姓名
王银松
职称
教授
所在部门
药学院
研究方向
纳米医学药剂学


办公室
药学院B楼202
办公电话
022-
**
电子邮箱
wangyinsong@tmu.edu.cn

教育背景

1993/9-1997/7， 沈阳药科大学， 药物分析专业，本科
2000/9-2003/7， 中国海洋大学， 药物化学专业，硕士
2003/9-2006/7， 中国医学科学院/北京协和医学院， 生物医学工程，博士

工作经历

1997/7-2000/8，青岛海尔药业，助理工程师
2006/8-2010/10，天津医科大学，药学院，讲师
2010/11-2015/10，天津医科大学，药学院，副教授
2015/11-至今，天津医科大学，药学院，教授
2010/1-2012/12，天津医科大学，博士后

研究成果（本人具有代表性的论著、论文及主持的科研项目）

论文
1.Guoyun Wan, Bowei Chen, Ling Li a, Dan Wang, Shurui Shi, Tao Zhang, Yue Wang, Lianyun Zhang, Yinsong Wang*. Nanoscaled red blood cells facilitate breast cancer treatment by combining photothermal/photodynamic therapy and chemotherapy. Biomaterials, 2018;155:25–40. SCI IF: 8.402.
2.Yuanyuan Liu, Linan Qiao, Sipei Zhang, Guoyun Wan, Bowei Chen, Ning Zhang*, Yinsong Wang*. Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immune- therapy and chemotherapy. Acta Biomater, DOI: 10.1016/j.actbio.2017.11.010. SCI IF: 6.319.
3.Yang Liu, Guoyun Wan, Huo Guo, Yuanyuan Liu, Ping Zhou, Hemei Wang, Dan Wang, Sipei Zhang, Yinsong Wang*, Ning Zhang*. A multifunctional nanoparticle system combines sonodynamic therapy and chemotherapy to treat hepatocellular carcinoma. Nano Research, 2017;10(3):834–855. SCI IF: 7.354.
4.Yue Wang, Guoyun Wan, Zhiyuan Li, Shurui Shi, Bowei Chen, Chunyu Li, Lianyun Zhan*, Yinsong Wang*. PEGylated doxorubicin nanoparticles mediated by HN-1 peptide for targeted treatment of oral squamous cell carcinoma. Int J Pharm, 2017;525:21–31. SCI IF: 3.649.

5.Xinghua Liu, Chunhui Gao, Junheng Gu, Wei Gao, Jingwei Fu, Yinsong Wang*, Xiaoying Yang*. Hyaluronic acid stabilized iodine-containing nanoparticles with Au nanoshell coating for X?ray CT imaging and photothermal therapy of tumors. ACS Appl Mater Interfaces, 2016;8:27622?27631. SCI IF: 7.504.
6.Cong Zhang, Tong An, Dan Wang, Guoyun Wan, Mingming Zhang, Hemei Wang, Sipei Zhang, Rongshan Li, Xiaoying Yang, Yinsong Wang*. Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma. J Control Release, 2016;226:193–204. SCI IF: 7.786.
7.Hemei Wang, Guoyun Wan, Yuanyuan Liu, Bowei Chen, Ning Zhang*, Yinsong Wang*. Dual-responsive nanoparticles based on oxidized pullulan and a disulfide-containing poly(β-amino) ester for efficient delivery of genes and chemotherapeutic agents targeting hepatoma. Polym Chem, 2016;7:6340–6353. SCI IF: 5.375.
8.Tong An, Cong Zhang, Xue Han, Guoyun Wan, Dan Wang, Zhe Yang, Yue Wang, Lianyun Zhang, Wang Yinsong*. Hyaluronic acid-coated poly(b-amino) ester nanoparticles as carrier of doxorubicin for overcoming drug resistance in breast cancer cells. RSC Adv, 2016;6:38624–38636. SCI IF: 3.108.
9.Yan Wang, Yuanyuan Liu, Yang Liu, Wen Zhou, Hemei Wang, Guoyun Wan, Duxin Sun, Ning Zhang*, Yinsong Wang*. A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma. Int J Pharm, 2015;483:89–100. SCI IF: 3.649.
10.Ping Zhou, Tong An, Chuan Zhao, Yuan Li, Rongshan Li, Rui Yang, YinsongWang*, Xiujun Gao*. Lactosylated PLGA nanoparticles containing e-polylysine for the sustained release and liver-targeted delivery of the negatively charged proteins. Int J Pharm, 2015;478:633–643. SCI IF: 3.649.
11.Yu Ren, Ruirui Wang, Yang Liu, Huo Guo, Xuan Zhou, Xubo Yuan, Chaoyong Liu, Jianguo Tian, Haifang Yin, Yinsong Wang*, Ning Zhang*. A hematoporphyrin-based delivery system for drug resistance reversal and tumor ablation. Biomaterials, 2014;35:2460–2470. SCI IF: 8.402.

12.Yuanyuan Liu, Yan Wang, Cong Zhang, Ping Zhou, Yang Liu, Tong An, Duxin Sun, Ning Zhang*, Yinsong Wang*. Core-shell nanoparticles based on pullulan and poly(β-amino) ester for hepatoma-targeted codelivery of gene and chemotherapy agent. ACS Appl Mater Interfaces, 2014;6:18712–18720. SCI IF: 7.504.
13.Yinsong Wang*, Yang Liu, Yuanyuan Liu, Yan Wang, Jing Wu, Rongshan Li, Jinrong Yang, Ning Zhang*. pH-sensitive pullulan-based nanoparticles for intracellular drug delivery. Polym Chem, 2014;5:423–432. SCI IF:5.375.
14.Huo Guo, Yuanyuan Liu, Yan Wang, Jing Wu, Xiaoying Yang, Rongshan Li, Yinsong Wang*, Ning Zhang*. pH-sensitive pullulan-based nanoparticle carrier for adriamycin to overcome drug-resistance of cancer cells. Carbohydr Polym, 2014;111:908–917. SCI IF: 4.811.
15.Yinsong Wang*, Hongli Chen, Yuanyuan Liu, Jing Wu, Ping Zhou, Yan Wang, Rongshan Li, Xiaoying Yang, Ning Zhang*. pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma. Biomaterials, 2013;34:7181–7190. SCI IF: 8.402.
16.Yuanyuan Liu, Yi Luo, Jing Wu, Yinsong Wang*, Xiaoying Yang, Rui Yang, Baiqi Wang, Ning Zhang*. Graphene oxide can induce in vitro and in vivo mutagenesis. Scientific Reports, 2013;3: e3469. SCI IF: 4.259.
17.Jing Wu, Yinsong Wang*, Xiaoying Yang, Yuanyuan Liu, Jinrong Yang, Rui Yang, Ning Zhang*. Graphene oxide used as a carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology, 2012;23:355101. SCI IF: 3.440.
18.Yinsong Wang, Xiaoying Yang, Jinrong Yang, Yumei Wang, Rou Chen, Jing Wu, Yuanyuan Liu, Ning Zhang*. Self-assembled nanoparticles of methotrexate conjugated O-carboxymethyl chitosan: preparation, characterization and drug release behavior in vitro. Carbohydr Polym, 2011;86:1665–1670. SCI IF: 4.811.
19.Yinsong Wang, Shaoli Tu, Rongshan Li, Xiaoying Yang, Lingrong Liu, Qiqing Zhang. Cholesterol succinyl chitosan anchored liposomes: preparation, characterization, physical stability, and drug release behavior. Nanomedicine- NBM, 2010;6:471–477. SCI IF: 5.720.


20.Yinsong Wang, Qian Jiang, Rongshan Li, Linglong Liu, Qiqing Zhang*, Yumei Wan, Jing Zhao. Self-assembled nanoparticles of cholesterol-modified O-carboxymethyl chitosan as a novel carrier for paclitaxel. Nanotechnology, 2008;19:145101. SCI IF: 3.440.
21.Yinsong Wang, Lingrong Liu, Qiqing Zhang. Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O- carboxymethyl chitosan conjugates. Carbohydr Polym, 2007;69:597–606. SCI IF: 4.811.
22.Yinsong Wang, Qian Jiang, Lingrong Liu, Qiqing Zhang*. Interaction between bovine serum albumin and self-aggregated nanoparticles of cholesterol- modified O-carboxymethyl chitosan. Polymer, 2007;48:4135–4142. SCI IF: 3.648.
23.Yinsong Wang, Lingrong Liu, Qian Jiang, Qiqing Zhang*. Self-aggregated nanoparticles of cholesterol-modified chitosan conjugate as a novel carrier of epirubicin. Eur Polym J, 2007;43:43–51. SCI IF: 3.531.

科研项目
1.国家自然科学基金面上项目（No. **）：联合声动力、化疗与免疫疗法的多功能纳米治疗体系的构建及其靶向抗肝癌作用研究（2016.01--2019.12），68万，主持人。
2.国家自然科学基金面上项目（No. **）：双重响应的基因/化疗药物共载时序释放纳米递送体系靶向抗肝癌研究（2014.01--2017.12），70万，主持人。
3.“973”计划项目（No. 2011CB933100）：基于纳米技术的肝癌早期诊断的研究（2011.01--2015.12），2500万元，学术骨干。
4.国家自然科学基金青年基金项目（No. **）：一种用于肿瘤联合治疗的pH敏感纳米药物输送体系的研究（2010.01--2012.12），21万，主持人。
5.博士后基金特别资助（No. ）：细胞核靶向的pH敏感普鲁兰多糖纳米载体逆转肿瘤多药耐药的研究（2011.10-2013.10），10万，主持人。
6.博士后基金面上项目（No. ）：基于逆转肿瘤多药耐药的pH敏感普鲁兰多糖纳米载药体系的研究（2010.12-2012.12），3万，主持人。

荣誉奖励

天津市高校中青年骨干创新人才；天津医科大学“十三五”卓越人才PI；天津医科大学“十一五”新世纪优秀人才；天津市2013年度自然科学奖二等奖

其他事项

中国抗癌协会纳米肿瘤学专业委员会委员；中国生物材料学会纳米生物材料分会委员；天津药学会青年工作者委员会委员