宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
研究方向:
海洋电能细胞合成生物学与生物制药实验室 e-Cells SynBio (Synthetic Biology Laboratory of Electroactive Cells and Biopharmaceuticals)


本实验室以海洋电能细胞为主要研究对象，开展半导体合成生物学和“光-电遗传学”的基础理论研究，及在海洋能源与环境、生物制药领域的工程应用研究。具体研究内容为：
（一） 光电遗传学：
利用半导体合成生物学、和基因线路设计方法，构建光-电控制的智能电能细胞，调控“细胞-酶-材料”表界面动力学过程，实现海洋微生物发电和微生物电合成等应用。研究内容包括：（1）海洋微生物电池：；利用光-电遗传学、半导体合成生物学、基因线路设计理论，揭示海洋菌群的“物质-能量代谢”系统互作机制，构建电能细胞，实现高效“化学能-电能”的能量转化。（2）微生物光-电合成：构建"细胞-材料"人工光合系统，实现可再生电能（和光能）驱动微生物 CO₂生物还原固定、和定向合成高附加值化学品和燃料；光-电驱动微生物高效固氮。（3）合成微生物生态系统：应用于海洋环境，生物医学。
（二）生物制药与营养品生产：
利用合成生物学、代谢工程理论和方法，设计构建微生物细胞进行高效药物生物合成，酶催化不对称药物的生物转化。本实验室正在开发的核心产品系列：维生素（VK2，VB12等），甜味剂，甾体药物，糖尿病治疗药物，抗菌抗病毒药物，单克隆抗体等医药品和营养品；并与制药公司合作，实现这些医药品生产过程的放大，优化和产业化生产。

Education:
The University of Houston:Department of Chemical & Biomolecular Engineering,Ph.D. in Chemical Engineering, 2004,Advisor: Prof. Dan Luss (member of the National Academy of Engineering, USA)

Nankai University：Department of Chemistry, 1994, B.S. in Chemistry

Working Experience:

Tianjin University: School of Chemical Engineering and Technology, Professor,2013-now
Nanyang Technological University (Singapore): 2009-2013, School of Chemical & Biomedical Engineering,Assistant Professor
Duke University:Research Associate (Synthetic Biology),2006-2009,Supervisor: Prof. Lingchong You
The University of Texas Medical School:Postdoc (Systems & Computational Neurobiology), 2004-2006, Supervisor: Prof. John H. Byrne


研究生（博士生、硕士生）招生：
本实验室每年有多名博士生、和硕士生的招生名额。欢迎有志于科研，在生物化学、分子生物学，生物化工、制药、化学、材料等相关专业的同学申请。有意向，请直接电邮联系：hsong@tju.edu.cn
请务必注意报考填报专业：
博士生报考专业：生物化工专业（博士生）。

硕士生报考专业：制药工程专业（学硕、或专硕）、合成生物学专业（学硕）。

与美国杜克大学、加州大学、得克萨斯大学、新加坡南洋理工大学、新加坡国立大学等国外著名研究型学府和研究所，建立了长期密切合作关系，为学生提供了大量的出国交流、联合培养的机会。优秀学生，还可推荐到大型企业、上市公司和研究所的工作机会。
副教授、助理教授（讲师）、博士后招聘：
国内外著名大学取得博士学位，有志于在合成生物学、代谢工程、生物化学、分子生物学、酶催化、材料等领域开展高水平研究的申请人，欢迎申报。相关待遇将按照天津大学相关职位执行，待遇优厚。请直接电邮联系：hsong@tju.edu.cn

实验室链接

---

宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
研究方向:
海洋电能细胞合成生物学与生物制药实验室 e-Cells SynBio (Synthetic Biology Laboratory of Electroactive Cells and Biopharmaceuticals)


本实验室以海洋电能细胞为主要研究对象，开展半导体合成生物学和“光-电遗传学”的基础理论研究，及在海洋能源与环境、生物制药领域的工程应用研究。具体研究内容为：
（一） 光电遗传学：
利用半导体合成生物学、和基因线路设计方法，构建光-电控制的智能电能细胞，调控“细胞-酶-材料”表界面动力学过程，实现海洋微生物发电和微生物电合成等应用。研究内容包括：（1）海洋微生物电池：；利用光-电遗传学、半导体合成生物学、基因线路设计理论，揭示海洋菌群的“物质-能量代谢”系统互作机制，构建电能细胞，实现高效“化学能-电能”的能量转化。（2）微生物光-电合成：构建"细胞-材料"人工光合系统，实现可再生电能（和光能）驱动微生物 CO₂生物还原固定、和定向合成高附加值化学品和燃料；光-电驱动微生物高效固氮。（3）合成微生物生态系统：应用于海洋环境，生物医学。
（二）生物制药与营养品生产：
利用合成生物学、代谢工程理论和方法，设计构建微生物细胞进行高效药物生物合成，酶催化不对称药物的生物转化。本实验室正在开发的核心产品系列：维生素（VK2，VB12等），甜味剂，甾体药物，糖尿病治疗药物，抗菌抗病毒药物，单克隆抗体等医药品和营养品；并与制药公司合作，实现这些医药品生产过程的放大，优化和产业化生产。

Education:
The University of Houston:Department of Chemical & Biomolecular Engineering,Ph.D. in Chemical Engineering, 2004,Advisor: Prof. Dan Luss (member of the National Academy of Engineering, USA)

Nankai University：Department of Chemistry, 1994, B.S. in Chemistry

Working Experience:

Tianjin University: School of Chemical Engineering and Technology, Professor,2013-now
Nanyang Technological University (Singapore): 2009-2013, School of Chemical & Biomedical Engineering,Assistant Professor
Duke University:Research Associate (Synthetic Biology),2006-2009,Supervisor: Prof. Lingchong You
The University of Texas Medical School:Postdoc (Systems & Computational Neurobiology), 2004-2006, Supervisor: Prof. John H. Byrne


研究生（博士生、硕士生）招生：
本实验室每年有多名博士生、和硕士生的招生名额。欢迎有志于科研，在生物化学、分子生物学，生物化工、制药、化学、材料等相关专业的同学申请。有意向，请直接电邮联系：hsong@tju.edu.cn
请务必注意报考填报专业：
博士生报考专业：生物化工专业（博士生）。

硕士生报考专业：制药工程专业（学硕、或专硕）、合成生物学专业（学硕）。

与美国杜克大学、加州大学、得克萨斯大学、新加坡南洋理工大学、新加坡国立大学等国外著名研究型学府和研究所，建立了长期密切合作关系，为学生提供了大量的出国交流、联合培养的机会。优秀学生，还可推荐到大型企业、上市公司和研究所的工作机会。
副教授、助理教授（讲师）、博士后招聘：
国内外著名大学取得博士学位，有志于在合成生物学、代谢工程、生物化学、分子生物学、酶催化、材料等领域开展高水平研究的申请人，欢迎申报。相关待遇将按照天津大学相关职位执行，待遇优厚。请直接电邮联系：hsong@tju.edu.cn

实验室链接

---

宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
讲授课程:
本科生课程：
（1）《合成生物学导论》
（2）《基因线路》
研究生课程：
（1）《基因线路》
（2）《制药工程前沿研究专题》
（3）《英文科技论文写作》



实验室链接

---

宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
学术兼职:
中国生物工程学会 合成生物学专业委员会－ 副主任
担任“合成生物学”领域，如下重要国际、国内学术期刊的编委会成员、或者副主编：

《Frontiers in Bioengineering and Biotechnology》, Associate Editor of Synthetic Biology, 2019-
《Advanced Biosystems》, International Advisory Board，2016-
《Engineering》, 客座编辑
《Engineering Biology》,The Institution of Engineering and Technology (IET, UK), Associate Editor，2016-
《Journal of Functional Biomaterials》, Editorial Board，2013-
《化学工业与工程》编委
《MarineLife Science & Technology》，Editorial Board, 2019-
《Frontiers in Microbiology（Microbial Physiology and Metabolism）》, Review Editor
《Frontiers in Bioengineering and Biotechnology（Process and Industrial Biotechnology）》, Review Editor


ad hoc Peer-reviewer for Journals：
Angewandte Chemie International Edition
Energy & Environmental Science
Metabolic Engineering
ACS Nano
ACS Catalysis
ACS Applied Materials & Interfaces
Environmental Science & Technology Letters (ACS)
Energy and Fuels (ACS)
Journal of Physical Chemistry （ACS）
Industrial & Engineering Chemistry Research (ACS)
Small
Chemical Engineering Science
Nanoscale (RSC)
RSC-Polymer Chemistry
Electrochimica Acta
Electrochemistry Communications
Biotechnology and Bioengineering
Bioresource Technology
Biotechnology Journal
International Journal of Hydrogen Energy
PLoS Computational Biology
Bioinformatics
Metabolomics
Journal of Theoretical Biology
Bulletin of Mathematical Biology
Journal of Biological Engineering
Biochemical Engineering Journal
Industrial Biotechnology
Frontiers in Microbiology
OMICS-An Integrative Biology
Fuel
Desalination
Journal of Chemical Science and Technology (JCST)
Chinese Journal of Chemical Engineering
Mathematical Biosciences
International Journal of Molecular Sciences
Sensors







实验室链接

---

宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
学术成就:
宋浩，天津大学化工学院教授、博士生导师。入选国家中青年科技创新领军人才，国家青年特聘专家，天津市创新人才推进计划“重点领域创新团队”负责人。科技部合成生物学重点研发专项首席科学家，中国生物工程学会合成生物学专业委员会副主任。2004年，获得美国休斯顿大学化学工程博士学位；2004-2009年，在美国得克萨斯大学、和杜克大学从事合成生物学博士后研究；2009-2013年，在新加坡南洋理工大学任助理教授；2013年在天津大学化工学院任教授至今。现任制药工程系系主任。研究方向是合成生物学和电能细胞，侧重电能细胞设计构建、及在能源环境领域的工业应用。并利用合成生物学和代谢工程方法，设计构建微生物细胞进行高效药物生物合成，酶催化不对称药物的生物转化，开发包括多种维生素，甜味剂，甾体，多肽药物，单克隆抗体等营养品、医药品的生物合成与产业化放大研究。近几年主持承担了多项国家级项目，包括国家合成生物学“重点研发专项”（首席科学家）、重大“863”、科技委、国家自然科学基金、国家海洋局等项目等，总计8500多万元。在合成生物学相关领域发表SCI文章100多篇，包括Nature Chemical Biology、Nature Communications、Angewandte Chemie Int Ed、Energy & Environmental Science、Nano Energy、Chemical Society Reviews等本领域重要核心期刊。


实验室链接

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宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
科研项目:
主持承担10多项国家级、省部级科研项目： 主持承担科技部“合成生物学”重点研发专项、科技委、重大863项目、973子课题、国家基金委、国家海洋局、以及多项大型制药公司项目10多项，近5年累计主持承担科研经费共计8500多万元。其中，代表性项目包括：
1、国家重点研发专项（科技部）：电能细胞合成生物学（首席科学家），1996万元
2、国家高技术研究发展计划（科技部“863”计划）：能源与医药产品模块化设计合成， 3810万元
3、国家自然科学基金：希瓦氏菌电子传递途径改造实现，80万元
4、科技部“973” 计划项目子课题：微生物多细胞体系的设计与合成，100万元
5、国家海洋局：高效微生物采油技术和装备开发及产业化示范，728万元
6、国家青年特聘专家：合成生物学，300万元
7、大型企业联合研发项目：如中化健康（青岛）、赤峰制药、扬州联澳制药等


实验室链接

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宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
论著专利:


代表性论文（Representative publications）:
Feng Li#, Yuanxiu Li#, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi, Hao Song*, “Modular engineering to increase intracellular NAD(H/⁺) promotes rate of extracellular electron transfer of Shewanella oneidensis”, Nature Communications,(2018) 9:3637. DOI: 10.1038/s41467-018-05995-8.
Hao Song, S. Payne, M. Gray, Lingchong You*. “Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem”, Nature Chemical Biology, 5, 929–935 (2009).
Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bingzhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Liwi, Hong Liu, Baode Sun, Heming Xu, Jiamei zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Hao Song*, Yingjin Yuan*. “A three-species microbial consortium for power generation”, Energy & Environmental Science, 2017, 10, 1600--1609.
Tong Lin, Wenqi Ding,Liming Sun,Lei Wang, Chen-Guang Liu, Hao Song*, “Engineered Shewanella oneidensis-reduced graphene oxide biohybrid with enhanced biosynthesis and transport of flavins enabled a highest bioelectricity output in microbial fuel cells”,Nano Energy,50 (2018) 639–648.
Tong Lin#, Xue Bai#, Yun Yang, Jingyu Wang, Yidan Hu, Bingzhi Li, Ying-Jin Yuan, Hao Song*, “Synthetic Saccharomyces cerevisiae-Shewanella oneidensis consortium enables glucose-fed microbial fuel cell”, AIChE Journal，2017, 63(6):1830-1838.
Yang-Chun Yong, Yang-Yang Yu, Xinhai Zhang, Hao Song*. “Highly Active Bidirectional Electron Transfer by a Self-Assembled Electroactive Reduced-Graphene-Oxide-Hybridized Biofilm", Angewandte Chemie International Edition, 53, 4480-4483 (2014).
Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan*. "Synthetic microbial consortia: from systematic analysis to construction and applications", Chemical Society Reviews, 43, 6954-6981 (2014).
Chen Xiaoli#, Cao Yingxiu#, Li Feng#, Tian Yao,Hao Song*, “Enzyme-Assisted Microbial Electrosynthesis of Poly(3-hydroxybutyrate) via CO2 Bioreduction by EngineeredRalstonia eutropha”,ACS Catalysis,2018,8, 4429-4437.
Yingxiu Cao＃, Xiaofei Li＃, Feng Li, Hao Song*, “CRISPRi-sRNA: transcriptional-translational regulation of extracellular electron transfer of Shewanella oneidensis“, ACS Synthetic Biology, DOI: 10.1021/acssynbio.6b00374, 2017 in press.
Feng Li; Yuanxiu Li; Liming Sun; Xiaofei Li; Changji Yin; Xingjuan An; Xiaoli Chen; Yao Tian; Hao Song*, “Engineering Shewanella oneidensis enables Xylose-fed Microbial Fuel Cell”, Biotechnology for Biofuels, 2017,10: 196.
Yang-Chun Yong＃, Xiao-Cheng Dong＃, Mary B. Chan-Park, Hao Song*, Peng Chen*. “Macroporous and monolithic anode based on polyaniline hybridized three-dimensional graphene for high-performance microbial fuel cells”, ACS Nano, 6 (3), 2394–2400 (2012).
Yun Yang, Yichao Wu, Yidan Hu, Yingxiu Cao, Poh Chueh Loo, Cao Bin*, Hao Song*. “Engineering electrode-attached microbial consortia for high-performance xylose-fed microbial fuel cell”, ACS Catalysis, 5 (11), 6937–6945 (2015).
Yun Yang, Yuanzhao Ding, Yidan Hu, Bin Cao, Scott A. Rice, Staffan Kjelleberg, Hao Song*. "Enhancing bidirectional electron transfer of Shewanella oneidensis by a synthetic flavin pathway", ACS Synthetic Biology,4 (7), 815–823 (2015).
Ting Liu, Yang-yang Yu, Xiao-peng Deng, Chun Kiat Ng, Bin Cao, Jing-Yuan Wang, Scott Rice, Staffan Kjelleberg,Hao Song*. "EnhancedShewanellabiofilm promotes bioelectricity generation",Biotechnology & Bioengineering, 112, 2051–2059 (2015).
Yidan Hu, Yun Yang, Evgeny Katz,Hao Song*. "Programming Quorum Sensing-based AND Gate inShewanella oneidensisfor logic gated-Microbial Fuel Cells”,Chemical Communications, 51, 4184-4187 (2015).
Shaomei Yang, Yingxiu Cao, Liming Sun, Congfa Li, Xue Lin, Zhigang Cai, Guoyin Zhang,Hao Song*, “Modular pathway engineering ofBacillus subtilisto promote de novo biosynthesis of menaquinone-7”,ACS Synthetic Biology,2019, 8(1), 70-81.
Shaomei Yang, Yong-Ping Wang, Zhigang Cai, Guoyin Zhang,Hao Song*,“Metabolic Engineering ofBacillus subtilisfor High-Titer Production of Menaquinone-7”,AIChE Journal,2020: 66:e16754.



Peer-reviewed publications
2020 Yang Shaomei, Yong-Ping Wang, Zhigang Cai, Guoyin Zhang, Hao Song*, “Modular Engineering of Bacillus subtilis for High-Titer Production of Menaquinone-7”, AIChE Journal, 2020: 66:e16754.
Jinhua Zhang, Yanshu Zhao, Yingxiu Cao, Zhenpeng Yu, Guoping Wang, Yiqun Li, Xiaoqiong Ye, Congfa Li, Xue Lin, and Hao Song*, “Synthetic sRNA-Based Engineering of Escherichia coli for Enhanced Production of Full-Length Immunoglobulin G”, Biotechnology Journal 2020, 15, **.
Jinhua Zhang, Yanshu Zhao, Yingxiu Cao, Zhenpeng Yu, Guoping Wang, Yiqun Li, Xiaoqiong Ye, Congfa Li, Xue Lin, and Hao Song*, “sRNA-Based Screening Chromosomal Gene Targets and Modular Designing Escherichia coli for High-Titer Production of Aglycosylated Immunoglobulin G”, ACS Synthetic Biology, 2020, 9, 6, 1385-1394.
Zhang Jinhua#, Zhao Yanshu#, Hao Song*, “Multi-enzyme pyruvate removal system to enhance (R)-selective reductive amination of ketone”, RSC Advances, 2020, 10, 28984–28991.
Sun, Hong#, Jingli Yang, Jingli#, Lin, Xue; Li, Congfa; He, Yongjin; Cai, Zhigang; Zhang, Guoyin; Song, Hao*, “de novo high-titer production of delta-tocotrienol in recombinant Saccharomyces cerevisiae”, Journal of Agriculture and Food Chemistry, 2020, 68, 29, 7710-7717.
Hong Sun, Jingli Yang, Hao Song*, “Engineering mycobacteria artificial promoters and ribosomal binding sites for enhanced sterol production”, Biochemical Engineering Journal, 2020, 162, **.
Hong Sun, Kun He, Yong-Ping Wang, Yingxiu Cao, Zhenpeng Yu, Guoping Wang, Yiqun Li, Xiaoqiong Ye, Hao Song*, “Modular engineering of Mycobacteria for high-titer production of 9α-hydroxyandrostene 4-ene-3,17-dione from phytosterols”, Chemical Engineering Science 返修中
Yao Tian#, Yinuo Zhou#, Yongchao Zong, Jiansheng Li, Nan Yang, Mai Zhang, Zhiqi Guo, Hao Song*, “Construction of Functionally Compartmental Inorganic Photocatalyst-Enzyme System via Imitating Chloroplast for Efficient Photoreduction of CO2 to Formic Acid”, ACS Applied Materials and Interfaces, 2020, 12, 34795-34805.
Huan Yu#, Ziying Gong#, Junqi Zhang, Li Feng*, Hao Song*, “Bidirectional electron transfer-driven chemicals biosynthesis”, Systems and Synthetic Biology, 2020, 5: 304-313.
Jiansheng Li#, Yao Tian#, Yinuo Zhou, Yongchao Zong, Nan Yang, Mai Zhang, Zhiqi Guo, Hao Song*, “Abiotic-Biological Hybrid Systems for CO2 Conversion to Value-Added Chemicals and Fuels“, Transactions of Tianjin University (in press)
Yao Tian#, Yongchao Zong#, Yinuo Zhou, Jiansheng Li, Nan Yang, Mai Zhang, Zhiqi Guo, and Hao Song*, “Thiophene-Conjugated Porous C3N4 Nanosheets for Boosted Photocatalytic Nicotinamide Cofactors Regeneration to Facilitate Solar-to-Chemical Enzymatic Reactions”, Transactions of Tianjin University（in press)
Bo‐Yu Geng, Lian‐Ying Cao, Feng Li, Hao Song, Chen‐Guang Liu*, Xin‐Qing Zhao and Feng‐Wu Bai, “Potential of Zymomonas mobilis as an electricity producer in ethanol production”, Biotechnology for Biofuels, 2020, 13: 36.
Yuan Yu, Aamir Rasool, Haoran Liu, Bo Lv, Pengcheng Chang, Hao Song, Ying Wang*, Chun Li*, “Engineering Saccharomyces cerevisiae for high yield production of α-amyrin via synergistic remodeling of α-amyrin synthase and expanding the storage pool”, Metabolic Engineering, (in press)
Longsheng Zhang?, Haiyang Yuan?, Liping Wang, Hui Zhang, Yijing Zang, Yao Tian, Yunzhou Wen, Fenglou Ni, Hao Song, Haifeng Wang*, Bo Zhang*, and Huisheng Peng*, ”The critical role of electrochemically-activated adsorbates in neutral OER”, SCIENCE CHINA Materials （in press)
赵妍淑#，张金华#，宋浩*，“工程原核生物和酵母菌中生产单克隆抗体和抗体片段的研究进展”, 《中国生物工程杂志》（in press）
杨景丽, 孙鸿，宋浩*, “维生素E生物合成的相关进展和现状”, 《科学通报》(in press)
徐静, 由紫暄，张君奇，吴德光， 李锋*，宋浩*，“合成生物学改造电活性生物膜的研究进展”, 《化工学报》(李春教授邀稿）（in press）
陈媛媛#，张保财#，李锋*，宋浩*，“产电微生物的筛选方法研究进展”，《生物工程学报》（in press）
丁倩，曹英秀，李锋，林童，陈媛媛，陈正，宋浩*，““共轭聚合物-产电菌”复合生物电极构建及其在微生物燃料电池中的应用”，《生物工程学报》（in press）
周一诺#，杨楠#，田瑶, 宗永超, 李建圣, 张劢, 郭之旗, 宋浩*，“基于辅酶的光驱动酶催化体系”，《科学通报》（in press）
刘向#，张君奇#，吴德光，李锋*，宋浩*， “强化电能细胞-电极界面作用的研究进展”，《生物工程学报》（in press）
Lixia Fang, Jie Fan, Congya Wang, Yingxiu Cao* and Hao Song*, “Systematic and genome-wide targets identification to engineer Escherichia coli for high-titer production of free fatty acids”, 返修中
Xue Bai#, Tong Lin#, Nan Liang, Bing-Zhi Li, Hao Song*, Ying-Jin Yuan*, “Engineering synthetic microbial consortium to efficiently convert glucose and xylose co-substrates into electricity power”,submitted
Guizhu Wu, Yan Zhang, Jingyu Sun, Xue Chen, Ze Zhang, Guichang Wang*, Mingyang Liu*, Hao Song*, “Bi metal doping regulating concentrations of oxygen vacancy on BiOBr nanoflowers for antibiosis of high activity through photodynamic therapy”, submitted
Wang, Zhenyang#; Hong, Jiefang#; Ma, Siyuan; Huang, Tong; Ma, Yuanyuan*; Liu, Wei; Liu, Wenbin; Liu, Zhiming; Song, Hao*，”Heterologous expression of EUGT11 from Oryza sativa in Pichia pastoris for highly efficient one-pot production of rebaudioside D from rebaudioside A”,submitted
Zhenyang Wang#, Wenbin Liu#, Wei Liu#, Yuanyuan Ma*, Hao Song*, “Co-immobilized recombinant glycosyltransferases efficiently convert Rebaudioside A to M in cascade”, submitted
Enze Zhou#, Feng Li#, Ziyu Li#, Dake Xu*, Zhong Li, Ru Jia, Yuting Jin, Hao Song*, Dawei Zhang*, Xiaogang Li, Tingyue Gu, Johannes M.C. Mol, Fuhui Wang, Jessica A. Smith, Derek R. Lovley, “Bidirectional extracellular electron transfer during accelerated microbiologically influenced corrosion of stainless steel”, submitted



2019
Shaomei Yang, Yingxiu Cao, Liming Sun, Congfa Li, Xue Lin, Zhigang Cai, Guoyin Zhang, Hao Song*, “Modular pathway engineering of Bacillus subtilis to promote de novo biosynthesis of menaquinone-7”, ACS Synthetic Biology, 2019, 8(1), 70-81.
Ying-Xiu Cao, Meng-yuan Song, Congfa Li, Xue Lin, Hao Song*，”Development of Synthetic Gene Toolkit of Shewanella oneidensis MR-1”, Frontiers in Microbiology, March 2019 | Volume 10 | Article 410. (doi: 10.3389/fmicb.2019.00410)
Feng Li#, Xingjuan An#, Deguang Wu, Jing Xu, Yuanyuan Chen, Wenchao Li, Yingxiu Cao, Xuewu Guo, Xue Lin, Congfa Li, Sixin Liu,Hao Song*, “Engineering microbial consortia for high-performance cellulosic hydrolyzates-fed microbial fuel cells”, Frontiers in Microbiology, March 2019 | Volume 10 | Article 409. (doi: 10.3389/fmicb.2019.00409)
Ziyin Zhang, Feng Li, Yingxiu Cao, Hong Sun, Yao Tian, Zhenpeng Yu, Guoping Wang, Yiqun Li, Xiaoqiong Ye,Hao Song*,“Electricity-driven P450 Enzyme-catalyzed 7α-hydroxylation of steroid in engineered yeast”,Catalysis Science & Technology,2019,9,4877–4887. (Journal Front Cover)
Jialin Meng#, Yao Tian#, Xiaohui Wu, Yinuo Zhou, Jiansheng Li, Nan Yang,Yongchao Zong, and Hao Song*, “Thiophene-Modified Doubleshell Hollow g-C3N4 Nanosphere Boosts NADH Regeneration via Synergistic Enhancement of Charge Excitation and Separation”, Catalysis Science & Technology,2019, 9, 1911 - 1921.
Cong-Ya Wang#, Ying-Xiu Cao#, Yong-Ping Wang, Li-Ming Sun,Hao Song*, “CRISPRi to systematically identify crucial genes in amino acids metabolism for enhanced surfactin biosynthesis in engineeredBacillus subtilis”，Microbial Cell Factories, (2019) 18:90.
Mingzhu Ding, Biqiang Chen, Xiaojun Ji, Jingwen Zhou, Huiyuan Wang, Xiwei Tian, Xudong Feng, Hua Yue, Yongjin Zhou, Hailong Wang, Jianping Wu, Pengpeng Yang, Yu Jiang, Xuming Mao, Gang Xiao, Cheng Zhong, Wenhai Xiao, Bingzhi Li, Lei Qin, Jingsheng Cheng, Mingdong Yao, Ying Wang, Hong Liu, Lin Zhang, Linling Yu, Tao Chen, Xiaoyan Dong, Xiaoqiang Jia, Songping Zhang, Yanfeng Liu, Yong Chen, Kequan Chen, Jinglan Wu, Chenjie Zhu, Wei Zhuang, Sheng Xu, Pengfei Jiao, Lei Zhang, Hao Song, Sheng Yang, Yan Xiong, Yongquan Li, Youming Zhang, Yingping Zhuang, Haijia Su, Weiping Fu, Yingming Huang, Chun Li, Zongbao K. Zhao, Yan Sun, Guo-Qiang Chen, Xueming Zhao, He Huang, Yuguo Zheng, Lirong Yang, Zhiguo Su, Guanghui Ma, Hanjie Ying, Jian Chen,Tianwei Tan and Yingjin Yuan*, “Biochemical engineering in China”, Reviews in Chemical Engineering, 2019. DOI:https://doi.org/10.1515/revce-2017-0035
XuetingHe#, TingliXue#, YuanyuanMa*, JunyanZhang, ZhiquanWang, JiefangHong, LanfengHui, JianjunQiao, HaoSongand MinhuaZhang, “Identification of functional butanol-tolerant genes from Escherichia coli mutants derived from error-prone PCR-based whole genome shuffling”, Biotechnology for Biofuels,2019, 12:73.
Cong?Cong Jin#, Jin?Lai Zhang#, Hao Song, and Ying?Xiu Cao* “Boosting the biosynthesis of betulinic acid and related triterpenoids in Yarrowia lipolytica via multimodular metabolic engineering”, Microbial Cell Factories, (2019) 18:77.

2018 Feng Li#, Yuanxiu Li#, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi, Hao Song*, “Modular engineering to increase intracellular NAD(H/⁺) promotes rate of extracellular electron transfer of Shewanella oneidensis”,Nature Communications,(2018) 9:3637. DOI: 10.1038/s41467-018-05995-8.
Tong Lin, Wenqi Ding,Liming Sun,Lei Wang, Chen-Guang Liu, Hao Song*, “Engineered Shewanella oneidensis-reduced graphene oxide biohybrid with enhanced biosynthesis and transport of flavins enabled a highest bioelectricity output in microbial fuel cells”,Nano Energy,50 (2018) 639–648.
Chen Xiaoli#, Cao Yingxiu#, Li Feng#, Tian Yao,Hao Song*, “Enzyme-Assisted Microbial Electrosynthesis of Poly(3-hydroxybutyrate) via CO2 Bioreduction by EngineeredRalstonia eutropha”,ACS Catalysis,2018,8, 4429-4437.
Li, Feng＃; Li, Yuanxiu＃; Sun, Li-ming; Chen, Xiaoli; An, Xingjuan; Yin, Changji ; Cao, Yingxiu; Wu, Hui;Song, Hao*. “Modular engineering intracellular NADH regeneration boosts extracellular electron transfer ofShewanella oneidensisMR-1”,ACS Synthetic Biology,2018.7(3): 885–895.
Feng Li, Lei Wang, Chenguang Liu, Deguang Wu,Hao Song*,”Engineering exoelectrogens by synthetic biology strategies”,Current Opinion in Electrochemistry,2018, 10: 37-45.
Shiqin Yu＃, Bin Lai＃, Manuel R. Plan, Mark P. Hodson, Endah A. Lestari, Hao Song, Jens O. Kr?mer*, “Improved performance of Pseudomonas putida in a bioelectrochemical system through overexpression of periplasmic glucose dehydrogenase”, Biotechnology and Bioengineering, 2018, 115(1):145-155.
Yang-Yang Yu, Zhen Fang, Lu Gao, Hao Song, Liang Yang, Baodong Mao, Weidong Shi, Yang-Chun Yong*^,“Engineering of bacterial electrochemical activity with global regulator manipulation”, Electrochemistry Communications, 2018, 86: 117–120.
Kun He, Hong Sun,Hao Song*, “Engineering phytosterol transport system inMycobacteriumsp. strain MS136 enhances production of 9α-hydroxy-4-androstene-3,17-dione”,Biotechnology Letters,2018, 40(4), 673-678.
SuzhenHuang, TingliXue, ZhiquanWang, YuanyuanMa*, XuetingHe, JiefangHong, ShaolanZou,HaoSong*, MinhuaZhang, “Furfural-tolerantZymomonas mobilisderived from error-prone PCR-based whole genome shuffling and their tolerant mechanism”,Applied Microbiology and Biotechnology, 2018, 102 (7): 3337-3347.
Yuan Yu, Pengcheng Chang, Huan Yu, Huiyong Ren, Danning Hong, Zeyan Li, Ying Wang, Hao Song, Yixin Huo*, Chun Li*, “Productive Amyrin Synthases for Efficient α-Amyrin Synthesis in Engineered Saccharomyces cerevisiae”, ACS Synthetic Biology, 2018, 7 (10), pp 2391–2402.

2017 Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bingzhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Liwi, Hong Liu, Baode Sun, Heming Xu, Jiamei zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang,Hao Song*, Yingjin Yuan*. “A three-species microbial consortium for power generation”,Energy & Environmental Science, 2017, 10, 1600-1609.(Journal Back Cover)
Yingxiu Cao＃, Xiaofei Li＃, Feng Li,Hao Song*, “CRISPRi-sRNA: transcriptional-translational regulation of extracellular electron transfer ofShewanella oneidensis“,ACS Synthetic Biology,2017,6 (9):1679.
Feng Li, Yuanxiu Li, Liming Sun, Xiaofei Li, Changji Yin, Xingjuan An, Xiaoli Chen, Yao Tian,Hao Song*, “EngineeringShewanella oneidensisenables Xylose-fed Microbial Fuel Cell”,Biotechnology for Biofuels, 2017,10: 196.
Tong Lin＃, Xue Bai＃, Yun Yang, Jingyu Wang, Yidan Hu, Bingzhi Li, Ying-Jin Yuan,Hao Song*, “SyntheticSaccharomyces cerevisiae-Shewanella oneidensisconsortium enables glucose-fed microbial fuel cell”,AIChE Journal，2017, 63(6):1830-1838.
Feng Li＃, Changji Yin＃, Yuanxiu Li, Xuewu Guo,Hao Song* , “SyntheticKlebsiella pneumoniae-Shewanella oneidensisconsortium enablesglycerol-fed high-performance microbial fuel cells”,Biotechnology Journal, 2017, in press
Yiyuan Wang＃, Yingxiu Cao＃, Yuanxiu Li,Jiayu Jin, Jinliang Li,Hao Song*，“Asymmetric biosynthesis of intermediates of anti-HIV drugs: A recent progress”,Tetrahedron: Asymmetry, 2017, 28: 745-757.

2016 Tran Chien Dang,Yuan Yin,Yangyang Yu, Dinh-Tuan Phan, Chun Yang, Bin Cao*,Hao Song*, Yuejun Kang*,“A Membrane-free Microfluidic Microbial Fuel Cell for Rapid Characterization of Exoelectrogenic Bacteria”,Microfluidics and Nanofluidics,(2016) 20: 144.
Ting Liu, Yang-yang Yu, Dongzhe Li,Hao Song, Xiaoli Yan, Wei Ning Chen*.“The effect of external resistance on biofilm formation and internal resistance inShewanellainoculated microbial fuel cells”,RSC Advances, 2016, 6, 20317-20323.


2015 Yun Yang, Yichao Wu, Yidan Hu, Yingxiu Cao, Poh Chueh Loo, Cao Bin*,Hao Song*. “Synthetic bacterial consortium for high-performance microbial fuel cell using xylose as carbon source”,ACS Catalysis,2015,5(11), pp 6937–6945.
Yun Yang,Yuanzhao Ding,Yidan Hu,Bin Cao,Scott A. Rice,Staffan Kjelleberg,Hao Song*. "Enhancing bidirectional electron transfer ofShewanella oneidensisby asynthetic flavin pathway",ACS Synthetic Biology,4 (7), 815–823 (2015).
Ting Liu, Yang-yang Yu, Xiao-peng Deng, Chun Kiat Ng, Bin Cao, Jing-Yuan Wang, Scott Rice, Staffan Kjelleberg,Hao Song*. "EnhancedShewanellabiofilm promotes bioelectricity generation",Biotechnology & Bioengineering, 112, 2051–2059 (2015).Highlighted in the Journal’s Spotlight feature.
Yidan Hu, Yun Yang, Evgeny Katz,Hao Song*. "Programming Quorum Sensing-based AND Gate inShewanella oneidensisfor logic gated-Microbial Fuel Cells”,Chemical Communications, 51, 4184-4187 (2015).
Yangchun Yong*, Xiang-Yang Wu, Jian-Zhong Sun, Ying-Xiu Cao, Hao Song*. "Engineering quorum sensing signaling of Pseudomonas for enhanced wastewater treatment and electricity harvest: A review", Chemosphere, 140, 18–25 (2015).
Yu Yangyang, Guo Chunxian, Yong Yangchun, Li Changming, Hao Song*. "Nitrogen doped carbon nanoparticles enhanced extracellular electron transfer for high-performance microbial fuel cells anode", Chemosphere, 140, 26–33 (2015).
Ming-Hua Shen, Hao Song, Bing-Zhi Li*, Ying-Jin Yuan. “Deletion of d-ribulose-5-phosphate 3-epimerase (RPE1) induces simultaneous utilization of xylose and glucose in xylose-utilizing Saccharomyces cerevisiae”, Biotechnology Letters, 37(5), 1031-1036 (2015).

2014 Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan*. "Synthetic microbial consortia: from systematic analysis to construction and applications", Chemical Society Reviews, 43, 6954-6981 (2014).
Yang-Chun Yong, Yang-Yang Yu, Xinhai Zhang, Hao Song*. “Highly Active Bidirectional Electron Transfer by a Self-Assembled Electroactive Reduced-Graphene-Oxide-Hybridized Biofilm", Angewandte Chemie International Edition, 53, 4480-4483 (2014).
Robert Smith, Cheemeng Tan, K. Riccione, Anand Pai, Hao Song, Lingchong You*. “Programmed Allee effect in bacteria causes a tradeoff between population spread and survival”, Proceedings of National Academy of Sciences USA (PNAS), 111 (5), 1969-1974 (2014).
Huiqing Chong, Hefang Geng,Hongfang Zhang, Hao Song, Lei Huang, Rongrong Jiang*. "Enhancing E. coli isobutanol tolerance through engineering its global transcription factor cAMP receptor protein (CRP)", Biotechnology & Bioengineering, 111(4): 700–708 (2014).
Jian Zha, Ming-Hua Shen, Meng-Long Hu,Hao Song, Ying-Jin Yuan*. “Enhanced expression of genes involved in initial xylose metabolism and the oxidative pentose phosphate pathway in the improved xylose-utilizingSaccharomyces cerevisiaethrough evolutionary engineering”,Journal of Industrial Microbiology & Biotechnology,41(1):27-39 (2014).
Qian Ma, Yang Zou, Ya-jin Lv, Hao Song, Ying-Jin Yuan*. “Comparative Proteomic Analysis of Experimental Evolution of the Bacillus cereus-Ketogulonicigenium vulgare Co-Culture”, PLOS One, 9(3): e91789 (2014).
Mingzhu Ding, Zou Yang, Hao Song, Ying-Jin Yuan*. "Metabolomic Analysis of Cooperative Adaptation between Co-Cultured Bacillus cereus and Ketogulonicigenium vulgare", PLOS One, 9(4): e94889 (2014).

2013 Y. Yong, Z. Cai, Y. Yu, P. Chen, RR Jiang, B. Cao, J-Y Wang, H. Song*. “Increase of riboflavin biosynthesis underlies enhancement of extracellular electron transfer of Shewanella in alkaline microbial fuel cells”, Bioresource Technology, 130, 763-768 (2013).
Y. Yong, Y. Yu, Y. Yang, J. Liu, J-Y Wang, H. Song*. "Enhancement of extracellular electron transfer and bioelectricity output by synthetic porin", Biotechnology and Bioengineering, 110 (2): 408-416 (2013).
T. Nguyen, Y. Yu, X. Wang, J.-Y. Wang, H. Song*. “3D Mesoporous Polysulfone-Carbon Nanotube Anode for Enhanced Bioelectricity Output in Microbial Fuel Cells“, Chemical Communications, 49, 10754-10756 (2013).
Y. Yong*, Z. Liao, J. Sun, T. Zheng, R.R. Jiang, H. Song*. "Enhancement of Coulombic Efficiency and Salt Tolerance in Microbial Fuel Cells by Graphite/Alginate Granules Immobilization of Shewanella oneidensis MR-1", Process Biochemistry, 48, 1947-1951 (2013).
C. Ng, K. Sivakumar, X. Liu, M. Madhaiyan, L. Ji, L. Yang, C. Tang, H. Song, S. Kjelleberg, Bin Cao*. “Influence of Outer Membrane c-type Cytochromes on Particle Size and Activity of Extracellular Nanoparticles Produced by Shewanella oneidensis”, Biotechnology and Bioengineering, 110(7):1831-7 (2013).
Chun Kiat Ng, Tian Kou Cai Tan, Hao Song, Bin Cao*. "Reductive Formation of Palladium Nanoparticles by Shewanella oneidensis: Role of Outer Membrane Cytochromes and Hydrogenases", RSC Advances, 3 (44), 22498-22503, (2013).
V. Wang, S. Chua, B. Cao, E. Marsili, S. Kjelleberg, T. Tolker-Nielsen, M. Givskov, H. Song, J. Loo, Liang Yang*. “Engineering PQS biosynthesis pathway for enhancement of bioelectricity production in Pseudomonas aeruginosa microbial fuel cells”, PLOS One, 8(5): e63129 (2013).
J. Du, W. Bai, H. Song, Y-J Yuan*. “Combinational expression of sorbose/sorbosone dehydrogenases and cofactor pyrroloquinoline quinone increases 2-keto-gulonic acid production in Ketogulonigenium vulgare-Bacillus cereus consortium”, Metabolic Engineering, 19, 50-56 (2013).
Y. Zou, M. Hu, Y. Lv, Y. Wang, H. Song, Y-J Yuan*. “Enhancement of 2-keto-gulonic acid yield by serial subcultivation of co-cultures of Bacillus cereus and Ketogulonigenium vulgare”, Bioresource Technology, 132:370-3 (2013).
J. Zha, BZ Li, M. Shen, ML Hu, H. Song, Y-J Yuan*. “Optimization of CDT-1 and XYL1 Expression for Balanced Co-Production of Ethanol and Xylitol from Cellobiose and Xylose by Engineered Saccharomyces cerevisiae”, PLOS One, 8(7): e68317 (2013).
Ivy Wang; Jian Wei Yeow,; Hongfang Zhang, Hao Song, Rongrong Jiang*. “Improving ethanol tolerance of Escherichia coli by rewiring its global regulator cAMP receptor protein (CRP)”, PLOS One, 8(2): e57628 (2013).
Huiqing Chong, Jianwei Yeow, Ivy Wang, Hao Song, Rongrong Jiang*. “Improving acetate tolerance of Escherichia coli by rewiring its global regulator cAMP receptor protein (CRP)”，PLOS One, October 2013 | Volume 8 | Issue 10 | e77422.
T. Phan, P. Saraf, A. Kiparissides, A. Mantalaris, H. Song, Mayasari Lim*. “An in silico erythropoiesis model rationalizing synergism between stem cell factor and erythropoietin”, Bioprocess and Biosystems Engineering, 36(11), 1689-1702 (2013).


2012及之前 Y. Yong, X. Dong, M.B. Chan-Park, H. Song*, P. Chen*. “Macroporous and monolithic anode based on polyaniline hybridized three-dimensional graphene for high-performance microbial fuel cells”, ACS Nano, 6 (3), 2394–2400 (2012).
J. Liu, Y. Yong, H. Song*, C.M. Li*. “Activation enhancement of citric acid cycle to promote bioelectrocatalytic activity of ArcA knockout Escherichia coli toward high-performance microbial fuel cell”, ACS Catalysis, 2, 1749-1752 (2012).
Y. Yong, Y. Yu, Y. Yang, C.M. Li, RR Jiang, X. Wang, J-Y Wang, H. Song*. “Increasing intracellular releasable electrons dramatically enhances bioelectricity output in microbial fuel cells”, Electrochemistry Communications, 19, 13-16 (2012).
专著 H. Song*, L. You. “Modeling spatiotemporal dynamics of bacterial populations” (Chapter 11, page 243-254), Computational Modeling of Signaling Networks: Methods and Protocols, Methods in Molecular Biology, Vol. 880, Edited by Liu, Xuedong; Betterton, Meredith D., Humana Press (2012), ISBN 978-1-61779-832-0. (Book Chapter)
J. Liu, Y. Qiao, Z. Lu, H. Song, C.M. Li*. “Enhance electron transfer and performance of microbial fuel cells by perforating the cell membrane”, Electrochemistry Communications, 15 (1), 50-53 (2012).
J. Liu, Y. Qiao, C. Guo, S. Lim, H. Song, C.M. Li*. “Graphene/carbon cloth anode for high-performance mediatorless microbial fuel cells”, Bioresource Technology, 114, 275–280 (2012).
J. Du, J. Zhou, J. Xue, H. Song, Y-J Yuan*. “Metabolomic profiling elucidates community dynamics of the Ketogulonicigenium vulgare-Bacillus megaterium consortium”, Metabolomics, 8 (5), 960-973 (2012).
H. Zhang, H. Chong, C. Ching, H. Song, RR Jiang*. "Engineering Global Transcription Factor Cyclic AMP Receptor Protein for Improved 1-Butanol Tolerance", Applied Microbiology and Biotechnology, 94, 1107–1117 (2012).
S. Basak, H. Song, RR Jiang*. “Error-prone PCR of Global Transcription Factor Cyclic AMP Receptor Protein for Enhanced Organic Solvent (Toluene) Tolerance”, Process Biochemistry, 47(12), 2152-2158 (2012).
Y. Yan, L. Zhang, X. Qi, Hao Song, J-Y Wang, Hua Zhang, Xin Wang*. “Template-Free Pseudomorphic Synthesis of Tungsten Carbide Nanorods”, Small, 8 (No. 21), 3350–3356 (2012).
X. Dong, J. Wang, Hao Song, X. Li, L. Wang, MB Chan-Park, Peng Chen*. “Synthesis of a MnO₂-graphene foam hybrid with controlled MnO₂ particle shape and its use as supercapacitor electrode”, Carbon, 50, 4865-4870 (2012).
X. Dong, X. Wang, L. Wang, Hao Song, H. Zhang, W. Huang, P. Chen*. “3D graphene foam as a monolithic and macroporous carbon electrode for electrochemical sensing”, ACS Applied Materials & Interfaces, 4(6), 3129-3133 (2012).
DT Dam, KD Nam, Hao Song, Xin Wang, J-M Lee*. “Partially oxidized titanium carbonitride as a non-noble catalyst for oxygen reduction reactions”, International Journal of Hydrogen Energy, 37(20), 15135-15139 (2012).
Y. Yu, H. Chen, Y. Yong, D. Kim*, H. Song*. "Conductive artificial biofilm dramatically enhances bioelectricity production in Shewanella-inoculated microbial fuel cells”, Chemical Communications, 47, 12825-12827 (2011).
Y. Yong, Y. Yu, C.M. Li, JJ Zhong, H. Song*. “Bioelectricity enhancement via overexpression of quorum sensing system in Pseudomonas aeruginosa-inoculated microbial fuel cells”, Biosensors and Bioelectronics, 30, 87-92 (2011).
H. Song*, S. Payne, C. Tan, L. You. “Programming microbial population dynamics by engineered cell-cell communication”, Biotechnology Journal, 6, 837-849 (2011).
J. Zhou, Q. Ma, H. Yi, L. Wang, H. Song, YJ Yuan*. "Metabolome profiling reveals metabolic cooperation between Bacillus megaterium and Ketogulonigenium vulgare during induced swarm motility", Applied and Environmental Microbiology, 77, 7023-7030 (2011).
H. Song, S. Payne, M. Gray, L. You. “Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem”, Nature Chemical Biology, 5, 929–935 (2009).
F. Balagadde, H. Song, J. Ozaki, C. H. Collins, M. Barnet, F. H. Arnold, S. R. Quake, L. You. “A synthetic Escherichia coli predator-prey ecosystem”, Molecular Systems Biology, 2008, 4:187. doi: 10.1038/msb.2008.24. Faculty 1000 recommended; highlighted by Nature Reviews Genetics (Vol. 9, 417, June 2008).
C. Smith, H. Song, L. You. “Signal discrimination by differential regulation of protein stability in quorum sensing”, Journal of Molecular Biology, 382, 1290-1297 (2008).
J. Wong, H. Song, L. You. “A whole more than the sum of its synthetic parts”, ACS Chemical Biology, 3(1): 27 (2008).
Cheemeng Tan, Hao Song, J. Niemi, Lingchong You. “A synthetic biology challenge: making cells compute”, Molecular Biosystems, 3: 343 – 353 (2007).
Hao Song, Cheemeng Tan, Lingchong You. “Living Computers”, RSC Chemical Biology, 2: B31 (2007).
Hao Song, P. Smolen, E. Av-Ron, D. Baxter, John H. Byrne. “Dynamics of a Minimal Model of Interlocked Positive and Negative Feedback Loops of Transcriptional Regulation by CREB Proteins”, Biophysical Journal,92: 3407-3424 (2007).
Hao Song, P. Smolen, E. Av-Ron, D. Baxter, John H. Byrne. “Bifurcation and Singularity Analysis of a Molecular Network for the Induction of Long-Term Memory”, Biophysical Journal,90:2309-2325 (2006).
Hao Song, Lingchong You. “Evolving sensitivity”, ACS Chemical Biology, 1(11):681 (2006).
P. Hamillton, H. Song, Dan Luss. “Design of dual-site supported metallocene catalysts for synthesis of bimodal polyolefins”, AIChE Journal 53:687-694 (2007).
Hao Song, Dan Luss. “Bounds on operating conditions leading to melting during olefin polymerization”, Industrial & Engineering Chemistry Research, 43(2):270-282 (2004).
Hao Song, Dan Luss. “Impact of Initiation and Deactivation on Melting during Gas-Phase Olefin Polymerization”, Industrial & Engineering Chemistry Research, 43(16):4789-4795 (2004).
Y. Li, H. Song, et al. “New chaotic behavior and its effective control in Belousov–Zhabotinsky reaction”, Canadian Journal of Chemistry, 79:29-34 (2001).
H. Song, Y. Li, et al. “Controlling Belousov-Zhabotinsky-continuous stirred tank reactor chaotic chemical reaction by discrete and continuous control strategies”, Phys. Chem. Chem. Phys., 1:813-819 (1999).
H. Song, Z. Cai, et al. “A new method to the control of chemical chaos–nonlinear artificial neural network (ANN) and occasional perturbation feedback control in the whole chaotic region”, Science in China - Series B: Chemistry, 42:624-630 (1999).
H. Song, et al., “Experimental controlling Belousov-Zhabotinsky CSTR chemical chaotic reaction”, ACTA CHIMICA SINICA, 57(10): 1047 (1999).




















实验室链接

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宋　浩现任职称/职务：教授，博士生导师／制药工程系（系主任）
通讯地址：天津大学化工学院，天津大学北洋园校区54楼E座263，天津海河教育园区
电子邮箱：hsong@tju.edu.cn
办公电话：
合作交流: 与美国杜克大学、加州大学、得克萨斯大学等、新加坡南洋理工大学、新加坡国立大学等国外著名研究型学府和研究所，建立了长期密切合作关系，为学生提供了大量的出国交流、联合培养的机会。优秀学生，还可推荐到大型企业、上市公司和研究所的工作机会。

国内外会议、交流报告：
宋浩，“电能细胞设计与合成”, 第五届合成生物学青年****论坛，中国科学院天津工业生物技术研究所－天津大学联合主办，2019年8月17-18日，天津滨海空港经济区，天津。
宋浩，“电能细胞设计与合成”，研究生“创客学堂“项目之生命科学论坛（2019），东北大学生命科学与健康学院，2019年6月28日，东北大学浑南校区图书馆报告厅，沈阳。
宋浩，“电能细胞设计与合成”，工业生物催化教育部重点实验室，清华大学化工系，2019.05.22，北京。
宋浩，“合成生物学工程改造电能细胞双向电子传递系统 ”，中国生物工程学会第十二届学术年会暨2018年全国生物技术大会，中国生物工程学会合成生物学专业委员会（筹）揭牌仪式暨合成生物学研讨会，2018.11.11，湖南长沙。
Hao Song, “Engineering intracellular and extracellular electron pathways for cellular energy metabolism”, Nature Conferences: Synthetic Biology – Resource Allocation in Natural and Unnatural Systems, hosted by The Institute of Plant Physiology & Ecology, SIBS, CAS, Nature Communications, Shanghai Jiao Tong University, and East China University of Science and Technology, October 15-17, 2018, Citic Pacific Zhujiajiao Jin Jiang Hotel, Shanghai, China.
Hao Song, “Engineering Electron Transfer Pathways of Exoelectrogens: Synthetic Biology Meets Energy and the Environment”, 2017 China-America Frontiers of Engineering (CAFOE) Symposium, 中国工程院主办，Shanghai, China, June 22-24, 2017.
Workshop “Global Challenges: Scoping future collaborative opportunities”, UK Centre for Mammalian Synthetic Biology, School of Biological Sciences, The University of Edinburgh, March 22-23, 2017, Edinburgh.
Hao Song, “Engineering electron transfer pathways of exoelectrogens: synthetic biology meets energy and environments”, Metabolic Science: DrivingBioindustryand Beyond, International Conference on Metabolic Science (ICMS 2016) www.icms-sjtu.org, Nanjiao hotel, Shanghai, October 20-23, 2016.
Hao Song, “Engineering electron transfer pathways of exoelectrogens: synthetic biology meets energy and environments”, Cold Spring Harbor Asia Conference on Synthetic Biology, Organised by Cold Spring Harbor Asia (CSH Asia), November 28 – December 2, 2016, Suzhou, China.
宋浩，“工程微生物胞外电子传递系统——合成生物学在能环境能源中的应用”， 第八届工业生物技术高峰论坛（The 8th China Summit Forum on Industrial Biotechnology Development), 天津空港经济区中心大道55号，2015年12月11-12。
Hao Song, “Engineering Extracellular Electron Transfer Pathways: Synthetic Biology Meets Energy and Environments”, The 2nd Chinese-German Workshop on Biotechnology in a Bioeconomy (CGW-BTBE 2015), Nanjing Tech University（南京工业大学）, Nanjing, September 14, 2015.
Hao Song, “Engineering Extracellular Electron Transfer Pathways: Synthetic Biology Meets Energy and Environments”, 2015 Metabolic Engineering and Green Manufacturing in Microorganisms, Beijing University of Chemical Technology (北京化工大学), Beijing, July 8-11, 2015.
Hao Song, “Engineering Extracellular Electron Transfer Pathways: Synthetic Biology Meets Energy and Environments”, Synthetic Biology Young Scholar Forum (SynBioYSF,合成生物学青年****论坛), Tsing Hua University（清华大学）, Beijing, May 23, 2015.
Hao Song, “Engineering Extracellular Electron Transfer Pathways: Synthetic Biology Meets Energy and Environments”, International Conference on Clean Energy & Advanced Materials (ICCEAM), November 14-17, 2014, Southwest University（西南大学），Chongqing, China.
Hao Song, "Engineering bacterial extracellular electron transfer pathways–Synthetic biology meets bioenergy and environments", UK- Singapore workshop on Synthetic Biology, jointed organized by UK Science and Innovation Network (SIN) based at the British High Commission in Singapore, and organized in partnership with National University of Singapore (NUS) and Nanyang Technological University(NTU), Biopolis, February 18 - 19, 2014.
Hao Song, "Engineering bacterial extracellular electron transfer pathways – A synthetic biology application in bioenergy and environments", NTU-UIUC Food Science and Technology Symposium, School of Biological Sciences, Nanyang Technological University (NTU), Singapore, January 20-21 2014.
H. Song, “Engineering bacterial extracellular electron transfer pathways”, 2013 Sino-USA Chinese Collaborative Workshop—Opportunities and Challenges in Synthetic Biology (SUCC SynBio 2013, 中美合成生物学研讨会2013), Tianjin University, Tianjin, June 21-22, 2013.
H. Song, “Engineering cell-electrode interactions to enhance extracellular electron transfer in microbial electrochemical systems”, International Conference on Cellular & Molecular Bioengineering (ICCMB3), Singapore, December 8-10, 2012.
H. Song, “Engineering extracellular electron transfer pathways and electroactive biofilms: Synthetic biology meets environments and energy”, 2012 Sino-USA Chinese Collaborative Workshop—Opportunities and Challenges in Synthetic Biology (SUCC SynBio 2012), Tianjin University, Tianjin, China, August 1-4, 2012.
H. Song, “Enhancement of extracellular electron transfer and bioelectricity production in microbial fuel cells by synthetic porin”, The International Symposium on Exploring the Frontiers of Chemical and Biochemical Engineering (SCBE 2012), Tsinghua University, Beijing, China, May 6-7, 2012.
H. Song, “Engineering electroactive biofilms: synthetic biology meets environments and energy”, The NTU-Imperial College Symposium on Synthetic Biology, Singapore, April 20, 2012.
H. Song, “Rewiring intracellular metabolic flux enhances extracellular electron transfer in microbial fuel cells”, Sino-Singapore symposium on functional nanomaterials and bioelectronics (S3NBE 2011), Nanjing, China, November 12-15, 2011.
H. Song, “Synthesizing Microbial Ecosystems via Engineering Cell-Cell Communication”, International Symposium of Synthetic Biology (ISSB), Singapore, October 18, 2010.
H. Song, S. Payne, M. Gray, L.C. You, “Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem”, Summit on Systems Biology 2009, The Microbial World and Beyond, Richmond, Virginia, June 16-19, 2009.
H. Song, M. Gray, L.C. You, “Spatiotemporal modulation of biodiversity in a synthetic predator-prey ecosystem”, AIChE Annual Conference, Philadelphia, PA, November 2008.
H. Song, L. You, “Engineering multicellular spatiotemporal dynamics by a synthetic predator-prey ecosystem”. 2nd Annual Duke Systems Biology Symposium. Duke University, 20-21 September 2007.
H. Song, J.H. Byrne, “Bifurcation and singularity analysis of a signal transduction and gene regulatory network underlying the induction and long-term memory”, 2nd North American Symposium on chemical reaction engineering (NASCRE-2), February 4-7, 2007, Houston, TX.
H. Song, J.H. Byrne, “ Nonlinear dynamics of minimal models of interlocked positive and negative feedback loops of transcriptional regulation by CREB proteins: deterministic and stochastic analysis”, Mathematics in chemical and biochemical kinetics and engineering (MACKiE-2), February, 8, 2007, Houston, TX.
H. Song, P. Smolen, E. Av-Ron, D. Baxter, J.H. Byrne, “Nonlinear dynamics of a minimal model of interlocked positive and negative feedback loops of CREBs: deterministic and stochastic analysis”, Society for Neuroscience (SfN-2006), Annual conference-2006, October 14-18, Atlanta, GA.
H. Song, E. Av-Ron, D. Baxter, J.H. Byrne, “Steady state bifurcation analysis and dynamic simulation of a molecular network underlying the induction and memory”, 22nd Annual Houston Conference on Biomedical Engineering Research (ASEMB 2005), The University Hilton Hotel, University of Houston, February 10-11, 2005.


实验室链接