.7，晟康生物医药技术(上海)有限公司, 助理研究员
2004.9–2009.8，美国Purdue University化学系, 博士研究生(导师：E. Negishi)
2009.8–2011.6，美国Purdue University化学系, 博士后 (导师：E. Negishi)
2011.7–2014.5，上海源力生物技术有限公司(江苏恒瑞医药上海工艺研发中心), 副主任、主任
2014.6 - 至今 天津大学理学院化学系
讲授主要课程：
1、本科生课程：《精细合成化学》,《有机化学(全英文)》,《有机化学实验》等。
2、研究生课程：《金属有机化学》
荣誉和奖励：
2017年 天津大学2017届本科生毕业设计(论文)优秀指导教师
2016年 天津大学2016届本科生毕业设计(论文)优秀指导教师
2009年 Herbert C. Brown有机化学研究生奖
2008年 Negishi研究室杰出贡献奖
2006年 普度大学Henry B. Hass 奖学金
1997年 兰州大学社会实践先进个人
1996年 兰州大学优秀本科生
课题组成立之后发表的文章：
44. Dai,Q.; Zhao,H.; Cao,H.;Yang,J.; Zhao,W.; Wang,T.; Liu,L.; Fan, Z.; Wang, G. Photo-triggered conversion of hydrophilicfluorescent biomimetic nanostructures forcell imaging. Chem. Commun. 2018, 54, in press. DOI: 10.1039/c8cc07197g
43. Liu, J.; Wang, G. N, N, N’, N’’, N’’-Pentamethyldiethylenetriamine. In Encyclopedia of Reagents for Organic Synthesis, Wiley,2018,in press.
42. Zhou, S.; Yuan, F.; Guo,M.; Wang, G.; Tang, X.; Zhao,W. Switchable synthetic strategy toward trisubstituted and tetrasubstituted exocyclic alkenes. Org. Lett. 2018, 20, 6710-6714. DOI: 10.1021/acs.orglett.8b02814
41. Yuan, F.; Zhou, S.; Yang, Y.; Guo,M.; Tang, X.; Wang, G.Copper Catalyzed One-Pot Difluoroalkylation and Lactonization ofUnsaturated Carboxylic Acids. Org. Chem. Front.2018, 5, 3306-3309. DOI: 10.1039/C8QO00940F
40. Wang,X.;Liu, J.; Yu, Z.; Guo,M.; Tang,X.; Wang, G.Desulfonylation-Initiated Distal Alkenyl Migration in Copper-Catalyzed Alkenylation of Unactivated Alkenes. Org. Lett. 2018, 20, 6516-6519. DOI: 10.1021/acs.orglett.8b02840
39. Dai,Q.;Zhao,H.;Fan,Z.;Zhao,W.;Wang,G.;Zhang,J.; Hou,R.;Du,P.; Cao, H.*In Situ Nanoreactors: Controllable PhotoluminescentCarbon-Rich Polymer Nanodots Derived from Fatty Acidunder Photoirradiation. Macromol. Rapid Commun.2018, 39, **. DOI: 10.1002/marc.
38. Feng,X.;Wang,X.;Chen,H.; Tang,X.; Guo,M.; Zhao,W.; Wang, G.Copper-Mediated Regioselective Hydrodifluoroalkylation of Alkynes. Org. Biomol. Chem., 2018, 16,2841-2845. 10.1039/C8OB00256H
37. Wang,X.;Li, M.; Yang, Y.; Guo, M.;Tang, X.;Wang,G.One-pot Construction of Difluorinated Pyrrolizidine and Indolizidine Scaffolds via Copper-Catalyzed Radical Cascade Annulation. Adv. Synth. Cat.2018, 360, 2151-2156. DOI: 10.1002/adsc.
36. Li, Y.; Liu,J.;Zhao, S.; Du, X.; Guo, M.;Zhao, W.; Tang, X.;Wang,G.Copper-Catalyzed Fluoroolefination of Silyl Enol Ethers and Ke-tones towards the Synthesis of β-Flouroenones. Org. Lett. 2018, 20, 917？920. DOI: 10.1021/acs.orglett.7b03700
35. Wang, G.; Ma, J.-A. NFSI and its analogs electrophilic fluorination for preparing alkyl fluorides. In Fluorination. Synthetic Organofluorine Chemistry, vol. 1, Hu, J.; Umemoto, T., Eds, Springer, 2018, Chap. 6.1 (DOI: 10.1007/978-981-10-1855-8_6-1).
34. Chen, H.; Wang, X.; Guo, M.; Zhao, W.; Tang, X.; Wang, G.Highly Efficient and Versatile Synthesis of α,α-Difluoro-γ-lactams via Aminodifluoroalkylation of Alkenes. Org. Chem. Front.2017, 4, 2403-2407.
33. Li, H.; Ren, X.; Zhao, W.; Tang, X.; Wang, G.The cross-coupling of directed C-H and organometallic reagents for C-C bond formation. Chin. J. Org. Chem.2017, 37, 2287-2302.
32. Wang, X.; Zhao, S.; Liu, J.; Zhu, D.; Guo, M.; Tang, X.; Wang, G.Copper-Catalyzed C？H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes. Org. Lett.2017, 19, 4187-4190.
31. Jing, H.; Feng, X.; Guo, M.; Zhou, S.; Li, Y.; Zhang, J.; Zhao, W.; Tang, X.; Wang, G.Copper-catalyzed regioselective formal allylboration of arylsubstituted terminal alkynes with bis(pinacolato)diboron and allyl halides/sulfonates. Asian J. Org. Chem.2017, 6, 1375-1379.
30. Zhang, H.; Ren, X.; Zhao, W.; Tang, X.; Wang, G.One-pot Synthesis of p-Amino-substituted Unsymmetrical Benzils and Benzil Derivatives. Adv. Synth. Cat.2017, 359, 395-401.
29. Wu, J.; Wang, D.; Chen, X.; Gui, Q.; Li, H.; Tan, Z.; Huang, G.; Wang, G.Synthesis of 4-benzylpyridines via Pd-catalyzed CH₃-arylation of 4-picoline. Org. Biomol. Chem., 2017, 15, 7509–7512.
28. Chen, X.; Tan, Z.; Gui, Q.; Hu, L.; Liu, J.; Wu, J.; Wang, G.Photocatalytic/Cu-promoted C-H activations: Visible-light-induced ortho-selective perfluoroalkylation of benzamides. Chem. Eur. J.2016, 22, 6218–6222.
27. Du, J.; Xu. G.; Lin, H.; Wang, G.;Tao, M.; Zhang, W. Highly efficient reduction of carbonyls, azides, and benzyl halides by NaBH₄in water catalyzed by PANF-immobilized quaternary ammonium salts. Green Chem.2016, 18, 2726–2735.
26. Du, J.; Shuai, B.; Tao, M.; Wang, G.;Zhang, W. Pyrrolidine modified PANF catalyst for asymmetric Michael addition of ketones to nitrostyrenes in aqueous phase. Green Chem.2016, 18, 2625–2631.
25. Ren, X.; Wang, G.; Tang, X.; Zhao, W. Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons. Chin. J. Org. Chem.2015, 35, 1733-1738.
课题组成立之前发表的文章：
24. Wang, G.;Xu, S.; Hu, Q.; Zeng, F.; Negishi, E., Search for Highly Efficient, Stereoselective, and Practical Synthesis of Complex Organic Compounds of Medicinal Importance as Exemplified by the Synthesis of the C21-C37 Fragment of Amphotericin B, Chem. Eur. J.2013, 19, 12938-12942.
23. Xu, S.; Lee, C.-T.; Wang, G.;Negishi, E., Widely Applicable Synthesis of Enantiomerically Pure Tertiary Alkyl-Containing 1-Alkanols by Zirconium-Catalyzed Asymmetric Carboalumination of Alkenes and Palladium- or Copper-Catalyzed Cross-Coupling, Chem. Asian J.2013, 8, 1829-1835.
22. Wang, G.;Mohan, S.; Negishi, E., Highly (≥98%) Selective Synthesis of Conjugated Dienoic and Trienoic Esters of All Possible Configurations Consisting of Eand/or ZDisubstituted Alkenes via Alkyne Elementometalation–Pd-Catalyzed Cross-Coupling, Proc. Natl. Acad. Sci. USA, 2011, 108, 11344-11349.
21.Wang, G.;Yin, N.; Negishi, E., Highly Selective Total Synthesis of Fully Hydroxy-Protected Mycolactones A & B and Their Stereoisomerization upon Deprotection, Chem. Eur. J.2011, 17, 4118-4130.
20.Negishi, E.; Wang, G.; Xu, Z., Alkyne Elementometalation–Pd-Catalyzed Cross-Coupling. Towards Synthesis of Any Alkenes in High Yields, Efficiently, Selectively, Economically, and Safely–“Green” Way, J. Org. Chem.2010, 75, 3151-3182.
19.Pitsinos, E.; Athinaios, N.; Xu, Z.; Wang, G.; Negishi, E., A Highly Convergent Total Synthesis of (+)-Scyphostatin, Chem. Comm.2010, 46, 2200-2202.
18.Negishi, E.; Wang, G., Synthesis of Alkenes from Alkynes by Carbometallation and Subsequent Coupling Reactions, Science of Synthesis, Vol. 47, Jacobsen, E. N.; de Meijere, A.; Eds., Thieme, Stuttgart, 2009, Chap. 47.1.5.4, 971-1016.
17.Negishi, E.; Wang, G., Synthesis of Alkenes from Alkynes by Hydrometallation and Subsequent Coupling Reactions, Science of Synthesis, Vol. 47, Jacobsen, E. N.; de Meijere, A.; Eds., Thieme, Stuttgart, 2009, Chap. 47.1.5.3, 909-970.
16.Negishi, E.; Wang, G., Synthesis of 1,3-Dienes by Metal-Mediated Coupling Reactions, Science of Synthesis, Vol. 46, Rawal, V.; Kozmin, S., Eds, Thieme, Stuttgart, 2009, Chap. 46.6, 239-352.
15.Wang, G.; Huang, Z.; Negishi, E., Highly stereoselective and Efficient Synthesis of w-Heterofunctional Di and Trienoic Esters for Horner-Wadsworth-Emmons Reaction via Alkyne Hydrozirconation and Pd-Catalyzed Alkenylation, Tetrahedron Lett. 2009, 50, 3220-3223.
14.Wang, G.; Negishi, E., AlCl₃-Promoted Facile E-to-ZIsomerization Route to (Z)-2-Methyl-1-buten-1,4-ylidene Synthons for Highly Efficient and Selective (Z)-Isoprenoid Synthesis, Eur. J. Org. Chem.2009, 1679-1682.
13.Wang, G.; Huang, Z.; Negishi, E.,Efficient and Selective Syntheses of (all-E)- and (6E, 10Z)-2’-O-Methylmyxalamides D via Pd-Catalyzed Alkenylation–Carbonyl Olefination Synergy, Org. Lett. 2008, 10, 3223-3226.
12.Negishi, E.; Huang, Z.; Wang, G.; Mohan, S.; Wang, C.; Hattori, H., Recent Advances in Efficient and Selective Synthesis of Di-, Tri-, and Tetrasubstituted Alkenes via Pd-Catalyzed Alkenylation–Carbonyl Olefination Synergy, Acc. Chem. Res. 2008, 41, 1474-1485.
11. Wang, G.; Zhu, G.; Negishi, E., Zirconium-catalyzed methylalumination of heterosubstituted arylethynes: Factors affecting the regio-, stereo-, and chemoselectivities, J. Organomet. Chem.2007, 692, 4731-4736.
10. Negishi, E.; Hu, Q.; Huang, Z.; Wang, G.; Yin, N., Palladium- or Nickel-Catalyzed Cross-Coupling with Organozincs and Related Organometals, in The Chemistry of Organic Zinc Compounds, Rappoport, Z., Ed., Wiley, 2006, p. 457-553.
9.Negishi, E.; Wang, G.; Zhu, G., Palladium-Catalyzed Cyclization via Carbopalladation and Acylpalladation, in Topics in Organometallic Chemistry. Metal Catalyzed Cascade Reactions, Müller, T.J.J., Ed., Springer, Berlin, 2006, Vol. 19, p. 1-48.
8. Yin, N.; Wang, G.; Qian, M.; Negishi, E., Highly Stereoselective Synthesis of the Side-Chains of Mycolactones A and B Featuring Stepwise Double Substitutions of 1,1-Dibromo-1-alkenes, Angew. Chem. Int. Ed., 2006, 45, 2916-2920.
7. Negishi, E.; Hu, Q.; Huang, Z.; Qian, M.; Wang, G., Palladium-Catalyzed Alkenylation via Negishi Coupling, Aldrichim. Acta, 2005, 38, 71-88.
6. Ma, S.; Wang, G., Regioselectivity Control by A Ligand Switch in the Coupling Reaction Involving Allenic/Propargylic Palladium Species, Angew. Chem. Int. Ed.2003, 42, 4215-4217.
5. Ma, S.; Wang, G.,Unexpected S_N2’-Type Addition-Elimination Reactions of 1-Aryl-2, 3-Allenols with LiX. Synthesis and Synthetic Application of 1-Aryl-3-halo-1, 3-dienes, Tetrahedron Lett.2002, 43, 5723-5726.
4.Ma, S.; Hou, H.; Zhao, S.; Wang, G.,Efficient Synthesis of Optically Active 2, 3-Allenols via the Simple CuBr-Mediated Reaction of Optically Active Propargylic Alcohols with Paraformaldehyde, Synthesis2002, 1643-1645.
3. Ma, S.; Xie, H.; Wang, G.;Zhang, J.; Shi, Z., Hydrohalogenation Reaction of Substituted 1, 2-Allenic Carboxylic Acids, Esters, Amides, Nitriles, and Diphenyl Phosphine Oxides, Synthesis2001, 713-730.
2. Ma, S.; Li, L.; Wei, Q.; Xie, H.; Wang, G.; Shi, Z.; Zhang, J., Hydrohalogenation Reaction of Electron-Deficient Allenes, Pure & Appl. Chem.2000, 72, 1739-1743.
1. Ma, S.; Wang, G., Highly Selective Hydrohalogenation Reaction of Substituted 2, 3-Allenoates, Chin. J. Chem.1999,17, 545-549.