陈曦 副教授
劳动卫生与环境卫生学系
陈曦，副教授，将环境内分泌干扰物和持久性有机污染物的健康影响作为主要研究方向，主持完成国家自然基金青年基金1项，主持完成天津市科委应用基础与前沿项目1项，发表相关SCI论文23篇，被纳入天津市“131”创新型人才培养工程第二层次人选，担任中华预防医学会环境卫生分会委员，中国毒理学会工业毒理学专业委员会委员，天津市预防医学会劳动卫生与职业病分会委员。
电子邮件 chenxi@tmu.edu.cn
研究方向
1. 环境内分泌干扰物(EDCs)和持久性有机污染物(POPs)的健康影响。2. 大气污染健康影响的队列研究和机制探索。
学习经历
1. 2009～2012年，天津医科大学，公共卫生学院流行病学与卫生统计学，博士学位。
2. 2006～2009年，天津医科大学，公共卫生学院劳动卫生与环境卫生学，硕士学位。
3. 2001～2006年，天津医科大学，公共卫生学院预防医学专业，学士学位。
工作经历
1. 2015.01～至今，天津医科大学，公共卫生学院，劳动卫生与环境卫生学习，副教授。
2. 2012.07～2014.12，天津医科大学，公共卫生学院，劳动卫生与环境卫生学习，讲师。
主要承担或参与的课题
1. 全氟化合物暴露对乳腺癌发生的影响及雌激素受体介导机制研究. 国家自然科学基金面上项目. **. 主持. 在研. 56万. 2020.01.01-2023.12.31
2.二噁英通过干扰线粒体相关蛋白影响人胎盘类固醇激素生成的机制初探，国家自然科学基金青年项目，**，2015.1-2017.12，已结题，主持。
3. 神经元与胶质细胞反馈调节在TCDD诱导神经毒性中的作用，天津市科委应用基础与前沿项目，14JCQNJC11300，2014.4-2017.3，已结题，主持。
4. 四溴双酚A影响人胎盘激素生成的线粒体干扰机制研究，中国博士后科学基金第61批面上项目一等资助，2017M610122，2017.5-2019.9，在研，主持。
5.EZH2介导二噁英影响ER阳性乳腺癌发生发展的表观遗传机制研究，国家自然科学基金面上项目，**，2016/01-2019/12，在研，参加
6. 大气污染对呼吸和心血管系统健康影响的早期识别技术，“十三五”国家重点研发计划“大气污染成因与控制技术研究”重点专项，2017YFC**；课题5：大气污染对呼吸和心血管系统影响的早期效应标志物人群验证， 2017YFC**，在研，参加
近五年发表文章
1. Shan A, Li M, Li X, Li Y, Yan M, Xian P, Chang Y, Chen X*, Tang NJ. BDE-47 decreases progesterone levels in BeWo cells by interfering with mitochondrial functions and genes related to cholesterol transport. Chem Res Toxicol. 2019 Feb 4. doi: 10.1021/acs.chemrestox.8b00312. [Epub ahead of print]
2. Zhang HJ, Liu YN, Xian P, Ma J, Sun YW, Chen JS, Chen X*,Tang NJ*. Maternal exposure to TCDD during gestation advanced sensory-motor development, but induced impairments of spatial learning and memory in adult male rat offspring. Chemosphere. 2018 Aug 23;212:678-686.
3. Chen X, Wang X, Huang JJ, Zhang LW, Song FJ, Mao HJ, Chen KX, Chen J, Liu YM, Jiang GH, Dong GH, Bai ZP, Tang NJ*. Nonmalignant respiratory mortality and long-term exposure to PM10 and SO2: A 12-year cohort study in northern China. Environ Pollut. 2017 Aug 30;231(Pt 1):761-767.
4. Chen X, Zhang LW, Huang JJ, Song FJ, Zhang LP, Qian ZM, Trevathan E, Mao HJ, Han B, Vaughn M, Chen KX, Liu YM, Chen J, Zhao BX, Jiang GH, Gu Q, Bai ZP, Dong GH, Tang NJ*. Long-term exposure to urban air pollution and lung cancer mortality: A 12-year cohort study in Northern China. Sci Total Environ. 2016 Nov 15;571:855-61.
5. Chen X, Chen JS, Zhang L, Li JG, Yao L, Self SG, Sun X, Tang NJ*. Levels of PCDDs, PCDFs and dl-PCBs in the blood of childbearing-aged women living in the vicinity of a chemical plant in Tianjin: A primary study. Chemosphere. 2015, 118: 1-4.
6. Chen X, Leng L, Yu H, Yang XL, Dong GH, Yue S, Chen JS, Tang NJ*. Psychological distress and dyslipidemia in chinese police officers: a 4-year follow-up study in Tianjin, China. J Occup Environ Med. 2015, 57(4):400-5.
7. Chen X, Zhou QH, Leng L, Chen X, Sun ZR, Tang NJ*. Effects of di(n-butyl) and monobutyl phthalate on steroidogenesis pathways in the murine Leydig tumor cell line MLTC-1. Environ Toxicol Pharmacol. 2013, 36(2):332-8.
8. Chen X, Liu YN, Zhou QH, Leng L, Chang Y, Tang NJ*. Effects of low concentrations of di-(2-ethylhexyl) and mono-(2-ethylhexyl) phthalate on steroidogenesis pathways and apoptosis in the murine leydig tumor cell line MLTC-1. Biomed Environ Sci. 2013, 26(12):986-9.
9. Chen X, Ma SW, Ma XM, Xu YJ, Tang NJ*. Changes in fibrinopeptide A peptides in the sera of rats chronically exposed to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Environ Toxicol Pharmacol. 2012, 33(2):191-6.
10. Chen X, Ma XM, Ma SW, Coenraads PJ, Zhang CM, Liu J, Zhao LJ, Sun M, Tang NJ*. Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). J Toxicol Environ Health A. 2009, 72(11-12):717-26.
11. Ma J, Chen X (Co-first Authors), Liu Y, Xie Q, Sun Y, Chen J, Leng L, Yan H, Zhao B, Tang N*. Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs.Toxicol Appl Pharmacol. 2015, 289(2):193-202.
12. Zhang LW, Chen X (Co-first Authors), Xue XD, Sun M, Han B, Li CP, Ma J, Yu H, Sun ZR, Zhao LJ, Zhao BX, Liu YM, Chen J, Wang PP, Bai ZP*, Tang NJ*. Long-term exposure to high particulate matter pollution and cardiovascular mortality: a 12-year cohort study in four cities in northern China. Environ Int. 2014, 62:41-7.
13. Dong GH, Zhang P, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and respiratory disease mortality in Shenyang, China: a 12-year population-based retrospective cohort study. Respiration. 2012, 84(5):360-8.
14. Bao J, Zeng XW, Qin XD, Lee YL, Chen X, Jin YH, Tang NJ, Dong GH*. Phthalate Metabolites in Urine Samples from School Children in Taipei, Taiwan. Arch Environ Contam Toxicol. 2015, 69(2):202-7.
15. Zhang P, Dong G, Sun B, Zhang L, Chen X,Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and mortality due to cardiovascular disease and cerebrovascular disease in Shenyang, China. PLoS One. 2011;6(6):e20827.
16. Liu J, Zhang CM, Coenraads PJ, Ji ZY, Chen X, Dong L, Ma XM, Han W, Tang NJ*. Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins. Toxicol Lett. 2011, 25;201(3):230-4.
17. Guo L, Peng C, Xu H, Wilson A, Li PH, Wang H, Liu H, Shen L, Chen X, Qi X, Tang NJ, Barrow TM, Byun HM. Age at menarche and prevention of hypertension through lifestyle in young Chinese adult women: result from project ELEFANT. BMC Womens Health. 2018 Nov 9;18(1):182.
18. Li C, Liu JC, Xiao X, Chen X, Yue S, Yu H, Tian FS, Tang NJ. Psychological distress and type 2 diabetes mellitus: a 4-year policemen cohort study in China. BMJ Open. 2017 Jan 27;7(1):e014235.
19. Yu H, Liu JC, Fan YJ, Li C, Zhang LX, Chen X, Yue S, Lu WL, Yang XL, Tang NJ. Association between occupational stressors and type 2 diabetes among Chinese police officers: a 4-year follow-up study in Tianjin, China. Int Arch Occup Environ Health. 2016 Feb;89(2):277-88.
20. Leng L, Chen X, Li CP, Luo XY, Tang NJ. 2,3,7,8-Tetrachlorodibezo-p-dioxin exposure and prostate cancer: a meta-analysis of cohort studies. Public Health. 2014 Mar;128(3):207-13.
21. Regazzoni LG, Grigoryan H, Ji Z, Chen X, Daniels SI, Huang D, Sanchez S, Tang N, Sillé FC, Iavarone AT, Williams ER, Zhang L, Rappaport SM. Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood. Toxicol Lett. 2017 Feb 15;268:26-35.
研究生培养情况
硕士生在读1名
招生专业
预防医学，劳动卫生与环境卫生学
社会兼职
中华预防医学会环境卫生分会委员
中国毒理学会工业毒理学专业委员会委员
获奖情况
2015年度天津市“131”创新型人才第二层次人才