姓 名

郭浩然

职 称

讲师


所在系/团队

微生物与免疫系
研究领域

病毒与宿主相互作用
Email

sheng315640@163.com
教育经历

2010.9-2013.6 中国吉林大学第一临床医学院生物化学与分子生物学专业 博士

2007.9-2009.7 中国吉林大学药学院药物化学专业 硕士

2003.9-2007.7 中国吉林大学药学院药学专业 本科
代表性论文及科研成果

1.Wei Wei?,Haoran Guo?,Xue Han,Xianjun Liu,Xiaohong Zhou,Wenyan Zhang,Xiao-Fang Yu*.A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest[J]. Cellular Microbiology,2012,14(11):1745-1756.

2.Haoran Guo?, Wei Wei?, Zhenhong Wei?, Xianjun Liu, Sean L. Evans, Weiming Yang,Hong Wang, Ying Guo, Ke Zhao, Jian-Ying Zhou, Xiao-Fang Yu*.Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation[J]. Plos One, 2013,8(7):e66201.

3. Wei Wei, Haoran Guo, Xianjun Liu, Hong Zhang, Lei Qian, Kun Luo,Richard Markham and Xiao-Fang Yu* .A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in

myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation[J].Journal of Virology, Online published: http://www.ncbi.nlm.nih.gov/pubmed/**.

4. Wei Wei, Haoran Guo, Qimeng Gao, Richard Markham and Xiao-Fang Yu*.Variation of two primate lineage-specific residues in human SAMHD1 confer resistance to N-terminus targeted SIV Vpx proteins[J].Journal of Virology, Online published: http://www.ncbi.nlm.nih.gov/pubmed/**.