姓　名 范真真
职　称 副教授
所在系别 生物医学工程系
电子邮件 zhenzhen.fan@tju.edu.cn
办公地址 天津大学17楼220
主讲课程
导师类型 生物医学工程——硕导
通讯地址 天津大学精密仪器与光电子工程学院
邮政编码 300072

个人经历或学术经历
2014.6月至今 天津大学精仪学院生物医学工程系，副教授
（2016-2018 在美国密歇根大学做访问****）
2013.3-2014.4 中国科学院声学研究所，工程师
2012.01-2012.10 美国密歇根大学生物医学工程系，博士后
2012年获得美国密歇根大学生物医学工程系，博士学位
2008年获得美国密歇根大学生物医学工程系，硕士学位
2006年获得上海交通大学生物医学工程系，学士学位。


研究方向
1. 生物医学超声；
2. 药物和基因导入技术；
3. 细胞力学；
4. 干细胞生物学；
5. 生物微纳制造。


主持的科研项目
1. “超声镊诱导干细胞分化：技术革新及机理研究” 天津市自然科学基金重点项目（2019.04-2022.03），资助金额20万元。
2. “细胞外基质的物理特性对超声导入技术发生机理及效果的影响”国家自然科学基金面上项目（2019.01-2022.12），资助金额78.8万元。
3.“细胞外基质的物理特性影响超声导入的若干物理问题” 中国科学院声学研究所声场声信息国家重点实验室开放课题（2019.01-2020.12），资助金额7万元。
4.“细胞基质的刚性对超声介导的药物和基因导入技术发生机理及效果的影响”中国科学院声学研究所声场声信息国家重点实验室开放课题（2017.01-2018.12），资助金额8万元。
5. “在单细胞水平超声和靶向微泡转基因的动态过程研究” 国家自然科学基金青年基金（2016.01-2018.12），资助金额28万元。


论文（*通讯作者，#共同第一作者）
期刊论文：
1. Ning Rong, Meiru Zhang, Yulin Wang, Hao Wu, Hui Qi, Xing Fu, Dachao Li, Chunmei Yang, Yan Wang, Zhenzhen Fan*, “Effects of extracellular matrix rigidity on sonoporation facilitated by targeted microbubbles: bubble attachment, bubble dynamics, and cell membrane permeabilization”, Ultrasonics sonochemistry, 2020, (影响因子7.3)
2. Tugba Topal#, Zhenzhen Fan#, Laura Y. Deng, Paul H. Krebsbach, Cheri X Deng, “Integrin-targeted cyclic forces accelerate neural tube-like formation from human embryonic stem cells.” Advanced biosystem, 2019.
3. Ning Rong, Hao Zhou, Mingru Liu, Yan Wang, Zhenzhen Fan*, “Ultrasound and microbubble mediated plasmid DNA uptake: A fast, global and multi-mechanisms involved process. ”Journal of Controlled Release, 2018. 273: p. 40-50, (SCI一区，影响因子7.6)
4. Zhenzhen Fan#, Xufeng Xue#, Reshani Perera, Sajedeh Nasr Esfahani, Agata A. Exner, Jianping Fu and Cheri X Deng, “Acoustic actuation of integrin-bound microbubbles for mechanical phenotyping during differentiation and morphogenesis of human embryonic stem cells,” Small 2018 (SCI一区，影响因子9.6)
5. Tugba Topal#, Xiaowei Hong#, Xufeng Xue, Zhenzhen Fan, Ninad Kanetkar, Joe T Nguyen, Jianping Fu, Cheri X Deng*, and Paul H Krebsbach*, “Acoustic tweezing cytometry induces rapid initiation of human embryonic stem cell differentiation”, Scientific Reports, Article number 12977, published 28 Aug 2018 (影响因子4.3)
6. Zhenzhen Fan, Di Chen, and Cheri X Deng, “Characterization of the dynamic activities of a population of microbubbles driven by pulsed ultrasound exposure in sonoporation”, Ultrasound in Medicine and Biology, 2014 40(6) 1260-1272, (影响因子2.3)
7. Zhenzhen Fan, Ronald E Kumon, and Cheri X Deng, “Mechanisms of microbubble-facilitated sonoporation for drug and gene delivery”, Therapeutic Delivery, 2014 5(4), 467-486
8. Zhenzhen Fan, Di Chen, and Cheri X. Deng, “Improving ultrasound gene transfection efficiency by controlling ultrasound excitation of microbubbles”, Journal of Controlled Release 2013 170(3) 401-413, (SCI一区，影响因子7.6)
9. Zhenzhen Fan#, Yubing Sun#, Di Chen#, D Tay, W Chen, Cheri X. Deng, and Jianping Fu, “Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton”, Scientific Reports, Article number 2176, published 12 July 2013, (2014年SCI一区，影响因子5.2)
10. John P. Frampton#, Zhenzhen Fan#, Arlyne Simon#, Di Chen, Cheri X. Deng, and Shuichi Takayama, “Aqueous Two‐Phase System Patterning of Microbubbles: Localized Induction of Apoptosis in Sonoporated Cells”, Advanced Functional Materials, 2013 23(27) 3420-3431, (SCI一区，影响因子10.2)
11. Zhenzhen Fan, Haiyan Liu, Michael Mayer, and Cheri X. Deng, “Spatiotemporally controlled single cell sonoporation,” Proceedings of the National Academy of Sciences of the United States of America 2012 109 (41) 16486-16491 (SCI一区，影响因子9.7)
12. Zhenzhen Fan, Ronald E. Kumon, Juyoung Park, and Cheri X. Deng, “Intracellular delivery and calcium transients generated in sonoporation facilitated by microbubbles,” Journal of Controlled Release 2010 142(1) 31-39 (SCI一区，影响因子7.6).
13. Juyoung Park, Zhenzhen Fan, Ronald E. Kumon, Mohamed E.H. El-Sayed, and Cheri X. Deng, “Modulation of intracellular Ca2+ concentration in brain microvascular endothelial cells in vitro by acoustic cavitation,” Ultrasound in Medicine and Biology 2010 36(7) 1176-1187 (影响因子2.3).
14. Juyoung Park, Zhenzhen Fan, and Cheri X. Deng, “Effects of shear stress cultivation on cell membrane disruption and intracellular calcium concentration in sonoporation of endothelial cells,” Journal of Biomechanics 2010 44(1) 164-169 (影响因子 2.5).
15. Jifeng Zhang#, Luis Villacorta#, Lin Chang#, Zhenzhen Fan, Milton Hamblin, Tianqing Zhu, Chen S. Chen, Marsha P. Cole, Francisco J. Schopfer, Cheri X. Deng, Minerva T. Garcia-Barrio, Ying-Hong Feng, Bruce A. Freeman and Y. Eugene Chen, “Nitro-Oleic Acid Inhibits Angiotensin II–Induced Hypertension,” Circulation Research 2010 107(4) 540-548 (SCI一区，影响因子9.5).
16. Zhen Xu, Zhenzhen Fan, Timothy L. Hall, Frank Winterroth, J. Brian Fowlkes and Charles A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound in Medicine and Biology 2009 35(2) 245-255 (影响因子2.3).
近期国内、国际学术会议报告：
1. 荣宁、汪曣、范真真*，“超声微泡介导的质粒转染机理的实验研究”，2018年全国声学大会，北京（2018年11月）（口头学术报告形式已录用）
2. Ning Rong, Yan Wang, and Zhenzhen Fan*, “Dynamics and mechanisms of ultrasound and microbubble facilitated intracellular plasmid DNA uptake”, 2018 IEEE International Ultrasonics Symposium, Kobe, Japan (Oct 2018) (口头学术报告形式已录用)
3. Ning Rong, Ruming Liu, Hao Zhou, Yan Wang and Zhenzhen Fan*, “Dynamic of plasmid DNA intracellular uptake facilitated by ultrasound and targeted microbubbles”, the 2017 International Symposium of Therapeutic Ultrasound, Nanjing, China (May 2017)
4. Cheri X. Deng and Zhenzhen Fan, “To improve the outcomes of intracellular delivery by microbubble-facilitated sonoporation,” the 161th Meeting of the Acoustical Society of America, Seattle, Washington, United State (May 2011).
5. Zhenzhen Fan and Cheri X. Deng, “Targeted microbubble facilitated sonoporation for high efficiency delivery to mammalian cells,” 2010 IEEE International Ultrasonics Symposium, San Diego, California, United State (Oct. 2010).
6. Zhenzhen Fan, Juyoung Park, Ronal E. Kumon and Cheri X Deng, “Sonoporation outcome correlated with time-resolved measurements of microbubble dynamics”, the 9th International Symposium of Therapeutic Ultrasound, Aix en Provence, France (Sep. 2009)
7. Kun Yang, Yun Zhou, Zhenzhen Fan, Jingyong Ye and Cheri X Deng, “Dynamic measurements of the generation and trapping of bubbles by a self-focused femtosecond laser beam”, 2008 IEEE International Ultrasonics Symposium, Beijing, China (Nov.2008)